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The Application of Artificial Intelligence in Alzheimer’s Research

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Tsinghua Science and Technology 2024年第1期29卷 13-33页

作者： qing zhao Hanrui Xu Jianqiang Li Faheem Akhtar Rajput Liyan Qiao Faculty of Information Technology Beijing University of TechnologyBeijing 100124China School of Medicine Tsinghua UniversityBeijing 100084China Department of Computer Science Sukkur IBA UniversitySukkur 65200Pakistan Department of Neurology Tsinghua University Yuquan HospitalBeijing 100040China

Alzheimer's disease(AD)is an irreversible and neurodegenerative disease that slowly impairs memory and neurocognitive function,but the etiology of AD is still *** the explosive growth of electronic health data,the application of artificial inteligence(Al)in the healthcare setting provides excellent potential for exploring etiology and personalized treatment approaches,and improving the disease's diagnostic and prognostic *** paper first briefly introduces Al technologies and applications in medicine,and then presents a comprehensive review of Al in *** simple,it includes etiology discovery based on genetic data,computer-aided diagnosis(CAD),computer-aided prognosis(CAP)of AD using multi-modality data(genetic,neuroimaging and linguistic data),and pharmacological or non-pharmacological approaches for treating ***,some popular publicly available AD datasets are introduced,which are important for advancing Al technologies in AD ***,core research challenges and future research directions are discussed.

关键词： Alzheimer's disease artificial intelligence etiology discovery computer-aided diagnosis computer-aided prognosis treatment

Dark matter with chiral symmetry admixed with hadronic matterin compact stars

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Chinese Physics C 2022年第4期46卷 1-9页

作者： Si-Na Wei zhao-qing Feng School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

Using the two-fluid Tolman-Oppenheimer-Volkoff equation,the properties of dark matter(DM)admixed neutron stars(DANSs)have been *** contrast to previous studies,we find that an increase in the maximum mass and a decrease in the radius of 1.4 M_(⊙)NSs can occur simultaneously in *** stems from the ability of the equation of state(EOS)for DM to be very soft at low density but very stiff at high *** is well known that the IU-FSU and XS models are unable to produce a neutron star(NS)with a maximum mass greater than 2.0 M_(⊙).However,by considering the IU-FSU and XS models for DANSs,there are interactions with DM that can produce a maximum mass greater than 2.0 M_(⊙)and a radius of 1.4 M_(⊙)NSs below 13.7 *** considering a DANS,the difference between DM with chiral symmetry(DMC)and DM with meson exchange(DMM)becomes obvious when the central energy density of DM is greater than that of nuclear matter(NM).In this case,the DMC model with a DM mass of 1000 MeV can still produce a maximum mass greater than 2.0 M_(⊙)and a radius of a 1.4 M_(⊙)NS below 13.7 ***,although the maximum mass of the DANS using the DMM model is greater than 2.0 M_(⊙),the radius of a 1.4 M_(⊙)NS can surpass 13.7 *** the two-fluid system,the maximum mass of a DANS can be larger than 3.0 M_(⊙).Consequently,the dimensionless tidal deformabilityΛCP of a DANS with 1.4 M_(⊙),which increases with increasing maximum mass,may be larger than 800 when the radius of the 1.4 M_(⊙)DANS is approximately 13.0 km.

关键词： chiral symmetry dark matter two-fluid TOV equation neutron star

Influence of chromium on the initial corrosion behavior of low alloy steels in the CO_2–O_2–H_2S–SO_2 wet–dry corrosion environment of cargo oil tankers

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International Journal of Minerals,Metallurgy and Materials 2015年第8期22卷 829-841页

作者： qing-he zhao Wei Liu Jie zhao Dong Zhang Peng-cheng Liu Min-xu Lu Institute for Advanced Materials and Technology University of Science and Technology Beijing Marine Product Management Department China Classification Society Headquarters

The influence of Cr on the initial corrosion behavior of low-alloy steels exposed to a CO2–O2–H2S–SO2 wet–dry corrosion environment was investigated using weight-loss measurements, scanning electron microscopy, N2 adsorption tests, X-ray diffraction analysis, and electrochemical impedance spectroscopy. The results show that the corrosion rate increases with increasing Cr content in samples subjected to corrosion for 21 d. However, the rust grain size decreases, its specific surface area increases, and it becomes more compact and denser with increasing Cr content, which indicates the enhanced protectivity of the rust. The results of charge transfer resistance(Rct) calculations indicate that higher Cr contents can accelerate the corrosion during the first 7 d and promote the formation of the enhanced protective inner rust after 14 d; the formed protective inner rust is responsible for the greater corrosion resistance during long-term exposure.

