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扬子地块中太古宙地壳增生:来自黄陵背斜南部地区花岗闪长质片麻岩的证据

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现代地质 2023年第2期37卷 433-442页

作者：王庆蒋幸福中煤科工集团西安研究院有限公司陕西西安710077 东华理工大学核资源与环境国家重点实验室江西南昌330013 东华理工大学地球科学学院江西南昌330013

扬子地块黄陵背斜南部出露的花岗闪长质片麻岩是太古宙TTG片麻岩的重要组成单元,具有高Al2O3、Na2O、Sr以及低Rb、Nb等特征,属于高铝TTG系列,且具埃达克质岩石属性。结合片麻岩微量元素蛛网图显示的Nb、Ta和Hf等高场强元素富集以及Th、P... 详细信息

扬子地块黄陵背斜南部出露的花岗闪长质片麻岩是太古宙TTG片麻岩的重要组成单元,具有高Al2O3、Na2O、Sr以及低Rb、Nb等特征,属于高铝TTG系列,且具埃达克质岩石属性。结合片麻岩微量元素蛛网图显示的Nb、Ta和Hf等高场强元素富集以及Th、Pb和U等大离子亲石元素亏损的特征,本文认为该岩石形成于俯冲环境下玄武质洋壳的部分熔融作用。黄陵背斜北部出露的2.9~3.0 Ga TTG片麻岩和弧性质角闪岩,反映该时期是扬子地块陆壳生长的一次重要阶段,且以洋壳俯冲产生岛弧或安第斯型岩浆作用的陆壳水平增生为主,通过微陆块拼贴或规模较小的板块构造模式而形成。

关键词：扬子地块黄陵背斜南部花岗闪长质片麻岩高铝TTG系列地壳增生

锻造温度对Ti60钛合金大规格棒材组织及性能的影响

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世界有色金属 2016年第10期41卷 45-47页

作者：陈秉刚李渭清田永强王青江郭佳林张雪敏宝钛集团有限公司陕西宝鸡721014 中国科学院金属研究所辽宁沈阳110015

研究了锻造温度对Ti60合金Φ350mm规格棒材组织、力学性能及探伤的影响。试验选用相同的试验坯料,按照变形方式、变形量相同而变形温度不同进行Ti60合金棒材α＋β两相区锻造。研究表明：Ti60合金棒材采用Tβ-40℃进行α＋β两相区锻造... 详细信息

研究了锻造温度对Ti60合金Φ350mm规格棒材组织、力学性能及探伤的影响。试验选用相同的试验坯料,按照变形方式、变形量相同而变形温度不同进行Ti60合金棒材α＋β两相区锻造。研究表明：Ti60合金棒材采用Tβ-40℃进行α＋β两相区锻造,其组织晶粒细小,且力学性能及探伤水平均优于采用Tβ-20℃进行α＋β两相区锻造的棒材。

关键词： Ti60 合金显微组织力学性能

Up-regulation of Ras/Raf/ERK1/2 signaling in the spinal cord impairs neural cell migration, neurogenesis, synapse formation, and dendritic spine development

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Chinese Medical Journal 2013年第20期126卷 3879-3885页

作者： Cao Fu-jiang Zhang Xu Liu Tao Li Xia-wen Malik, Mazar Feng Shi-qing Tianjin Med Univ Gen Hosp Dept Orthopaed Tianjin 300052 Peoples R China Univ Lancaster Grad Sch Lancaster LA1 4YQ England

Background The Ras/Raf/ERK1/2 signaling pathway controls many cellular responses such as cell proliferation, migration, differentiation, and death. In the nervous system, emerging evidence also points to a death-promoting role for ERK1/2 in both in vitro and in vivo models of neuronal death. To further investigate how Ras/Raf/ERK1/2 up-regulation may lead to the development of spinal cord injury, we developed a cellular model of Raf/ERK up-regulation by over- expressing c-Raf in cultured spinal cord neurons （SCNs） and dorsal root ganglions （DRGs）.

关键词： Ras/Raf/ERK1/2 spinal cord injury, neural circuit imbalances, signaling pathway

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浙江农村人群戊型肝炎感染率调查

复旦学报（医学版） 2006年第3期33卷 357-362页

作者：陆一涵宋建根姜庆五王法弟董晓莲朱连华范建良高眉扬郑英杰复旦大学公共卫生学院流行病学教研室-公共卫生安全教育部重点实验室上海200032 浙江省德清县疾病预防控制中心浙江德清313200

目的检测浙江德清农村人群中戊型肝炎血清抗体水平,调查并评价各种可能的戊型肝炎病毒感染的危险因素。方法通过调查表收集研究人群的一般资料并采用间接酶联免疫吸附法检测血清抗HEV-IgG抗体。结果在被调查且自愿采血的663人中,HEV-Ig... 详细信息

