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Chinese Science Bulletin 2014年第34期59卷 4758-4762页

作者： Peng L Xiao-Tong Wang Sheng-Zhi Yang Yan Li Xiu-Li Hou qing-Feng guan School of Materials Science and Engineering Jiangsu University

N-type Si(111) wafers have been processed by high-current pulsed electron beam(HCPEB) treatment with an increasing number of irradiation(1, 10 and 20pulses). The results of this work show that a highly porous nanostructure was formed after irradiation. Moreover, the high-density Si nanocrystals(Si-ncs) about 3 nm were distributed on the surface of Si wafers and exhibited3.02 e V Photoluminescence(PL) emission in blue *** PL intensity increases with the increase in the Si-ncs' density in accordance with the quantum confinement model, which can be ascribed to the different pulse time of HCPEB treatment. The possible formation mechanisms of micropores and Si-ncs are discussed.

关键词：纳米多孔硅电流脉冲纳米结构光致发光电子束辐照 Si(111) HCPEB 制作

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Effect of slag composition on kinetic behavior of deep deoxidation of 5 wt.% Si high-silicon austenitic stainless steel

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Journal of Iron and Steel Research International 2024年第8期31卷 1873-1885页

作者： guan-xiong Dou Han-jie Guo Jing Guo Xue-cheng Peng qing-yun Chen School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing 100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing 100083China

Based on a thermodynamic study of 5 wt.%Si high-silicon austenitic stainless steel(SS-5Si)smelting using CaF_(2)-CaO-Al_(2)0_(3)-Mg-Si0_(2) slag to obtain a low oxygen content of less than 10×10^(-4) wt.%,a kinetic mass transfer model for deep deoxidation was established through laboratory studies,and the effects of slag components and temperature on deoxidation during the slag-steel reaction process of sS-5Si were systematically *** experimental data verified the accuracy of the model *** results showed that the final oxygen content in the steel at 1873 K was mainly controlled by the oxygen content derived from the activity of SiO_(2) regulated by the[Si]-[O]equilibrium reaction in the slag system;in particular,when the slag basicity R(R=w(CaO)/w(SiO2),where w(CaO)and w(SiO_(2))are the contents of CaO and SiO_(2) in the slag,respectively)is 3,the Al2O3 content in the slag needs to be less than 2.7%.The mass transfer rate equation for the kinetics of the deoxidation reaction revealed that the mass transfer of oxygen in the liquid metal is the rate-controlling step under different slag conditions at 1873 K,and the oxygen transfer coefficient ko.m increases with increasing the slag basicity from 4.0×10^(-6)m s^(-1)(R=1)to 4.3×10^(-5) m s^(-1)(R=3).ko.m values at R=2 and R=3 are almost the same,indicating that high slag basicity has little *** integral of the mass transfer rate equation for the deoxidation reaction of SS-5Si under different slag conditions is *** total oxygen content of the molten steel decreases with increasing basicity from an initial content of 22×10^(-4) to 3.2×10^(-4) wt.%(R=3),consistent with the change in ko.m with slag *** R=2,the slag-steel reaction takes 15 min to reach equilibrium(w[O]=5.5×10^(-4) wt.%),whereas at R=3,the slag-steel reaction takes 30 min to reach equilibrium(w[0]=3.2×10^(-4) wt.%).Considering the depth of deoxidation and reaction time of SS-5Si smelting,it is recommended the slag b

关键词： Slag-steel reaction Kinetics Rate-controlling step Deep deoxidation Transfer coefficient

Anti-inflammatory effect and antihepatoma mechanism of carrimycin

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World Journal of Gastroenterology 2023年第14期29卷 2134-2152页

作者： Xiu-Yan Li Yu-Ting Luo Yan-Hong Wang Zhi-Xin Yang Yu-Zhou Shang qing-Xia guan Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese MedicineHarbin 150040Heilongjiang ProvinceChina

