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Immune checkpoint inhibitors:breakthroughs in cancer treatment

Cancer Biology & Medicine 2024年第6期21卷 451-472页

作者： Xueqing Kong Jinyi Zhang Shuwei Chen Xianyang Wang qing Xi Han shen Rongxin Zhang Laboratory of Immunology and Inflammation School of Life Sciences and BiopharmaceuticsGuangdong Pharmaceutical UniversityGuangzhou 510006China Department of Biology School of Life Sciences and BiopharmaceuticsGuangdong Pharmaceutical UniversityGuangzhou 510006China

Over the past two decades,immunotherapies have increasingly been considered as first-line treatments for most *** such treatment is immune checkpoint blockade(ICB),which has demonstrated promising results against various solid tumors in clinical *** antibodies(mAbs)are currently available as immune checkpoint inhibitors(ICIs).These ICIs target specific immune checkpoints,including cytotoxic T-lymphocyte-associated antigen-4(CTLA-4)and programmed cell death protein 1(PD-1).Clinical trial results strongly support the feasibility of this immunotherapeutic ***,a substantial proportion of patients with cancer develop resistance or tolerance to treatment,owing to tumor immune evasion mechanisms that counteract the host immune ***,substantial research focus has been aimed at identifying additional ICIs or synergistic inhibitory receptors to enhance the effectiveness of anti-PD-1,anti-programmed cell death ligand 1(anti-PD-L1),and anti-CTLA-4 ***,several immune checkpoint molecular targets have been identified,such as T cell immunoreceptor with Ig and ITIM domains(TIGIT),mucin domain containing-3(TIM-3),lymphocyte activation gene-3(LAG-3),V-domain immunoglobulin suppressor of T cell activation(VISTA),B and T lymphocyte attenuator(BTLA),and signal-regulatory proteinα(SIRPα).Functional m Abs targeting these molecules are under ***-4,PD-1/PD-L1,and other recently discovered immune checkpoint proteins with distinct structures are at the forefront of *** review discusses these structures,as well as clinical progress in m Abs targeting these immune checkpoint molecules and their potential applications.

关键词： Immunotherapy cancer ICIs PD-1 CTLA-4

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High expression circRALGPS2 in atretic follicle induces chicken granulosa cell apoptosis and autophagy via encoding a new protein

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Journal of Animal Science and Biotechnology 2024年第3期15卷 971-986页

作者： Haorong He Yuanhang Wei Yuqi Chen Xiyu Zhao Xiaoxu shen qing Zhu Huadong Yin Key Laboratory of Livestock and Poultry Multi‑Omics Ministry of Agriculture and Rural AffairsCollege of Animal Science and TechnologySichuan Agricultural UniversityChengduSichuan 611130China Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengduSichuan 611130China

Background The reproductive performance of chickens mainly depends on the development of ***-mal follicle development can lead to decreased reproductive performance and even ovarian disease among *** is the only non-human animal with a high incidence of spontaneous ovarian *** recent years,the involvement of circRNAs in follicle development and atresia regulation has been *** In the present study,we used healthy and atretic chicken follicles for circRNA *** results showed differential expression of *** was then confirmed that circRALGPS2 can translate into a protein,named cir-cRALGPS2-212aa,which has IRES ***,we found that circRALGPS2-212aa promotes apoptosis and autophagy in chicken granulosa cells by forming a complex with PARP1 and *** Our results revealed that circRALGPS2 can regulate chicken granulosa cell apoptosis and autophagy through the circRALGPS2-212aa/PARP1/HMGB1 axis.