目的检测浙江德清农村人群中戊型肝炎血清抗体水平,调查并评价各种可能的戊型肝炎病毒感染的危险因素。方法通过调查表收集研究人群的一般资料并采用间接酶联免疫吸附法检测血清抗HEV-IgG抗体。结果在被调查且自愿采血的663人中,HEV-IgG抗体阳性率为63.50%,男性(70.03%)显著高于女性(57.14%)。各年龄组阳性率随年龄升高而增加,20岁以下组最低,仅为23.53%;20岁以上组为55.00%,之后虽然继续升高,但保持在一个稳定水平。既往肝炎史、输血史、饲养和接触动物与戊型肝炎抗体阳性率的关系无统计学意义。结论浙江农村地区戊型肝炎病毒感染情况普遍,男性高于女性,有随着年龄的增加而升高的趋势。

关键词：肝炎病毒,戊型抗HEV—IgG抗体血清流行病学研究人兽共患病

Reconstruction of Community Fiscal System: Background, Principles and Proposals

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当代财经 2013年第S1期 38-49页

作者： jiang Jin-fa LUO qing-lin School of Taxation and Public Administration jiangxi University of Finance and Economics

After the collapse of the unit-neighborhood system,the communities in China have got a nature of duality,from which a mixed dual duty structure is derived.This structure calls for a re-establishment of the principals for community financial system from such aspects as fund raising mode,budget supervision,and allocation program,etc.There exist some defects in the present community financial system,such as one-sided design,insufficient fund resource for community outlay,lower efficiency of fund operation,lacking of coordination in community construction investment,etc.which seriously restrict the functions of modern community.In order to construct a community oriented public fiscal system,we need to clarify the division of responsibilities between the government and the community,give full play to community’s potential in self-governance and construct a comprehensive fund allocation mechanism.

关键词： community duality dual power structure community oriented public fiscal system

IGF-Ⅰ、GH和CLA对脂肪前体细胞增殖、分化和基因表达的影响

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农业生物技术学报 2007年第4期15卷 649-653页

作者：江青艳陈胜锋朱晓彤束刚高萍高淑静宾艳芳华南农业大学动物科学学院广州510642 华南农业大学动物科学学院

为探讨类胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、生长激素(GH)和共轭亚油酸(CLA)对不同部位来源脂肪前体细胞的增殖和分化程度的影响,以大鼠(Rattus norveaicus)为实验模型,分别从附睾及皮下脂肪组织分离得到脂肪前体细胞,并在不同浓度的IGF-Ⅰ... 详细信息

为探讨类胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、生长激素(GH)和共轭亚油酸(CLA)对不同部位来源脂肪前体细胞的增殖和分化程度的影响,以大鼠(Rattus norveaicus)为实验模型,分别从附睾及皮下脂肪组织分离得到脂肪前体细胞,并在不同浓度的IGF-Ⅰ、GH和CLA处理后,用MTT法检测脂肪前体细胞的增殖,用油红O染色法检测脂肪前体细胞的分化聚脂程度。实验结果表明,各剂量IGF-Ⅰ和CLA均能够显著地促进大鼠附睾及皮下脂肪前体细胞的增殖与分化,但GH对大鼠附睾及皮下脂肪前体细胞的增殖与分化均无明显作用。为进一步观察IGF-Ⅰ和CLA对皮下脂肪组织的作用机制,实验采用半定量RT-PCR法检测细胞中PPARγ和C/EBPα基因表达水平,结果发现,100ng/mL IGF-I可显著上调大鼠脂肪前体细胞中PPARγ与C/EBPα基因表达水平;48ng/m LGH和100μmol/L CLA可显著促进PPARγ基因表达,但对C/EBPα mRNA表达无显著影响。结果示IGF-I可能主要通过上调PPARγ与C/EBPα基因的高水平表达进而促进大鼠脂肪前体细胞的分化,而CLA对脂肪前体细胞的作用在上调PPARγ的表达的同时,还作为PPARγ的配体激活该受体而发挥作用。

关键词：脂肪前体细胞分化转录因子胰岛素样生长因子-Ⅰ(IGF-Ⅰ) 生长激素(GH) 共轭亚油酸(CLA)

Current role of surgery for the treatment of fulminant Clostridium difficile colitis

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中华医学杂志(英文版) 2013年第5期126卷 949-956页

作者： WANG Ming-fei DING Zhao ZHAO Jian jiang Cong-qing LIU Zhi-su QIAN Qun Department of Colorectal Surgery Clinical Research Center for Intestinal and Colorectal Diseases of Hubei ProvinceHubei Key Laboratory of IntestinalColorectal DiseasesZhongnan Hospital of Wuhan University

Objective This review discusses the current status and progress in studies on fulminant Clostridium difficile colitis(FCDC),including the definition,risk factor,diagnostic role of CT,surgical treatment,postoperative mortality,and new therapeutic strategy.Data sources A literature search was conducted mainly in Medline and PubMed published in English between January2000 and May 2011.The search terms were "fulminant Clostridium difficile colitis","treatment"","surgery" and "mortality".Results Recent studies show that the overall mortality rate for FCDC remains high despite early surgical intervention.It has been difficult to identify the real value for surgical intervention in patients with FCDC due to the absence of prospective,randomized studies.Early recognition of patients with FCDC will help a clinician decide the need for treatment in an intensive care setting,multi-disciplinary consultation,and appropriate therapeutic selection.Some studies emphasize the importance of early recognition and emergent surgery at a less severe stage.Monoclonal antibody therapy and intravenous immunoglobulin treatment may be useful for the treatment of FCDC.Conclusions Present studies do not provide strong evidence for guiding the surgical treatment of FCDC;hence,creation of collaborative research networks is crucial in order to undertake large prospective multi-center studies for improvement in overall survival.

