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Erxian decoction potentially prevents postmenopausal osteoporosis by modulating miR-335: a study based on bioinformatics analysis and preliminary clinical case validation

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Traditional Medicine Research 2023年第6期8卷 1-8页

作者： Hao-Qiang Huang Ye Feng Xiao-Feng Shen yu Zhou Li Qin Feng Xu qing Wang Department of Orthopaedics Kunshan Hospital of Traditional Chinese MedicineKunshan 215300China School of Stomatology Xuzhou Medical UniversityXuzhou 221000China Department of Orthopedics Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese MedicineSuzhou 215100China Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism School of PharmacyEast China University of Science and TechnologyShanghai 200237China.

Background:miRNAs are closely related to bone *** have shown that Erxian decoction can improve bone metabolism,possibly achieving this regulatory effect through miRNA *** was used to predict the miRNA targets of Erxian decoction for the treatment of postmenopausal osteoporosis,and the results were validated by clinical ***:In this study,we identified possible targets of Erxian decoction in osteoporosis by means of network pharmacological analysis and bioinformatic *** cases of postmenopausal osteoporosis with kidney Yin and Yang deficiency(In traditional Chinese medicine,kidney Yin nourishes and moistens the tissues of the internal organs of the body,while kidney Yang promotes and warms the tissues of the internal organs of the body.)were treated with Erxian decoction for four weeks,and serum bone metabolism indices(P1NP,osteocalcin,andβ-CTX)and miRNA-335-5p expression were measured before and after ***:The constructed miRNA postmenopausal osteoporosis related gene network of the effective compound of the Erxian decoction has 296 points and 981 *** 39 postmenopausal osteoporosis related genes regulated by miRNA-335-5p were enriched in ossification,while the signaling pathways were enriched in rheumatoid arthritis,the Toll signaling pathway,the HIF-1 signaling pathway,and the MAPK signaling *** taking Erxian decoction,the expression of the serum bone formation index(P1NP,osteocalcin)and miRNA-335-5p gene expression levels increased *** alterations in P1NP and osteocalcin were correlated with the changes in ***:Circulating miRNA-335-5p may serve as an important target of Erxian decoction in the treatment of postmenopausal *** effect of Erxian decoction on bone formation is significant,but the underlying mechanism requires further investigation.

关键词： Erxian decoction postmenopausal osteoporosis miRNA-335-5p bone formation bioinformatics clinical cases

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圆根酸菜风味成分分析

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食品安全质量检测学报 2024年第9期15卷 205-212页

作者：赖海梅颜朗王雅利杨梦露黄玉立曾雪晴梅源朱永清葛黎红赵楠西昌学院攀西特色作物研究与利用四川省重点实验室西昌615000 四川省农业科学院农产品加工研究所(四川省农业科学院食物与营养健康研究所) 成都610021 四川师范大学生命科学学院成都610066

目的研究川西地区传统圆根酸菜风味成分。方法采用高效液相色谱法和顶空固相微萃取-气相色谱-质谱技术测定圆根酸菜的有机酸和挥发性物质。结果圆根酸菜中共检测出5种有机酸,乙酸和乳酸是主要有机酸。乙酸风味强度值最高,对酸菜呈味贡... 详细信息

目的研究川西地区传统圆根酸菜风味成分。方法采用高效液相色谱法和顶空固相微萃取-气相色谱-质谱技术测定圆根酸菜的有机酸和挥发性物质。结果圆根酸菜中共检测出5种有机酸,乙酸和乳酸是主要有机酸。乙酸风味强度值最高,对酸菜呈味贡献最大,其次是乳酸和琥珀酸。此外,苹果酸和柠檬酸也是影响圆根酸菜呈味贡献的重要因素。圆根酸菜中共检测到挥发性物质263种,主要包括酮类、酯类、醛类、酸类和醇类。44种挥发性物质是所有样品共有的,占挥发性物质含量的76.07%~88.19%。5-羟甲基糠醛和4-丙基苯酚是主要的挥发性物质,分别占挥发性物质含量的33.4%和28.1%。结论圆根酸菜挥发性物质种类和含量存在较大差异,5-羟甲基糠醛和4-丙基苯酚可以作为区分圆根酸菜品质的重要指标。

关键词：圆根酸菜气相色谱-质谱法有机酸挥发性物质

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The Structure, Function, and Stability of Pyruvate Dehydrogenase PDHA1

The Structure, Function, and Stability of Pyruvate Dehydroge...

