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China Foundry 2024年第5期21卷 588-598页

作者： Yuan-cai Xu Wen-ming Jiang qing-qing Li Ling-hui Yu Xiao-peng Yu Zi-tian Fan State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

In this work,a new treatment method combining ultrasonic vibration with FeCoNiCrCu high entropy alloy(HEA)coating was used to prepared Al/Mg bimetal through the lost foam compound *** effects of composite treatment involving ultrasonic vibration and HEA coating on interfacial microstructure and mechanical properties of Al/Mg bimetal were *** demonstrate that the interface thickness of the Al/Mg bimetal with composite treatment significantly decreases to only 26.99%of the thickness observed in the untreated Al/Mg *** HEA coating hinders the diffusion between Al and Mg,resulting the significant reduction in Al/Mg intermetallic compounds in the *** Al/Mg bimetal interface with composite treatment is composed of Al_(3)Mg_(2)and Mg_(2)Si/AlxFeCoNiCrCu+FeCoNiCrCu/δ-Mg+Al_(12)Mg_(17)eutectic *** interface resulting from the composite treatment has a lower hardness than that without *** acoustic cavitation and acoustic streaming effects generated by ultrasonic vibration promote the diffusion of Al elements within the HEA coating,resulting in a significant improvement in the metallurgical bonding quality on the Mg *** fracture position shifts from the Mg side of the Al/Mg bimetal only with HEA coating to the Al side with composite *** shear strength of the Al/Mg bimetal increases from 32.16 MPa without treatment to 63.44 MPa with ultrasonic vibration and HEA coating,increasing by 97.26%.

关键词： ultrasonic vibration FeCoNiCrCu HEA coating Al/Mg bimetal interfacial microstructure shear strength compound casting

Is concomitant radiotherapy necessary with gemcitabinebased chemotherapy in pancreatic cancer?

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World Journal of Gastroenterology 2014年第46期20卷 17648-17655页

作者： Xin Zhang He-Jing Huang Dan Feng De-Jun Yang Chang-Ming Wang qing-Ping cai Department of Gastrointestinal Surgery Changzheng HospitalSecond Military Medical University Department of Hematology Changzheng HospitalSecond Military Medical University Department of Oncology Changhai HospitalSecond Military Medical University

AIM: To evaluate the efficacy and safety of gemcitabine (GEM) plus radiotherapy compared with GEM alone for pancreatic cancer (PC).

关键词： Pancreatic cancer Radiotherapy Chemotherapy Gemcitabine Meta-analysis

Theoretical analysis for AlGaN avalanche photodiodes with mesa and field plate structure

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Chinese Physics B 2020年第8期29卷 520-524页

作者： Ke-Xiu Dong Dun-Jun Chen qing cai Yan-Li liu Yu-Jie Wang School of Mechanical and Electrical Engineering Chuzhou UniversityChuzhou 239000China Key Laboratory of Advanced Photonic and Electronic Materials School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China School of Information and Electronic Engineering Shandong Technology and Business UniversityYantai 264005China

To suppress the electric field crowding at sidewall and improve the detection sensitivity of the AlGaN separate absorption and multiplication(SAM)avalanche photodiodes(APDs),we propose the new AlGaN APDs structure combining a large-area mesa with a field plate(FP).The simulated results show that the proposed AlGaN APDs exhibit a significant increase in avalanche gain,about two orders of magnitude,compared to their counterparts without FP structure,which is attributed to the suppression of electric field crowding at sidewall of multiplication layer and the reduction of the maximum electric field at the p-type GaN sidewall in p-n depletion ***,the APDs can produce an obviously enhanced photocurrent due to the increase in cross sectional area of multiplication region.

关键词： AlGaN avalanche photodiodes mesa field plate

Experimental Study on Uniaxial and Multiaxial Strain CyclicCharacteristics and Ratcheting of 316L Stainless Steel

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Journal of Materials Science & Technology 2001年第2期17卷 219-223页

作者： GuoZheng KANG, qing GAO, Lixun cai, Xianjie YANG and Yafang SUN Department of Applied Mechanics and Engineering, Southwest Jiaotong University, Chengdu 610031, China Dept. of Appl. Mech. Southwest Jiaotong Univ. Chengdu 610031 China

An experimental study was carried out on the strain cyclic characteristics and ratcheting of 316L stainless steel subjected to uniaxial and multiaxial cyclic loading. The strain cyclic characteristics were researched under the strain-controlled uniaxial tension-compression and multiaxial circular paths of loading. The ratcheting tests were conducted for the stress-controlled uniaxial tension-compression and multiaxial circular, rhombic and linear paths of loading with different mean stresses, stress amplitudes and histories. The experiment results show that 316L stainless steel features the cyclic hardening, and its strain cyclic characteristics depend on the strain amplitude and its history apparently. The ratcheting of 316L stainless steel depends greatly on the Values of mean stress, stress amplitude and their histories. In the meantime, the shape of load path and its history also apparently influence the ratcheting.