BACKGROUND New drugs are urgently needed for the treatment of liver cancer, a feat that could be feasibly accomplished by finding new therapeutic purposes for marketed drugs to save time and costs. As a new class of national anti-infective drugs, carrimycin(CAM) has strong activity against gram-positive bacteria and no cross resistance with similar drugs. Studies have shown that the components of CAM have anticancer *** To obtain a deeper understanding of CAM, its distribution, metabolism and antiinflammatory effects were assessed in the organs of mice, and its mechanism of action against liver cancer was predicted by a network pharmacology *** In this paper, the content of isovaleryl spiramycin Ⅲ was used as an index to assess the distribution and metabolism of CAM and its effect on inflammatory factors in various mouse tissues and organs. Reverse molecular docking technology was utilized to determine the target of CAM, identify each target protein based on disease type, and establish a target protein-disease type network to ascertain the effect of CAM in liver cancer. Then, the key action targets of CAM in liver cancer were screened by a network pharmacology method, and the core targets were verified by molecular docking and visual *** The maximum CAM concentration was reached in the liver, kidney, lung and spleen 2.5 h after intragastric administration. In the intestine, the maximum drug concentration was reached 0.5 h after administration. In addition, CAM significantly reduced the interleukin-4(IL-4) levels in the lung and kidney and especially the liver and spleen;moreover, CAM significantly reduced the IL-1β levels in the spleen, liver, and kidney and particularly the small intestine and lung. CAM is predicted to regulate related pathways by acting on many targets,such as albumin, estrogen receptor 1, epidermal growth factor receptor and caspase 3, to treat cancer, inflammation and other *** We determined that C

关键词： Carrimycin Reverse molecular docking Network pharmacology Liver cancer Antiinflammatory Anti-hepatoma

MMP-2 gene polymorphisms in type 2 diabetes mellitus diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2010年第2期3卷 137-140页

作者： Jie Yang Xiao-Hui Fan Yong-qing guan Yan Li Wei Sun Xin-Zhi Yang and Rui Liu Department of Ophthalmology the Fourth Hospital of Hebei Medical University Shijiazhuang 050011 Hebei Province China

AIMTo study the association between polymorphisms of the MMP-2 gene and diabetic retinopathy (DR).

关键词： MMP-2 diabetic retinopathy gene single nucleotide polymorphism

A general aerosol-assisted biosynthesis of functional bulk nanocomposites

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National Science Review 2019年第1期6卷 64-73页

作者： qing-Fang guan Zi-Meng Han Tong-Tong Luo Huai-Bin Yang Hai-Wei Liang Si-Ming Chen guang-Sheng Wang Shu-Hong Yu Division of Nanomaterials & Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleDepartment of Chemistry University of Science and Technology of China School of Chemistry and Environment Beihang University CAS Center for Excellence in Nanoscience Collaborative Innovation Center of Suzhou Nano Science and Technology Hefei Science CenterDepartment of Chemistry University of Science and Technology of ChinaHefei 230026 China3.School of Chemistry and EnvironmentBeihang University

Although a variety of nanoparticles with better-than-bulk material performances can be synthesized, it remains a challenge to scale the extraordinary properties of individual nanoscale units to the macroscopic level for bulk nanostructured materials. Here, we report a general and scalable biosynthesis strategy that involves simultaneous growth of cellulose nanofibrils through microbial fermentation and co-deposition of various kinds of nanoscale building blocks(NBBs) through aerosol feeding on solid culture substrates. We employ this biosynthesis strategy to assemble a wide range of NBBs into cellulose nanofibril-based bulk nanocomposites. In particular, the biosynthesized carbon nanotubes/bacterial cellulose nanocomposites that consist of integrated 3D cellulose nanofibril networks simultaneously achieve an extremely high mechanical strength and electrical conductivity, and thus exhibit outstanding performance as high-strength lightweight electromagnetic interference shielding materials. The biosynthesis approach represents a general and efficient strategy for large-scale production of functional bulk nanocomposites with enhanced performances for practical applications. Industrial-scale production of these bulk nanocomposite materials for practical applications can be expected in the near future.

