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Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 29-35页

作者： Shi-Qiong Zhou Peng Wan Seng Zhang Yuan Ren Hong-Tao Li qing-Hua ke Department of Chemoradiotherapy The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor *** it metastasizes to the liver,treatment options become particularly limited and *** treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves ***,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on *** study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic *** To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic *** Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer *** in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable *** in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight *** June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy *** The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,P<0.05)and progression-free survival(9.6 months vs 5.4 months,P<0.05).compared to the chemotherapy *** incidence of severe adverse events did not differ sign

关键词： Immunotherapy Programmed cell death 1 inhibitor Sintilimab Chemotherapy Metastatic Pancreatic ductal adenocarcinoma

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WAVELET ANALYSIS OF MULTIFRACTAL AND ITS APPLICATION TO PROCESSING TEMPERATURE DATA IN RAYLEIGH-BENARD CONVECTION

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Journal of Hydrodynamics 2001年第4期13卷 34-41页

作者： Fu, Qiang Xia, ke-qing Div. of Appl. Mech. Inst. of Sci. Univ. of Sci. and Technol. of PLA Nanjing 211101 China

Wavelet transform was firstly used to analyze te singularity of a given signal, and then with the method of wavelet transform modulus maximum(WTMM), the characters of fractal set of triadic Cantor was studied. The results show that one can, not only determine the position of singular of signal, but also estimate the Holder exponent h which describes the strength of singularity and other parameters, such as D(h) and τ(q) correctly. Finally, after applying this method to process temperature data in the Rayleigh-Benard convection further, we found that the multifractal hierarchical and multi-scale structure underlying this flow could be entirely revealed from the parameters h, D(h) and τ(q), and the obtained results agree well with the ones determined from the viewpoint of fractal measures.

关键词： Heat convection Wavelet transforms

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Current trends and future directions in turbulent thermal convection

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Theoretical & Applied Mechanics Letters 2013年第5期3卷 1-12页

作者： ke-qing Xia Department of Physics The Chinese University of Hong Kong

The system of turbulent thermal convection is introduced. Progresses in recent decades in the four major areas of research in turbulent convection are briefly reviewed. Some of the recent trends of the field are then discussed, which also serve to point out that the future directions in this important field of fluid mechanics lie in the extension to the non-standard or non-classical Rayleigh-Bénard configuration.

关键词： turbulence thermal convection turbulent heat transport thermal plumes large-scaleflow small-scale turbulence

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Prolonging warm ischemia reduces the cold preservation limits of liver grafts in swine

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Hepatobiliary & Pancreatic Diseases International 2006年第4期5卷 515-520页

作者： De-ke qing Hepatobiliary Surgery Centre of Chengdu Military Unit Department of Hepatobiliary Surgery Kunming General Hospital of PLA Kunming 650032 China. qdkzjqy@***

BACKGROUND: The critical shortage of transplantable organs necessitates utilization of unconventional donors. But the safe time limits of cold preservation of liver grafts subjected to warm ischemia (WI) for up to 30 minutes from non-heart-beating-donors (NHBDs) has not been delineated. In this study, we investigated how the limits of cold ischemia (CI) in University of Wisconsin (UW) solution are changed in liver grafts subjected to WI from 10 to 30 minutes.METHODS: A simple porcine NHBD liver transplantation (LT) model was developed. In donors, livers were subjected to 10, 20 or 30 minutes of WI and subsequent different times of CI in UW solution. Animals were divided into three groups (WI 10 min, WI 20 min, WI 30 min, n=13 in each group) and nine subgroups (from CI 6 h to CI 28 h). One-week survival rates of recipients, hepatic function, liver energy metabolism, grafted liver microcirculation and pathological observations of the liver were compared.RESULTS: In the WI 10 min group, the one-week survival rate of the CI 20 h subgroup was significantly higher than in the other two subgroups (CI 24 h and CI 28 h) (P<0.05). Furthermore, the CI 20 h subgroup had a lower level of alanine aminotransferase (ALT), less pathological damage, a higher concentration of adenosine triphosphate (ATP) and microcirculatory blood flow in the grafted livers at 1 hour after reperfusion than the other two subgroups. The same trends were also found in the other two groups (WI 20 min and WI 30 min) and their subgroups.CONCLUSIONS: The cold preservation limits of the liver grafts shortened from 20 to 12 to 6 hours when WI time was prolonged from 10 to 20 to 30 minutes. Only the liver grafts within these time limits could be safely transplanted.

