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Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase

World Journal of Hepatology 2024年第6期16卷 920-931页

作者： De-Liang Huang qin-xian cai Guang-De Zhou Hong Yu Zhi-Bin Zhu Jing-Han Peng Jun Chen Department of Liver Diseases The Third People’s Hospital of ShenzhenShenzhen 510000Guangdong ProvinceChina Department of Pathology Beijing Youan HospitalCapital Medical UniversityBeijing 100000China Department of Pathology National Clinical Research Centre for Infectious DiseaseThe Third People's Hospital of Shenzhen and the Second Hospital Affiliated with the Southern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina

BACKGROUND Studies with large size samples on the liver histological changes of indeterminate phase chronic hepatitis B(CHB)patients were not previously *** To assess the liver histological changes in the indeterminate phase CHB patients using liver *** The clinical and laboratory data of 1532 untreated CHB patients were collected,and all patients had least once liver biopsy from January 2015 to December *** significant differences among different phases of CHB infection were compared with t-test,and the risk factors of significant liver histological changes were analyzed by the multivariate logistic regression *** Among 1532 untreated CHB patients,814(53.13%)patients were in the indeterminate *** liver histological changes(defined as biopsy score≥G2 and/or≥S2)were found in 488/814(59.95%)CHB patients in the indete-rminate *** liver histological changes were significant differences among different age,platelets(PLTs),and alanine aminotransferase(ALT)subgroup in indeterminate *** logistic regression analysis indicated that age≥40 years old[adjust odd risk(aOR),1.44;95%confidence interval(CI):1.06-1.97;P=0.02],PLTs≤150×10^(9)/L(aOR,2.99;95%CI:1.85-4.83;P<0.0001),and ALT≥upper limits of normal(aOR,1.48;95%CI:1.08,2.05,P=0.0163)were independent risk factors for significant liver histological changes in CHB patients in the indeterminate *** Our results suggested that significant liver histological changes were not rare among the untreated CHB patients in indeterminate phase,and additional strategies are urgently required for the management of these patients.

关键词： Chronic hepatitis B Indeterminate phase Gray-zone Liver biopsy Pathological histology Risk factors

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Heat Transfer and Flow Structure of a Turbine Blade's Air-cooled Leading Edge Considering Different Hole Shapes and Additional Flow Angles

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Journal of Thermal Science 2024年第4期33卷 1421-1442页

作者： qin Runxuan ZHOU Xun WANG Songtao cai Le School of Energy Science and Engineering Harbin Institute of TechnologyHarbin150001China

A numerical study is conducted to elucidate the impact of hole shapes and additional flow angles on the flow structure of the coolant and temperature field in the leading edge area of the gas turbine *** typical hole shapes are considered for the GE-E3 *** impact of the additional flow angle(E)within each hole shape on the temperature field is *** results indicate that for the leading edge area and suction surface,the fan-shaped hole case performs best in decreasing temperatures,with a decrease of about 43 *** is mainly due to the fact that the fan-shaped hole has the maximum expansion in hole spanwise *** the pressure surface,the console hole case performs best in decreasing temperatures,with a maximum reduction of about 47.2 *** influence of E on the surface temperature at leading edge area varied between the different hole *** the cylinder hole and console hole,the E=-20°case has the lowest area-averaged *** both the fan-shaped hole and the 7-7-7 shaped hole are expansion holes,the pattern of variation of the leading edge area temperature with increasing E is similar for the fan-shaped hole case and 7-7-7 shaped hole *** E=20°case shows the lowest spanwise-averaged temperature near the hole outlet,and the E=-20°case shows the lowest spanwise-averaged temperature further downstream.

关键词： film cooling GE-E3 turbine rotor blade conjugate heat transfer leading edge

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Microstructure and mechanical properties of Ti/Al/Ti clad plates prepared via powder-in-tube method

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Journal of Iron and Steel Research International 2024年第3期31卷 670-687页

作者： xian-lei Hu qin-cheng Xie Yi Yuan Ying Zhi State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina Suzhou Dongbao Haixing Metal Material Technology Co. Ltd.Suzhou 215600JiangsuChina School of Material Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina

The Ti/Al/Ti clad plates exhibit a broad spectrum of potential ***,the conventional techniques of hot-pressing composite and explosive composite are intricate and environmentally hazardous.A novel method was introduced for preparing clad plates,namely,the powder-in-tube *** method involves a combination of cold rolling,annealing at a temperature of 550℃,and double *** morphology of the intermetallic compound layer was analyzed through the utilization of interface stripping test,tensile test,and microscopic *** interface morphology,interface bonding properties,tensile fracture structures,and properties of plates under the first and second rolling were compared,along with the effects of intermetallic compounds on the interface *** results indicate that the powder-in-tube method,when annealed at 550℃,can produce a composite plate featuring a complete and uniform Ti/Al *** obtained plate exhibits a peeling strength of 21.5 N/mm,tensile strength of 424 MPa,and elongation of 11.5%.Furthermore,a systematic analysis was conducted to determine the causes of performance degra-dation observed during annealing at temperatures of 600 and 650℃.

