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油电混合动力船舶动力系统研究

舰船科学技术 2024年第9期46卷 111-116页

作者：安伟张庆范赵建平宋莎莎吴翌丹高迪驹中海油能源发展股份有限公司安全环保分公司天津300452 上海海事大学航运技术与控制工程交通运输行业重点实验室上海201306

为了响应国家对航运业绿色可持续发展的需求,以某小型油电混合动力客船为研究对象,进行动力系统研究。根据船舶基本参数与设计指标,给出混合动力系统总成方案。在满足船舶动力性指标要求的前提下,对船舶混合动力系统进行参数匹配;并进... 详细信息

为了响应国家对航运业绿色可持续发展的需求,以某小型油电混合动力客船为研究对象,进行动力系统研究。根据船舶基本参数与设计指标,给出混合动力系统总成方案。在满足船舶动力性指标要求的前提下,对船舶混合动力系统进行参数匹配;并进一步提出了油电混合动力船舶能量控制策略,最后在混合动力实验平台上进行仿真试验验证。实验结果表明,相同工况下,混合动力船舶会比柴油发动机作为主机的船舶消耗更少的燃料,可以有效提高船舶的经济性并改善其排放性能。

关键词：油电混合系统参数匹配电力推进控制策略

Gene replacement therapy in Bietti crystalline corneoretinal dystrophy:an open-label,single-arm,exploratory trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2275-2284页

作者： Jinyuan Wang Jinlu Zhang Shicheng Yu Hongyan Li shaohong Chen Jingting Luo Haibo Wang Yuxia Guan Haihan Zhang Shiyi Yin Huili Wang Heping Li Junle Liu Jingyuan Zhu Qiong Yang Ying sha Chuan Zhang Yuhang Yang Xuan Yang Xifang Zhang Xiuli Zhao Likun Wang Liping Yang Wenbin Wei Beijing Tongren eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical University100730 BeijingChina School of Clinical Medicine Tsinghua University100084 BeijingChina Chigenovo Co. Ltd.102206 BeijingChina Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third Hospital100191 BeijingChina Department of Ophthalmology The Third People’s Hospital of Dalian116091 DalianChina Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Institute of Systems Biomedicine Department of PathologySchool of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina

Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2,which results in blindness in the working-age population,and there is currently no available treatment.Here,we report the results of the first-in-human clinical trial(NCT04722107)of gene therapy for Bietti crystalline corneoretinal dystrophy,including 12 participants who were followed up for 180-365 days.This open-label,single-arm exploratory trial aimed to assess the safety and efficacy of a recombinant adeno-associated-virus-serotype-2/8 vector encoding the human CYP4V2 protein(rAAV2/8-hCYP4V2).Participants received a single unilateral subretinal injection of 7.5×10^(10)vector genomes of rAAV2/8-hCYP4V2.Overall,73 treatment-emergent adverse events were reported,with the majority(98.6%)being of mild or moderate intensity and considered to be procedure-or corticosteroid-related;no treatment-related serious adverse events or local/systemic immune toxicities were observed.Compared with that measured at baseline,77.8%of the treated eyes showed improvement in best-corrected visual acuity(BCVA)on day 180,with a mean±standard deviation increase of 9.0±10.8 letters in the 9 eyes analyzed(p=0.021).By day 365,80%of the treated eyes showed an increase in BCVA,with a mean increase of 11.0±10.6 letters in the 5 eyes assessed(p=0.125).Importantly,the patients’improvement observed using multifocal electroretinogram,microperimetry,and Visual Function Questionnaire-25 further supported the beneficial effects of the treatment.We conclude that the favorable safety profile and visual improvements identified in this trial encourage the continued development of rAAV2/8-hCYP4V2(named ZVS101e).

