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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu qinghua Zeng qing tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

New Expected Value Expansions of Rooted Graphs

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Acta Mathematicae Applicatae Sinica 2015年第1期31卷 81-88页

作者： Xiao-qing tang School of Mathematics & Information Shanghai Lixin University of Commerce

We propose a new expected value of rooted graph in this article,that is, when G is a rooted graph that each vertex may independently succeed with probability p when catastrophic thing happened, we consider the expected number of edges in the operational component of G which containing the root. And we get a very important and useful compute formula which is called deletion-contraction edge formula. By using this formula, we get the computational formulas of expected value for some special graphs. We also discuss the mean of expected value when parameter p has certain prior distribution. Finally, we propose mean-variance optimality when rooted graph has the equilibrium point which has larger mean and smaller variance.

关键词： rooted graph expected value deletion-contraction edge formula mean-variance optimality

Analysis of dipole noise level characteristics of NACA0015 hydrofoil under different working conditions

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Journal of Hydrodynamics 2021年第1期33卷 63-73页

作者： An Yu Yi-fu Wang qing-hong tang Da-qing Zhou College of Energy and Electrical Engineering Hohai UniversityNanjing 210098China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China

In this paper,the flow field around NACA0015 hydrofoil is calculated under the condition of two-phase cavitating flow to provide a theoretical guidance for reducing the cavitation noise.A modified turbulence model coupled with the Zwart cavitation model is used to calculate the flow *** to the computed sound source data,the dipole sound pressure distribution diagrams for the extremely short time and the complete time around the hydrofoil under different working conditions are *** sound pressure distribution and the sound pressure amplitude are analyzed in *** addition,the field points around the hydrofoil are selected to generate the corresponding frequency response function curves,which are analyzed from the aspects of the trend,the variation and the extreme *** results show that the dipole characteristics are gradually diminished and finally disappear with the increase of the *** the frequency of the vapor volume fraction fluctuation,the noise level at the field point will have an extreme value.

关键词： Cavitating flow dipole noise sound field distribution frequency response

Hypersonic boundary-layer transition on a flared cone

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Acta Mechanica Sinica 2013年第1期29卷 48-53页

作者： Chuan-Hong Zhang qing tang Cun-Biao Lee Department of Aeronautics & Astronautics College of Engineering Peking University

Transition on a flared cone with zero angle of at- tack was studied in our newly established Mach 6 quiet wind tunnel （M6QT） via wall pressure measurement and flow visualization. High-frequency pressure transducers were used to measure the second-mode waves＇ amplitudes and frequencies. Using pulsed schlieren diagnostic and Rayleigh scattering technique, we got a clear evolution of the second-mode disturbances. The second-mode waves exist for a long distance, which means that the second-mode waves grow linearly in a large region. Strong Mach waves are radiated from the edge of the boundary layer. With further development, the second-mode waves reach their maximum magnitude and harmonics of the second-mode instability appear. Then the disturbances grow nonlinearly. The second modes become weak and merge with each other. Finally, the nonlinear interaction of disturbance leads to a relatively quiet zone, which further breaks down, resulting in the transition of the bound- ary layer. Our results show that transition is determined by the second mode. The quiet zone before the final breakdown is observed in flow visualization for the first time. Eventual transition requires the presence of a quiet zone generated by nonlinear interactions.

关键词： PCB pressure sensor - Pulsed schlieren - Flared cone Transition Second-mode waves

Effects of low frequency electromagnetic fields on osteoblasts proliferation and cell cycle

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Chinese Science Bulletin 1999年第23期44卷 2174-2177页

作者： qing tang Nanming Zhao Tsing Hua Univ Dept Biol Sci & Biotechnol State Key Lab Biomembrane & Membrane Biol Beijing 100084 Peoples R China

After primary mouse osteoblasts and ROS osteo-like cells were exposed to 50 Hz low frequency electromagnetic fields (EMF), the MTT method and flow cytometry have been used to determine cell proliferation, cell cycle a... 详细信息

关键词： low frequency electromagnetic fields biological effects cell proliferation cell cycle.

Atomically precise alkynyl-protected Ag_(20)Cu_(12)nanocluster:Structure analysis and electrocatalytic performance toward nitrate reduction for NH_(3)synthesis

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Nano Research 2023年第8期16卷 10867-10872页

作者： Guanyu Ma Fang Sun Liang Qiao Quanli Shen Lei Wang qing tang Zhenghua tang New Energy Research Institute School of Environment and EnergySouth China University of TechnologyGuangzhou Higher Education Mega CentreGuangzhou 510006China School of Chemistry and Chemical Engineering Chongqing Key Laboratory of Theoretical and Computational ChemistryChongqing UniversityChongqing 401331China China Petrochemical Research Institute PetroChina Company LimitedBeijing 102206China