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中国生物化学与分子生物学会2016年全国学术会议

作者： Weicai Chen Zhifa Cao qing Sheng Wen-Bin ou Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine College of Life Sciences Zhejiang Sci-Tech University Zhejiang Provincial Key Laboratory of Applied Enzymology Yangtze Delta Region Institute of Tsinghua University

Pyruvate dehydrogenase(PDH)is a multi-enzyme complex in mitochondrion,which plays the crucial function in substance and energy *** catalyzes the decarboxylation of pyruvic acid to produce acetyl coenzyme A,and acetyl coenzyme A serves as the primary raw material to bring the glucose into the aerobic oxidation of tricarboxylic acid cycle

关键词： PDHA1 mutation activity structure

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Characteristics of Traditional Chinese Medicine Syndrome in Patients with Coronary Heart Disease at Different Disease Stages

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World Journal of Traditional Chinese Medicine 2022年第2期8卷 218-224页

作者： yu-Mo Xia Hui Gao qing-Sheng Wang Xiao Feng Yi-Qin Wang Zhao-Xia Xu Shanghai Key Laboratory of Health Identification and Assessment Basic Medical CollegeShanghai University of Traditional Chinese MedicineShanghaiChina

Coronary atherosclerotic heart disease(CHD)has a high incidence,disability rate,and mortality rate,which severely affect people’s health,work,and *** on its clinical manifestations,traditional Chinese medicine(TCM)has classified CHD as“chest impediment”and“heart pain”for the *** course of CHD is protracted,and the pathogenesis is complex and ***,different disease stages have different syndrome ***,this article aimed to summarize the classification and distribution characteristics of the TCM syndrome in various stages of CHD,such as before and after percutaneous coronary intervention therapy,disease progression,age,and complications,to provide references for the TCM clinical diagnosis and treatment of CHD.

关键词： Coronary heart disease different disease stages review traditional Chinese medicine syndromes

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结构无线应变传感器设计、制作与测试

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电子器件 2005年第3期28卷 461-465页

作者：喻言欧进萍哈尔滨工业大学土木工程学院哈尔滨150090

针对传统的应变采集传输方法存在的问题,结合电阻应变片工作机理,提出了一种用于结构局部应变监测的无线传感器及其系统;重点介绍了系统的核心部分,即无线应变传感器,的组成及功能;并详细讨论了该无线采集传输装置中典型电路的设计,给... 详细信息

针对传统的应变采集传输方法存在的问题,结合电阻应变片工作机理,提出了一种用于结构局部应变监测的无线传感器及其系统;重点介绍了系统的核心部分,即无线应变传感器,的组成及功能;并详细讨论了该无线采集传输装置中典型电路的设计,给出了软件流程图;最后对所研制的系统进行了实验。结果表明:所研制的无线传感器及其系统,具有采集准确、传输可靠、价格低廉、携带方便、简单实用等特点,适合在实际工程中应用推广。

关键词：无线传感器应变系统集成放大滤波微处理器

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Clinical Observation of Chinese Herbal Fumigation plus Mulberry Stick Beating for Heel Pain

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Journal of Acupuncture and Tuina Science 2014年第6期12卷 350-353页

作者： Shen qing-he Shen Zhi-fang Yan yu-qin Zhu Gao-feng Hong Jue Jiaxing Hospital of Chinese Medicine

Objective： To observe the clinical efficacy of Chinese herbal fumigation plus beating with mulberry stick in treating heel pain. Methods： Sixty patients with heel pain were randomized into a treatment group and a control group, 30 in each group. The treatment group was intervened by Chinese herbal fumigation plus beating with mulberry stick, and the control group was by orally taking Diclofenac Sodium Sustained Release Tablets plus external use of She Xiong Zhen Tong Gao （Moschus Analgesic Plaster）. After one treatment course, the visual analogue scale （VAS） was used to observe the change of pain, and the clinical efficacies were also evaluated. Results： After intervention, the improvement of VAS score in the treatment group was more significant than that in the control group （P〈0.01）. The total effective rate of the treatment group was significantly higher than that of the control group （P〈0.01）. Conclusion： Chinese herbal fumigation plus beating with mulberry stick can produce a higher clinical efficacy than orally taking Diclofenac Sodium Sustained Release Tablets in treating heel pain.

关键词： Drugs, Chinese Herbal Fumigation Flapping Therapy Tuina Massage Points, Ashi Heel Pain

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Spatial and Temporal Variations of Pneumoconiosis in the Pearl River Delta Region in 2006–2015

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Biomedical and Environmental Sciences 2020年第3期33卷 191-195页

作者： LI Xu Dong TU Hong Wei LIU Yi Ming WEN Xian Zhong yu Hong Wei QU Hong Ying CHEN qing Department of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou 510515GuangdongChina Guangdong Province Hospital for Occupational Disease Prevention and Treatment Guangzhou 510300GuangdongChina Guangodng Provincial Center for Diseases Control and Prevention Guangzhou 511430GuangdongChina Guangzhou No.12 Hospital Guangzhou 510620GuangdongChina Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment Guangzhou 510300GuangdongChina

