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Hemorrhagic activity and mechanism of FIIa,a fibrinolytic enzyme from Agkistrodon acutus venom

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Acta Pharmacologica Sinica 2004年第4期25卷 116-123页

作者： qing-qing wang2, Jia-shu CHEN, Xiu-xia LIANG3, Peng-xin QIU, Yi-wen wang, Guang-mei YAN Department of Pharmacology, Zhongshan Medical College, Sun Yat-Sen University, Guangzhou 510080, China Now in Beijing Universityof Chinese Medicine,Beijing 100029,China. Department of Pharmacology Zhongshan Medical College Sun Yat-Sen University

AIM: To study the local hemorrhagic activity of a fibrinolytic enzyme (FIIa) from Agkistrodon acutus venom and its mechanism. METHODS: The local hemorrhagic activity was determined by subcutaneous injection on the back of mouse. The effects of FIIa on factor X, prothrombin, gelatin, and collagen were visualized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Platelet aggregation assays were performed in rat platelet- rich plasma (PRP). Human umbilical vein endothelial cells (HUVEC) were cultured and passaged in complete M199 medium. Cell viability and nuclear morphology change were determined by fluorescein diacetate (FDA) staining and Hoechst 33258 staining, respectively. RESULTS: The minimum hemorrhagic dose (MHD) of FIIa was 89 μg. In vitro, FIIa (0.25 g/L) degraded factor X, prothrombin, collagen, and gelatin, and dose-dependently (0.25, 0.50, 0.75, and 1.00 g/L) inhibited the platelet aggregation induced by ADP in rat PRP. When HUVEC in culture treated with FIIa, HUVEC showed detachment in a dose-dependent manner, but no apoptosis sign was observed. CONCLUSION: FIIahad local hemorrhagic activity, and the mechanism was related to the degradation of factor X, prothrombin, gelatin, and collagen, the inhibition of ADP-induced platelet aggregation, and inducement of HUVEC detachment.2Now in Beijing Universityof Chinese Medicine,Beijing 100029,China.3Correspondence to Dr Xiu-xia LIANG.

关键词： Agkistrodon acutus venom fibrinolytic enzyme hemorrhagic protease endothelial cells

Designing Proportional-Integral Consensus Protocols for Second-Order Multi-Agent Systems Using Delayed and Memorized State Information

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 878-892页

作者： Honghai wang qing-Long Han the College of Information Science and Engineering State Key Laboratory of Synthetical Automation for Process IndustriesNortheastern UniversityShenyang 110819China the School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourneVIC 3122Australia

This paper is concerned with consensus of a secondorder linear time-invariant multi-agent system in the situation that there exists a communication delay among the agents in the network.A proportional-integral consensus protocol is designed by using delayed and memorized state *** the proportional-integral consensus protocol,the consensus problem of the multi-agent system is transformed into the problem of asymptotic stability of the corresponding linear time-invariant time-delay *** that the location of the eigenvalues of the corresponding characteristic function of the linear time-invariant time-delay system not only determines the stability of the system,but also plays a critical role in the dynamic performance of the *** this paper,based on recent results on the distribution of roots of quasi-polynomials,several necessary conditions for Hurwitz stability for a class of quasi-polynomials are first *** allowable regions of consensus protocol parameters are *** necessary and sufficient conditions for determining effective protocol parameters are *** designed protocol can achieve consensus and improve the dynamic performance of the second-order multi-agent ***,the effects of delays on consensus of systems of harmonic oscillators/double integrators under proportional-integral consensus protocols are ***,some results on proportional-integral consensus are derived for a class of high-order linear time-invariant multi-agent systems.

关键词： Consensus protocol Hurwitz stability multi-agent systems quasi-polynomials time delay

Vertically grown MoS_(2)nanosheets on graphene with defect-rich structure for efficient sodium storage

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Rare Metals 2024年第3期43卷 1062-1071页

作者： Ying wang Jia-Peng He Han-qing Pan qing-Peng wang Lei Zhang Yong-Chang Liu qing-Hong wang School of Chemistry&Materials Science Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional MaterialsJiangsu Normal UniversityXuzhou221116China Institute of Biopharmaceutical Research Liaocheng UniversityLiaocheng252059China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyState Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing100083China Centre for Catalysis and Clean Energy Gold Coast CampusGriffith UniversityGold CoastQLD4222Australia

