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经济安全治理体系的生成逻辑和实现路径

新疆师范大学学报（哲学社会科学版） 2024年第5期45卷 77-90,F0002页

作者：郭冠清中国社会科学院经济研究所北京100836 中国社会科学院大学经济学院北京102488

经济安全是国家安全的基础,是经济发展的前提。首先,文本从人民至上的价值观、唯物史观、科学思想方法三个层面,探索了经济安全治理体系演变的方法论基础;其次,以开放条件下社会再生产理论为依托,对经济安全治理体系生成的理论逻辑进行... 详细信息

经济安全是国家安全的基础,是经济发展的前提。首先,文本从人民至上的价值观、唯物史观、科学思想方法三个层面,探索了经济安全治理体系演变的方法论基础;其次,以开放条件下社会再生产理论为依托,对经济安全治理体系生成的理论逻辑进行研究,对为什么要更好地发挥政府的作用、为什么要提高自主生产能力、为什么要提高经济增长的内生动力进行分析;再次,以经济思想史为视角,对经济安全治理理念标识性概念从统筹革命与建设的关系到统筹经济建设和国防建设的关系,再到正确处理改革发展稳定关系,最后到统筹发展和安全演化进行梳理;最后,从全面深入贯彻新发展理念和总体国家安全观、健全宏观经济治理体系、加快科技自立自强步伐、提高国内外双循环的动力和活力等方面,对如何增强经济安全性的主动权,推动经济安全治理体系和能力现代化进行分析。

关键词：唯物史观科学思想方法统筹发展和安全关系科技自立自强增强发展安全性的主动权

仿生低碳建筑材料:从沙塔蠕虫巢穴到新一代建筑

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Science Bulletin 2024年第4期69卷 431-433页

作者：管庆方俞书宏 New Cornerstone Science Laboratory Department of ChemistryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Department of Chemistry Department of Materials Science and EngineeringInstitute of Innovative MaterialsSouthern University of Science and TechnologyShenzhen 518055China

Traditional production process of cement-based building materials is always accompanied with massive carbon emissions and tremendous energy consumptions because of the calcination process under ultra-high temperature.

关键词： temperature 低碳建筑沙塔

论新质生产力理论对马克思主义生产力理论的创新发展

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上海经济研究 2024年第5期 16-24页

作者：郭冠清谷雨涵中国社会科学院经济研究所 100836 中国社会科学院大学 102488

本文以唯物史观为方法论基础,首先对传统教科书的生产力范畴、生产力核心要素、生产力核心命题进行了批判性分析,并以此为基础搭建了马恩经典作家的生产力理论;然后,对马克思主义生产力理论中国化时代化历史进程进行了研究,概括了毛泽... 详细信息

本文以唯物史观为方法论基础,首先对传统教科书的生产力范畴、生产力核心要素、生产力核心命题进行了批判性分析,并以此为基础搭建了马恩经典作家的生产力理论;然后,对马克思主义生产力理论中国化时代化历史进程进行了研究,概括了毛泽东和邓小平对生产力理论的创新发展;最后从对符合新发展理念的先进生产力范畴进行了术语革命、对生产关系的内涵和形式进行了创新表述、对生产力和生产关系原理进行了创造性思考、构建了以科技创新为核心要素的高质量发展引擎等方面概括总结了新质生产力理论对马克思主义生产力理论的创新发展。

关键词：唯物史观新质生产力生产力理论生产力要素

Omics-imaging signature-based nomogram to predict the progression-free survival of patients with hepatocellular carcinoma after transcatheter arterial chemoembolization

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World Journal of Clinical Cases 2024年第18期12卷 3340-3350页

