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Electroencephalogram findings in 10 patients with post-stroke epilepsy:A retrospective study

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World Journal of Clinical Cases 2024年第2期12卷 249-255页

作者： Li-Min Wen Ran Li Yan-Ling Wang qing-Xia kong Min Xia Clinical Medicine College Jining Medical UniversityJining 272067Shandong ProvinceChina School of Basic Medical Sciences Shandong UniversityJinan 250012Shandong ProvinceChina Department of Neurology The Affiliated Hospital of Jining Medical UniversityJining 272007Shandong ProvinceChina

BACKGROUND Post-stroke epilepsy is a common and easily overlooked complication of acute cerebrovascular disease.Long-term seizures can seriously affect the prognosis and quality of life of patients.Electroencephalogram(EEG)is the simplest way to diagnose epilepsy,and plays an important role in predicting seizures and guiding medication.AIM To explore the EEG characteristics of patients with post-stroke epilepsy and improve the detection rate of inter-seizure epileptiform discharges.METHODS From January 2017 to June 2020,10 patients with post-stroke epilepsy in our hospital were included.The clinical,imaging,and EEG characteristics were collected.The stroke location,seizure type,and ictal and interictal EEG manifestations of the patients with post-stroke epilepsy were then retrospectively analyzed.RESULTS In all 10 patients,epileptiform waves occurred in the side opposite to the stroke lesion during the interictal stage;these manifested as sharp wave,sharp-wave complex,or spike discharges in the anterior head lead of the side opposite to the lesion.CONCLUSION In EEG,epileptiform waves can occur in the side opposite to the stroke lesion in patients with post-stroke epilepsy.

关键词： Post-stroke epilepsy Electroencephalogram Seizure Stroke Slow wave

Bioinspired design of integral molded Janus silk fibroin-MXene evaporator for efficient solar vapor generation

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Nano Research 2024年第4期17卷 2824-2835页

作者： Ling-qing kong Zhi-Cheng Zeng Guang-Zong Min Zhao-Hui Meng Guo-qing Meng Xiao-Xiao Guo Nai-Bo Lin Xiang-Yang Liu The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Research Center of Biomedical Engineering of XiamenDepartment of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361005China The State Key Laboratory of Marine Environmental Science(MEL) College of Ocean and Earth SciencesXiamen UniversityXiamen 361005China

Solar vapor generation is a promising sustainable technology that uses solar distillation to produce fresh water from seawater and wastewater,helping relieve global water resource shortage.Here,inspired by naturally grown integrally molded mulberry leaves with a Janus hydrophilic and hydrophobic structure,a novel,simple,and efficient integrated molding method is proposed to break through the limitations of the traditional split manufacturing strategy and realizes the integrated formation of Janus evaporator.Based on the spontaneous sedimentation characteristics of MXene in silk fibroin solution and its regulation of mesoscopic structure and hydrophilicity of silk fibroin,layered structures with different compositions and hydrophilicities were obtained in one step.Meanwhile,ethanol and glutaraldehyde were added to construct a physical crystallization-chemical crosslinking dual stabilization structure in silk fibroin.Our evaporator has the evaporation rate of 3.07 kg·m^(-2)·h^(-1) and the efficiency of 86.8%under 1 sun and maintains high evaporation performance under various extreme test conditions including vigorous washing,repeated compression,and high-intensity ultraviolet(UV)irradiation.Additionally,the evaporator performs well in practical application scenarios,its evaporation rate in the simulated Dead Sea seawater exceeds 2.13 kg·m^(-2)·h^(-1),and more than 99.9%of the salt,heavy metal ions,oil pollution,and dyes are purified.