关键词： Apoptosis Autophagy Chicken CircRALGPS2 Follicle atresia PARP1 RNC-seq

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Quantum transport in topological semimetals under magnetic fields

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Frontiers of physics 2017年第3期12卷 43-60页

作者： Hai-Zhou Lu Shun-qing shen Department of Physics The University of Hong Kong Pokfulam Road Hong Kong China

Topological semimetals are three-dimensional topological states of matter, in which the conduction and valence bands touch at a finite number of points, i.e., the Weyl nodes. Topological semimetals host paired monopoles and antimonopoles of Berry curvature at the Weyl nodes and topologically protected Fermi arcs at certain surfaces. We review our recent works on quantum transport in topo- logical semimetals, according to the strength of the magnetic field. At weak magnetic fields, there are competitions between the positive magnetoresistivity induced by the weak anti-localization effect and negative magnetoresistivity related to the nontrivial Berry curvature. We propose a fitting formula for the magnetoconductivity of the weak anti-localization. We expect that the weak localization may be induced by inter-valley effects and interaction effect, and occur in double-Weyl semimetals. For the negative magnetoresistance induced by the nontrivial Berry curvature in topological semimetals, we show the dependence of the negative magnetoresistance on the carrier density. At strong magnetic fields, specifically, in the quantum limit, the magnetoconductivity depends on the type and range of the scattering potential of disorder. The high-field positive magnetoconductivity nmy not be a com- pelling signature of the chiral anomaly. For long-range Gaussian scattering potential and half filling, the magnetoconductivity can be linear in the quantum limit. A minimal conductivity is found at the Weyl nodes although the density of states vanishes there.

关键词： topological semimetal magnetoconductivity magnetoresistance localization,anti-localization chiral anomaly

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An Implementation Model of Parlay MMCCS API Based on SIP

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The Journal of China Universities of Posts and Telecommunications 2006年第2期13卷 43-49页

作者： GUAN You-qing shen Su-bin Research Center of Network Technology Nanjing University of Posts and Telecommunications Nanjing 210003 P.R. China

Parlay Multi Media Call Control Services （ MMCCS） Application Programming Interfaces （API） based on Session Initiation Protocol （SIP） is essential for the implementation of Parlay Call Control （ CC） API. This paper first proposes an implementation model of Parlay MMCCS API based on SIP, then presents a mapping between SIP and MMCCS AP1 as far as methods and parameters are concerned, illustrates corresponding relationships between different components of SIP and MMCCS API by means of an application collaboration diagram, and finally presents an application using Java codes as well as some SIP messages. The application shows that a majority of MMCCS API based on SIP can be implemented and therefore verifies our mapping between MMCCS API and SIP.

关键词： SIP parlay MMCCS API

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经管类实验教学中心多专业教学支撑体系建设研究

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教育教学论坛 2024年第20期 36-40页

作者：沈庆宁张海霞陶红娜张雪妍候彤彤中国石油大学〔北京〕经济管理学院北京102249

经管类实验教学中心旨在培养具有创新和创业能力的高素质人才,具有多专业教学的特点,建设具有多专业教学特色的生态化实验教学中心对当代大学生专业应用创新能力及高校创新创业人才的培养具有不可替代的作用。然而,目前国内高校经管类... 详细信息

经管类实验教学中心旨在培养具有创新和创业能力的高素质人才,具有多专业教学的特点,建设具有多专业教学特色的生态化实验教学中心对当代大学生专业应用创新能力及高校创新创业人才的培养具有不可替代的作用。然而,目前国内高校经管类实验室建设普遍存在重视性不足、不成规模、缺乏专业化等问题,分别从实验教学平台支撑建设、课程体系支撑建设、实验教学方式方法改革及安全体系建设四个方面详细介绍了中国石油大学(北京)如何解决这些问题,并成功打造了高校经管类生态化实验教学中心。

关键词：教学实验室多专业生态化建设经济管理

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Winter extreme precipitation over the Tibetan Plateau influenced by Arctic sea ice on interdecadal timescale

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Advances in Climate Change Research 2024年第1期15卷 42-51页

作者： qing-Quan LI Miao BI Song YANG qing-Yuan WU Yi-Hui DING Xin-Yong shen Xiao-Ting SUN Meng-Chu ZHAO China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China CMA Key Open Laboratory of Transforming Climate Resources to Economy Chongqing Institute of Meteorological SciencesChongqing 401147China School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen University Zhuhai 519082China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