关键词： cor dystrophy crystalline

Lu-eu共掺杂Ga_(2)O_(3)的光电性质的第一性原理计算

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原子与分子物理学报 2024年第3期41卷 144-151页

作者：邹梦真肖清泉姚云美付莎莎叶建峰唐华谢泉贵州大学大数据与信息工程学院新型光电子材料与技术研究所贵阳550025

宽禁带半导体β-Ga_(2)O_(3)因为具有优良的物理化学性能而成为研究热点.本文基于DFT(Density Functional Theory)的第一性原理方法,先采用PBe(Perdew-Burke-ernzerhof)中的GGA(Generalized Gradient Approximation)和GGA+U(Generalized Gradient Approximation-Hubbard U)的方法计算了本征β-Ga_(2)O_(3),Lu掺杂浓度为12.5%的β-Ga_(2)O_(3)及Lu-eu共掺杂浓度为25%的β-Ga_(2)O_(3)结构的晶格常数、能带结构和体系总能量.发现采用GGA+U的方法计算的带隙值更接近实验值,于是采用GGA+U的方法计算了本征β-Ga_(2)O_(3),Lu掺杂的β-Ga_(2)O_(3)以及Lu-eu共掺杂的β-Ga_(2)O_(3)结构的能态总密度、介电函数、吸收谱以及反射率等.由计算结果得知β-Ga_(2)O_(3)的带隙为4.24 eV,Lu掺杂浓度为12.5%的β-Ga_(2)O_(3)的带隙为2.23 eV,Lu-eu共掺杂浓度为25%的β-Ga_(2)O_(3)的带隙为0.9 eV,均为直接带隙半导体,掺杂并未改变β-Ga_(2)O_(3)的带隙方式.光学性质计算结果表明在低能区掺杂浓度为12.5%的Lu和Lu-eu共掺杂浓度为25%的β-Ga_(2)O_(3)的吸收系数和反射率均强于本征β-Ga_(2)O_(3),Lu-eu掺杂β-Ga_(2)O_(3)的吸收系数和反射率又略强于Lu掺杂β-Ga_(2)O_(3),表明Lu-eu掺杂β-Ga_(2)O_(3)的材料有望应用于制备红外光电子器件.

关键词：第一性原理 Lu-eu共掺β-Ga_(2)O_(3) 电子结构光学性质

Stratigraphic framework and sedimentary evolution during the Cryogenian-ediacaran transition in northeastern Sichuan Basin,South China

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Petroleum Science 2024年第2期21卷 823-835页

作者： Yi Zhang Hong-Wei Kuang Yong-qing Liu Qiang Shi Dong-Ge Wang Ke-Ning Qi Yu-Chong Wang Da-Wei Qiao Xiao-Shuai Chen Li-Zhi Wu Meng Tian Long Chen Yi Wei Liao-Yuan Song Jian Li Zi-Gang Wu Yun-Qian Liu Xuan-Chun Liu An-qing Chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China Chongqing Institute of Geological Survey Chongqing401122China Key Laboratory of Deep-time Geography and environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern Yangtze margin has unique ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent years.However,the Cryogenian-ediacaran(C-e)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic pattern.This study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-e transition strata in northeastern Sichuan.The results showed that the ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied area.The Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original Chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb dating.Regional stratigraphic correlations indicate that the C-e transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three Gorges.Typically,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast sandstones.The proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing strata.During the C-e transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ediacaran.Overall,the early ediacaran of northeastern Sichuan succeeded the paleogeogr

关键词： Marinoan glaciation Doushantuo formation Cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating

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习近平关于讲好思想政治理论课重要论述研究

大连理工大学学报（社会科学版） 2024年第3期45卷 1-6页

作者：徐志宏赵莎首都师范大学马克思主义学院北京100089

办好思想政治理论课,关键在教师。党的十八大以来,习近平总书记对教师如何讲好思想政治理论课做了诸多论述。他认为,思想政治理论课教师应遵循根本之“道”,以党的教育方针为指引,为学生讲授科学理论、传递先进观念。同时,思想政治理论... 详细信息

办好思想政治理论课,关键在教师。党的十八大以来,习近平总书记对教师如何讲好思想政治理论课做了诸多论述。他认为,思想政治理论课教师应遵循根本之“道”,以党的教育方针为指引,为学生讲授科学理论、传递先进观念。同时,思想政治理论课教师既要具备精深之“学”,以扎实的学识功底和透彻的学理分析赢得学生信赖,也要掌握亲和之“术”,以激发学生的学习兴趣、发挥学生的主体性作用。

关键词：习近平思想政治理论课思想政治理论课教学

Development of a stable attenuated double-mutant of tobacco mosaic virus for cross-protection

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Journal of Integrative Agriculture 2024年第7期23卷 2318-2331页