关键词： liver transplantation non-heart-beating donor warm ischemia cold preservation ischemia/reperfusion

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Mathematical analysis of SOFC based on co-ionic conducting electrolyte

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Acta Mechanica Sinica 2013年第3期29卷 388-394页

作者： ke-qing Zheng Meng Ni Qiong Sun Li-Yin Shen Building Energy Research Group Department of Building and Real Estate The Hong Kong Polytechnic University

In co-ionic conducting solid oxide fuel cell （SOFC）, both oxygen ion （O2） and proton （H＋） can transport through the electrolyte, generating steam in both the an-ode and cathode. Thus the mass transport phenomenon in the electrodes is quite different from that in conventional SOFC with oxygen ion conducting electrolyte （O-SOFC） or with proton conducting electrolyte （H-SOFC）. The generation of steam in both electrodes also affects the concentration over-potential loss and further the SOFC performance. However, no detailed modeling study on SOFCs with co-ionic electrolyte has been reported yet. In this paper, a new mathematical model for SOFC based on co-ionic electrolyte was developed to predict its actual performance considering three major kinds of overpotentials. Ohm＇s law and the Butler-Volmer formula were used to model the ion conduction and electrochemical reactions, respectively. The dusty gas model （DGM） was employed to simulate the mass transport processes in the porous electrodes. Parametric simulations were performed to investigate the effects of proton transfer number （tH） and current density （jtotal） on the cell performance. It is interesting to find that the co-ionic conducting SOFC could perform better than O-SOFC and H-SOFC by choosing an appropriate proton transfer number. In addition, the co-ionic SOFC shows smaller difference between the anode and cathode concentration overpotentials than O-SOFC and H-SOFC at certain t H values. The results could help material selection for enhancing SOFC performance.

关键词： Co-ionic electrolyte Proton transport number Concentration overpotential Mass transport Model

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Recovery of iron from copper slag by deep reduction and magnetic beneficiation

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International Journal of Minerals,Metallurgy and Materials 2013年第11期20卷 1035-1041页

作者： ke-qing Li Shuo Ping Hong-yu Wang Wen Ni key Laboratory of the Ministry of Education of China for High-Efcient Mining and Safety of Metal Mines University of Science and Technology Beijing School of Civil and Environmental Engineering University of Science and Technology Beijing

Aiming at recovering iron from high-iron-content copper slag, this article introduced a combination technol- ogy of deep reduction and magnetic beneficiation, investigated the iron recovery efficiency and optimized the technical conditions. When coke powder with 86wt% fixed carbon was used as a reductant, iron was successfully extracted from the copper slag. Under the optimized condition of the coke powder content of 14wt%, the calcium-to-silicon mass ratio （Ca/Si） of 0.2, the roasting temperature of 1300℃, the roasting time of 3 h, the grinding time of 20 min, and the magnetic field intensity of 61 kA-m-1, the iron recovery rate of the copper slag can reach 91.82%, and the extracted iron powder has an iron grade of 96.21%. With the characteristics of high iron grade and low impurity content, the extracted iron powder can be used as high-quality raw materials of weathering steel.

关键词： copper slag waste utilization ore reduction magnetic separation beneficiation

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Monitoring Multi-Temporal Changes of Lakes on the Tibetan Plateau Using Multi-Source Remote Sensing Data from 1992 to 2019:A Case Study of Lake Zhari Namco

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Journal of Earth Science 2024年第5期35卷 1679-1691页

作者： Juan Wu Chang-qing ke Yu Cai Zheng Duan Jiangsu Provincial key Laboratory of Geographic Information Science and Technology Key Laboratory for Land Satellite Remote Sensing Applications of Ministry of Natural ResourcesSchool of Geography and Ocean ScienceNanjing UniversityNanjing 210023China Collaborative Innovation Center of Novel Software Technology and Industrialization Nanjing 210023China Guangxi Water and Power Design Institute Co. LtdNanning 530022China Collaborative Innovation Center of South China Sea Studies Nanjing 210023China Department of Physical Geography and Ecosystem Science Lund UniversityLund 22362Sweden