The Tibetan Plateau(TP)and the Arctic are the most sensitive regions to global climate ***,the interdecadal varibility of winter extreme precipitation over the TP and its linkage with Arctic sea ice are still *** this study,the characteristics and mechisnems of the TP extreme precipitation(TPEP)influenced by Arctic sea ice on interdecadal timescale are studied based on the daily precipitation,monthly sea ice concentration and ERA5 reanalysis data from 1980 to *** found that the dominant mode of the TPEP in winter mostly exhibits a uniform spatial variation on the interdecadal timescale,with an opposite weak variation in the southeastern TP,and the Arctic sea ice concentration(SIC)before 2002 are larger than that after *** interdecadal variation of TPEP is affected by two teleconnection wave trains regulated by the Barents and Kara Sea *** the light ice years,a remarkable positive geopotential height(HGT)anomaly appears over the Barents-Kara Sea and a remarkable negative HGT anomaly is located over the Lake *** wave trains originating over the Barents-Kara Sea can be *** southern branch forms a wave train through the North Atlantic along the subtropical westerly jet stream,showing a‘+-+-+'pattern of HGT anomalies from Arctic to the *** HGT anomaly controls the western TP,which creates dynamic and water vapor conditions for the *** northern branch forms a wave train through the Lake Baikal and the southeast of the TP,showing a‘+-+'HGT anomaly *** HGT anomaly controls the southeastern TP,which is not conducive to precipitation in the *** the SIC in the Barents-Kara Sea increases,the situation is *** above analysis also reveals the reason for the difference in the east-west distribution of the TPEP.

关键词： Arctic sea ice Tibetan Plateau Winter extreme precipitation Rossby wave activity Interdecadal variation

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大豆DHQ-SDH基因家族生物信息学分析

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内蒙古民族大学学报（自然科学版） 2024年第2期39卷 62-68,74页

作者：张安宁毛庆丰孙浩楠申晴李志刚刘中奇内蒙古民族大学农学院内蒙古通辽028043

运用生物信息学方法,对鉴定出的13个大豆DHQ-SDH基因家族成员的理化性质、染色体定位、基因结构、顺式作用元件、系统发育进化树、二级结构、三级结构、保守基序以及转录后调控等进行了预测及分析。结果表明,Gm DHQ-SDH基因家族的13个... 详细信息

运用生物信息学方法,对鉴定出的13个大豆DHQ-SDH基因家族成员的理化性质、染色体定位、基因结构、顺式作用元件、系统发育进化树、二级结构、三级结构、保守基序以及转录后调控等进行了预测及分析。结果表明,Gm DHQ-SDH基因家族的13个成员分别分布在5条染色体上;13个家族成员的蛋白质分子量介于44.36~62.98 k D之间,均属于稳定蛋白,且大多数为疏水蛋白;二级结构与三级结构预测结果发现,13个家族成员均以α-螺旋为主,其次为随机卷曲,其三级结构具有很高的相似性;保守基序结果表明,Gm DHQSDHs分为4组,每个家族成员均含有DHQas_1结构域。大豆DHQ-SDH基因家族成员的启动子区域含有光响应元件、逆境胁迫响应元件、激素应答响应元件、生长发育调控响应元件,其中,光响应元件占比最高,可对低温、干旱以及厌氧胁迫做出反应。

关键词：大豆 DHQ-SDH基因基因家族生物信息学分析

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50-110 GHz,high isolation,and high-power linearity single-pole double-throw switch utilizing 100-nm GaN HEMT technology

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The Journal of China Universities of Posts and Telecommunications 2024年第2期31卷 38-43,71页

作者： Han Qunfei Hu Sanming Zhang Tianyu Chen qing shen Yizhu Wang Weibo Tao Hongqi School of Information Science and Engineering Southeast UniversityNanjing 210096China Nanjing Electronic Devices Institute Nanjing 210016China State Key Laboratory of Millimeter Waves Southeast UniversityNanjing 210096China

This article presents the design and performance of a single-pole double-throw(SPDT)switch operating in 50-110 *** switch is fabricated in a 100-nm GaN high-electron-mobility transistors(HEMT)*** realize high-power capability,the dimensions of GaN HEMTs are selected by simulation *** enhance the isolation,an improved structure of shunt HEMT with two ground holes is *** extend the operation bandwidth,the SPDT switch with multi-section resonant units is proposed and *** verify the SPDT switch design,a prototype operating in 50-110 GHz is *** measured results show that the fabricated SPDT switch monolithic microwave integrated circuit(MMIC)achieves an input 1 dB compression point(P_(1dB))of 38 dBm at 94 GHz,and isolation within the range of 33 dB to 54 dB in 50-110 *** insertion loss of the switch is less than 2.1 dB,while the voltage standing wave ratios(VSWR)of the input port and output port are both less than 1.8 in the operation *** on the measured results,the presented SPDT switch MMIC demonstrates high power capability and high isolation compared with other reported millimeter-wave SPDT MMIC designs.