The synthesis of a perpendicular growth structure of MoS_(2)nanosheets on graphene for efficient sodium storage is challenging yet ideal due to the benefits of open ion diffusion channels and high electronic *** this study,we have successfully fabricated a novel structure of vertical MoS_(2)nanosheets on graphene,with ZnS nanoparticles serving as bonding points(MoS_(2)/ZnS/G),through a facile hydrothermal *** the synthesis process,Zn^(2+)not only acts as a landing site for the vertical growth of MoS_(2)nanosheets but also triggers the formation of a defect-rich structure in the final *** unique architecture of MoS_(2)/ZnS/G effectively combines the advantages of a vertically aligned geometry and a defectrich structure for energy *** resulting structure displays shortened transport paths for electrons/ions,enhanced conductivity,improved structural integrity,and an increased number of active sites for promising electrochemical *** expected,when used as anode for sodium-ion batteries,the as-synthesize d MoS_(2)/ZnS/G exhibits excellent rate capability(high capacity of 298 mAh·g^(-1)at 5 A·g^(-1))and good cycling stability(a capacity decay of 0.056%per cycle after 500 cycles at 1 A·g^(-1)).According to the kinetic investigations,the electrochemical process of the MoS_(2)/ZnS/G sample is primarily governe d by a pseudocapacitive behavior,which enhances the charge/discharge kinetics and allows the MoS_(2)/ZnS/G structure to remain intact during cycling.

关键词： MoS_(2) Perpendicular growth Graphene Sodium storage Electrochemical performance

Open-Shell Oligomers and Polymers: Theory, Characterization Methods, Molecular Design, and Applications

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Chinese Journal of Polymer Science 2024年第4期42卷 417-436页

作者： Xue-qing wang Cheng Song Ting Lei Key Laboratory of Polymer Chemistry and Physics(Ministry of Education) School of Materials Science and EngineeringPeking UniversityBeijing100871China

Open-shell oligomers and polymers have exhibited intriguing electronic and magnetic properties, making them highly desirable for a wide range of applications, including ambipolar organic field-effect transistors (OFETs), photodetectors, organic thermoelectrics, and spintronics. Although open-shell ground states have been observed in certain small molecules and doped organic semiconductors, the exploration of open-shell ground-state conjugated polymers is still limited, and the strategies for designing these polymers remain obscure. This review aims to briefly introduce the theory and characterization methods of open-shell conjugated polymers, along with an overview of recent progress and applications. The objective is to stimulate further advancements and investigations in this promising area by shedding light on the potential of open-shell conjugated polymers and the challenges that lie ahead.

关键词： Conjugated polymers Open-shell molecules High-spin ground state Donor-acceptor(D-A)polymers Optoelectronic and magnetic properties

Applications of mercury stable isotopes for tracing volcanism in the geologic record

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Science China Earth Sciences 2024年第5期67卷 1436-1458页

作者： qing GONG Ming-Xing LING wang ZHENG State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China School of Earth System Science Institute of Surface-Earth System ScienceTianjin UniversityTianjin 300072China

Mercury(Hg)enrichments in ancient sediments have been used as a proxy of volcanism,especially large igneous province(LIP)***,considering the existence of other potential Hg sources besides volcanoes and the diverse factors(e.g.,organic matters,clay minerals,sulfide minerals and Fe oxides)that can affect Hg sequestration,there are considerable uncertainties to simply regard sedimentary Hg anomalies as signatures of volcanic *** stable isotopes,a promising tool for tracing the origins and transformations of Hg,have been increasingly used for determining the causes of Hg spikes and understanding the geochemical behavior of Hg in the geologic *** date,lots of researches have applied Hg concentrations and Hg isotopes to identify LIP volcanisms linking with significant geological events such as mass extinctions,ocean anoxic events and other environmental perturbations that mainly occurred in the ***,the results in previous studies clearly show that not all Hg enrichments are derived from volcanic inputs,which emphasize the need for more caution in using Hg as a fingerprint of *** a better understanding of Hg isotopes in the future,there will be important implications for Hg isotopes to reconstruct volcanic activities in the rock records and their impacts on biological evolution.

关键词： Mercury stable isotopes Large igneous province Mass extinction event Ocean anoxic event

Nonlinear Filtering With Sample-Based Approximation Under Constrained Communication:Progress, Insights and Trends

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1539-1556页

作者： Weihao Song Zidong wang Zhongkui Li Jianan wang qing-Long Han IEEE the State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceCollege of Engineering Peking University the Department of Computer Science Brunel University London the School of Aerospace Engineering Beijing Institute of Technology the School of Science Computing and Engineering Technologies Swinburne University of Technology

The nonlinear filtering problem has enduringly been an active research topic in both academia and industry due to its ever-growing theoretical importance and practical *** main objective of nonlinear filtering is to infer the states of a nonlinear dynamical system of interest based on the available noisy measurements. In recent years, the advance of network communication technology has not only popularized the networked systems with apparent advantages in terms of installation,cost and maintenance, but also brought about a series of challenges to the design of nonlinear filtering algorithms, among which the communication constraint has been recognized as a dominating concern. In this context, a great number of investigations have been launched towards the networked nonlinear filtering problem with communication constraints, and many samplebased nonlinear filters have been developed to deal with the highly nonlinear and/or non-Gaussian scenarios. The aim of this paper is to provide a timely survey about the recent advances on the sample-based networked nonlinear filtering problem from the perspective of communication constraints. More specifically, we first review three important families of sample-based filtering methods known as the unscented Kalman filter, particle filter,and maximum correntropy filter. Then, the latest developments are surveyed with stress on the topics regarding incomplete/imperfect information, limited resources and cyber ***, several challenges and open problems are highlighted to shed some lights on the possible trends of future research in this realm.