关键词： Powder-in-tube method-Ti/Al/Ti clad plate Annealing Cold rolling-Mechanical property

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Upgrading waste NO_(x) into amino acids via electrocatalysis on Co nanoparticles encapsulated in hollow carbon nanofibers

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Science China Chemistry 2024年第6期67卷 1946-1952页

作者： Jiahui xian Kaixing cai Peisen Liao Shihan Wang Guangqin Li Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education LIFMIGCMESchool of ChemistrySun Yat-Sen UniversityGuangzhou510275China

Electrocatalytic conversion of waste nitrogen oxide(NO_(x))into value-added nitrogenous chemicals,especially amino acid,is an emerging strategy to alleviate NO_(x)***,this process suffers from the coexistence of multiple competitive reactions leading to complex product distribution and low efficiency,and thus the rational design and modulation of efficient catalysts remains a formidable ***,well-designed Co nanoparticles encapsulated in hollow carbon nanofiber(CoHCNF)were constructed to promote the amino acid electrosynthesis via dealing waste NO_(x)coupling with biomass-derived keto *** to the rapid reactant diffusion,electron transport and efficient contact with abundant accessible Co catalytic sites stemmed from the unique hollow nanotubular structure,Co-HCNF manifested impressive glycine synthesis performance in one-pot adopting NO as the nitrogen source with Faradaic efficiency(FE)of 41.7%and a corresponding yield rate of 222.3μmol h^(-1)as well as 120 h robust ***,it also demonstrates an excellent performance with the FE of 42.8%for NO_(3)~-solution as the nitrogen ***,this strategy displays a broad universality for the synthesis of other amino *** work not only highlights the importance of hollow-structuring electrocatalyst towards upgrading wasted NO_(x)species into amino acids,but also promotes the further development of electrosynthetic systems for high-valued N-containing organic chemicals.

关键词： electrocatalysis NO_(x)reduction amino acid porous materials hollow structure

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A review of inorganic particles synthesized through electrical discharge in different dielectric media: from devices, structures and components to applications

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Frontiers of Materials Science 2024年第2期18卷 1-35页

作者： Yifan Liu Guilu qin Liangjun Yin xian Jian xianglong Li School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China School of Mechanical Engineering Sichuan UniversityChengdu 610065China

Size effects and compositions constitute new properties for inorganic particles in different application *** physical method has recently attracted more attention in the preparation of inorganic ***,a low-cost,eco-friendly,simple-operating,and time-saving technique,named electrical discharge,is reviewed in relation to developments from the nature of this technique in different dielectric media to the practical experience in controlling the main processing parameters,apparatuses,types of discharge,from the various structures and components to the wide *** development of the electrical discharge technique will play an important role in improving the technology to prepare superfine inorganic particles with high ***,electrical discharge contributes to easily mixing solid materials from the atomic scale to several micrometers with different ***,metal oxides or doping materials are accessible as the dielectric medium is *** some excellent advantages,new inorganic particles exploited through the electrical discharge method will promise to be the most rewarding in some potential applications.

关键词： electrical discharge gas/liquid-phase dielectric medium inorganic particle sizeandcomposition application

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A quasi-zero stiffness energy harvesting isolator with triple negative stiffness

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Acta Mechanica Sinica 2024年第8期40卷 219-238页

作者： xiangyu cai Tao Yang Weiyang qin Zhongliang Xie Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518057China Department of Engineering Mechanics Northwestern Polytechnical UniversityXi’an710072China

Vibration isolation for low frequency excitation and the power supply for low power monitoring sensors are important issues in bridge *** main problem is how to effectively combine the vibration isolator with the energy harvester to form a multi-functional *** this paper,a system called quasi-zero stiffness energy harvesting isolator(QZS-EHI)with triple negative stiffness(TNS)is *** TNS structure consists of linear springs,rigid links,sliders,and ring permanent ***’s second law and Kirchhoff’s law construct dynamic equations of the QZS-EHI,and a comparison is made to contrast it with other QZS and linear *** comparison field includes the QZS range,amplitude-frequency relationship,force transmissibility,and energy harvested *** isolator can be applied to many engineering fields such as bridges,automobiles,and railway *** paper selects bridge engineering as the main field for the dynamic analysis of this *** the multi-span beam bridge,this paper compares different situations including the bridge with QZS-EHI support,with linear stiffness isolator support,and with single beam *** results show that the QZS-EHI is not only better than the traditional isolator with linear stiffness under both harmonic and stochastic excitation,but also better than some QZS isolators with double or single negative stiffness in bridge vibration isolation and energy *** analysis is verified to correspond to the simulation analysis,which means the proposed QZS-EHI has practical application value.