作者： qing-Long guan Hai-Xiao Zhang Jun-Peng Gu Geng-Fei Cao Wei-Xin Ren Department of Interventional Radiology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous regionChina Department of Interventional Radiology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND Enhanced magnetic resonance imaging(MRI)is widely used in the diagnosis,treatment and prognosis of hepatocellular carcinoma(HCC),but it can not effectively reflect the heterogeneity within the tumor and evaluate the effect after *** imaging analysis of voxel changes can effectively reflect the internal heterogeneity of the tumor and evaluate the progression-free survival(PFS).AIM To predict the PFS of patients with HCC before operation by building a model with enhanced MRI *** Delineate the regions of interest(ROI)in arterial phase,portal venous phase and delayed phase of enhanced *** extracting the combinatorial features of ROI,the features are fused to obtain deep learning radiomics(DLR)_***'s test was used to evaluate the diagnostic performance of different typological features.K-M analysis was applied to assess PFS in different risk groups,and the discriminative ability of the model was evaluated using the *** Tumor diameter and diolame were independent factors influencing the prognosis of ***'s test revealed multi-phase combined radiomic features had significantly greater area under the curve values than did those of the individual phases(P<0.05).In deep transfer learning(DTL)and DLR,significant differences were observed between the multi-phase and individual phases feature sets(P<0.05).K-M survival analysis revealed a median survival time of high risk group and low risk group was 12.8 and 14.2 months,respectively,and the predicted probabilities of 6 months,1 year and 2 years were 92%,60%,40%and 98%,90%,73%,*** C-index was 0.764,indicating relatively good consistency between the predicted and observed *** and DLR have higher predictive value for 2-year PFS in *** Based on the multi-temporal characteristics of enhanced MRI and the constructed Nomograph,it provides a new strategy for predicting the PFS of transarterial chemoembolization treatment of HCC.

关键词： Magnetic resonance imaging Radiomics Deep learning Progression-free survival Transcatheter arterial chemoembolization Hepatocellular carcinoma

基于2D-LC-HR-MS/MS法的头孢丙烯原料药杂质谱分析

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药物评价研究 2024年第6期47卷 1316-1325页

作者：林辉李庆关晴刁富城广州白云山医药集团股份有限公司白云山化学制药厂广东广州510515

目的基于二维液相色谱-高分辨串联质谱(2D-LC-HR-MS/MS)法分析头孢丙烯原料药杂质谱。方法一维色谱条件进行样品色谱图采集,确认各杂质的出峰位置,采用YMC Hydrosphere色谱柱(250 mm×4.6 mm,5μm),以11.5 g·L^(-1)磷酸二氢铵(用磷酸调... 详细信息

目的基于二维液相色谱-高分辨串联质谱(2D-LC-HR-MS/MS)法分析头孢丙烯原料药杂质谱。方法一维色谱条件进行样品色谱图采集,确认各杂质的出峰位置,采用YMC Hydrosphere色谱柱(250 mm×4.6 mm,5μm),以11.5 g·L^(-1)磷酸二氢铵(用磷酸调节pH为4.4)为流动相A,乙腈-流动相A(50∶50)为流动项B,梯度洗脱;柱温40℃;体积流量1.0 mL·min^(-1);检测波长230 nm;进样量4μL。二维液相脱盐后切进高分辨串联质谱进行分析,根据结果推断杂质结构及生成机制,采用Waters BEH C_(18)色谱柱(50 mm×2.1 mm,1.7μm),以0.01%甲酸水溶液为流动相A,乙腈为流动相B,切峰后开始A相由98%到1%,柱温40℃,体积流量0.3 mL·min^(-1),质谱采用Xevo G2-XS QTof MS系统,离子源为ESI源,毛细管电压3.0 kV,雾化器温度450℃,扫描范围m/z 100~2000。结果头孢丙烯样品中存在9个杂质色谱峰,其中5个杂质为已知杂质,峰3为杂质B(头孢羟氨苄)、峰5为杂质D、峰6为杂质F、峰7为杂质G、峰9为杂质I;对其中3个未知杂质可能的结构式进行了初步推测以及探讨了可能的生成途径,峰2分子式为C_(18)H_(19)N_(3)O_(6)S,该化合物比头孢丙烯多一个氧,分析其为头孢丙烯的氧化杂质;峰4分子式为C_(16)H_(15)N_(3)O_(6)S,与杂质B相比增加了1个氧原子,减少了2个氢原子,判断其为7-ACA内酯与对羟基苯甲甘氨酸甲酯(HPGM)反应产物中的硫原子继续发生了氧化生成的;峰8分子式为C_(8)H_(9)NO_(2)S,该组分为头孢丙烯分子结构的一部分。峰1有待进一步研究。结论该方法有效解决了头孢丙烯流动相中含不挥发性磷酸盐的色谱体系与色谱-质谱快速鉴定杂质不兼容的难题,可以简单、快速地对头孢丙烯有关物质进行定性分析及杂质谱研究。

