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Asian summer monsoon responses to the change of land‒sea thermodynamic contrast in a warming climate:CMIP6 projections

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Advances in Climate Change Research 2022年第2期13卷 205-217页

作者： qing-yuan wu qing-Quan LI Yi-Hui DING Xin-Yong SHEN Meng-Chu ZHAO Yu-Xiang ZHU Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory on Climate and Environment ChangeNanjing University of Information Science&TechnologyNanjing 210044China bLaboratory for Climate Studies National Climate CentreChina Meteorological AdministrationBeijing 100081China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Training Centre China Meteorological AdministrationBeijing 100081China

It is of practical significance to use the updated Coupled Model Intercomparison Project Phase 6(CMIP6)models to study the impact of changes in land‒sea thermodynamic contrast(TC)on the Asian summer monsoon under different scenarios and to compare the similarities and differences of the impact mechanisms between different monsoon *** this study,we investigated future changes of the Asian summer monsoon under four Shared Socioeconomic Pathway(SSP)scenarios using 19 CMIP6 *** intensity of the South Asian summer monsoon(SASM)is projected to decrease by 2.6%,6.3%,10.1%,and 11.1%,while the East Asian summer monsoon(EASM)intensity is projected to increase by 4.6%,7.9%,7.4%,and 9.8%until the end of the 21st century for SSP126,SSP245,SSP370,and SSP585 scenarios,***,summer precipitation in Asia is projected to increase remarkably in 2015-2099 under all four *** inconsistent warming trends over the Tibetan Plateau(TP),Northwest Pacific,and tropical Indian Ocean would greatly impact the monsoon *** upper-troposphere warming trend over the surrounding oceans is remarkably greater than that over the TP,while the near-surface warming trend over the surrounding oceans is smaller than that over the *** decrease of upper-troposphere TC between the TP and tropical Indian Ocean results in a weakening of the SASM *** enhancement of the lower-troposphere TC between the TP and Northwest Pacific would strengthen the EASM *** budget analysis shows that the water-vapor would increase in the future,which would thermodynamically enhance summer precipitation through the anomalous vertical moisture transport associated with mean *** strengthening of the meridional circulation of the EASM would increase monsoon precipitation,while the weakening of zonal circulation of the SASM would dynamically reduce South Asian summer precipitation.

关键词： South Asian summer monsoon East Asian summer monsoon Land‒sea thermodynamic contrast Global warming CMIP6 projection

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Winter extreme precipitation over the Tibetan Plateau influenced by Arctic sea ice on interdecadal timescale

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Advances in Climate Change Research 2024年第4期15卷 42-51页

作者： qing-Quan LI Miao BI Song YANG qing-yuan wu Yi-Hui DING Xin-Yong SHEN Xiao-Ting SUN Meng-Chu ZHAO China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China CMA Key Open Laboratory of Transforming Climate Resources to Economy Chongqing Institute of Meteorological SciencesChongqing 401147China School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen University Zhuhai 519082China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

The Tibetan Plateau(TP)and the Arctic are the most sensitive regions to global climate ***,the interdecadal varibility of winter extreme precipitation over the TP and its linkage with Arctic sea ice are still *** this study,the characteristics and mechisnems of the TP extreme precipitation(TPEP)influenced by Arctic sea ice on interdecadal timescale are studied based on the daily precipitation,monthly sea ice concentration and ERA5 reanalysis data from 1980 to *** found that the dominant mode of the TPEP in winter mostly exhibits a uniform spatial variation on the interdecadal timescale,with an opposite weak variation in the southeastern TP,and the Arctic sea ice concentration(SIC)before 2002 are larger than that after *** interdecadal variation of TPEP is affected by two teleconnection wave trains regulated by the Barents and Kara Sea *** the light ice years,a remarkable positive geopotential height(HGT)anomaly appears over the Barents-Kara Sea and a remarkable negative HGT anomaly is located over the Lake *** wave trains originating over the Barents-Kara Sea can be *** southern branch forms a wave train through the North Atlantic along the subtropical westerly jet stream,showing a‘+-+-+'pattern of HGT anomalies from Arctic to the *** HGT anomaly controls the western TP,which creates dynamic and water vapor conditions for the *** northern branch forms a wave train through the Lake Baikal and the southeast of the TP,showing a‘+-+'HGT anomaly *** HGT anomaly controls the southeastern TP,which is not conducive to precipitation in the *** the SIC in the Barents-Kara Sea increases,the situation is *** above analysis also reveals the reason for the difference in the east-west distribution of the TPEP.