关键词： bacterial cellulose nanoscale building blocks biosynthesis electromagnetic shielding scalable fabrication

基于RNA-Seq技术分析经穴推拿对产后大鼠的生物学机制作用

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中医康复 2024年第4期1卷 6-10,17页

作者：李可梁笑语李一凡张皓淋官庆烨北京中医药大学北京100029

目的:通过转录组学测序技术(RNA-Seq)探究经穴推拿对产后大鼠基因差异性表达的影响,并分析生物机制特征。方法:采用随机数字表法将6只健康雌性大鼠随机分为空白对照组、经穴推拿组,每组3只,与雄性大鼠合笼交配。经穴推拿组大鼠产后立刻... 详细信息

目的:通过转录组学测序技术(RNA-Seq)探究经穴推拿对产后大鼠基因差异性表达的影响,并分析生物机制特征。方法:采用随机数字表法将6只健康雌性大鼠随机分为空白对照组、经穴推拿组,每组3只,与雄性大鼠合笼交配。经穴推拿组大鼠产后立刻连续推拿干预7天。取大鼠腹主动脉血提取RNA,采用RNA-Seq技术进行转录组学测序,将筛选的差异基因进行GO和KEGG生物信息学分析。结果:经穴推拿组与空白对照组大鼠相比,共959个差异表达基因,其中889个表达上调,70个表达下调。GO分析发现差异基因主要集中在代谢、合成、免疫相关生物学过程,KEGG分析发现差异基因主要参与信号转导、免疫系统、运输和分解通路,并与细胞的生长、分化、衰老与凋亡相关。结论:经穴推拿能够影响产后大鼠的基因表达水平,参与调控产后机体代谢、免疫、细胞衰老进程,为推拿干预产后机能恢复提供了研究基础,有助于未来进一步挖掘经穴推拿促进产后恢复的作用机制。

关键词：产后经穴推拿 RNA测序

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Effect of the catalyzing combustion of coke breeze on the energy saving in sinter process

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Journal of Central South University of Technology 2001年第4期8卷 234-238页

作者： ZHU De qing,QIU guan zhou,JIANG Tao,ZHU Bao jun (Department of Mineral Engineering, Central South University, Changsha 410083, China) 1. Department of Mineral Engineering Central South University 410083 Changsha China

The mechanism of additive ZC 1 for catalyzing combustion of coke breeze in sintering of iron ore fines was studied by using X ray Diffraction, TGA and GC(Gas Chromatographer), by which energy saving was achieved on sinter pot test. The results show that the distance between cleavage planes is enlarged and the π electrons are re distributed because of the insertion of cations/molecules of ZC 1 into the cleavage planes of carbon , resulting in the weakening of C-C bond, improving the adsorption of oxygen and lowering the activation energy of gasification of carbon from 25.8 kJ/mol to 18.9 kJ/mol , and the burning rate being increased and combustion residual reduced, all of which can lead to lower solid fuel consumption . Compared with the sintering test without addition of additives , the solid fuel consumption is reduced by 16.0%, meanwhile, the rate of finished sinter, the output of finished sinter and the tumbling index are increased by 2.03%, 7.0% and 3.71% , respectively, with incorporating 0.2% of additive ZC 1 in the sintering mixture, which is in agreement with the catalyzing mechanism of ZC 1.

关键词： sintering coke breeze additive catalyzing combustion energy saving

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Predicting prognosis of rectal cancer patients with total mesorectal excision using molecular markers

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World Journal of Gastroenterology 2007年第21期13卷 3009-3015页

作者： Jun-Jie Peng San-Jun Cai Hong-Feng Lu Guo-Xiang Cai Peng Lian Zu-qing guan Ming-He Wang Ye Xu Department of Oncology Shanghai Medical Coliege Fudan University Shanghai 2000321 China Department of Pathology Cancer Hospital Fudan University Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China