关键词： 2D-LC-HR-MS/MS 头孢丙烯有关物质杂质谱杂质控制

Magnesium lithospermate B enhances the potential of human-induced pluripotent stem cell-derived cardiomyocytes for myocardial repair

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Chinese Medical Journal 2024年第15期137卷 1857-1869页

作者： Chengming Fan Kele Qin Chukwuemeka Daniel Iroegbu Kun Xiang Yibo Gong qing guan Wenxiang Wang Jun Peng Jianjun Guo Xun Wu Jinfu Yang Department of Cardiovascular Surgery The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Department of Pharmacology Xiangya School of Pharmaceutical SciencesCentral South UniversityChangshaHunan 410078China Hunan Fangsheng Pharmaceutical Co. Ltd.ChangshaHunan 410000China Department of Thoracic Surgery The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunan 41000China

Background:We previously reported that activation of the cell cycle in human-induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs)enhances their remuscularization capacity after human cardiac muscle patch transplantation in infarcted mouse ***,we sought to identify the effect of magnesium lithospermate B(MLB)on hiPSC-CMs during myocardial repair using a myocardial infarction(MI)mouse ***:In C57BL/6 mice,MI was surgically induced by ligating the left anterior descending coronary *** mice were randomly divided into five groups(n=10 per group);a MI group(treated with phosphate-buffered saline only),a hiPSC-CMs group,a MLB group,a hiPSC-CMs+MLB group,and a Sham operation *** function and MLB therapeutic efficacy were evaluated by echocardiography and histochemical staining 4 weeks after *** identify the associated mechanism,nuclear factor(NF)-κB p65 and intercellular cell adhesion molecule-1(ICAM1)signals,cell adhesion ability,generation of reactive oxygen species,and rates of apoptosis were detected in human umbilical vein endothelial cells(HUVECs)and ***:After 4 weeks of transplantation,the number of cells that engrafted in the hiPSC-CMs+MLB group was about five times higher than those in the hiPSC-CMs ***,MLB treatment significantly reduced tohoku hospital pediatrics-1(THP-1)cell adhesion,ICAM1 expression,NF-κB nuclear translocation,reactive oxygen species production,NF-κB p65 phosphorylation,and cell apoptosis in HUVECs cultured under ***,treatment with MLB significantly inhibited the apoptosis of hiPSC-CMs via enhancing signal transducer and activator of transcription 3(STAT3)phosphorylation and B-cell lymphoma-2(BCL2)expression,promoting STAT3 nuclear translocation,and downregulating BCL2-Associated X,dual specificity phosphatase 2(DUSP2),and cleaved-caspase-3 expression under ***,MLB significantly suppressed the production of malondialdehyde and lactat

关键词： Myocardial infarction Cell therapy Induced pluripotent stem cells Magnesium lithospermate B Cardiomyocyte Disease modeling hiPSC-CMs

“新工科”背景下复合材料与工程专业生产实践教学探索与思考

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高分子通报 2024年第3期37卷 400-404页

作者：管清宝孙巍游正伟东华大学材料科学与工程学院上海201620

“新工科”建设是国家对高等教育的一项重大战略部署,是新形势下人才培养模式的一次新探索,对促进我国高等教育改革和发展具有重要意义。着眼于培养符合国家战略和新产业发展需求的复合材料与工程专业高水平复合型人才,本教学团队于201... 详细信息

