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Laryngopharyngeal reflux disease:Updated examination of mechanisms,pathophysiology,treatment,and association with gastroesophageal reflux disease

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World Journal of Gastroenterology 2024年第16期30卷 2209-2219页

作者： Na Cui Ting Dai Yang Liu Ya-Yu Wang Jia-Yu Lin qing-fan Zheng Dong-Dong Zhu Xue-Wei Zhu Department of Otorhinolaryngology Head and Neck Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Ultrasound China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Gastroenterology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

Laryngopharyngeal reflux disease(LPRD)is an inflammatory condition in the laryngopharynx and upper aerodigestive tract mucosa caused by reflux of stomach contents beyond the *** commonly presents with symptoms such as hoarseness,cough,sore throat,a feeling of throat obstruction,excessive throat *** complex condition is thought to involve both reflux and reflex mechanisms,but a clear understanding of its molecular mechanisms is still ***,there is no standardized diagnosis or treatment *** strategies for LPRD mainly include lifestyle modifications,proton pump inhibitors and endoscopic *** paper seeks to provide a comprehensive overview of the existing literature regarding the mechanisms,pathophysiology and treatment of *** also provide an in-depth exploration of the association between LPRD and gastroesophageal reflux disease.

关键词： Laryngopharyngeal reflux Gastroesophageal reflux Head neck surgery Laryngitis Otolaryngology

Yiwei Xiaoyu granules for treatment of chronic atrophic gastritis with deficiency syndrome of the spleen and stomach

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World Journal of Clinical Cases 2024年第13期12卷 2201-2209页

作者： Wan-Qun Chen qing-Feng fan Yuan-Jun He Fei Li Xin Wu Yan-Ping Li Xiao-Jun Yang Department of Gastroenterology Chongqing Hospital of Traditional Chinese MedicineChongqing 400000China

BACKGROUND The Correa sequence,initiated by Helicobacter pylori(***),commonly progresses to gastric cancer through the stage of chronic atrophic gastritis(CAG).Although eradication of *** only reduces the risk of gastric cancer,it does not eliminate the risk for neoplastic *** Xiaoyu granules(YWXY)are a commonly used composite preparation in Chinese ***,the pursuit of excellence in clinical trials and the establishment of standardized animal experiments are still needed to contribute to full understanding and application of traditional Chinese medicine in the treatment of *** To demonstrate the effectiveness of YWXY in patients with CAG and spleenstomach deficiency syndrome(DSSS),by alleviating histological scores,improving response rates for pathological lesions,and achieving clinical efficacy in relieving DSSS *** We designed a double-blind,randomized,controlled *** study enrolled seventy-two ***-negative patients(mean age,52.3 years;38 men)who were randomly allocated to either the treatment group or control group in a 1:1 ratio,and treated with 15 g YWXY or 0.36 g Weifuchun(WFC)tablet combined with the respective dummy for 24 *** pre-randomization phase resulted in the exclusion of 72 patients:50 participants did not meet the inclusion criteria,12 participants declined to participate,and 10 participants were excluded for various other *** visits were conducted during the study,and histopathological examination with target endoscopic biopsy of narrow-band imaging was requested before the first and seventh *** also evaluated endoscopic performance scores,total symptom scores,serum pepsinogen and *** Six patients did not complete the trial *** with YWXY improved the Operative Link on Gastric Intestinal Metaplasia Assessment(OLGIM)stage,compared with WFC(P<0.05).YWXY provided better relief from symptoms of DSSS and better improvement in serum gastric fun

关键词： Chronic atrophic gastritis Yiwei Xiaoyu granules Randomized clinical trial Weifuchun tablet Traditional Chinese medicine Helicobacter pylori

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“V着”存在句的语体结构与语法属性

汉语学习 2024年第3期 51-61页

作者：段清钒北京语言大学语言科学院北京100083

将有“在”与无“在”的“V着”存在句视为相同的结构无法解释存在句中有无“在”造成的合法与非法。考察有无“在”“V着”的存在结构发现:(1)“LocP_(1)+VP”与“P+LocP_(2)+VP”是两个不同的句法结构,前者是口语体,后者是正式体,内... 详细信息