关键词： Quasi-zero stiffness Triple negative stiffness Vibration isolation Energy harvesting

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Modeling of multiphase flow in low permeability porous media:Effect of wettability and pore structure properties

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1127-1139页

作者： xiangjie qin Yuxuan Xia Juncheng Qiao Jiaheng Chen Jianhui Zeng Jianchao cai National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China Research Institute of Petroleum Exploration and Development Beijing10083China

Multiphase flow in low permeability porous media is involved in numerous energy and environmental ***,a complete description of this process is challenging due to the limited modeling scale and the effects of complex pore structures and *** address this issue,based on the digital rock of low permeability sandstone,a direct numerical simulation is performed considering the interphase drag and boundary slip to clarify the microscopic water-oil displacement *** addition,a dual-porosity pore network model(PNM)is constructed to obtain the water-oil relative permeability of the *** displacement efficiency as a recovery process is assessed under different wetting and pore structure *** show that microscopic displacement mechanisms explain the corresponding macroscopic relative *** injected water breaks through the outlet earlier with a large mass flow,while thick oil films exist in rough hydrophobic surfaces and poorly connected *** variation of water-oil relative permeability is significant,and residual oil saturation is high in the oil-wet *** flooding is extensive,and the residual oil is trapped in complex pore networks for hydrophilic pore surfaces;thus,water relative permeability is lower in the water-wet *** the displacement efficiency is the worst in mixed-wetting systems for poor water *** negatively correlates with invading oil volume fraction due to strong capillary resistance,and a large microporosity corresponds to low residual oil *** work provides insights into the water-oil flow from different modeling perspectives and helps to optimize the development plan for enhanced recovery.

关键词： Low permeability porous media Water-oil flow Wettability Pore structures Dual porosity pore network model(PNM) Free surface model

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Lithium-induced graphene layer containing Li_(3)P alloy phase to achieve ultra-stable electrode interface for lithium metal anode

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Rare Metals 2024年第2期43卷 562-574页

作者： Jia-Xin Chen Guo-Qiang Zhang xian-Ying qin Kui Lin Zi-Jin Yang Ge-Meng Liang Yue Xia Guo-Bin Zhang Hai-Kun Wu Qiu-Chan cai Hai Lin Bao-Hua Li Shenzhen Key Laboratory on Power Battery Safety Research and Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolShenzhen518055China Shenzhen Graphene Innovation Center Co. Ltd.Shenzhen518107China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA5005Australia Department of Chemistry City University of Hong KongHong Kong990077China

Uncontrolled growth of lithium dendrite will lead to low Coulombic efficiency and poor cycle stability,which hinders the commercialization of lithium metal ***,a novel modified lithium anode with reduced graphene oxide conductive network containing trace lithiophilic phosphorus(P-rGO/Cu)is prepared by electrospraying technique combined with heat treatment *** rGO layer has a concave and undulating conductive structure,which can significantly improve the effective electrical contact between lithium metal and the current collector,speed up the kinetics of interfacial electron transport and reaction,and improve the resistance of the negative electrode to the internal stress caused by volume change of the lithium,which is advantageous for the stability of the SEI *** extremely small and uniformly distributed red phosphorus element avoids the volume change caused by lithiation to the maximum *** two-phase compound Li_(3)P obtained by alloying P with Li can directionally induce the homogeneous nucleation and dense deposition of lithium metal,address the issue of lithium dendrites and extend the cycle life of the *** obtained P-rGO/Cu exhibits excellent electrochemical performance with an average Coulombic efficiency(CE)of 98%at a current density of 1 mA·cm^(−2) for 400 cycles,and the capacity retention rate of the full cell matched with lithium iron phosphate(LFP)is 83%after 400 cycles at 1C.

