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Theoretical study on the reaction of VS^+(~3∑^-,~1Γ)with CO

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Chinese Chemical Letters 2008年第8期19卷 1008-1011页

作者： Shi Wen Yu Li qing yin Li Feng Yao Ming Li Xiao Guang Xie Department of Chemistry Yunnan University Kunming 650091 China

Two possible reaction mechanisms of VS^＋（^3∑^-, 1^Г） with CO in the gas phase have been studied by using B3LYP/TZVP and CCSD（T）/6-311＋G （3df, 3pd） methods： the O/S exchange reaction （VS^＋＋CO→VO^＋＋CS） and the S-transfer reaction （VS^＋＋ CO → V^＋＋ COS）. The two reactions proceed via two-step and one-step mechanism, respectively. The barriers of the triplet and singlet PESs are 30.6 and 50.9 kcal/mol, respectively, for O/S exchange reaction and 7.3 and 50.2 kcal/mol, respectively, for the S-transfer reaction. The results indicate that the triplet ground state reaction is more favorable, and the S-transfer reaction is more favorable than the O/S exchange reaction, which is in good agreement with the experimental observation.

关键词： Vanadium sulfide ion CO Reaction CCSD(T)

New therapeutic options for persistent low-level viremia in patients with chronic hepatitis B virus infection:Increase of entecavir dosage

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World Journal of Gastroenterology 2021年第8期27卷 666-676页

作者： Guo-qing yin Jun Li Bei Zhong Yong-Fong Yang Mao-Rong Wang Department of Infectious Diseases Nanjing Zhong-Da HospitalSoutheast University School of MedicineNanjing 210009Jiangsu ProvinceChina Department of Infectious Diseases The First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina The Sixth Affiliated Hospital Guangzhou Medical University/Qingyuan People’s HospitalQingyuan 511518Guangdong ProvinceChina Department of Liver Disease The Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003Jiangsu ProvinceChina Department of Infectious Diseases and Liver Disease Center The Affiliated Nanjing Jinling HospitalNanjing UniversityNanjing 210002Jiangsu ProvinceChina

Chronic hepatitis B virus(HBV)infection(CHB)is a public health concern *** therapies utilizing nucleos(t)ide analogs(NA)have not resulted in a complete cure for ***,patients on long-term NA treatment often develop low-level viremia(LLV).Persistent LLV,in addition to causing the progression of liver disease or hepatocellular carcinoma,may shed light on the current plight of NA ***,we review the literature on LLV,NA treatment,and various doses of entecavir to find a strategy for improving the efficacy of this antiviral *** LLV patients,three therapeutic options are available,switching to another antiviral monotherapy,interferon-αswitching therapy,and continuing *** real-world clinical practice,entecavir overdose has been used in antiviral therapy for CHB patients with NA refractory and persistent LLV,which encouraged us to conduct further in-depth literature survey on dosage and duration related entecavir *** studies of pharmacodynamics and pharmacokinetics show that entecavir has the maximal selected index for safety,and has great potential in inhibiting HBV replication,in all of the *** the particular section of the drug approval package published by the United States Food and Drug Administration,entecavir doses 2.5-20 mg/d do not increase adverse events,and entecavir doses higher than 1.0 mg/d might improve the antiviral *** literature survey led us to two suggestions:(1)Increasing entecavir dose to 1.0 mg/d for the treatment of NA naïve patients with HBV DNA>2×106 IU/mL is feasible and would provide better prognosis;and(2)Further research is needed to assess the long-term toxic effects of higher entecavir doses(2.5 and 5.0 mg/d),which may prove beneficial in treating patients with prior NA treatment,partial virological response,or LLV state.