将有“在”与无“在”的“V着”存在句视为相同的结构无法解释存在句中有无“在”造成的合法与非法。考察有无“在”“V着”的存在结构发现:(1)“LocP_(1)+VP”与“P+LocP_(2)+VP”是两个不同的句法结构,前者是口语体,后者是正式体,内含体原子不同。(2)“P+LocP_(2)+VP”的合法与否是由“三维语法”中的语体之法决定,只有“P+LocP_(2)”满足双步平衡律,结构才能合法。同时,这也是“在”后音节数较多的本质原因。

关键词： “V着”存在句 (在)+LocP+VP 语体语法三维语法

Exploring the impact of pericentric inversion of chromosome 9 on fertility in sperm donors

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Asian Journal of Andrology 2024年第3期26卷 302-307页

作者： Qian Liu Wen-Jun Zhou Zeng-Hui Huang Xiu-Hai Huang Jian Wu Xi-Ren Ji Xue-Feng Luo Yu-Ling Tang Rui-Jun Wang Li-qing fan Chuan Huang Wen-Bing Zhu Institute of Reproductive and Stem Cell Engineering Basic Medicine CollegeCentral South UniversityChangsha 410013China Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive and Genetic Hospital of CITIC-XiangyaChangsha 410005China

Pericentric inversion of chromosome 9(inv[9])is a common chromosomal structural variant,but its impact on clinical outcomesremains *** screening criteria of sperm banks are rarely mentioned to individuals with inv(9).In this study,we evaluatedthe fertility of sperm donors with inv(9)who met eligibility criteria for sperm banks(inv[9]-eligible donors).From March 2004 toMay 2022,chromosomal analysis of 16124 sperm donors at CITIC-Xiangya Human Sperm Bank in Hunan Province(Changsha,China)found that 251(1.6%)had chromosome variations,with inv(9)being the most prevalent at 1.1%.All 169 inv(9)-eligibledonors were contacted to collect fertility outcome data,along with 206 eligible donors without inv(9)as *** addition,semen samples from inv(9)-eligible donors and eligible donors underwent assessments of sperm fluorescence in situ hybridization(FISH),mitochondrial membrane potential,DNA fragmentation index,acrosome integrity,reactive oxygen species(ROS),andsperm *** showed that inv(9)did not significantly increase reproductive risks *** detecting ROSlevel differences,the clinical impact may be *** study provides new data on the inv(9)population that can serveas a valuable reference for decision-making by sperm banks as well as for genetic counseling and clinical guidance for individualscarrying inv(9)variant.

关键词： male fertility pericentric inversion of chromosome 9 sperm bank sperm functional parameters

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强迫症反应抑制缺陷(综述)

中国心理卫生杂志 2024年第4期38卷 306-311页

作者：张晨范青上海交通大学医学院附属精神卫生中心上海200030

强迫症是一种常见的高致残性精神障碍,伴随多种认知功能的缺陷。其中,反应抑制缺陷可能是强迫症的一种潜在的内表型,对于理解强迫症的病理生理机制和开发新的临床治疗方法具有重要意义。本文综述了强迫症反应抑制缺陷及其神经机制和临... 详细信息

强迫症是一种常见的高致残性精神障碍,伴随多种认知功能的缺陷。其中,反应抑制缺陷可能是强迫症的一种潜在的内表型,对于理解强迫症的病理生理机制和开发新的临床治疗方法具有重要意义。本文综述了强迫症反应抑制缺陷及其神经机制和临床干预效果,以期为进一步理解强迫症反应抑制缺陷和促进强迫症的临床诊疗提供依据。

关键词：强迫症反应抑制额叶-基底神经节模型综述

面向科技文献多维语义组织的混合倒排索引构建方法

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现代情报 2024年第2期44卷 107-114,129页

作者：张敏李唯范青中国科学院武汉文献情报中心湖北武汉430071 武汉软件工程职业学院(武汉开放大学) 湖北武汉430205 华中师范大学国家文化产业研究中心湖北武汉430079 科技大数据湖北省重点实验室湖北武汉430071