AIM:To explore the prognostic variables in rectal cancer patients undergoing curative total mesorectal excision and the effect of postoperative chemotherapy in advanced rectal cancer. METHODS:A total of 259 consecutive rectal cancer patients treated with curative total mesorectal excision between 1999 and 2004 were collected. p53,p21,PCNA,and CD44v6 were examined using immunohistochemistry (IHC). The correlation between clinicopathological or molecular variables and clinical outcomes,including local recurrence,metastasis,disease-free survival and overall survival,was analyzed. RESULTS:The median follow-up was 44 mo. Five-year survival rates and 5-year disease free survival rates were 75.43% and 70.32%,respectively. Multi-analysis revealed TNM staging,preoperative CEA,and CD44v6 level were independent risk factors predicting overall survival or disease free survival. The hazard ratio of peroperative CEA was 2.65 (95% CI 1.4-5) and 3.10 (95% CI 1.37-6.54) for disease free survival and overall survival,respectively. The hazard ratio of CD44v6 was 1.93 (95% CI 1.04-3.61) and 2.21 (95% CI 1.01-4.88) for disease free survival and overall survival,respectively. TNM staging was the only risk factor predicting local recurrence. Postoperative chemotherapy without radiotherapy did not improve patients' outcome. CONCLUSION:TNM staging,preoperative CEA and CD44v6 were independent prognostic factors for rectal cancer patients with total mesorectal excision. Postoperative chemotherapy may be only used together with radiotherapy for rectal cancer patients.

关键词： Rectal cancer Total mesorectal excision Immunohistochemistry Disease free survival p53 p21 PCNA CD44v6 CEA Prognosis

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新疆伊吾县沙棘气候品质认证技术研究

沙漠与绿洲气象 2024年第2期18卷 169-174页

作者：李战超关清张山清火勋国刘纪疆杨明凤新疆兴农网信息中心/新疆农业气象台新疆乌鲁木齐830002 哈密市气象局新疆哈密839000 乌兰乌苏农业气象试验站新疆石河子832000

沙棘是新疆伊吾县的特色产业,沙棘的优质高产与气象因素密切相关。气候品质认证是反映气象条件对农产品影响程度的最直接方式之一。开展沙棘气候品质认证工作,有利于保护特色种质资源、提升企业的品牌价值和市场竞争力。利用伊吾县1991... 详细信息

沙棘是新疆伊吾县的特色产业,沙棘的优质高产与气象因素密切相关。气候品质认证是反映气象条件对农产品影响程度的最直接方式之一。开展沙棘气候品质认证工作,有利于保护特色种质资源、提升企业的品牌价值和市场竞争力。利用伊吾县1991—2020年国家基本气象站和2010—2021年盐池镇区域自动站的气象观测数据和沙棘发育期资料,根据沙棘的生长习性、种植区气候适宜性和管理状况对品质影响的分析,构建沙棘气候品质认证模型,对伊吾县种植的特色气候品质沙棘进行认证和评价。结果表明:伊吾县盐池镇沙棘种植基地位于最适宜气候种植区;2021年沙棘关键生育期气候资源条件属于丰年;企业生产管理状况良好;伊吾县沙棘2021年气候品质等级为特优。

关键词：沙棘伊吾县气象因素气候品质认证

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治疗前NLR对ICIs治疗非小细胞肺癌患者的预后预测价值的Meta分析

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医学信息 2024年第7期37卷 30-35页

作者：张冠卿龙勇余海彬赵冲曹宗宇苏彦河郑州大学第二附属医院胸外科郑州大学第二附属医院介入科

目的通过Meta分析探讨治疗前NLR在接受ICIs治疗的NSCLC患者中的预后预测价值。方法系统检索中文数据库(中国知网、维普、万方)和英文数据库(EMbase、PubMed、The Cochrane Library)中自建库至2022年6月发表的关于治疗前NLR与接受ICIs... 详细信息

目的通过Meta分析探讨治疗前NLR在接受ICIs治疗的NSCLC患者中的预后预测价值。方法系统检索中文数据库(中国知网、维普、万方)和英文数据库(EMbase、PubMed、The Cochrane Library)中自建库至2022年6月发表的关于治疗前NLR与接受ICIs治疗的NSCLC患者预后关系的文献，使用NOS评分量表评价文献质量，采用STATA 15.0统计软件进行Meta分析。结果最终纳入24篇中英文文献，共2471位患者。接受ICIs治疗的患者中高NLR与较短的PFS(HR:1.82,95%CI:1.61～2.05)和较差的OS(HR:2.52,95%CI:2.18～2.90)有关，亚组分析结果与合并结果一致(P<0.001)。结论治疗前NLR可作为接受ICIs治疗的NSCLC患者的潜在预后生物学标志物。

关键词：非小细胞肺癌中性粒细胞与淋巴细胞比值免疫检查点抑制剂