关键词： Experimental Study on Uniaxial and Multiaxial Strain CyclicCharacteristics and Ratcheting of 316L Stainless Steel

Screening potential mitochondria-targeting compounds from traditional Chinese medicines using a mitochondria-based centrifugal ultrafiltration/liquid chromatography/mass spectrometry method

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Journal of Pharmaceutical Analysis 2018年第4期8卷 240-249页

作者： Xing-Xin Yang Yu-Zhen Zhou Feng Xu Jie Yu Gegentana Ming-Ying Shang Xuan Wang Shao-qing cai Department of Natural Medicines School of Pharmaceutical Sciences Peking University Department of Chemical Biology School of Pharmaceutical Sciences Peking University College of Pharmaceutical Science Yunnan University of Traditional Chinese Medicine

Mitochondria regulate numerous crucial cell processes, including energy production, apoptotic cell death, oxidative stress, calcium homeostasis and lipid metabolism. Here, we applied an efficient mitochondria-based centrifugal ultrafiltration/liquid chromatography/mass spectrometry（LC/MS） method,also known as screening method for mitochondria-targeted bioactive constituents（SM-MBC）. This method allowed searching natural mitochondria-targeting compounds from traditional Chinese medicines（TCMs）, including Puerariae Radix（PR） and Chuanxiong Radix（CR）. A total of 23 active compounds were successfully discovered from the two TCMs extracts. Among these 23 hit compounds, 17 were identified by LC/MS, 12 of which were novel mitochondria-targeting compounds. Among these, 6 active compounds were analyzed in vitro for pharmacological tests and found able to affect mitochondrial functions. We also investigated the effects of the hit compounds on Hep G2 cell proliferation and on loss of cardiomyocyte viability induced by hypoxia/reoxygenation injury. The results obtained are useful for in-depth understanding of mechanisms underlying TCMs therapeutic effects at mitochondria level and for developing novel potential drugs using TCMs as lead compounds. Finally, we showed that SM-MBC was an efficient protocol for the rapid screening of mitochondria-targeting constituents from complex samples such as PR and CR extracts.

关键词： Mitochondria Bioactive constituents Traditional Chinese medicines Centrifugal ultrafiltration Liquid chromatography/mass spectrometry

Reading Expertise in the Brain

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Reading Expertise in the Brain

Acute Ischemic Stroke Following Acute Myocardial Infarction： Adding Insult to Injury

中国神经科学学会第十二届全国学术会议

作者： qing cai School of Psychology and Cognitive Science East China Normal University NYU-ECNU Institute of Brain and Cognitive Science

Reading is a capacity unique to humans. Studies in recent years have already demonstrated a neural network underlying word reading. However, we still know little about how the neural response to written language emerges, and how it interacts with other cognitive functions. We therefore investigated the neural mechanism of word reading in adults with atypical right hemispheric（RH） dominance for speech, and in children in their first year of learning to read. With the adult group, we attempted to clarify the influences of language processing in the frontal cortex on visual word recognition in the ventral occipito-temporal（v OT） region. By tracking the acquisition of reading in young children, we examined the emergence of word-specific response in the v OT region, particularly regarding when and how it develops. Beyond that, as a complex higher-order cognitive function, comprising a variety of processes from different levels, text reading is affected by both top-down and bottom-up factors. I will present some of our recent work on natural text reading investigating how syntactic information and individual cognitive capacities could affect reading performance, and discuss how this kind of research could shed light on the cognitive and neural mechanisms of reading.

关键词： Language reading cognitive functions visual word recognition text reading

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Chinese Medical Journal 2017年第9期130卷 1129-1130页

作者： Xiao-qing cai Jin Wen Ying Zhao Ya-Li Wu Han-Ping Zhang Wei-Ze Zhang Department of Cardiology Lanzhou General Hospital of Lanzhou Command PLA Lanzhou Gansu 730050 China Department of Medical Administration Lanzhou General Hospital of Lanzhou Command PLA Lanzhou Gansu 730050 China Department of Anesthesiology and Surgery Lanzhou General Hospital of Lanzhou Command PLA Lanzhou Gansu 730050 China Department of Neurology Lanzhou General Hospital of Lanzhou Command PLA Lanzhou Gansu 730050 China

To the Editor： Concurrence of acute ischemic stroke and acute myocardial infarction （AMI） is rare but serious in clinical scenarios,Reperfusion therapy, with no or minimal delay~ is optimized strategy to save both vital organs in such urgency. Here, we report a case of successful salvage with urgent thrombolysis plus carotid angioplasty, followed by elective percutaneous coronary intervention （PC1）.