关键词： Chronic hepatitis B virus infection Low-level viremia Therapeutic options Entecavir Dose Efficacy

Acupuncture for cervical dystonia associated with anxiety and depression: A case report

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World Journal of Clinical Cases 2024年第1期12卷 204-209页

作者： Ya-Ting Zhang Jin-Jing Zhang Bi-Xiang Zha yin-Qiu Fan Yuan-Bo Xu Jun Yang qing-Ping Zhang The First School of Clinical Medicine Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Acupuncture and Rehabilitation Department First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina College of Acupuncture and Tuina Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina

BACKGROUND Cervical dystonia(CD)is a type of muscle tone disorder that usually occurs in the neck *** to the intermittent or continuous involuntary contraction of the neck muscles,the head and neck are twisted and skewed and some postural abnormalities ***-term abnormal posture or pain can cause negative emotions in patients,which can affect their quality of *** SUMMARY This case report included a 37-year-old woman who was diagnosed with CD associated with anxiety and depression;the accompanying symptoms were head and neck tilt of approximately 90°to the right and mental *** two courses of acupuncture treatment,the patient’s head and neck can be maintained in a normal position,and the negative emotions can be *** This case indicates that acupuncture can effectively improve CD and the emotional state and quality of life of patients,making it an effective alternative treatment for the condition.

关键词： Cervical dystonia Anxiety and depression Neurological disease Acupuncture Case report

Clinicopathological features and prognosis of membranoproliferative-like Henoch-Schönlein purpura nephritis in children

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World Journal of Pediatrics 2015年第4期11卷 338-345页

作者： Yan-Jie Huang Xiao-qing Yang Wen-Sheng Zhai Xian-qing Ren qing-yin Guo Xia Zhang Meng Yang Tatsuo Yamamoto Yuan Sun ying Ding Department of Pediatrics First Affi liated Hospital of Henan University of Traditional Chinese MedicineChina Second Department of Medicine Numazu City HospitalNumazuJapan Department of Anesthesia Stanford University School of MedicineCaliforniaUSA

Background: The aim of this retrospective study was to defi ne the clinical manifestations, pathological features and prognosis of children with membranoproliferative-like Henoch-Schönlein purpura nephritis (HSPN), representing International Study of Kidney Disease in Children (ISKDC) grade VI. Methods: Among 245 patients with HSPN treated in our hospital between 2008 and 2010, nine patients (3.7%) were diagnosed with HSPN of ISKDC grade VI (males=5, females=4, age: 9.5±2.03 years, mean±SD). The clinical features, laboratory and pathologicalfi ndings, treatment and outcome of the 9 patients were retrospectively analyzed. Results: Of the 9 patients, 7 (78%) presented with hematuria and nephrotic syndrome, and were treated with steroids (oral prednisone or intravenous methylprednisolone pulse therapy) and immunosuppressants (oral tripterygium glycosides or intravenous cyclophosphamide pulse therapy). One (11%) patient had hematuria and nephrotic range proteinuria (>50 mg/kg per 24 hours) and was treated with oral prednisone and tripterygium glycosides. Another (11%) patient presented with hematuria and moderate proteinuria (25-50 mg/kg per 24 hours) and was treated with oral tripterygium glycoside only. Histopathological examination showed diffuse glomerular mesangial and endocapillary proliferation, mesangial interposition, double-contour formation, podocyte hypertrophy, shedding, and cytoplasmic absorption droplets. The percentages of glomeruli with small cellular crescents varied from 4%-25% in 6 of 9 patients. Follow-up for 2 to 4 years showed excellent recovery in all patients. Conclusions: The main clinical feature of ISKDC grade VI HSPN in children is a nephrotic syndrome with hematuria. The excellent prognosis of the disease was probably related to early diagnosis and treatment with steroids and/or immunosuppressants, and mild degree of glomerulosclerosis and tubulointerstitial damage.

关键词： clinicopathological features Henoch-Schönlein purpura nephritis prognosis

Inhibition of α5 GABAA receptors has preventive but not therapeutic effects on isoflurane-induced memory impairment in aged rats

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Neural Regeneration Research 2019年第6期14卷 1029-1036页

作者： Zi-Fang Zhao Lei Du Teng Gao Lin Bao Yuan Luo Yi-qing yin Yong-An Wang Department of Anesthesiology China-Japan Friendship Hospital Department of Radiology China-Japan Friendship Hospital Department of Anesthesiology Beijing Shijitan Hospital Affiliated to Capital Medical University Institute of Pharmacology and Toxicology Academy of Military Medical Sciences