关键词： Arctic sea ice Tibetan Plateau Winter extreme precipitation Rossby wave activity Interdecadal variation

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Potential mechanism of teneligliptin in the treatment of diabetic cardiomyopathy

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World Journal of Diabetes 2024年第10期15卷 2002-2005页

作者： Jing Guo Yi Cao qing-yuan wu Lu-Sha Cen Department of Dermatology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006Zhejiang ProvinceChina Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

Diabetic cardiomyopathy(DCM),a complication of diabetes,poses a significant threat to public health,both its diagnosis and treatment presents *** has promising applications and research implications in the treat-ment of diabetes *** et al observed the therapeutic effect of tenelig-liptin on cardiac function in mice with *** validated that teneligliptin’s mechanism of action in treating DCM involves cardiomyocyte protection and inhibition of NLRP3 inflammasome *** that the NLRP3 inflammasome plays a crucial role in the onset and progression of DCM,it presents a promising therapeutic ***,further clinical validation is required to ascertain the preventive and therapeutic efficacy of teneligliptin in DCM.

关键词： Teneligliptin NLRP3 inflammasome Diabetes Diabetic cardiomyopathy Diabetes complications

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Depressed female cynomolgus monkeys(Macaca fascicularis) display a higher second-to-fourth(2D:4D)digit ratio

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Zoological Research 2019年第3期40卷 219-225页

作者： Wei Li Ling-Yun Luo Xun Yang Yong He Bin Lian Chao-Hua Qu qing-yuan wu Jian-Guo Zhang Peng Xie Department of Neurology Army Medical Center of PLAChongqing 400042China Institute of Neuroscience Chongqing Medical UniversityChongqing 400016China Chongqing Key Laboratory of Neurobiology of Chongqing Medical University Chongqing 400016China Department of Neurology the Third Affiliated Hospital of Sun Yat-Sen University Yuedong HospitalGuangzhou Guangdong 514700China

This research aimed to provide evidenee of a relationship between digit ratio and depression status in the cynomolgus monkey(Macaca fascicularis).In stable cyno molgus mon key social groups,we selected 15 depressed monkeys based on depressive-like behavioral criteria and 16 normal control mon *** animals were video recorded for two weeks,with the duration and frequency of the core depressive behaviors and 58 other behaviors in 12 behavioral categories then evaluated via behavioral *** ger len gths from the right and left forelimb hands of both groups were measured by X-ray imagi *** ger length and digit ratio comparisons between the two groups were con ducted using Stude nt's *** terms of the durati on of each behavior,signifies nt differences emerged in“Huddling”and five other behavioral categories,including Ingestive,Amicable,Parental,Locomotive,and *** addition to the above five behavioral categories,we found that depressed mon keys spent less time in parental and rubbing back and forth behaviors than the control ***,the 4th fin gers were significantly Ion ger in the left and right hands in the control group relative to the depressed mon *** sec ond?to?fourth(2D:4D)digit ratio in the left and right forelimb hands was significantly lower in the control group tha n that in the depressed *** fin dings revealed significant differences in finger lengths and digit ratios between depressed mon keys and healthy controls,which concords with our view that relatively high fetal testosterone exposure may be a protective factor against developing depressive symptoms(or that low fetal testosterone exposure is a risk factor).

关键词： Fin ger length Digit ratio Major depressive disorder Cynomolgus mon key

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Ectopic bronchogenic cyst of liver misdiagnosed as gallbladder diverticulum: A case report

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World Journal of Gastroenterology 2022年第33期28卷 4920-4925页