关键词： silk fibroin MXene bioinspired integrated molding Janus structure solar vapor generation

Influence of sintering time on microstructure and properties of hot oscillatory pressing sintered W–Cu refractory alloys

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Tungsten 2024年第2期6卷 323-332页

作者： Zi-Qian Wu Wei Zhao Ka Gao Shi-Hao Du qing-Quan kong De-Jian Sun Yang Gao School of Materials Science and Engineering Zhengzhou University of AeronauticsZhengzhou 450015China School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of General Medicine Changhai HospitalShanghai 200000China Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering Wuhan University of Science and TechnologyWuhan 430081China Sichuan Province Engineering Technology Research Center of Powder Metallurgy Chengdu UniversityChengdu 610106China

W–Cu refractory alloys are widely used in aerospace,aviation,electronics,power,and other fi elds.However,because of its large melting point diff erence between alloy elements,the conventional powder metallurgy method required a long time of high temperature sintering is very likely to cause low density and abnormal grain size growth.Therefore,90W-10Cu refractory alloys were successfully prepared by hot oscillatory pressing(HOP)under diff erent sintering time in this work.Then the infl uence of sintering time on the microstructure,grain size,density,Vickers hardness,room-tensile property,and electrical conductivity of the W–Cu refractory alloy was systematically invested.The results showed that during the short sintering time(30–90 min),the density,Vickers hardness,tensile strength,and electrical conductivity of the W–Cu refractory alloy increased signifi cantly to 98.7%,163.29 HV 30,507.3 MPa,and 14.2%International Annealed Copper Standard with the sintering time increasing,respectively,while its grain size showed no obvious change.When the sintering time further increased to 120 min,the density was basically consistent with the sintering time of 90 min.Nevertheless,the prolonged high temperature sintering resulted in the grain growth of the samples,which caused the deterioration of the Vickers hardness,room-tensile strength,and conductivity properties of the W–Cu refractory alloy.At the same sintering time,the density,Vickers hardness,and electrical conductivity of the HOP sintered W–Cu refractory alloy were signifi cantly higher than those of the HP sintered sample.It was indicated that high density,fi ne-grain,and excellent properties W–Cu refractory alloys could be prepared by hot oscillatory pressing under appropriate sintering time.

关键词： W–Cu refractory alloy Hot oscillatory pressing Sintering time Microstructure Property

钢筋混凝土剪力墙抗震滞回性能的多元时序深度神经网络预测

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工程力学 2024年第6期41卷 66-76页

作者：袁程熊青松孔庆钊同济大学土木工程防灾国家重点实验室上海200092

钢筋混凝土剪力墙结构抗震性能优越且造价合理,广泛用于抗震烈度较高的地区。准确地预测剪力墙的滞回性能与骨架曲线,直接决定了结构设计与分析的准确度与可靠性。该文提出了一种基于深度学习的剪力墙结构滞回性能预测方法,可以根据结... 详细信息

钢筋混凝土剪力墙结构抗震性能优越且造价合理,广泛用于抗震烈度较高的地区。准确地预测剪力墙的滞回性能与骨架曲线,直接决定了结构设计与分析的准确度与可靠性。该文提出了一种基于深度学习的剪力墙结构滞回性能预测方法,可以根据结构的基本设计参数(如材料属性、几何尺寸、荷载工况等),直接预测出其承载力。通过3组剪力墙的滞回试验预测1组结构的滞回曲线,结果表明:通过比较时域的特征,深度学习方法具有较高的预测精度。通过与有限元仿真结果对比,深度学习仅需输入不同参数就能够快速预测滞回曲线,其优势还在于具有较高的计算效率,而有限元仿真需要几何建模、本构模型选取、材料属性输入和荷载工况定义,整个过程相较于深度学习耗时耗力。

关键词：钢筋混凝土剪力墙多元时序深度神经网络滞回曲线抗震性能骨架曲线

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从系统论看人们对领导认识的阶段和层次

系统科学学报 2024年第1期32卷 65-70页

作者：孔庆新山西大学电力与建筑学院山西太原030031

从系统论看,人们对领导的认识经历了传统领导观、领导系统观、新领导系统观三个不同的阶段和层次,实现了对领导认识的两次飞跃。新领导系统观的确立和贯彻落实是领导观的一场深刻革命,不仅是对领导认识的系统化、深化和优化,而且是对领... 详细信息

