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Involvement of NLRP3-inflammasome pathway in noise-induced hearing loss

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Neural Regeneration Research 2022年第12期17卷 2750-2754页

作者： Na Sai Yuan-Yuan Yang Long Ma Da Liu qing-qing jiang Wei-Wei Guo Wei-Ju Han College of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalBeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment for Prevention and Treatment BeijingChina Department of Otolaryngology Head and Neck Surgery Peking University Shenzhen HospitalShenzhenGuangdong ProvinceChina PLA Rocket Force Characteristic Medical Center Department of Stomatology China

The inflammasome is a multiprotein oligomer in the cell cytoplasm and is part of the innate immune *** plays a crucial role in the pathological process of noise-induced hearing loss(NIHL).However,the mechanisms of NLR family pyrin domain containing 3(NLRP3)inflammasome activation in NIHL have not been clearly *** this study,miniature pigs were exposed to white noise at 120 dB(A)and auditory brainstem response measurements were used to measure their hearing *** staining,confocal laser scanning microscopy,western blot assay,and quantitative reverse transcription-polymerase chain reaction were used to analyze inflammasome-related protein distribution and ***3,interleukin-1β,interleukin-18,and cleaved-caspase-1 were highly expressed in the cochlea after 120 dB(A)white noise *** findings suggest that NLRP3-inflammasomes in the cochlea may be activated after acoustic trauma,which may be an important mechanism of noise-induced hearing loss.

关键词： acoustic injury inflammasome interleukin-1β miniature pig NLR family pyrin domain containing 3(NLRP3) noise-induced hearing loss sensorineural hearing loss

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai Jian Hui Jia Yu Wang Chun Cheng Yang qing jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

A preliminary study of the mechanism of compound hearing loss caused by ototoxic drugs combined with impulse noise

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iLABMED 2024年第1期2卷 38-52页

作者： Xin Qiu qing‐qing jiang Wei‐wei Guo Ning Yu Shi‐ming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Chinese PLA Medical School BeijingChina

Background:Hearing loss(HL)is becoming increasingly common and is more commonly caused by noise,ototoxic substances,or a combination of ototoxic ***,so far,few studies have examined the mechanism by which compound factors cause *** only relevant study is about occupational ototoxic substances combined with environmental noise at 85-110 dB *** this study,to address the shortcomings of existing research,we innovatively focused on HL induced by loud noise(impulse noise,>160 dB SPL)combined with common ototoxic *** aim of this study was to establish and validate a mature animal model,and then to compare the characteristics of audiology,pathomorphology and molecular features,and to preliminarily predict pathogenesis in compound *** and Methods:We selected guinea pigs to construct in vivo HL model groups for different extents of exposure,including a blank control group,a single-drug group,a single-impulse noise group,and a compound *** animal model of the mature compound HL group was established using gentamicin combined with impulse *** then performed audio-logical and pathological *** analyzed the auditory brainstem response(ABR),pathological morphology of the cochlea,and molecules(including important self-radicals,cytokines,and apoptosis signal trans-duction pathway proteins in the pathogenesis of drug-and noise-induced HL),compared the effect of different extents of exposure on HL,and preliminarily predict the pathogenic mechanism of compound ***:Four groups of animal models were established successfully and verified by audiology and *** audiology,there were no sig-nificant differences in the ABR thresholds before exposure(p>0.05),but differences emerged among the groups after ***,after 3,7,and 14 days of exposure,there were significant differences in the ABR thresholds between the compound group and both the drug and noise groups(p<0.01),and after 14 days,the HL of the compoun

关键词： auditory brainstem response gentamicin hearing loss impulse noise molecular mechanisms pathomorphology

氢化物发生-催化共振瑞利散射光谱法测定痕量砷

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光谱学与光谱分析 2016年第11期36卷 3689-3692页

作者：梁爱惠杨铎温桂清刘庆业蒋治良珍稀濒危动植物生态与环境保护教育部重点实验室广西师范大学广西桂林541004

在硫酸介质中,以硼氢化钠(NaBH_4)为还原剂,可将As(Ⅲ)还原为砷化氢(AsH_3)气体使其逸出,用Ce(SO_4)_2-H_2SO_4-KI混合液做吸收液,在催化剂KI存在下四价铈与AsH_3气体反应生成具有共振瑞利散射(RRS)的砷微粒和具有荧光的三价铈,导致体系... 详细信息