作者： Xiaojie Xu shaoyan Jiang Chunju Liu Xujie Sun qing Zhu Xiuzhai Chen Pengchao Jiang Fenglong Wang Yanping Tian Xiangdong Li The engineering Research Institute of Agriculture and Forestry Ludong UniversityYantai 264025China Laboratory of Plant Virology Department of Plant PathologyCollege of Plant ProtectionShandong Agricultural UniversityTai’an 271018China Weifang Tobacco Corporation Weifang 261031China Linyi Tobacco Corporation Linyi 276000China Tobacco Research Institute Chinese Academy of Agricultural SciencesQingdao 266101China

Tobacco(Nicotiana tabacum)and tomato(Solanum lycopersicum)are two major economic crops in China.Tobacco mosaic virus(TMV;genus Tobamovirus)is the most prevalent virus infecting both crops.Currently,some widely cultivated tobacco and tomato cultivars are susceptible to TMV and there is no effective strategy to control this virus.Cross-protection can be a safe and environmentally friendly strategy to prevent viral diseases.However,stable attenuated TMV mutants are scarce.In this study,we found that the substitutions in the replicase p126,arginine at position 196(R196)with aspartic acid(D),glutamic acid at position 614(e614)with glycine(G),serine at position 643(S643)with phenylalanine(F),or D at position 730(D730)with S,significantly reduced the virulence and replication of TMV.However,only the mutation of S643 to F reduced the RNA silencing suppression activity of TMV p126.A double-mutant TMV-e614G-S643F induced no visible symptom and was genetically stable through six successive passages in tobacco plants.Furthermore,our results showed that TMV-e614G-S643F double-mutant could provide effective protection against the wild-type TMV infection in tobacco and tomato plants.This study reports a promising mild mutant for cross-protection to control TMV in tobacco and tomato plants.

关键词： cross-protection double-mutant p126 tobacco mosaic virus virulence

Anomalous thermal expansion and enhanced magnetocaloric effect in <001>-textured MnxFe5–xSi3alloys

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Rare Metals 2024年第5期43卷 2263-2274页

作者： Yong Gong Xue-Fei Miao Tapas Samanta Chris Taake Jun Liu Feng-Jiao Qian Yan-Yan shao Yu-Jing Zhang qing-Yong Ren Luana Caron Feng Xu MIIT Key Laboratory of Advanced Metallic and Intermetallic Materials Technology School of Materials Science and Engineering Nanjing University of Science and Technology Department of Physics Bielefeld University College of Physics Nanjing University of Aeronautics and Astronautics Institute of High energy Physics Chinese Academy of Sciences Spallation Neutron Source Science Center Guangdong-Hong Kong-Macao Joint Laboratory for Neutron Scattering Science and Technology Helmholtz-Zentrum Berlin fu¨r Materialien und energie

The development of zero and negative therma expansion （i.e.,ZTe and NTe） materials is of crucial importance to the control of undesirable thermal expansion for high-precision devices.In the present work,ZTe and NTe were obtained in directionally-solidified MnxFe5–xSi3alloys with a strongtexture,in striking contrast to positive thermal expansion in their isotropic counterparts Magnetometry and in-situ X-ray diffraction （XRD） measurements were performed to uncover the origin of the anomalous thermal expansion.Magnetic measurements indicate a strong easy-plane magnetocrystalline anisotropy in the textured samples,where the magnetic moments are aligned within the ab plane of the hexagonal structure Temperature-dependent XRD on the x=1 sample reveals a ZTe character in the ab plane that is coupled to a ferromagnetic transition.As a result,the macroscopic ZTe(～0.22×10–6K-1) in the x=1 sample can be attributed to the microscopic magneto volume effect within the ab plane,which is realized by the introduction of the-textured microstructure.Besides,the competition between antiferromagnetic and ferromagnetic exchange coupling leads to NTe in textured x=1.5 and 2 samples.Additionally,textured x=1 sample displays enhanced magnetocaloric properties as compared to the conventional counterparts with randomly-oriented grains.Consequently this work demonstrates a new strategy toward the exploration of anomalous thermal expansion properties as well as the enhancement of magnetocaloric properties for materials with a strong magnetocrystalline anisotropy.