从系统论看,人们对领导的认识经历了传统领导观、领导系统观、新领导系统观三个不同的阶段和层次,实现了对领导认识的两次飞跃。新领导系统观的确立和贯彻落实是领导观的一场深刻革命,不仅是对领导认识的系统化、深化和优化,而且是对领导科学的创新、丰富和发展,对建立领导者与被领导者的新型关系、形成不断提高领导效率和效益的长效机制和开创领导科学发展的新局面都具有重大的现实意义和深远的历史意义,对深化领导体制机制改革、加强领导作风建设和贯彻落实群众路线都具有重要的理论价值和现实意义。

关键词：系统论领导新领导系统观三个阶段三个层次两次飞跃

Refiector Deformation Measurement and Correction Methodology of Large Antenna Based on Phased Array Feed

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Research in Astronomy and Astrophysics 2024年第3期24卷 297-308页

作者： Zan Wang De-qing kong Hong-Bo Zhang Yan Su Xin-Ying Zhu Cong-Si Wang Yu-Chen Liu Key Laboratory of Lunar and Deep Space Exploration National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Electronic Equipment Structure Design Ministry of EducationXidian UniversityXi'an 710071China

To solve the problem of time-consuming measurement and correction of large antennas’reflector deformation,a new microwave holography methodology based on a Phased Array Feed(PAF)is proposed.Starting from the known expression of receiving signals in microwave holography,the theory of PAF holography is derived through Geometrical Optics.Reflector deformation,as well as pointing deviation and subreflector offset,can be calculated out by applying the derived equations.A measurement and correction system based on PAF holography is depicted,and two kinds of measurement methods are illustrated.The proposed measurement methodology is verified by numerical simulation,and its measurement error is analyzed.The results indicate that our proposed methodology is feasible,especially for Cassegrain antennas.

关键词： telescopes-methods analytical--methods numerical

Response of Salmonella enterica serovar Typhimurium to alginate oligosaccharides fermented with fecal inoculum:integrated transcriptomic and metabolomic analyses

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Marine Life Science & Technology 2023年第2期5卷 242-256页

作者： Jiaying Cheng Mengshi Xiao Xinmiao Ren Francesco Secundo Ying Yu Shihao Nan Weimiao Chen Changliang Zhu qing kong Youtao Huang Xiaodan Fu Haijin Mou College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Istituto di Scienze e Tecnologie Chimiche“Giulio Natta” Consiglio Nazionale delle Ricerche20131 MilanItaly State Key Laboratory of Food Science and Technology China-Canada Joint Laboratory of Food Science and Technology(Nanchang)Key Laboratory of Bioactive Polysaccharides of Jiangxi ProvinceNanchang UniversityNanchang 330047China School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China

Alginate oligosaccharides(AOS),extracted from marine brown algae,are a common functional feed additive;however,it remains unclear whether they modulate the gut microbiota and microbial metabolites.The response of Salmonella enterica serovar Typhimurium,a common poultry pathogen,to AOS fermented with chicken fecal inocula was investigated using metabolomic and transcriptomic analyses.Single-strain cultivation tests showed that AOS did not directly inhibit the growth of S.Typhimurium.However,when AOS were fermented by chicken fecal microbiota,the supernatant of fermented AOS(F-AOS)exhibited remarkable antibacterial activity against S.Typhimurium,decreasing the abundance ratio of S.Typhimurium in the fecal microbiota from 18.94 to 2.94%.Transcriptomic analyses showed that the 855 diferentially expressed genes induced by F-AOS were mainly enriched in porphyrin and chlorophyll metabolism,oxidative phosphorylation,and Salmonella infection-related pathways.RT-qPCR confrmed that F-AOS downregulated key genes involved in fagellar assembly and the type III secretory system of S.Typhimurium,indicating metabolites in F-AOS can infuence the growth and metabolism of S.Typhimurium.Metabolomic analyses showed that 205 microbial metabolites were signifcantly altered in F-AOS.Among them,the increase in indolelactic acid and 3-indolepropionic acid levels were further confrmed using HPLC.This study provides a new perspective for the application of AOS as a feed additive against pathogenic intestinal bacteria.