关键词： fulminant Clostridium difficile colitis treatment surgery mortality

Effects of Crop Development on the Emission of Volatiles in Leaves of Lycopersicon esculentum and Its Inhibitory Activity to Botrytis cinerea and Fusarium oxysporum

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Journal of Integrative Plant Biology 2008年第1期50卷 84-91页

作者： Peng-Ying Zhang Kao-Shan Chen Pei-qing He Sheng-Hao Liu Wan-Feng jiang College of Life Sciences Shandong University Jinan 250100 China Key Laboratory of Marine Bioactive Substances First Institute of Oceanography State Oceanic Administration Qingdao 266061 China qingdao Quafity Supervision and Inspection Center for Shopping Basket Commodity Qingdao 266003 China

Volatiles emitted from the leaves of Lycopersicon esculentum at the two-, ten-leaf and anthesis periods were collected by a gas absorbing method and analyzed by gas chromatography （GC）-mass spectrometry. In total, 33 compounds of volaUles emitted from three developmental stage plants were separated and identified, and quantitatively analyzed by the internal standard addition method. All of the samples of volatile were found to be rich in monoterpenes and sesquiterpenes.β-phellandrene and caryophyllene predominated in the volatiles of the leaves of plants at the two- and ten-leaf stages. Furthermore, （E）-2-hexenal were the dominant components in the volatiles emitted from anthesis plants. The results of volatiles analyzed show that the compositions varied depending on the developmental stages. The volatiles emitted from crushed tomato leaves of plants at the anthesis stage had the most strongly inhibitory activity against the spore germination and hyphal growth of Botrytis cinerea and Fusarium oxysporum, followed by ten- and two-leaf plants. However, the activity of volatiles, emitted from the leaves of plants at the two-leaf stage, in inhibiting F. oxysporum was greater than B. cinerea.

关键词： development inhibitroy activity Lycopersicon esculentum volatiles.

Role of RhoA in platelet-derived growth factor-BB-induced migration of rat hepatic stellate cells

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Chinese Medical Journal 2010年第18期123卷 2502-2509页

作者： LI Lei LI Jing WANG Ji-yao YANG Chang-qing JIA Ming-lei jiang Wei Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Gastroenterology Tongji Hospital Tongji University Shanghai 200065 China Department of Gastroenterology Huadong Hospital Fudan University Shanghai 200040 China

Background Although the migration of hepatic stellate cells （HSCs） is essential for hepatic fibrotic response, the detailed mechanisms involved are poorly understood. The aim of this study was to examine the role of Rho GTPases （especially RhoA） in platelet-derived growth factor （PDGF）-BB-induced migration of HSCs. Methods The migration of primary rat HSCs was evaluated using transwell Boyden chamber, while cytoskeletal changes were visualized by immunofluorescence staining of intracellular actins and vinculin. Quantitative real-time PCR and Western blotting analysis were used to detect the expression of Rho GTPases （RhoA, Racl and Cdc42） within HSCs and their activation was determined by glutathione S-transferase pull-down assay. Finally, the effects of RhoA on PDGF-BB-induced cell migration and cytoskeletal remodeling were analyzed using HSC-T6 cells stably transfected with constitutively active （CA, Q63L） or dominant negative （DN, T19N） RhoA mutants. Data were analyzed using SPSS 16.0 software. Student＇s t test was used to analyze differences between two groups and one-way analysis of variance （ANOVA） was used among multiple groups. Results Rapid cytoskeletal remodeling led to a significant increase in the motility of primary rat HSCs after haptotactic （direct） and chemotactic （indirect） stimulation by PDGF-BB： PDGF-BB caused a dramatic elevation in the levels of both total and active RhoA protein. However, the levels of mRNA for Rho GTPases, including RhoA, Racl and Cdc42, were unaffected. Furthermore, PDGF-BB induced increased formation of stress fibers and focal adhesions in HSC-T6 cells transfected with CA-RhoA, but not in HSC-T6 transfected with DN-RhoA. Surprisingly, both CA- and DN-RhoA-transfected HSC-T6 cells showed decreased migratory potential in the absence or presence of PDGF-BB compared with controls. Conclusions PDGF-BB induced cytoskeletal remodeling in rat HSCs and promoted their migration via regulation of intracellular RhoA. RhoA may be one of the determinants in PDGF-BB-induced HSC miaratio

关键词： platelet-derived growth factor BB hepatic stellate cells cell movement RhoA protein liver fibrosis