“新工科”建设是国家对高等教育的一项重大战略部署,是新形势下人才培养模式的一次新探索,对促进我国高等教育改革和发展具有重要意义。着眼于培养符合国家战略和新产业发展需求的复合材料与工程专业高水平复合型人才,本教学团队于2016年开始筹建“生产实践”课程,作为本专业主要实践课,从“复合材料+X”产教融合交叉人才培养模式、多方协同的实践和创新能力培养平台等多方位入手,并从教学手段、教学方法、教学内容等方面对该课程进行深度优化。本专业于2019年入选复合材料与工程专业全国第一个国家级一流本科专业建设点;2021年顺利通过专业教育工程认证;学生工程实践和创新能力显著提升,2017~2022年连续6年就业率达100%,深造率连年攀升,2022年达到82%。“生产实践”课程在从无到有、从有到精的建设和教学过程中所做的探索与实践为相关新工科专业人才培养体系的构建提供了有益的参考。

关键词：生产实践复合材料课程设计教学方法

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黄河下游花园口以上河段滞沙能力分析

泥沙研究 2024年第2期49卷 48-55,47页

作者：申冠卿王平张武欣黄河水利委员会黄河水利科学研究院河南郑州450003 巩义黄河河务局河南巩义451200

黄河下游河床调整主要取决于来水来沙和河床边界条件,河床调整沿程不均衡特征明显,花园口以上河段床演变对水沙条件的变化响应尤为突出,泥沙冲淤调整幅度最大。基于河道冲淤及水沙演进特性、滞沙可行性、河槽几何特性等分析,提出了花园... 详细信息

黄河下游河床调整主要取决于来水来沙和河床边界条件,河床调整沿程不均衡特征明显,花园口以上河段床演变对水沙条件的变化响应尤为突出,泥沙冲淤调整幅度最大。基于河道冲淤及水沙演进特性、滞沙可行性、河槽几何特性等分析,提出了花园口以上河段可作为泥沙天然反调节“库”概念,结合黄河下游实测洪水资料,采用水力计算方法,计算了花园口以上河段的河槽排洪能力及不同河槽规模条件下河槽允许滞沙量,提出了反调“库”滞沙能力,可为小浪底水库排沙指标的确定提供依据,对维持小浪底水库有效库容、弥补后续清水河床沙源不足、改善黄河下游河槽冲淤不均衡现象具有重要意义。

关键词：不均衡调整河槽动态库容滞沙能力泥沙反调节库水沙调控黄河下游

Highly efficient discovery of the covalent Minhibitors from crude Pu-erh tea by integrating biochemical and chemoproteomic approaches

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Food Science and Human Wellness 2024年

作者： guang-Hao Zhu Ya-Ni Zhang Sheng-Lan Qi Jian-Rong Xu Yuan Xiong Zhao-Qin Zhang Xi-Xiang Chen Yuan-Yuan Xie Xiao-qing guan Wei-Dong Zhang Wei Liu guang-Bo Ge Shanghai Frontiers Science Center of TCM Chemical Biology， Institute of Interdisciplinary Integrative Medicine Research， Shanghai University of Traditional Chinese Medicine Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

The main proteases (Mpros) are hydrolases playing essential roles in the replication of β-coronaviruses including SARS-CoV-2. Herein， a highly efficient strategy was developed for discovering the Mproinactivators from crude plant extract integrating target-based biochemical assay and chemoproteomic approaches. Firstly， Pu-erh tea was found to potently suppress SARS-CoV-2 Mproin a time-dependent manner. Next， global chemical analysis coupling with peptide-modification profiling were used to identify the cysteine-modified constituents in Pu-erh tea. The results suggested that seven constituents in Pu-erh tea could modify SARS-CoV-2 Mpro， which turned out that epigallocatechin， gallocatechin and gallic acid were the most efficacious Mproinactivators. Further investigations demonstrated that epigallocatechin and gallocatechin could inactivate SARS-CoV-2 Mprovia blocking the formation of the homodimers. Collectively， this work proposed a novel and practical strategy for highly efficient discovery of time-dependent inhibitors of SARS-CoV-2 Mprofrom plant extracts， while three constituents in Pu-erh tea have emerged as robust SARS-CoV-2 Mproinactivators.

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