作者： Cheng-Ji Dong Ru-Ming Yang Qi-Long Wang qing-yuan wu Da-Ji Yang De-Cai Kong Ping Zhang Department of Hapatopancreatobiliary Surgery The First Bethune Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Breast Surgery The First Bethune Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Vascular Surgery The First Bethune Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Ectopic bronchogenic cysts are a type of congenital cystic tumor that are extremely difficult to diagnose and can be ectopically located in various organs,with the possibility of malignant transformation. Here we report a case of an ectopic bronchogenic cyst in the liver initially misdiagnosed as a gallbladder *** SUMMARY The patient was a middle-aged woman whose chief complaint was intermittent pain in the upper abdomen. Imaging examination revealed a cystic space in the left inner lobe of the liver. She was admitted to our hospital for treatment. Based on abdominal examination and imaging findings, the initial diagnosis was gallbladder diverticulum with cholestasis combined with chronic ***, following intraoperative observations and postoperative pathologic assessment, the diagnosis was revised to ectopic bronchogenic cyst of the *** Radiologists, hepatobiliary and pancreatic surgeons, gastrointestinal surgeons,urologists, and even neurosurgeons should be aware and consider a possible diagnosis of ectopic bronchogenic cysts, especially when other types of cyst,cystadenoma, and other diseases are excluded. The disease and its complications should be detected and correctly diagnosed and treated as early as possible in order to avoid adverse outcomes.

关键词： Ectopic bronchogenic cyst Misdiagnosis Gallbladder diverticulum Benign tumor Cystadenoma Case report

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THE SYNTHESIS AND CRYSTAL STRUCTURE OF B-(32) MODEL COMPOUND: 1-C_4H_9Co(salen)(Py)

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Chinese Chemical Letters 1992年第7期3卷 559-560页

作者： Hui Lan CHEN De Yan HAN qing yuan wu Wen Xia TANG Yao YANG Hua Qin WANG Department of Chemistry and Coordination Chemistry Institute.Nanjing University.Nanjing 210008 Centre of Material Analysis.Nanjing University Nanjing 210008

The title complex i-C_4H_9Co(salen)(Py) (Py=pyridine. salen=dianion of disalicylideneethylenediamine) has been first synthesized. Its crystal structure has been determined by X-ray diffraction method. The crystsis are monoclinic with space group P2_1/ C. The unit cell parametes are presented. The structure has been refined to a final R of 0.038.

关键词： C4H9Co MODEL COMPOUND Py THE SYNTHESIS AND CRYSTAL STRUCTURE OF B salen

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Quantum metasurface holography

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Photonics Research 2022年第11期10卷 2607-2613页

作者： JIA-ZHI YANG RUI-ZHE ZHAO ZHE MENG JIAN LI qing-yuan wu LING-LING HUANG AN-NING ZHANG Center for Quantum Technology Research and Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements(MOE) School of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Engineering Research Center of Mixed Reality and Advanced Display School of Optics and PhotonicsBeijing Institute of TechnologyBeijing 100081China

Metasurface holography has great application potential in the fields of optical display, optical storage, and security. Traditional metasurface holography uses the well-designed subwavelength structure to modulate the incident laser beam. Although many researches about laser metasurface holography have been realized,metasurface holography based on quantum light sources is rare. Here, we realized quantum metasurface holography through single-photon and multichannel polarization multiplexing metasurfaces, and we compared the quantum results with laser results.

关键词： quantum surface rare

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Comparison of drug-eluting stent and bare-mental stent in the complex small vessel intervention

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Chinese Medical Journal 2006年第7期119卷 596-600页

作者： QIAO Shu-bin HOU qing XU Bo CHEN Jue LIU Hai-bo YANG Yue-jin wu Yong-jian yuan Jin-qing wu yuan DAI Jun YOU Shi-jie ZHANG Pei GAO Zhan DOU Ke-fei QIU Hong MU Chao-wei LI Jian-jun CHEN Ji-lin GAO Run-lin Cardiovascular Institute and Fuwai Hospital Chinese Academy ofMedical Sciences and Peking Union Medical University Beijing100037 China

Nowadays, coronary intervention has been dramatically improved in the drug-eluting stentera. The drug-eluting stent percutaneous coronary represents the dominant intervention modality beacause it significantly reduces the restenosis rate compared with bare mental stent. Such benefit was initially demonstrated in coronary vessels 3 mm or more in diameter. However, restenosis after coronary stent implantation is influenced by vessel size and length, and stent occlusion is more frequent in small vessels.

关键词： stents coronary restenosis

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Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei wu Zi-Yun yuan Zhi-yuan Liu Zi-Zhu Liu Zhi-Cong Xiao Jing-Hui Li Cheng-Zhi Huang Jun-Jiang Wang Xue-qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type II diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage III CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage III CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage III CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis Type II diabetes mellitus

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BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang qing-Rong Li Lei Xu Zi-Chun yuan Xiao Liu Mao-Ju Tang Man Luo Xiao-wu Zhong Qiang Ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

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