关键词： Communication constraints maximum correntropy filter networked nonlinear filtering particle filter sample-based approximation unscented Kalman filter

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混流集成式电池组热管理温均特性增效仿真

吉林大学学报（工学版） 2018年第5期48卷 1339-1348页

作者：王炎高青王国华张天时苑盟吉林大学汽车仿真与控制国家重点实验室长春130022 吉林大学汽车工程学院长春130022

电池组内良好的温度一致性是保证电动汽车切实可靠运行的必备条件,为了强化换热,减小组内温度差异性,本文提出了在电池模组内加设风扇的混流集成式电池组热管理方案。通过仿真计算,分析对比了单一液流与集成式两种热管理方式电池的温降... 详细信息

电池组内良好的温度一致性是保证电动汽车切实可靠运行的必备条件,为了强化换热,减小组内温度差异性,本文提出了在电池模组内加设风扇的混流集成式电池组热管理方案。通过仿真计算,分析对比了单一液流与集成式两种热管理方式电池的温降性和温均性,以温度相异系数和温度极差为标准,分析评价了风扇气动性强化和装配高度对电池组温均性的改善效果。仿真结果表明:随着风扇气动特性强化,组内温度一致性得到了有效改善,为了强化末端换热和改善液流板下置的传热延迟,风扇应优先装配在高位。本文提出的混流集成式电池热管理方案具有良好的温均增效性,利于保证电池寿命和电动汽车整车性能。

关键词：车辆工程混流电池热管理风扇气动性装配高度

Text Reasoning Chain Extraction for Multi-Hop Question Answering

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Tsinghua Science and Technology 2024年第4期29卷 959-970页

作者： Pengming wang Zijiang Zhu qing Chen Weihuang Dai School of Data Science and Artificial Intelligence Wenzhou University of TechnologyWenzhou 325035China School of Computer Science and also with Institute of Intelligent Information ProcessingSouth China Business CollegeGuangdong University of Foreign StudiesGuangzhou 510545China School of Psychology Jiangxi Normal UniversityNanchang 330022China also with School of Science East China Jiaotong UniversityNanchang 330013China Institute of Intelligent Information Processing South China Business CollegeGuangdong University of Foreign StudiesGuangzhou 510545China

With the advent of the information age, it will be more troublesome to search for a lot of relevant knowledge to find the information you need. Text reasoning is a very basic and important part of multi-hop question and answer tasks. This paper aims to study the integrity, uniformity, and speed of computational intelligence inference data capabilities. That is why multi-hop reasoning came into being, but it is still in its infancy, that is, it is far from enough to conduct multi-hop question and answer questions, such as search breadth, process complexity, response speed, comprehensiveness of information, etc. This paper makes a text comparison between traditional information retrieval and computational intelligence through corpus relevancy and other computing methods. The study finds that in the face of multi-hop question and answer reasoning, the reasoning data that traditional retrieval methods lagged behind in intelligence are about 35% worse. It shows that computational intelligence would be more complete, unified, and faster than traditional retrieval methods. This paper also introduces the relevant points of text reasoning and describes the process of the multi-hop question answering system, as well as the subsequent discussions and expectations.

关键词： intelligent computing multi-hop quiz text reasoning document retrieval text complex network

A generalized deep neural network approach for improving resolution of fluorescence microscopy images

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 53-65页

作者： Zichen Jin qing He Yang Liu Kaige wang State Key Laboratory of Cultivation Base for Photoelectric Technology and Functional Materials National Center for International Research of Photoelectric Technology&Nano-Functional Materials and ApplicationKey Laboratory of Photoelectronic Technology of Shaanxi ProvinceInstitute of Photonics and Photon-TechnologyNorthwest UniversityXi'an 710127P.R.China

Deep learning is capable of greatly promoting the progress of super-resolution imaging technology in terms of imaging and reconstruction speed,imaging resolution,and *** paper proposes a deep neural network based on a generative adversarial network(GAN).The generator employs a U-Net-based network,which integrates Dense Net for the downsampling *** proposed method has excellent properties,for example,the network model is trained with several different datasets of biological structures;the trained model can improve the imaging resolution of different microscopy imaging modalities such as confocal imaging and wide-field imaging;and the model demonstrates a generalized ability to improve the resolution of different biological structures even out of the *** addition,experimental results showed that the method improved the resolution of caveolin-coated pits(CCPs)structures from 264 nm to 138 nm,a 1.91-fold increase,and nearly doubled the resolution of DNA molecules imaged while being transported through microfluidic channels.

关键词： Deep learning super-resolution imaging generalized model framework generation adversarial networks image reconstruction.