关键词： Lithium anode Dendrite-free Lithiophilicity Induced nucleation deposition

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Internal electric field modulation by copper vacancy concentration of cuprous sulfide nanosheets for enhanced selective CO_(2) photoreduction

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Journal of Energy Chemistry 2024年第4期91卷 324-330页

作者： xian Shi Weidong Dai Xiaoqian Li Yang Bai qin Ren Yao Lei Xing'an Dong School of Chemistry and Environmental Engineering Sichuan University of Science&EngineeringZigong 643000SichuanChina State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation School of Oil&Natural Gas EngineeringSouthwest Petroleum UniversityChengdu 610500SichuanChina Chongqing Key Laboratory of Photo-Electric Functional Materials College of Physics and Electronic EngineeringChongqing Normal UniversityChongqing 401331SichuanChina Research Center for Environmental and Energy Catalysis Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731SichuanChina

Although the internal electric field(IEF)of photocatalysts is acknowledged as a potent driving force for photocharge separation,modulating the IEF intensity to achieve enhanced photocatalytic performances remains a ***,cuprous sulfide nanosheets with different Cu vacancy concentration were employed to study IEF modulation and corresponding direct charge *** the samples,Cu_(1.8)S nanosheets possessed intensified IEF intensity compared with those of Cu_(2)S and Cu_(1.95)S nanosheets,suggesting that an enhanced IEF intensity could be achieved by introducing more Cu *** intensified IEF of Cu_(1.8)S nanosheets induced numerous photogenerated electrons to migrate to its surface,and the dissociative electrons were then captured by Cu vacancies,resulting in efficient charge separation *** addition,the Cu vacancies on Cu_(1.8)S nanosheets accumulated electrons as active sites to lower the energy barrier of rate-determining step of CO_(2)photoreduction,leading to the selective conversion of CO_(2)to ***,the manipulation of IEF intensity through Cu vacancy concentration regulation of cuprous sulfide photocatalysts for efficient charge separation has been discussed,providing a scientific strategy to rationally improve photocata lytic performances for solar energy conversion.

关键词： Internal electric field intensity Cuprous sulfide photocatalysts Cu vacancies Charge separation Selective CO_(2) photoreduction

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Ganoderma Lucidum Spore Oil enhances the effect of cyclophosphamide via inhibiting programmed death-1 and prolongs the survival of H22 tumor-bearing mice

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Journal of Traditional Chinese Medicine 2024年第4期44卷 652-659页

作者： JIANG Zhaojian cai Hongfei YUAN Cheng CAO Lin XU Wendong HAN Yaming ZHANG qin LI Jing WANG qin LIU Juyan Guangzhou HanFang Pharmaceutical Company Limited National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug InnovationGuangdong Provincial Key Laboratory of Medicinal LipidsGuangzhou 510240China Zhongshan Medical College Sun Yat-sen UniversityGuangzhou 510080China Guangzhou Pharmaceutical Holdings Limited Guangzhou 510130China National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug Innovation Guangzhou 510240China

OBJECTIVE:To investigate the effect of Ganoderma Lucidum Spore Oil(GLSO)on the tumor growth and survival of H22 tumor-bearing mice treated with cyclophosphamide(CTX),and explore the underlying ***:Allograft H22 hepatocellular carcinoma mouse model was applied to investigate the effect of GLSO on the tumor growth and survival of animals,and Kaplan-Meier survival analysis was used to analyze the life *** biochemical examination was used to determine the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),urea(UREA)and creatinine(CRE).Western blot analysis was performed to detect Programmed Death-1(PD-1),Programmed Death Ligand 1(PD-L1),Janus Kinase 2(JAK2),phosphorylated Signal Transducer and Activator of Transcription 3(p-STAT3),and Signal Transducer and Activator of Transcription 3(STAT3)***:GLSO increased the anti-tumor effect of CTX and prolonged the survival of H22 tumor-bearing mice treated with ***,GLSO increased the thymus index and showed no obvious toxicity to liver functions of *** also decreased the level of UREA in H22 tumor-bearing mice treated with ***,GLSO could inhibit the expression of PD-1 in spleen,which was independent of JAK2 expression and STAT3 ***,GLSO did not affect the expression of PD-L1,JAK2,and p-STAT3 in tumor ***:GLSO could strengthen the anti-tumor effect of CTX and prolong the life span of H22 tumorbearing mice,while the underlying mechanism might be relevant to the amelioration effect of thymus function and inhibition of PD-1 expression in ***,these findings implied the promising role of GLSO in combination with CTX to extend the survival of patients in clinical chemotherapy of hepatocellular carcinoma.

关键词： carcinoma,hepatocellular cyclophosphamide survival programmed cell death 1 receptor Ganoderma Lucidum SporeOil

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