The α5 subunit-containing gamma-amino butyric acid type A receptors(α5 GABAARs) are a distinct subpopulation that are specifically distributed in the mammalian hippocampus and also mediate tonic inhibitory currents in hippocampal neurons. These tonic currents can be enhanced by low-dose isoflurane, which is associated with learning and memory impairment. Inverse agonists of α5 GABAARs, such as L-655,708, are able to reverse the short-term memory deficit caused by low-dose isoflurane in young animals. However, whether these negative allosteric modulators have the same effects on aged rats remains unclear. In the present study, we mainly investigated the effects of L-655,708 on low-dose(1.3%) isoflurane-induced learning and memory impairment in elderly rats. Young(3-month-old) and aged(24-month-old) Wistar rats were randomly assigned to receive L-655,708 0.5 hour before or 23.5 hours after 1.3% isoflurane *** Morris Water Maze tests demonstrated that L-655,708 injected before or after anesthesia could reverse the memory deficit in young rats. But in aged rats, application of L-655,708 only before anesthesia showed similar effects. Reverse transcription-polymerase chain reaction showed that low-dose isoflurane decreased the mRNA expression of α5 GABAARs in aging hippocampal neurons but increased that in young animals. These findings indicate that L-655,708 prevented but could not reverse 1.3% isoflurane-induced spatial learning and memory impairment in aged Wistar rats. All experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of Academy of Military Medical Science of China(approval No. NBCDSER-IACUC-2015128) in December 2015.

关键词： isoflurane postoperative cognitive dysfunction hippocampus inverse agonist α5 GABAA receptors L-655,708 aged Morris Water Maze memory impairment neural regeneration

Biomechanical supporting effect of tantalum rods for the femoral head with various sized lesions： a finite-element analysis

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Chinese Medical Journal 2012年第22期125卷 4061-4065页

作者： LIU Wen-guang WANG Shao-jin yin qing-feng LIU Sheng-hou GUAN Yan-jin Shandong Univ Dept Orthoped Hosp 2 Jinan 250033 Shandong Peoples R China Shandong Univ Mould & Engn Technol Res Ctr Sch Mat Sci & Engn Jinan 250061 Shandong Peoples R China

Background Features of necrotic lesions and various interventions could affect the biomechanics of the femoral head. A three-dimensional finite-element analysis was designed to demonstrate necrotic femoral head stress changes with various sizes of necrotic lesions, and evaluate the effect of tantalum rods on preventing femoral head cracking. Methods Femoral computed tomography scans were used to build a normal three-dimensional finite-element femoral head model in a computer. Based on the normal model, necrotic models of different lesion diameters （15 mm, 20 mm and 30 mm） were created, as were the repaired models with tantalum rods for each diameter. After a series of meshing and force loading, the von Mises stress distributions, simulating single-legged stance, and stresses on specific points under loaded conditions were determined for each model. Results Deep exploration into the burdened area of the femoral head indicated that higher stresses to the femoral head were observed with a larger necrotic lesion; the largest stress concentration, 91.3 MPa, was found on the femoral head with a lesion diameter of 30 mm. By contrast, topical stress on the surface of the necrotic regions was lowered following implantation of a tantalum rod, and the changes in stress were significant in models with lesions of 15 mm and 30 mm in diameter, with the best biomechanical benefit from the tantalum rod found with a lesion diameter of 15 mm. Conclusions Femoral heads with larger necrotic lesions usually have a higher stress concentration and a higher risk of collapse. Various sized lesions on the femoral head can benefit from the mechanical support offered by the implantation of a tantalum rod; however, femoral heads with smaller sized lesions may benefit more. A thorough evaluation of the lesion size should be conducted prior to the use of tantalum rod implants in the treatment of femoral head necrosis.

关键词： femoral head necrosis biomechanics finite element analysis tantalum rods

Security of quantum key distribution with virtual mutually unbiased bases

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 13-21页

作者： Hong-Wei Li Chen-Peng Hao Zhi-Jiang Chen Li Gong Yi-Fei Lu Yang Wang Jia-Ji Li Chun-Mei Zhang Rong Wang Zhen-Qiang yin qing-Yu Cai Henan Key Laboratory of Quantum Information and Cryptography SSF IEUZhengzhou 450000China Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China Department of Physics University of Hong KongHong Kong 999077China Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China School of Information and Communication Engineering Hainan UniversityHaikou 570228China

In a perfect quantum key distribution(QKD)protocol,quantum states should be prepared and measured with mutually unbiased bases(MUBs).However,in a practical QKD system,quantum states are generally prepared and measured with imperfect MUBs using imperfect devices,possibly reducing the secret key rate and transmission *** analyze the security of a QKD system with imperfect MUBs,we propose virtual MUBs to characterize the quantum channel against collective attack,and analyze the corresponding secret key rate under imperfect state preparation and measurement *** generally,we apply the advantage distillation method for analyzing the security of QKD with imperfect MUBs,where the error tolerance and transmission distance can be sharply *** analysis method can be applied to benchmark and standardize a practical QKD system,elucidating the security analysis of different QKD protocols with imperfect devices.