在硫酸介质中,以硼氢化钠(NaBH_4)为还原剂,可将As(Ⅲ)还原为砷化氢(AsH_3)气体使其逸出,用Ce(SO_4)_2-H_2SO_4-KI混合液做吸收液,在催化剂KI存在下四价铈与AsH_3气体反应生成具有共振瑞利散射(RRS)的砷微粒和具有荧光的三价铈,导致体系在370nm处的RRS信号和在351nm处的荧光强度增大。在选定条件下,As(Ⅲ)浓度分别在0.006~0.76mg·L^(-1)和0.006~0.28mg·L^(-1)范围内与RRS增加值ΔI和荧光强度增大值ΔF351呈线性关系,检出限均为3.0μg·L^(-1)。据此可建立新的检测As(Ⅲ)的催化RRS和荧光光谱法。

关键词：砷砷化氢催化共振瑞利散射荧光

Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan Yang Lingxi qing Yifei Chen Jilian Zou Meiling Jia Qian Wang Runda jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

宫腹腔镜联合手术治疗剖宫产子宫切口瘢痕缺陷

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中国内镜杂志 2016年第1期22卷 83-85页

作者：蒋清清于鹏谢红斌福建省厦门市妇幼保健院妇科福建厦门361003

目的探讨剖宫产子宫切口瘢痕缺陷应用宫腹腔镜联合手术治疗的安全性及可行性。方法选择经阴道彩超及宫腔镜诊断的剖宫产切口瘢痕缺陷患者8例,在全麻下进行宫腹腔镜联合手术,放置举宫杯后分离子宫膀胱腹膜返折,宫腔镜定位后切除子宫切口... 详细信息

目的探讨剖宫产子宫切口瘢痕缺陷应用宫腹腔镜联合手术治疗的安全性及可行性。方法选择经阴道彩超及宫腔镜诊断的剖宫产切口瘢痕缺陷患者8例,在全麻下进行宫腹腔镜联合手术,放置举宫杯后分离子宫膀胱腹膜返折,宫腔镜定位后切除子宫切口瘢痕缺陷部位组织,缝合子宫肌层,再用宫腔镜进行评估。结果 8例患者手术顺利,平均手术时间为(86.24±25.36)min,平均术中出血量(93.25±28.24)ml,术后经期由原来的(13.00±3.65)d缩短至(5.85±1.54)d(P<0.05)。1例合并不孕症患者术后妊娠。结论宫腹腔镜联合手术治疗剖宫产子宫切口瘢痕缺陷是一种安全、可行的方法。

关键词：剖宫产子宫切口瘢痕缺陷宫腔镜腹腔镜

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li Jia Xiu-Jun Zhan Charity Ngina qing-Rui Zhang Xiao-Ge Li Qi-Bao jiang Shi Bai Miao-Miao jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

泛素样蛋白蛋白酶体系统对单耐异烟肼结核分枝杆菌耐药性机制研究

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中国病原生物学杂志 2017年第6期12卷 489-494页

作者：张帅张舜文吴芳吴江东章乐张杰董江涛张玉清柳小玲梁粟朱荟云张大龙武青青张万江石河子大学医学院病理生理学教研室新疆地方与民族高发病教育部重点实验室西部地区高发人兽共患传染性疾病防治协同创新中心新疆石河子832002 南京医科大学基础医学院石河子大学医学院第一附属医院

目的探讨泛素样蛋白蛋白酶体系统对单耐异烟肼结核分枝杆菌耐药性的影响及其机制。方法采用刃天青显色法,比较单耐异烟肼结核分枝杆菌(对照组)与4种基因(Pup、Dop、PafA、Mpa基因)分别过表达和缺失单耐异烟肼结核分枝杆菌菌株异烟肼最... 详细信息

目的探讨泛素样蛋白蛋白酶体系统对单耐异烟肼结核分枝杆菌耐药性的影响及其机制。方法采用刃天青显色法,比较单耐异烟肼结核分枝杆菌(对照组)与4种基因(Pup、Dop、PafA、Mpa基因)分别过表达和缺失单耐异烟肼结核分枝杆菌菌株异烟肼最低抑菌浓度(minimum inhibitory concentration,MIC)值的差异;比较加入改变细胞壁通透性试剂后,单耐异烟肼结核分枝杆菌(对照组)与4种基因分别过表达和缺失单耐异烟肼结核分枝杆菌菌株异烟肼MIC差值间的差异。结果 (1)与单耐异烟肼结核分枝杆菌相比,异烟肼的MIC值过表达PafA基因株增加1.03μg/ml,过表达Dop、Mpa基因株分别降低1.03μg/ml、0.68μg/ml,差异均无统计学意义(F=1.898,P>0.05);过表达Pup基因株异烟肼的MIC值增加8μg/ml,差异有统计学意义(t=2.185,P0.05)。结论结核分枝杆菌泛素样蛋白蛋白酶体系统可能通过调控单耐异烟肼结核分枝杆菌细胞壁的通透性影响其耐药性。

关键词：结核分枝杆菌泛素样蛋白-蛋白酶体系统耐药性异烟肼机制

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS