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Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates

Signal Transduction and Targeted Therapy 2022年第1期7卷 322-330页

作者： Hui Zhao Tie-Cheng Wang Xiao-Feng li Na-Na Zhang liang li Chao Zhou Yong-Qiang Deng Tian-Shu Cao Guan Yang Rui-Ting li\Yi-Jiao Huang yuan-Guo li Yi-Ming Zhang Fang-Xu li Yu-ren Zhou Yu-hang Jiang Xi-Shan Lu Shi-Hui Sun Meng-li Cheng Kai-ping Gu Mei Zhang qing-qing Ma Xiao Yang bo Ying Yu-Wei Gao Cheng-Feng qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAcademy of Military Medical Sciences100071 BeijingChina Key Laboratory of Jilin Province for Zoonosis Prevention and Control Changchun 130122China School of Medicine Tsinghua University100084 BeijingChina State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of Lifeomics102206 BeijingChina Shandong Normal University Jinan 250014China Suzhou Abogen Biosciences Suzhou 215123China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical Sciences100071 BeijingChina

Messenger RNA(mRNA)vaccine technology has shown its power in preventing the ongoing COVID-19 *** mRNA vaccines targeting the full-length S protein of SARS-CoV-2 have been authorized for emergency ***,we have developed a lipid nanoparticle-encapsulated mRNA(mRNA-LNP)encoding the receptor-binding domain(RBD)of SARS-CoV-2(termed ARCoV),which confers complete protection in mouse ***,we further characterized the protection efficacy of ARCoV in nonhuman primates and the Iong-term stability under normal refrigerator *** immunization of two doses of ARCoV elicited robust neutralizing antibodies as well as cellular response against SARS-CoV-2 in cynomolgus *** importantly,ARCoV vaccination in macaques significantly protected animals from acute lung lesions caused by SARS-CoV-2,and viral replication in lungs and secretion in nasal swabs were completely cleared in all animals immunized with low or high doses of *** evidenee of antibody-dependent enhancement of infection was observed throughout the ***,extensive stability assays showed that ARCoV can be stored at 2-8℃ for at least 6 months without decrease of *** these promising results strongly support the ongoing clinical trial.

关键词： doses stability protected

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基于白光中子源的^(197)Au中子辐射俘获截面测量及共振参数分析

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物理学报 2024年第7期73卷 104-113页

作者：罗淏天张奇玮栾广源王晓宇邹翀任杰阮锡超贺国珠鲍杰孙琪黄翰雄王朝辉吴鸿毅顾旻皓余滔解立坤陈永浩安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆韩长材韩子杰何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳蒋伟江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊羊奕伟易晗于莉于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏朱兴华中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系核探测与核电子学国家重点实验室合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083 华能山东石岛湾核电有限公司荣成264312

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室... 详细信息

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用28块六棱BaF_(2)晶体和12块五棱BaF_(2)晶体构成了外径25 cm,内径10 cm的球壳,覆盖了95.2%的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了197Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了197Au俘获反应的产额,利用SAMMY程序拟合得到了^(197)Au在1—100 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.

关键词：中子辐射俘获截面共振参数白光中子源伽马全吸收装置

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Safety profile of 0.0015%tafluprost eye drops in China:a post-marketing observational study

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 108-114页

作者： Xue-li Chen Yan-Jing Fu bo Qu Ye-Wei Wang Xin Tang Yu-Hong Wang Guo-Yi Zhou Ming-Kai lin Jing-yuan Shen Jin Yao Su-Yan li Miao-qin Wu Hua-Zong Peng Ming-Ying Lai ren-Yi Wu Yi-Nong Zhang Yan li Xiao-Jun Wu Ming-Chang Zhang Su-ping Guo Xing-Huai Sun Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200000China Department of Ophthalmology Daqing Ophthalmologic HospitalDaqing 163000Heilongjiang ProvinceChina Department of Ophthalmology the Fourth Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Ophthalmology Da Lian He Eye Specialist HospitalDalian 116000Liaoning ProvinceChina Department of Ophthalmology Beijing Tongren HospitalBeijing 100000China Department of Ophthalmology Xiamen Eye Center of Xiamen UniversityXiamen 361000Fujian ProvinceChina Department of Ophthalmology Yueqing People’s HospitalWenzhou 325600Zhejiang ProvinceChina Department of Glaucoma Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina Department of Ophthalmology Shengzhou Shen’s Eye HospitalShaoxing 312400Zhejiang ProvinceChina Department of Ophthalmology the Affiliated Eye Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Department of Ophthalmology Xuzhou No.1 Peoples HospitalXuzhou 221000Jiangsu ProvinceChina Department of Ophthalmology Zhejiang Provincial People’s HospitalHangzhou 310000Zhejiang ProvinceChina Department of Ophthalmology Wuhan Eyegood Ophthalmic HospitalWuhan 430014Hubei ProvinceChina Department of Ophthalmology Shenzhen Eye HospitalShenzhen 518001Guangdong ProvinceChina Department of Glaucoma Shanghai Heping Eye HospitalShanghai 200000China Department of Ophthalmology Wuxi Second People’s HospitalWuxi 214000Jiangsu ProvinceChina Department of Ophthalmology First Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina Department of Ophthalmology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518000Guangdong ProvinceChina Department of Ophthalmology Wuhan Union HospitalWuhan 430000Hubei ProvinceChina Department of Ophthalmology Shengyang He Eye Specialist HospitalShenyang 110000Liaoning ProvinceChina

AIM:To investigate the treatment pattern and safety of tafluprost for glaucoma and ocular hypertension(OH)in clinical practice in ***:This post-marketing observational study included patients who received tafluprost to lower intraocular pressure(IOP)within 30d between September 2017 and March 2020 in 20 hospitals in *** drug reactions(ADRs)during tafluprost treatment and within 30d after the treatment were ***:A total of 2544 patients were included in this study,of them 58.5%(1488/2544)had primary open angle glaucoma(POAG),21.9%(556/2544)had OH and 19.7%(500/2544)used tafluprost for other *** 359 ADRs occurred in 10.1%(258/2544)patients,and no serious adverse event *** most common ADR was conjunctival hyperemia(128 ADRs in 124 patients,4.9%).Totally 1670 participants(65.6%)combined tafluprost with carbonic anhydrase inhibitors(CAIs;37.1%,620/1670),sympathomimetics(33.5%,559/1670),β-blockers(33.2%,555/1670),other prostaglandin analogs(PGAs;15.6%,260/1670)and other eye drops(15.1%,253/1670).The highest incidence of conjunctival hyperemia was noted in patients who received tafluprost in combination with other PGAs(23 ADRs in 23 patients,8.8%,23/260)and the lowest was in combination with CAIs(16 ADRs in 16 patients,2.6%,16/620).Tafluprost was applied in primary angle-closure glaucoma(41.6%,208/500),after glaucoma surgery(17.8%,89/500)and after non-glaucoma surgery(15.8%,79/500).CONCLUSION:Tafluprost is safe for POAG and OH,and tolerable when combined with other eye drops and under various clinical circumstances.

关键词： tafluprost glaucoma ocular hypertension intraocular pressure adverse drug reactions

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Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou ren Yi-Wei Yang Yong-Hao Chen Rong liu Bang-Jiao Ye Jie Wen Hai-Rui Guo Zi-Jie han Qi-ping Chen Zhong-Wei Wen Wei-li Sun han Yi Xing-Yan liu Tao Ye Jiang-bo Bai Qi An Jie Bao Yu Bao ping Cao Hao-Lei Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-qing Feng Ke-qing Gao Xiao-Long Gao Min-Hao Gu Chang-Cai han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu han-Xiong Huang Xi-Ru Huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang han-Tao Jing ling Kang bo li Chao li Jia-Wen li Qiang li Xiao li Yang li Jie liu Shu-Bin liu Ze Long Guang-yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Jing-Yu Tang Xin-Yi Tang Bin-Bin Tian li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Xiao-Guang Wu Xuan Wu li-Kun Xie Xiao-Yun Yang li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-liang Zhang Zhi-Yong Zhang Lu-ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the China Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

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Back-n white neutron source at CSNS and its applications

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Nuclear Science and Techniques 2021年第1期32卷 95-104页

作者： Jing-Yu Tang Qi An Jiang-bo Bai Jie Bao Yu Bao ping Cao Hao-Lei Chen Qi-ping Chen Yong-Hao Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-qing Feng Ke-qing Gao Xiao-Long Gao Min-Hao Gu Chang-Cai han Zi-Jie han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu han-Xiong Huang Xi-Ru Huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang han-Tao Jing ling Kang bo li Chao li Jia-Wen li Qiang li Xiao li Yang li Jie liu Rong liu Shu-Bin liu Xing-Yan liu Ze Long Guang-yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie ren Zhi-Zhou ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Xin-Yi Tang Bin-Bin Tian li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu li-Kun Xie Xiao-Yun Yang Yi-Wei Yang han Yi li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-liang Zhang Zhi-Yong Zhang Lu-ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 无 State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China The CSNS Back-n Collaboration

Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March *** Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the *** addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the *** with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional *** article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn.

关键词： White neutron source Nuclear data measurements Experimental setups Neutron applications

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运载火箭起飞噪声环境缩比模型试验方法

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宇航学报 2015年第3期36卷 344-350页

作者：任方张正平李海波韩丽秦朝红刘振皓北京强度环境研究所可靠性与环境工程技术重点实验室北京100076

基于相似理论建立缩比模型试验相似准则,提出了火箭发动机喷流声场试验预示方法的流程。通过缩比模型系留点火试验,根据几何相似、喷流参数相似、发射环境相似来预示起飞噪声环境,在国内首次给出了运载火箭表面的噪声环境的空间相关特性... 详细信息

基于相似理论建立缩比模型试验相似准则,提出了火箭发动机喷流声场试验预示方法的流程。通过缩比模型系留点火试验,根据几何相似、喷流参数相似、发射环境相似来预示起飞噪声环境,在国内首次给出了运载火箭表面的噪声环境的空间相关特性,结果表明预测结果与遥测数据之差小于1.5 d B,校验了缩比模型方法的有效性。缩比模型方法对于我国新一代运载火箭的起飞噪声环境预示、噪声载荷设计、地面试验具有重要意义。

关键词：运载火箭起飞噪声环境缩比模型试验相似准则空间相关

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Lung-protective Ventilation in Patients with Brain Injury： A Multicenter Cross-sectional Study and Questionnaire Survey in China

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Chinese Medical Journal 2016年第14期129卷 1643-1651页

作者： Xu-Ying Luo Ying-Hong Hu Xiang-yuan Cao Yan Kang li-ping liu Shou-Hong Wang Rong-Guo Yu Xiang-You Yu Xia Zhang Bao-Shan li Zeng-Xiang Ma Yi-Bing Weng Heng Zhang De-Chang Chen Wei Chen Wen-Jin Chen Xiu-Mei Chen Bin Du Mei-li Duan Jin Hu Yun-Feng Hoang Gui-Jun Jia li-Hong li Yu-Min liang Bing-Yu qin Xian-Dong Wang Jian Xiong li-Mei Yan Zheng-ping Yang Chen-Ming Dong Dong-Xin Wang qing-yuan Zhan Shuang-lin FU lin Zhao Qi-Bing Huang Ying-Guang Xie Xiao-bo Huang Guo-Bin Zhang Wang-Bin Xu yuan Xu Yaling liu He-ling Zhao Rong-qing Sun Ming Sun qing-Hong Cheng Xin Qu Xiao-Feng Yang Ming Xu Zhong-Hua Shi han Chen Xuan He Yan-lin Yang Guang-Qiang Chen Xiu-Mei Sun Jian-Xin Zhou Department of Critical Care Medicine Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Critical Care Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Critical Care Medicine General Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China Department of Critical Care Medicine West China Hospital Sichuan University Chengdu Sichuan 610041 China Neurological Intensive Care Unit Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Critical Care Medicine Guangdong General Hospital Guangzhou Guangdong 510000 China Surgical Intensive Care Unit Fujian Province Hospital Fuzhou Fujian 350000 China Department of Critical Care Medicine First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Critical Care Medicine Bethune International Peace Hospital Shijiazhuang Hebei 050000 China Department of Critical Care Medicine Yuncheng Central Hospital Yuncheng Shanxi 044000 China Department of Emergency and Critical Care Medicine Cangzhou People's Hospital Cangzhou Hebei 061000 China Department of Critical Care Medicine Beijing Luhe Hospital Capital Medical University Beijing 101100 China Department of Critical Care Medicine First Hospital of China Medical University Shenyang Liaoning 110000 China Department of Critical Care Medicine Shanghai Changzheng Hospital Shanghai 200000 China Department of Critical Care Medicine Beijing Shijitan Hospital Capital Medical University Beijing 100038 China Department of Critical Care Medicine Xuanwu Hospital Capital Medical University Beijing 100053 China Department of Critical Care Medicine Miyun County Hospital Beijing 100038 China Medical Intensive Care Unit Peking Union Medical College Hospital Beijing 101500 China Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 Chin

Background： Over the years, the mechanical ventilation （MV） strategy has changed worldwide. The aim of the present study was to describe the ventilation practices, particularly lung-protective ventilation （LPV）, among brain-injured patients in China. Methods： This study was a multicenter, 1-day, cross-sectional study in 47 Intensive Care Units （ICUs） across China. Mechanically ventilated patients （18 years and older） with brain injury in a participating ICU during the time of the study, including traumatic brain injury, stroke, postoperation with intracranial tumor, hypoxic-ischemic encephalopathy, intracranial infection, and idiopathic epilepsy, were enrolled. Demographic data, primary diagnoses, indications for MV, MV modes and settings, and prognoses on the 60th day were collected. Multivariable logistic analysis was used to assess factors that might affect the use of LPV. Results： A total of 104 patients were enrolled in the present study, 87 （83.7%） of whom were identified with severe brain injury based on a Glasgow Coma Scale 〈8 points. Synchronized intermittent mandatory ventilation （SIMV） was the most frequent ventilator mode, accounting for 46.2% of the entire cohort. The median tidal volume was set to 8.0 ml/kg （interquartile range [IQR], 7.0-8.9 ml/kg） of the predicted body weight; 50 （48.1%） patients received LPV. The median positive end-expiratory pressure （PEEP） was set to 5 cmH20 （IQR, 5-5 cmH20）. No PEEP values were higher than 10 cmH20. Compared with partially mandatory ventilation, supportive and spontaneous ventilation practices were associated with LPV. There were no significant differences in mortality and MV duration between patients subjected to LPV and those were not. Conclusions： Among brain-injured patients in China, SIMV was the most frequent ventilation mode. Nearly one-half of the brain-injured patients received LPV. Patients under supportive and spontaneous ventilation were more likely to receive LPV.

关键词： Brain Injury Epidemiology Lung-protective Ventilation Mechanical Ventilation

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头颈肿瘤围术期静脉血栓栓塞症防治中国专家共识

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中国口腔颌面外科杂志 2024年第1期22卷 1-9页

作者：任振虎陈铭韬吴汉江张胜方坤谢尚刘宇胡传宇刘冰李春洁朱桂全王成高洋张晓晨石剑波张永红崔明哲季彤任国欣王延安陈伟良张陈平何悦张志愿上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海市口腔医学研究所上海200011 中南大学湘雅二医院口腔颌面外科湖南长沙410011 国家心血管病中心中国医学科学院阜外医院血管外科北京100037 国家口腔医学中心国家口腔疾病临床医学研究中心口腔生物材料和数字诊疗装备国家工程研究中心北京大学口腔医学院·口腔医院口腔颌面外科北京100081 浙江大学医学院附属口腔医院口腔颌面外科浙江杭州310020 华中科技大学同济医学院附属同济医院口腔颌面外科湖北武汉430030 武汉大学口腔医院口腔颌面外科湖北武汉430070 国家口腔医学中心国家口腔疾病临床医学研究中心口腔疾病防治全国重点实验室四川大学华西口腔医院头颈肿瘤外科四川成都610041 中山大学附属口腔医院口腔颌面外科广东广州510055 苏州大学第一附属医院口腔颌面外科江苏苏州215000 河南大学淮河医院口腔颌面外科河南开封475000 河南省人民医院血管外科河南郑州450000 复旦大学附属中山医院口腔颌面外科上海200032 中山大学孙逸仙纪念医院口腔颌面外科广东广州510120

静脉血栓栓塞症(venous thromboembolism, VTE)是外科术后常见并发症和医院内非预期死亡的重要危险因素,也是恶性肿瘤患者的第二大死亡原因。晚期头颈部恶性肿瘤患者通常需要接受大范围的肿瘤根治手术和同期修复重建手术,又由于高龄兼... 详细信息

静脉血栓栓塞症(venous thromboembolism, VTE)是外科术后常见并发症和医院内非预期死亡的重要危险因素,也是恶性肿瘤患者的第二大死亡原因。晚期头颈部恶性肿瘤患者通常需要接受大范围的肿瘤根治手术和同期修复重建手术,又由于高龄兼长时间手术、术后长时间卧床以及肿瘤和化疗药物导致的血液高凝状态等多种危险因素,提示头颈部恶性肿瘤患者应是VTE的极高危群体,但相关文献对头颈部恶性肿瘤患者的VTE发生情况却很少关注,有关VTE在头颈肿瘤术后发生率的数据也有限。迄今为止,国内对于头颈肿瘤围术期静脉血栓栓塞症缺乏相关治疗共识或指南,不同单位对于头颈肿瘤围术期静脉血栓栓塞症的预防与管理水平参差不齐,缺乏统一、科学的诊疗标准及客观的预防与管理评价体系。为统一和规范头颈肿瘤围术期静脉血栓栓塞症的诊治,减少医疗资源浪费,提高治疗效果,国内该研究领域的专家经反复讨论,汇集全国14家著名医学院校及附属医院专家的诊治意见,同时借鉴和参考国内外近年来对头颈肿瘤围术期静脉血栓栓塞症的研究成果与诊治经验,制订本专家共识,供相关临床医师参考。

关键词：静脉血栓栓塞症肺栓塞头颈肿瘤专家共识

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液相色谱-串联质谱法测定鸡蛋中氟虫腈及其代谢物的残留量

引用

现代食品科技 2019年第1期35卷 274-280页

作者：李晶马勤川王琢孙丽萍原克波陈俊任山东药品食品职业学院山东威海264210 威海德生技术检测有限公司山东威海264210

建立一种采用液相色谱-三重四级杆质谱测定鸡蛋中氟虫腈及其代谢物(氟甲腈、氟虫腈砜和氟虫腈硫醚)的快速筛查方法。鸡蛋样品经乙腈和正己烷提取,C18固相萃取柱净化,Shim-pack XR-ODSⅢ色谱柱(2.0 mm i.D×150 mm,2.1μm)分离,以乙腈-5 ... 详细信息

建立一种采用液相色谱-三重四级杆质谱测定鸡蛋中氟虫腈及其代谢物(氟甲腈、氟虫腈砜和氟虫腈硫醚)的快速筛查方法。鸡蛋样品经乙腈和正己烷提取,C18固相萃取柱净化,Shim-pack XR-ODSⅢ色谱柱(2.0 mm i.D×150 mm,2.1μm)分离,以乙腈-5 mmol/L乙酸铵(0.02%甲酸)水溶液为流动相,梯度洗脱,外标法定量。采用液相色谱-三重四级杆串联质谱动态多反应监测模式,以负离子采集进行定性筛查和定量分析。结果表明,氟虫腈及其代谢物在0～50μg/L质量浓度范围内线性关系良好,相关系数R2均大于0.999。以10倍信噪比确定各药物的定量限(LOQ),氟虫腈及其代谢物的定量限为0.3～0.6μg/kg。在0.5、5.0和10.0μg/kg添加水平下,氟虫腈及其代谢物的平均回收率为92.3%～105.1%,相对标准偏差(RSD)为1.2%～8.6%。该方法简便、快速、灵敏,适用于鸡蛋中氟虫腈及其代谢物的快速筛查和定量检测。

关键词：液相色谱-串联质谱鸡蛋氟虫腈及其代谢物

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The first data release(DR1) of the LAMOST regular survey

引用

Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai Deng Xiao-Wei liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-ping li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-yuan Chen Jian-Jun Chen Kun-Xin Chen li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong bo-Zhong Gu Yan-Xin Guo Zhan-Wen han bo-liang He Jin-liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-Wei li Hai-Ning li Jian li Qi li Shuang li Sha-Sha li Xin-Nan li Yan li Yin-Bi li Ye-ping li yuan liang Chien-Cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang qing-Sheng Tao yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-ling Wang Jian-ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui yuan Hai-bo yuan Hai-Long yuan Wei-Min yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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