关键词： quantum key distribution mutually unbiased bases advantage distillation

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Effects of loneliness and isolation on cardiovascular diseases:a two sample Mendelian Randomization Study

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Journal of Geriatric Cardiology 2024年第3期21卷 340-348页

作者： Jia-yin CAI Xin WANG Cong-Yi ZHENG Xue CAO Zhen HU Run-qing GU Yi-Xin TIAN Ye TIAN Lan SHAO Lin-Feng ZHANG Zeng-Wu WANG Division of Prevention and Community Health National Center for Cardiovascular DiseaseNational Clinical Research Center of Cardiovascular DiseaseState Key Laboratory of Cardiovascular DiseaseFuwai HospitalPeking Union Medical College&Chinese Academy of Medical SciencesBeijingChina

BACKGROUND Loneliness and isolation are associated with multiple cardiovascular diseases(CVDs),but there is a lack of research on whether they were causally *** conducted a Mendelian Randomization(MR)study to explore causal relationships between loneliness and isolation and multiple *** Single nucleotide polymorphisms associated with loneliness and isolation were identified from a genome-wide association study(GWAS)of 455,364 individuals of European ancestry in the IEU GWAS *** data for 15 CVDs were also obtained from the IEU GWAS *** used three MR methods including inverse variance weighting,MR-Egger,and weighted median estimation to assess the causal effect of exposure on ***'s Q test and MR-Egger intercept test were used to evaluate the heterogeneity and *** MR analysis showed that loneliness and isolation were significantly associated with essential hypertension(OR=1.07,95%CI:1.03-1.12),atherosclerotic heart disease(OR=1.04;95%CI:1.02-1.06),myocardial infarction(OR=1.02;95%CI:1-1.04)and angina(OR=1.04;95%CI=1.02-1.06).No heterogeneity and pleiotropy effects were found in this *** Causal relationship of loneliness and isolation with CVDs were found in this study.

关键词： diseases cardiovascular angina

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为消费经济而生的尹世杰教授

消费经济 2022年第6期38卷 31-41页

作者：尹向东尹清非湖南省社会科学院(湖南省人民政府发展研究中心)产业经济研究所湖南长沙410003 中南大学数学与统计学院湖南长沙410017 广州软件学院财经系广东广州510990

尹世杰教授是我国消费经济学创始人、开拓者和学术带头人。青年时代树立研究消费经济的初心,1979年打破消费经济研究“禁区”,1983年创立社会主义消费经济学,开创了消费经济研究的“六个全国第一”。随后30年,他致力于推动消费经济学发... 详细信息

尹世杰教授是我国消费经济学创始人、开拓者和学术带头人。青年时代树立研究消费经济的初心,1979年打破消费经济研究“禁区”,1983年创立社会主义消费经济学,开创了消费经济研究的“六个全国第一”。随后30年,他致力于推动消费经济学发展、拓展消费经济研究领域,引领我国消费经济学学科建设与发展。从20世纪80年代中期到90年代后期,在消费结构、消费模式、小康水平等方面进行了开创性和持续深化的研究。20世纪90年代以来,先后创立消费力经济学、消费文化学,深入研究消费力、闲暇消费、精神文化消费、绿色生态消费、扩大消费需求等重大问题。他提出了“解放消费力,发展消费力”“文化教育是第一消费力”“社会主义市场经济是消费者主权的经济”“市场经济是需求导向型经济,是消费需求推动型经济”等重要观点。以人为本是他消费经济研究的基本理念,是串联其消费经济思想的灵魂与主线。尹世杰教授的一生是为消费经济而生的一生,是为消费经济鞠躬尽瘁、死而后已的一生,是在消费经济研究的陡峭山路上不畏劳苦、永不停步、不断攀登、不断达到新高峰的一生。

关键词：消费消费经济学消费经济思想尹世杰