关键词：心肌梗死血管成形术一氧化氮胰岛素再灌注卒中

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基于压裂力筛选油菜抗裂角优异种质资源

种子 2024年第1期43卷 36-42页

作者：刘念李浩陈天花侯信哲李睿王玲徐宏蔡庆澳邓秀朱宗河闫贵欣蔡光勤伍晓明张付贵周可金安徽农业大学农学院合肥230036 中国农业科学院油料作物研究所/农业农村部油料作物生物学与遗传育种重点实验室武汉430062

油菜成熟后角果易开裂,导致收获损失率高,限制了产业的高质量发展。筛选抗裂角优异种质资源,对于培育抗裂角宜机收的油菜新品种具有重要意义。为了提高油菜抗裂角资源的筛选效率,本研究基于200份变异丰富的甘蓝型油菜种质资源,系统比较... 详细信息

油菜成熟后角果易开裂,导致收获损失率高,限制了产业的高质量发展。筛选抗裂角优异种质资源,对于培育抗裂角宜机收的油菜新品种具有重要意义。为了提高油菜抗裂角资源的筛选效率,本研究基于200份变异丰富的甘蓝型油菜种质资源,系统比较压裂法与随机碰撞法的鉴定结果,提出了一种基于压裂力的抗裂角高效鉴定方法。研究发现,基于随机碰撞法的抗裂角指数与基于压裂法的裂角力之间显著正相关,且压裂法比随机碰撞法重复性更好、效率更高、稳定性更强。基于抗裂角指数和裂角力之间的相关关系,制定了基于压裂力的抗性分级标准,最终基于压裂力筛选出5份高抗裂角的甘蓝型油菜优异种质资源。相关结果为进一步培育优质的油菜抗裂种质资源提供了高效的鉴定方法和重要的基因资源。

关键词：甘蓝型油菜压裂力抗裂角指数种质资源筛选

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麦穗干插花加工型小麦种质资源的筛选

山东农业科学 2024年第5期56卷 49-58页

作者：周国雁何思柳伍少云陈丹武晓阳刘圆圆白晓东蔡青云南省农业科学院生物技术与种质资源研究所/云南省农业生物技术重点实验室/农业农村部西南作物基因资源与种质创制重点实验室云南昆明650205 普洱学院云南普洱665000 武定县猫街镇农业农村服务中心云南武定651607

本研究以麦穗干插花(以下简称麦穗花)加工企业认可的云生1号、云麦53号品种为对照,采用芒长、穗长和茎秆强度3个加工企业认为影响麦穗花加工和销售的重要指标,对42份长芒小麦种质资源进行性状筛选与评价,并利用文献报道的与小麦茎秆强... 详细信息

本研究以麦穗干插花(以下简称麦穗花)加工企业认可的云生1号、云麦53号品种为对照,采用芒长、穗长和茎秆强度3个加工企业认为影响麦穗花加工和销售的重要指标,对42份长芒小麦种质资源进行性状筛选与评价,并利用文献报道的与小麦茎秆强度相关的SSR分子标记对参试资源进行茎秆强度辅助选择,挑选出在农艺性状和分子遗传学上都适合加工麦穗花的优异种质资源,为云南干花产业发展提供新的原材料。结果表明,通过两年的田间种植观测与数据分析,未发现3个性状都较两个对照优异的资源。其中,C6(小黑麦)两年的芒长都较两对照显著优异且穗长和茎秆强度差异不明显或也显著优异,是比两个对照更适合加工麦穗花的优异资源;其次是C3和C9,两年的穗长和茎秆强度都显著优于或与两个对照差异不显著,也是加工麦穗花的较理想资源;C4、C5、C7和C8的穗长较云麦53号显著优异,芒长和茎秆强度则差异不显著或也显著优异。对茎秆强度的SSR分子标记辅助选择结果表明,C4、C6可能携带有与云麦53号相同的BARC59、BARC134和WMC48位点以及与云生1号相同的BARC59位点,C3、C5、C8也可能携带与云麦53号相同的BARC59、BARC134和WMC48位点以及与云生1号相同的BARC59、BARC358位点,C9可能携带有与云麦53号相同的BARC59、BARC134位点以及与云生1号相同的BARC59、WMC48位点。但是,用这些引物获得的分子标记结果与表型评价结果之间的一致性都在50%及以下,可能这些分子标记都不适宜用作供试小麦材料茎秆强度的辅助筛选。今后还需进一步筛选适合评价麦穗花加工型小麦种质资源的指标及分子标记,为选育满足生产需求的优良小麦品种提供技术支持。

关键词：麦穗干插花小麦种质资源农艺性状分子标记辅助选择

Improved Method for Lacosamide Synthesis with Chemoenzymatic Method

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Chemical Research in Chinese Universities 2012年第5期28卷 833-836页

作者： WANG Zhi-yuan XU Li-sheng LIU Jun-zhong ZHANG Hong-juan GAO Ji LIU Qian JIAO qing-cai State Key Laboratory of Pharmaceutical Biotechnology School of Life ScienceNanjing UniversityNanjing 210093P.R.China

Lacosamide was prepared by chemical method coupled with enzymatic method. N-Acetyl-D, L-3-methoxy-alanine, derived from D,L-3-methoxy-alanine, was used in the resolution process catalyzed by immobilized Escherichia coli cells with aminoacylase（EC3.***.1.14） activity. N-Acetyl-D-3-methoxy-alanine and L-3- methoxy-alanine were obtained from the resolution system. Lacosamide was synthesized by the amidation of N-acetyl-D-3-methoxy-alanine with benzylamine.

关键词： Lacosamide Aminoacylase N-Acetyl-D L-3-methoxy-alanine Immobilized cell