Electrochemical nitrate reduction reaction(NtrRR)has been emerging as an appealing route for both water treatment and NH_(3)***,we report the structure analysis and electrocatalytic performance of a novel homoleptic alkynyl-protected Ag_(20)Cu_(12)nanocluster(Ag_(20)Cu_(12)in short)with atomic precision,which has eight free electrons and displays characteristic absorbance *** crystal X-ray diffraction(SC-XRD)discloses that,it adopts a Ag_(14)kernel capped by three Ag_(2)Cu_(4)(C≡CArF)_(8)metal–ligand binding motifs in the outer ***_(20)Cu_(12)exhibited excellent catalytic performance toward NtrRR,as manifested by the superior NH_(3)Faradaic efficiency(FE,84.6%)and yield rate(0.138 mmol·h^(−1)·mg−1)than the homoleptic alkynyl-protected Ag_(32)***,it demonstrates good catalytic recycling *** functional theory(DFT)calculations revealed that,the de-ligated Ag_(20)Cu_(12)cluster can expose the available AgCu bimetallic sites as the efficient active sites for NH_(3)*** particular,the participation of Cu sites greatly facilitates the initial capture of NO_(3)−and simultaneously promotes the selectivity of the final *** study discovers a novel homoleptic alkynyl-protected AgCu superatom,and offers a great example to elucidate the structure–performance relationship of bimetallic catalyst for NtrRR and other multiple protons/electrons coupled electrocatalytic reactions.

关键词： Ag_(20)Cu_(12)nanocluster alkynyl ligand nitrate reduction reaction(NtrRR) ammonia synthesis density functional theory(DFT)calculations

Cavitation erosion resistance of 316L stainless steel fabricated using selective laser melting

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Friction 2021年第6期9卷 1580-1598页

作者： Hongqin DING qing tang Yi ZHU Chao ZHANG Huayong YANG State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China Ningbo Research Institute Zhejiang UniversityNingbo 315100China

Cavitation erosion degrades the performance and reliability of hydraulic *** laser melting(SLM)is a type of metal additive manufacturing technology that can fabricate metal parts directly and provide lightweight design in various industrial ***,the cavitation erosion behaviors of SLM-fabricated parts have rarely been *** this study,SLM 316L stainless steel samples were fabricated via SLM technology considering the scanning strategy,scanning speed,laser power,and build *** effect of the process parameters on the cavitation erosion resistance of the SLM-fabricated 316L stainless steel samples was illustrated using an ultrasonic vibratory cavitation *** mass loss and surface topography were employed to evaluate the surface cavitation damage of the SLM-fabricated 316L stainless steel samples after the cavitation *** cavitation damage mechanism of the SLM-fabricated samples was *** results show that the degree of cavitation damage of the sample fabricated via SLM with a few defects,anisotropic build direction,and columnar microstructure is significantly *** such as pores,which are attributed to low laser power and high scanning speed,may severely aggravate the cavitation damage of the SLM-fabricated *** sample fabricated via SLM with a low laser power and exposure time exhibited the highest porosity and poor cavitation erosion *** cellular structures are more prone to cavitation damage compared with the columnar structures.A sample with a high density of grain boundaries will severely suffer cavitation damage.

关键词： selective laser melting stainless steel cavitation erosion process parameters microstructure

Cognitive-behavioral therapy for the management of irritable bowel syndrome

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World Journal of Gastroenterology 2013年第46期19卷 8605-8610页

作者： qing-Lin tang Guo-Yao Lin Ming-qing Zhang Department of Gastroenterology 175thHospital of PLA Affiliated Southeast Hospital of Xiamen University Institute of Applied Psychology Minnan Normal University

Irritable bowel syndrome(IBS)is a common disorder,reported to be found in 5%-20%of the general *** management accounts for up to 25%of a gastroenterologist’s workload in the outpatient department,and the main symptoms are abdominal pain,bloating,and altered bowel *** a great amount of available pharmacological treatments aimed at a wide variety of gastrointestinal and brain targets,many patients have not shown adequate symptom *** recent years,there has been increasing evidence to suggest that psychological treatments,in particular cognitive-behavioral therapy(CBT),are effective for the management of *** review discusses CBT for the management of *** has proved to be effective in alleviating the physical and psychological symptoms of IBS and has thus been recommended as a treatment option for the syndrome.

关键词： Cognitive-behavioral therapy Irritable bow-el syndrome Psychological treatment

Effects of a type-II RNA-binding protein on fatty acid composition in Synechocystis sp. PCC 6803

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Chinese Science Bulletin 2010年第22期55卷 2416-2421页

作者： tang qing TAN XiaoMing XU XuDong State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China

In the cyanobacterium Synechocystis 6803, rbp3, a type-II RNA-binding protein gene, is slightly induced by temperature downshift. An rbp3 mutant shows significant reduction in total polyunsaturated fatty acids (PUFA) in membrane lipids. However, the reduction in PUFA has not attained the extent that would significantly affect the growth of the mutant at low temperature. Transcripts of fatty acid desaturase genes desA, desB and desD, and ccr-1, a gene required for growth at 15°C, are significantly reduced in the mutant relative to the wild type, while transcripts of rbp1 (RNA-binding protein 1) and crhR (RNA helicase Light) are not affected. Rbp3 may directly or indirectly affect mRNA levels of certain genes.

关键词： RNA结合蛋白脂肪酸组成蓝藻多不饱和脂肪酸类型可持续发展教育作者 RNA解旋酶