关键词： low alloy steels corrosion rate chromium rust oil

Effects of the critical breakdown path on the ignition performance in heaterless hollow cathodes

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Plasma Science and Technology 2020年第6期22卷 164-179页

作者： Bo YU Yanda LEE Xiaolu KANG qing zhao Center for Information Geoscience School of Resources and EnvironmentUniversity of Electronic Science and Technology of ChinaChengdu 611731People's Republic of China Shanghai Institute of Space Propulsion Shanghai 201112People's Republic of China

The critical breakdown path(CBP)has a significant impact on the breakdown voltage curve and the ignition time of heaterless hollow cathodes(HHCs).To determine the pattern of the variation in the CBP position and its impact on ignition performance,a numerical model named the CBP evaluation(CBPE)was established in this paper to calculate the CBP of a *** CBPE model can be used to screen various potential breakdown paths to identify those that are most likely to satisfy the Townsend breakdown conditions,which are denoted as *** verify the calculation accuracy of the CBPE model,4.5 A-level HHC ignition tests were conducted on HHCs with three different *** comparing the test results and the calculated results of the breakdown voltage,the calculation errors of the CBPE under three HHC conditions ranged from 1.6%to 5.8%,and the trends of the calculated results were consistent with those of the test *** ignition test also showed the characteristics of the breakdown voltage curve and the ignition time for the three *** on the CBPE model,an in-depth analysis was conducted on the mechanism of the patterns revealed by the *** main conclusions are presented as follows:(1)the CBP always shifts from the long path to the short path in the HHCs with an increasing gas flow rate;and(2)the ignition time of the HHCs depends on the position of the CBP because different CBP positions can cause different mechanisms of heat transfer from the plasma to the *** study can guide the optimization of the CBP position and the corresponding ignition times of HHCs.

关键词： breakdown path heaterless hollow cathode breakdown voltage ignition time numerical calculation

Sub-10 fs laser pulses with repetition rate of 1.1 GHz by a Ti:sapphire oscillator

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Chinese Science Bulletin 2009年第20期54卷 3649-3652页

作者： ZHANG qing zhao YanYing WEI ZhiYi Institute of Physics Chinese Academy of Sciences Beijing 100190 China

We demonstrate a compact Ti:sapphire oscillator with ring cavity *** optimizing the intra-cavity dispersion with chirped mirrors,pulses with repetition rate of 1.1 GHz are coupled out by the uncoated wedges in the *** 7W CW pump laser centered at 532 nm,the average power of the output pulses is about 30 mW,the duration is less than 10fs and the spectrum spans from 670 nm to 920 nm.

关键词：激光脉冲重复率振荡器蓝宝石 GHz 财政 32纳米钛

Acute myocardial infarction in a young man with ankylosing spondylitis: A case report

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World Journal of Clinical Cases 2021年第36期9卷 11392-11399页

作者： Zhi-Hong Wan Jing Wang qing zhao Department of Rheumatology and Immunology Huaihe Hospital of Henan UniversityKaifeng 475000Henan ProvinceChina

BACKGROUND Ankylosing spondylitis(AS)is a chronic progressive inflammatory disease that mainly affects the spine and sacroiliac *** the best of our knowledge,AS with acute myocardial infarction(AMI)has rarely been ***,we report an unusual case of AS with AMI in a young *** SUMMARY A 37-year-old man was admitted to the Department of Rheumatology and Immunology of our hospital on March 14,2020,for low back *** evaluation with clinical examinations,laboratory tests,and imaging resulted in a diagnosis of *** with a non-steroidal anti-inflammatory drug and a tumor necrosis factor inhibitor partially improved his ***,his back pain *** 6 wk of treatment,he was admitted to the emergency room of another hospital in this city for sudden-onset severe chest pain consistent with a diagnosis of *** revealed severe narrowing of the coronary *** placement of two coronary stents completely relieved his back *** AS can cause cardiovascular diseases,including *** is important to consider the cardiovascular risks in the management of AS.

关键词： Ankylosing spondylitis Acute myocardial infarction Coronary stent placement Non-steroidal anti-inflammatory drugs Tumor necrosis factor inhibitors

Coexisting tubular adenoma with a neuroendocrine carcinoma of colon allowing early surgical intervention and implicating a shared stem cell origin

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World Journal of Gastroenterology 2017年第6期23卷 1106-1112页

作者： Mahmoud L Soliman Ashish Tiwari qing zhao Department of Pathology and Laboratory Medicine Boston University Medical Center Department of Gastroenterology Boston University Medical Center