Pneumoconiosis is a restrictive lung disease mostly caused by occupational exposure to dust,including silica dust,asbestos,and other *** particles smaller than 10μm can enter the bronchioles,injure lung cells,and ind... 详细信息

关键词： Spatial and Temporal Variations of Pneumoconiosis in the Pearl River Delta Region in 2006 Delta

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Production of high-quality agarwood in Aquilaria sinensis trees via whole-tree agarwood-induction technology

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Chinese Chemical Letters 2012年第6期23卷 727-730页

作者： Xing Li Zhang Yang Yang Liu Jian He Wei yun Yang Zheng Zhang Jun qing Huang Huai Qiong Chen yu Jun Liu College of Biological Science and Biotechnology Beijing Forestry University Beijing 100083 China Hainan Branch of Institute of Medicinal Plant Development （Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine） Chinese Academy of Medical Sciences Wanning 571533 China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Beijing 100193 China School of Food ＆ Bioengineering Shandong Polytechnic University Jinan 250353 China

We used whole-tree agarwood-induction technology to produce agarwood from Aquilaria sinensis trees within 20 months, and evaluated the quality of this agarwood. The results showed its characteristics were similar to those of high-grade wild agarwood in terms of texture, chemical constituents, essential oil content, and ethanol-soluble extract content, with the lattermost quality far surpassing the requirement of traditional Chinese medicine agarwood, as indicated in Chinese Pharmacopoeia 2010. To the best of our knowledge, this is first study to show that high-quality agarwood can be produced in whole A. sinensis trees via a chemically induced technology.

关键词： Agarwood Aquilaria sinensis Chemically induced Quality Whole-tree agarwood-induction technology

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Therapeutic effects of the TST36 stapler on rectocele combined with internal rectal prolapse

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World Journal of Gastrointestinal Surgery 2021年第5期13卷 443-451页

作者： Jin Meng Zhi-Tao Yin Ying-Yi Zhang Yong Zhang Xiu Zhao qing Zhai De-yu Chen Wei-Gang yu Lei Wang Zhi-Gang Wang Department of Anorectal Disease Shenyang Coloproctology HospitalShenyang 110000Liaoning ProvinceChina Department of Anorectal Disease Shenyang Hospital of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina First Department of General Surgery The Third People’s Hospital of DalianDalian 116000Liaoning ProvinceChina

BACKGRouND The most common causes of outlet obstructive constipation(OOC)are rectocele and internal rectal *** surgical methods for OOC are diverse and difficult,and the postoperative complications and recurrence rate are high,which results in both physical and mental pain in *** the continuous deepening of the surgeon’s concept of minimally invasive surgery and continuous in-depth research on the mechanism of OOC,the treatment concepts and surgical methods are continuously *** To determine the efficacy of the TST36 stapler in the treatment of rectocele combined with internal rectal *** From January 2017 to July 2019,49 female patients with rectocele and internal rectal prolapse who met the inclusion criteria were selected for treatment using the TST36 *** Forty-five patients were cured,4 patients improved,and the cure rate was 92%.The postoperative obstructed defecation syndrome score,the defecation frequency score,time/straining intensity,and sensation of incomplete evacuation were significantly decreased compared with these parameters before treatment,and the differences were statistically significant(P<0.05).The postoperative anal canal resting pressure and maximum squeeze pressure in patients decreased compared with before treatment,and the differences were statistically significant(P<0.05).The initial and maximum defecation thresholds after surgery were significantly lower than those before treatment,and the differences were statistically significant(P<0.05).The postoperative ratings of rectocele,resting phase,and defecation phase in these patients were significantly decreased compared with those before treatment,and the differences were statistically significant(P<0.05).CONCLUSION The TST36 stapler is safe and effective in treating rectocele combined with internal rectal prolapse and is worth promoting in clinical work.

关键词： TST36 stapler Rectocele Internal rectal prolapse outlet obstructive constipation Longo obstructed defecation syndrome score Constipation

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Design of a Novel Polarized Beam Splitter Based on a Two-Dimensional Photonic Crystal Resonator Cavity

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Chinese Physics Letters 2011年第8期28卷 102-104页

作者： ZHANG Xuan CHEN Shu-Wen LIAO qing-Hua yu Tian-Bao LIU Nian-Hua HUANG Yong-Zhen Department of Physics Nanchang UniversityNanchang 330031 The State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083

We propose and analyze a novel ultra-compact polarization beam splitter based on a resonator cavity in a two-dimensional photonic *** two polarizations can be separated efficiently by the strong coupling between the microcavities and the waveguides occurring around the resonant frequency of the *** transmittance of two polarized light around 1.55µm can be more than 98.6%,and the size of the device is less than 15µm×13µm,so these features will play an important role in future integrated optical circuits.

关键词： polarization resonator Crystal

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