关键词： MnFe 4 Si 3 Magnetocaloric effect Magnetic phase transition Negative thermal expansion

eikenella corrodens isolated from pleural effusion:A case report

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World Journal of Clinical Cases 2024年第18期12卷 3596-3602页

作者： Zi-Cong Liang Hao Ouyang Xue-Jing Song Jian-Xin Liang Wei-Hua Zheng Jian-Jun Chen Zheng-Gang Yin sha-Yan Chen Department of Laboratory Science Binhaiwan Central Hospital of DongguanDongguan 523905Guangdong ProvinceChina Key Laboratory of accurately etiological research on the pathogenesis of inflammation and cancer Dongguan 523905Guangdong ProvinceChina Central Laboratory Binhaiwan Central Hospital of DongguanDongguan 523905Guangdong ProvinceChina

BACKGROUND The bacterium eikenella,classified as a gram-negative member of the phylum Proteobacteria,is distinguished by its rarity,corrosive nature,facultative anaerobic properties,and conditional pathogenicity.It represents the sole species within its genus-eikenella corrodens(e.corrodens)-and can be found colonizing both human and animal oral and nasopharyngeal regions.Additionally,it occasionally inhabits the gastrointestinal or urogenital tracts.However,its slow growth rate can be attributed to its high nutritional requirements.However,there is an uneven distribution of construction and diagnostic capacity in China which poses undeniable challenges for the clinical examination and analysis of this case,especially in the basic hospitals.CASe SUMMARY Here we presented a case of empyema associated with e.corrodens infection in a 67-year-old male patient without any previous history of infectious diseases in our primary hospital in Dongguan district of China.The patient was admitted due to recurrent worsening cough,sputum production,and dyspnea for 3 d,which had persisted for over 20 years.Moreover,the patient experienced a onehour episode of unconsciousness.Upon admission,immediate comprehensive examinations were conducted on the patient which subsequently led to his admission to the intensive care unit.Meanwhile,the patient presented with drowsiness and profuse sweating along with bilateral conjunctival edema observed during initiation of non-invasive ventilation,suggesting empyema.A significant amount of coffee-colored malodorous pleural fluid was drained during the procedure above and sent to the laboratory department for inspection.Finally,laboratory culture results confirmed the presence of e.corrodens infection in the pleural fluid sample.The patient received antimicrobial therapy until died on day 22 in the hospital.CONCLUSION In this report,we presented a case of empyema associated with e.corrodens infection.Multiple courses of morphological examination,viable culture analysis,and biochemical identifica

关键词： eikenella corrodens Pleural fluid Morphology Viable culture Biochemical identification Case report

Dcalycinumines A-e,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum

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Chinese Journal of Chemistry 2024年第1期42卷 35-42页

作者： qing Tang Xiao-Yong Dai Qiang Lin Zhi-Peng Ling Yi-Kun Hao Tian-Xi Zhu Ji-Hui Zhang Yi-Bo Hou Yao-Lan Li Lai-Qiang Huang Jing-Hao Wang Guo-Cai Wang Yu-Bo Zhang Guangdong Clinical Translational Centerfor Targeted Drug Department of PharmacologySchoolof MedicineJinan University GuangzhouGuangdong 510632China Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollegeof PharmacyJinan UniversityGuangzhouGuangdong511443China Institute of Biopharmaceutical and Health engineering Shenzhen Key Laboratory of Gene and Antibody TherapyState Key Laboratory of Chemical OncogenomicsShenzhen International Graduate SchoolTsinghua UniversityShenzhenGuangdong 518055China The Guangzhou Key Laboratoryof Basic and Translational Research on Chronic Disease Department of PharmacyThe First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Fivenovel Daphniphyllum alkaloids,named dcalycinumines A-e(1-4,6),andeight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum calycinum.Compound 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3-methyl-1-azabicyclo[4,4,0]decane ring system.Compound 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1-aza-6-azaspiro[4,5]decane unit,whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of 2.Compound 4 is the second example of c-22-nor yuzurimine-type alkaloids.Their structures and absolute configurations were elucidated by HReSIMS,NMR spectroscopic analyses,ecD calculations,and single-crystal X-ray diffraction.Moreover,compound 1 showed remarkable antitumor activities,which could inhibit the proliferation,migration and invasion of nasopharyngeal carcinoma cells,and promoted nasopharyngeal carcinoma cells apoptosis.

关键词： Daphniphyllum calycinum Natural products Daphniphyllum alkaloid Structural elucidation Biological activity Apoptosis Nasopharyngealcarcinoma