High-grade colonic neuroendocrine carcinomas (NECs) are uncommon but extremely aggressive. Their co-existence with tubular adenoma (TA) has rarely been reported. We present a 68-year-old man who was found on routine colonoscopy to have multiple colorectal TAs and an ulcerated lesion in the ascending colon. Microscopically, a poorly-differentiated invasive carcinoma juxtaposed with a TA was identified. Differential diagnosis included a poorly-differentiated adenocarcinoma, medullary carcinoma, high-grade NEC and lymphoma. The immunohistochemical profile showed positive staining for keratins, synaptophysin and chromogranin but negative for LCA, CDX2, CK7, CK20, TTF-1 and PSA, supporting the NEC diagnosis. Upon subsequent laparoscopic right hemicolectomy, the tumor was identified as a 3.0 cm umbilicated and ulcerated mass with an adjacent TA. Both TA and NEC showed positive staining for β-catenin indicating a shared colonic origin. The mitotic counts (77/10 high power fields) and a high proliferation rate (75% by Ki-67) corroborated a high-grade stratification. Mutational analysis indicated a wild-type BRAF and KRAS with mismatch repair proficiency. The AJCC (7th edition) pathologic stage is pT3, pN0, pMx. The patient received adjuvant chemotherapy with cisplatin/etoposides for three cycles and will be followed up for a year to detect recurrence. In conclusion, the co-existence of TA with high grade-NEC in our case allowed early identification and intervention of the otherwise asymptomatic but aggressive tumor. In addition, the finding of a high-grade NEC within a large TA in this case suggests a link between the two lesions and could represent a shared stem cell origin.

关键词： Neuroendocrine carcinoma Tubular adenoma Colorectal Colocalization

Pre-hospital delay in patients with acute myocardial infarction in China:findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome(CCC-ACS)project

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Journal of Geriatric Cardiology 2022年第4期19卷 276-283页

作者： Dan-qing HU Yong-Chen HAO Jun LIU Na YANG Yi-Qian YANG zhao-qing SUN Dong zhao Jing LIU Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijingChina

OBJECTIVE To describe the duration of the pre-hospital delay time and identify factors associated with prolonged pre-hospital delay in patients with acute myocardial infarction(AMI)in *** Data were collected from November 2014 to December 2019 as part of the Improving Care for Cardiovascular Dis-ease in China-Acute Coronary Syndrome(CCC-ACS)project.A total of 33,386 patients with AMI admitted to the index hospitals were included in this ***-level logistic regression was conducted to explore the factors associated with the pre-hospital delay and the associations between different pre-hospital delay and in-hospital *** Of the 33,386 patients with AMI,70.7%of patients arrived at hospital≥2 h after symptom *** age,female,ru-ral medical insurance,symptom onset at early dawn,and non-use of an ambulance predicted a prolonged pre-hospital delay(all P<0.05).Hypertension and heart failure at admission were only significant in predicting a longer delay in patients with ST-seg-ment elevation myocardial infarction(STEMI)(all P<0.05).A pre-hospital delay of≥2 h was associated with an increased risk of mortality[odds ratio(OR)=1.36,95%CI:1.09-1.69,P=0.006]and major adverse cardiovascular events(OR=1.22,95%CI:1.02-1.47,P=0.033)in patients with STEMI compared with a pre-hospital delay of<2 *** Prolonged pre-hospital delay is associated with adverse in-hospital outcomes in patients with STEMI in *** study identifies that patient characteristics,symptom onset time,and type of transportation are associated with pre-hospital delay time,and provides focuses for quality improvement.

关键词： patients infarction admitted

Synthesis, Structure and Luminescent Property of a Zinc(Ⅱ) Coordination Polymer Incorporating Flexible Cyclohexane-1,2,3,4,5,6-hexacarboxylate Ligand

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Chemical Research in Chinese Universities 2011年第3期27卷 354-357页

作者： WANG jind LIU zhao-qing SU Ting-ting School of Chemistry and Chemical Engineering Guangzhou University Guangzhou 510006 P. R. China

The hydrothermal reaction of Zn（NO3）2·4H2O, cyclohexane-1,2,3,4,5,6-hexacarboxylic acid hydrate （H6LI·H2O, cis-conformation LI： a,e,a,e,a,e） and 2,2＇-bpy yielded a new coordination polymer [Zn2（H2LII）（2,2＇-bpy）]·2H2O（trans-conformation LII： e,e,e,e,e,e）, which was characterized by single-crystal X-ray diffraction, elemental analysis, IR and XRPD（X-ray powder diffraction）. This complex crystallized in the triclinic system, with P1 space group and parameters a=0.66922（5） nm, b=0.97291（8） nm, c=1.22184（9） nm, α=99.0020（10）°, β=99.1300（10）°, γ=99.1910（10）°, V= 0.76176（10） nm3 and Z=2. The structure is a three-dimensional supramolecular network based on linear coordination chains through π-π stacking and hydrogen bonding interactions. The confromation of the starting ligand H6LI transfromed to the H2LII. The complex emits strong luminescence at room temperature.

关键词： Coordination polymer Cyclohexane-1 2 3 4 5 6-hexacarboxylate Conformation Luminescent property