[目的/意义]为满足科研人员对科技文献内部细粒度语义信息进行高效查询的迫切需求,前期研究提出了面向科技文献的多维语义索引体系,然而基于HashMap的常见倒排索引会导致查询效率低下。本文旨在通过面向不同维度语义特征建立混合倒排索... 详细信息

[目的/意义]为满足科研人员对科技文献内部细粒度语义信息进行高效查询的迫切需求,前期研究提出了面向科技文献的多维语义索引体系,然而基于HashMap的常见倒排索引会导致查询效率低下。本文旨在通过面向不同维度语义特征建立混合倒排索引,以改进语义查询性能。[方法/过程]本文以Treap、B+树等多种数据结构探索适合不同语义维度的倒排索引构建方法,并将其组合形成多种适用于科技文献多维语义组织的混合倒排索引构建方法,并通过对比实验,在排序查询和布尔查询条件下分析验证不同类型倒排索引构建方法的查询性能。[结果/结论]实验结果表明,组合形成的8种混合倒排索引构建方法中,表2所示的C3(HHHB)被证明在排序查询条件下具有最高的效率,而C4(TTTB)则在布尔查询条件下被证明最为高效。本文的方法能有效解决单一索引结构导致的查询效率问题。

关键词：科技文献语义组织混合倒排索引 HashMap Treap B+树

Effects of respiratory muscle training on post-stroke rehabilitation:A systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第20期12卷 4289-4300页

作者： Yong-Tao Liu Xiao-Xin Liu Yi-qing Liu Lei Zhang Lin-Jing Zhang Jian-Hua Wang Yan Shi qing-fan Xie Department of Rehabilitation Xingtai People's HospitalXingtai 054001Hebei ProvinceChina Ophthalmologist Clinic Xingtai People's HospitalXingtai 054001Hebei ProvinceChina Department of Cardiology Xingtai People's HospitalXingtai 054001Hebei ProvinceChina Department of Ultrasound Xingtai People's HospitalXingtai 054001Hebei ProvinceChina

BACKGROUND Stroke often results in significant respiratory dysfunction in *** muscle training(RMT)has been proposed as a rehabilitative intervention to address these challenges,but its effectiveness compared to routine training remains *** systematic review and meta-analysis aim to evaluate the effects of RMT on exercise tolerance,muscle strength,and pulmonary function in post-stroke *** To systematically assess the efficacy of RMT in improving exercise tolerance,respiratory muscle strength,and pulmonary function in patients recovering from a stroke,and to evaluate whether RMT offers a significant advantage over routine training modalities in enhancing these critical health outcomes in the post-stroke *** Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines,a comprehensive search across PubMed,Embase,Web of Science,and the Cochrane Library was conducted on October 19,2023,without temporal *** were selected based on the predefined inclusion and exclusion criteria focusing on various forms of RMT,control groups,and outcome measures[including forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),maximal voluntary ventilation(MVV),peak expiratory flow(PEF),maximal inspiratory pressure(MIP),maximal expiratory pressure(MEP),and 6-min walking test(6MWT)].Only randomized controlled trials(RCTs)were *** extraction and quality assessment were conducted independently by two reviewers using the Cochrane Collaboration's risk of bias *** analyses,including those using the fixed-effect and random-effects models,sensitivity analysis,and publication bias assessment,were performed using Review Manager *** A total of 15 RCTs were *** indicated significant improvements in MIP(12.51 cmH2O increase),MEP(6.24 cmH2O increase),and various pulmonary function parameters(including FEV1,FVC,MVV,and PEF).A substantial i

关键词： Respiratory muscle training Stroke rehabilitation Pulmonary function Exercise tolerance Meta-analysis

GSZ Formula Enhances Sleep Quality:Exploring Its Active Ingredients and Mechanism Using a Network Medicine Approach

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 36-43页

作者： Airong Ren Mingxuan Ma Yongyin Liang Yarong Wang Zhengkun Li Yahui Liu qing fan Guozhen Cui School of Bioengineering Zhuhai Campus of Zunyi Medical UniversityZhuhai 519000GuangdongChina Basic Medical Science Department Zhuhai Campus of Zunyi Medical UniversityZhuhai 519000GuangdongChina

Background:Sleep is essential for maintaining human health,and insomnia is a widespread *** Chinese medicine(TCM)has been used for centuries to treat sleep disorders,with fewer reported side effects compared to conventional ***:This study seeks to investigate the sleep-promoting effects of the GSZ formula,which comprisesγ-aminobutyric acid(GABA),Schisandrae Chinensis Fructus(Wuweizi in Chinese),and Ziziphi Spinosae Semen(Suanzaoren in Chinese).In addition,this study aims to explore the active ingredients and potential mechanisms underlying the sleep-enhancing effects of the ***:The impact of GSZ on sleep was evaluated using two models,the complete sleep model and the sub-threshold sleep *** were randomly divided into five groups and orally administered GSZ solution(0.33 g/kg/day or 0.99 g/kg/day),positive drug diazepam(2.50 mg/kg)or a control solution for 30 ***-sis model was established in mice using pentobarbital *** duration and incidence were measured by recording when the righting reflex of mice disappeared for more than 1 *** and dopamine(DA)levels in mouse brain tissue were measured using ELISA *** ingredients of the GSZ formula were identified using mass spectrometry,and the targets of these ingredients and disease-related genes were retrieved from public databases.A network medicine approach was used to calculate the shortest path between ingredient targets and disease-related *** expression levels of potential proteins,such as Akt,p-Akt,GSK-3β,and p-GSK-3β,were analyzed using Western blotting based on the predicted ***:GSZ significantly prolonged sleep duration and enhanced the sleep rate in mice(P<0.05).Furthermore,it elevated GABA levels and reduced DA levels in the mouse brain(P<0.05).Network medicine analysis suggested that GABA,stearic acid,genistin,and coumestrol may be the most crucial active ingredients for sleep *** blotting analysis

关键词： Sleep quality Ziziphi spinosae semen Schisandrae chinensis fructus γ-aminobutyric acid Network medicine

Preliminary Model Study for Forecasting a Hot Weather Process in Guangdong Province Using CMA-TRAMS

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Atmospheric and Climate Sciences 2024年第1期14卷 101-117页

作者： Wenfan Wang Jiemin Zhan Dehui Chen Zitong Chen Yanxia Zhang qing fan Guangfeng Dai Yingying Luo Aifen Ye Department of Applied Mechanics and Engineering Shenzhen Campus of Sun Yat-sen University Shenzhen Guangdong China Guangzhou Institute of Tropical and Marine Meteorology/Guangdong Provincial Key Laboratory of Regional Numerical Weather Prediction CMA Guangzhou China

In this paper, the CMA-TRAMS tropical high-resolution system was used to forecast a typical hot weather process in Guangdong, China with different horizontal resolutions and surface coverage. The results of resolutions of 0.02° and 0.06° were presented with the same surface coverage of the GlobeLand30 V2020, companies with the results of resolution 0.02° with the USGS global surface coverage. The results showed that, on the overall assessment the 2 km model performed better in forecasting 2 m temperature, while the 6 km model was more accurate in predicting 10 m wind speed. In the evaluation of representative stations, the 2 km model performed better in forecasting 2 m temperature and 2 m relative humidity at the coastal stations, and the 2 km model was also better in forecasting 2 m pressure at the representative stations. However, the 6 km model performed better in forecasting 10 m wind speed at the representative stations. Furthermore, the 2 km model, owing to its higher horizontal resolution, presented a more detailed stratification of various meteorological field maps, allowing for a more pronounced simulation of local meteorological element variations. And the use of the surface coverage data of the GlobeLand30 V2020 improved the forecasting of 2 m temperature, and 10 m wind speed compared to the USGS surface coverage data.

关键词： High-Resolution Numerical Model CMA-TRAMS Model Test Evaluation Surface Coverage Numerical Simulation