关键词： Alginate oligosaccharides Gut microbiota Metabolite Salmonella enterica serovar Typhimurium Metabolomics Transcriptomic

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隧道支护加固参数对上部输气管线影响分析

公路 2024年第6期69卷 376-386页

作者：张婧孔庆梅温森河南大学土木建筑学院开封市475004

基于有限元软件MIDAS GTS NX和正交试验设计方法,建立新奥法隧道施工下穿输气管线模型,分析时以管线的变形和应力为指标,利用极差和方差分析探讨管隧正交情况下不同支护加固参数(加固范围、加固厚度、喷混厚度、喷混强度等级、二衬强度... 详细信息

基于有限元软件MIDAS GTS NX和正交试验设计方法,建立新奥法隧道施工下穿输气管线模型,分析时以管线的变形和应力为指标,利用极差和方差分析探讨管隧正交情况下不同支护加固参数(加固范围、加固厚度、喷混厚度、喷混强度等级、二衬强度等级、初支距掌子面距离)对上部管线变形的影响。结果表明:隧道加固范围和初期支护距掌子面距离对管线变形和应力的影响极为显著,加固范围从90°增加至360°,管线位移和最小主应力的减小幅度均超过69%;初期支护距掌子面的距离从1 m增加至4 m,管线竖向位移和最小主应力急剧增大,增幅均超过1倍;加固厚度、喷射混凝土强度等级对管线变形和应力的影响高度显著,喷射混凝土厚度影响显著,二次衬砌强度等级影响不显著。

关键词：隧道工程支护参数输气管线下穿施工正交试验设计数值模拟

Splicing of Receptor-Like Kinase-Encoding SNC4 and CERK1 is Regulated by Two Conserved Splicing Factors that Are Required for Plant Immunity

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Molecular Plant 2014年第12期7卷 1766-1775页

作者： Zhibin Zhang Yanan Liu Pingtao Ding Yan Li qing kong Yuelin Zhang Department of Botany University of British Columbia Vancouver Canada V6T 1Z4 National Institute of Biological Sciences Zhongguancun Life Science Park Beijing People's Republic of China 102206

Plant immune receptors belonging to the receptor-like kinase （RLK） family play important roles in the recog- nition of microbial pathogens and activation of downstream defense responses. The Arabidopsis mutant snc4-1D con- tains a gain-of-function mutation in the RLK SNC4 （SUPPRESSOR OF NPRI-1, CONSTITUTIVE4）, which leads to constitutive activation of defense responses. Analysis of suppressor mutants of snc4-1D identified two conserved splicing factors, SUA （SUPPRESSOR OF ABI3-5） and RSN2 （REQUIRED FOR SNC4-1D 2）, that are required for the constitutive defense responses in snc4-1D. In sua and rsn2 mutants, SNC4 splicing is altered and the amount of 5NC4 transcripts is reduced. Further analysis showed that SUA and RSN2 are also required for the proper splicing of CERK1 （CHITIN ELICITOR RECEPTOR KINASE1）, which encodes another RLK that functions as a receptor for chitin. In sua and rsn2 mutants, induction of reactive oxygen species by chitin is reduced and the non-pathogenic bacteria Pseudomonas syringae pv. tomato DC3OOOhrcC grows to higher titers than in wild-type plants. Our study suggests that pre-mRNA splicing plays important roles in the regulation of plant immunity mediated by the RLKs SNC4 and CERK1.

关键词： plant immunity receptor-like kinase alternative splicing SUA RSN2 SNC4 CERK1.