关键词： GaN high-electron-mobility transistors(HEMT) millimeter-wave single-pole double-throw(SPDT) switch

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Dose-individualization Efficiently Maintains Sufficient Exposure to Methotrexate without Additional Toxicity in High-dose Methotrexate Regimens for Pediatric Acute Lymphoblastic Leukemia

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Current Medical Science 2022年第4期42卷 769-777页

作者： Ya-qing shen Zhu-jun WANG Xiao-yan WU Kun LI Zhong-jian WANG Wen-fu XU Fen ZHOU Run-ming JIN Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective:Methotrexate(MTX)can be safely administered to most patients but may cause severe toxicity in *** study aimed to summarize the characteristics of high-dose methotrexate(HD-MTX)chemotherapy and to evaluate whether the modified dose-adjustment program was able to improve the maintenance of sufficient MTX exposure levels while minimizing ***:We evaluated 1172 cycles of high-dose MTX chemotherapy from 294 patients who were treated according to the CCCG-ALL-2015 protocol(clinical trial number:ChiCTR-IPR-14005706)and analyzed the data of actual MTX dosage,MTX concentration,toxicity,and *** compared data between the dose-adjustment Program 1(fixed 20%reduction in dose)and the dose-adjustment Program 2(dose-individualization based on reassessment of the creatine clearance rate and the MTX concentration-monitoring point at 16 h),which were applied if the MTX clearance was delayed in the previous ***:The patients who used Program 2 had higher actual MTX infusion doses and infusion rates and were able to better maintain the MTX concentration at 44 h at the established target value than those on Program 1(P<0.001).No significant differences in toxicities were found between these two programs except that abnormal serum potassium levels and prolonged myelosuppression in intermediate-risk/high-risk patients were more frequently observed in patients using Program 2(P<0.001).No significant correlations were observed between the MTX dose,dose-adjustment programs,or MTX concentrations and relapse-free ***:Adjusting the MTX dose using Program 2 is more efficient for maintaining sufficient MTX exposure without significantly increasing the toxicity.

关键词： methotrexate high-dose methotrexate individualizing methotrexate dose toxicity acute lymphoblastic leukemia prognosis

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An Innovative Coupled Common-Node Discrete Element Method-Smoothed Particle Hydrodynamics Model Developed with LS-DYNA and Its Applications

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China Ocean Engineering 2024年第3期38卷 467-482页

作者： shen Zhong-xiang WANG Wen-qing XU Cheng-yue LUO Jia-xin LIU Ren-wei School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China College of Harbor Coastal and Offshore EngineeringHohai UniversityNanjing 210098China

In this study,a common-node DEM-SPH coupling model based on the shared node method is proposed,and a fluid–structure coupling method using the common-node discrete element method-smoothed particle hydrodynamics(DS-SPH)method is developed using LS-DYNA *** DEM and SPH are established on the same node to create common-node DEM-SPH particles,allowing for fluid–structure *** simulations of various scenarios,including water entry of a rigid sphere,dam-break propagation over wet beds,impact on an ice plate floating on water and ice accumulation on offshore structures,are *** interaction between DS particles and SPH fluid and the crack generation mechanism and expansion characteristics of the ice plate under the interaction of structure and fluid are also *** results are compared with available data to verify the proposed coupling ***,the simulation results demonstrated that controlling the cutoff pressure of internal SPH particles could effectively control particle splashing during ice crushing failure.

关键词： common-node DEM-SPH fluid-structure interaction discrete element method smoothed particle hydrodynamics

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