Lake level,area and volume are sensitive indicators of climate *** present,many studies have focused on the interannual water balance of lakes,but lake level and area can change remarkably with seasons,especially for lakes with seasonal ice *** Namco,a seasonal frozen lake,was selected as an example to investigate its seasonal water ***-source altimetry and Landsat data were used to obtain the seasonal lake level and area from 1992 to 2019,and seasonal lake volume variations were also *** results indicated the average lake level,area and volume in autumn were the *** lake level,area,and volume experienced three turning points approximately in 2000,2010,and 2016,and showed an overall increasing trend from 1992 to 2019,with slopes of 0.15 m/year,2.17 km^(2)/year,and 0.14 km^(3)/year,*** lake area expanded significantly in autumn,which was related to the abundant *** time of land surface runoff,increased temperature,and evaporation may be the reason for the low lake level and volume in *** precipitation was the dominant factor of water balance,which explained 62.09%,62.43%,and 62.10%of the variations in lake level,area,and volume,respectively.

关键词： lake level lake area lake volume satellite altimetry landsat Zhari Namco hydrogeology

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Tuning heat transport via coherent structure manipulation:recent advances in thermal turbulence

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National Science Review 2023年第6期10卷 245-257页

作者： ke-qing Xia Shi-Di Huang Yi-Chao Xie Lu Zhang Center for Complex Flows and Soft Matter Research and Department of Mechanics and Aerospace Engineering Southern University of Science and Technology State key Laboratory for Strength and Vibration of Mechanical Structures and School of Aerospace Xi'an Jiaotong University

Tuning transport properties through the manipulation of elementary structures has achieved great success in many areas,such as condensed matter ***,the ability to manipulate coherent structures in turbulent flows is much less *** article reviews a recently discovered mechanism of tuning turbulent heat transport via coherent structure *** first show how this me chanism can be realized by applying simple geometrical confinement to a classical thermally driven turbulence, which leads to the condensation of elementary coherent structures and significant heat-transport enhancement,despite the resultant slower *** potential applications of this new paradigm in passive heat management are also *** then explain how the heat transport behaviors in seemingly different turbulence systems can be understood by this unified framework of coherent structure *** future directions in this research area are also outlined.

关键词： coherent structure turbulent flow heat transport geometrical confinement dynamical constraint

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A planar capacitive sensor for 2D long-range displacement measurement

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第4期14卷 252-257页

作者： Jian-ping YU Wen WANG ke-qing LU De-qing MEI Zi-chen CHEN Department of Mechanical Engineering Zhejiang University School of Mechanical Engineering Hangzhou Dianzi University

A planar capacitive sensor(PCS) capable of 2D large-scale measurement is presented in this *** interpretation depends on independently measuring the periodic variation in capacitance caused by the change in the overlapping area of sensing electrodes on a moving plate and a fixed *** accumulating the number of quarters in each direction and the specific position in the final quarter,the large-scale measurement is *** in Xand Y-direction can be measured independently and *** shows that a shorter gap distance and a longer electrode guarantee better *** based on a PCS test bench demonstrate that the PCS has a sensitivity of 0.198 mV/μm and a resolution of 0.308 μ*** electric fringe effect and other possible measurement errors on displacement interpretation accuracy are *** study confirms the high potential of PCSs as innovative 2D long-range displacement sensors.

关键词： Planar capacitive sensor (PCS) Displacement measurement 2D large-scale measurement

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Crystal Structure and Theoretical Calculation of N-[4-(2-Methoxyphenoxy)]phenyl Acetanilide

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Chinese Journal of Structural Chemistry 2010年第7期29卷 1077-1083页

作者： ZHANG Cheng-Gang LI Quan WANG Bi-Qin ZHAO ke-qing College of Chemistry and Material Science Sichuan Normal University key Laboratory of Advanced Functional Materials Sichuan Higher Education System Chengdu 610066 China

N-[4-（2-Methoxyphenoxy）]phenyl acetanilide has been synthesized and its structure was determined by X-ray diffraction analysis with a = 0.6152（4）, b = 1.1728（4）, c = 1.2367（4） nm, α = 91.34（3）, β = 93.22（4）, γ = 102.61（3）°, V = 0.8688（7） nm3 and Dc = 1.274 Mg/m3. Theoretical investigations on the title compound were carried out by full optimization on its structural unit at the B3LYP/6-31G＊＊ level. And ultimately, the infrared, Raman spectra, electronic absorption spectra, and the relationships between temperature and thermodynamic functions （Hm, Sin, Cpm） were obtained.

关键词： phenyl acetanilide crystal structure spectra thermodynamic properties

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