检索结果-南通市图书馆

Automated identification of retinopathy of prematurity by image-based deep learning

Eye and Vision 2020年第4期7卷 379-390页

作者： Yan Tong Wei Lu qin-qin deng Changzheng Chen Yin Shen Eye Center Renmin Hospital of Wuhan UniversityWuhan 430060HubeiChina Medical Research Institute Wuhan UniversityWuhanHubeiChina

Background:Retinopathy of prematurity(ROP)is a leading cause of childhood blindness worldwide but can be a treatable retinal disease with appropriate and timely *** study was performed to develop a robust intelligent system based on deep learning to automatically classify the severity of ROP from fundus images and detect the stage of ROP and presence of plus disease to enable automated diagnosis and further ***:A total of 36,231 fundus images were labeled by 13 licensed retinal experts.A 101-layer convolutional neural network(ResNet)and a faster region-based convolutional neural network(Faster-RCNN)were trained for image classification and *** applied a 10-fold cross-validation method to train and optimize our *** accuracy,sensitivity,and specificity were assessed in a four-degree classification task to evaluate the performance of the intelligent *** performance of the system was compared with results obtained by two retinal ***,the system was designed to detect the stage of ROP and presence of plus disease as well as to highlight lesion regions based on an object detection network using ***:The system achieved an accuracy of 0.903 for the ROP severity ***,the accuracies in discriminating normal,mild,semi-urgent,and urgent were 0.883,0.900,0.957,and 0.870,respectively;the corresponding accuracies of the two experts were 0.902 and ***,our model achieved an accuracy of 0.957 for detecting the stage of ROP and 0.896 for detecting plus disease;the accuracies in discriminating stage I to stage V were 0.876,0.942,0.968,0.998 and 0.999,***:Our system was able to detect ROP and differentiate four-level classification fundus images with high accuracy and *** performance of the system was comparable to or better than that of human experts,demonstrating that this system could be used to support clinical decisions.

关键词： Deep learning Retinopathy of prematurity Artificial intelligence Fundus image

来源：

维普期刊数据库

维普期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Isothermal reduction kinetics and reduction prediction for iron ore pellets

引用

Journal of Iron and Steel Research International 2025年第1期32卷 64-72页

作者： Fei Meng Hao Liu Yue-lin qin Huang-jie Hua Yin deng Ze-zheng Sun Long-hai Liu School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing401331China CISDI Group Co. Ltd.Chongqing401122China College of Materials Science and Engineering Chongqing UniversityChongqing400044China Sichuan Desheng Group Vanadium&Titanium Co. Ltd.Leshan614000SichuanChina

Iron ore pellets,as one of the main charges of blast furnaces,have a greater impact on the CO_(2)emission reduction and stable operation of blast *** isothermal reduction behavior of the pellets obtained from a Chinese steel plant was studied in the gas mixtures of CO and N_(2).The results showed the reduction process is divided into two *** reduction in the initial stage(time t≤40 min)is cooperatively controlled by internal diffusion and interface chemical reactions with the activation energy of 30.19 and 16.67 kJ/mol,*** controlling step of the reduction in the final stage(t>40 min)is internal diffusion with the activation energy of 34.60 kJ/*** reduction process can be described by two equations obtained from kinetic *** reduction degree can be predicted under different temperatures and time,and the predicted results showed an excellent correlation with the experimental *** reduction mechanisms were confirmed by the analysis of the scanning electron microscope equipped with an energy dispersive spectrometer and optical microscope.

关键词： Pellet Reduction behavior Kinetics Mechanism Reduction prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-coding RNAs in acute ischemic stroke:from brain to periphery

引用

Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Activation of somatostatin receptor 5 suppresses AMPA responses in rat retinal ganglion cells

Activation of somatostatin receptor 5 suppresses AMPA respon...

引用

中国神经科学学会第十届全国学术会议

作者： qin-qin deng Wen-Long SHENG Shi-Jun WENG Xiong-Li YANG Yong-Mei ZHONG Institute of Neurobiology Institutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan University

Objective Somatostatin(SRIF),a peptide neurotransmitter present in the central nervous system,exerts its actions via five distinct G-protein-coupled receptors,*** a previous study we showed the expression of sst in rat retinal neurons by immunohistochemistry,but the functional role of this receptor is largely *** this work,we investigated effects of SRIF on AMPA receptor-mediated currents in isolated rat retinal ganglion cells(GCs) andexplored the underlying intracellular signaling *** The expression of sst in retinal GCs was identified by *** cell patch-clamp techniques were used to investigate effects of SRIF on AMPA receptor-mediated currents in freshly dissociated *** in intracellular calcium levels in GCs were measured by calcium imaging *** Immunofluorescence double labeling showed that sst was strongly expressed in ***-clamp experiments demonstrated that SRIF suppressed AMPA currents of GCs *** SRIF effect was mimicked by the sst agonist BIM-23206/L-817,818,but reversed by the sstantagonist BEM-23056,suggesting the involvement of the sst *** and sst agonists had no effects on the AMPA ***-induced suppression was blocked by intracellular dialysis of GDP-p-S,a G-protein inhibitor,or preincubation with pertussis toxin,a G protein *** intracellular signaling pathway responsible for the SRIF-induced suppression of AMPA currents was further *** PKA activator cAMP suppressed the AMPA currents,and in the presence of cAMP,SRIF no longer suppressed the *** addition,the application of the PKA inhibitors Rp-cAMP,H-89/KT5720 abolished the SRIF *** contrast,internal infusion of cGMP failed to induce suppression of the AMPA currents,none of the PKG inhibitor KT5823,PC-PLC inhibitor D609 and PI-PLC inhibitor U73122 blocked the SRIF-induced *** data suggest no involvement of cGMP-PKG and PC/PI-PLC signaling ***

关键词： somatostatin sst5 AMPA currents retinal ganglion cells ryanodine receptor neuromodulation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

构造旋回与大地构造年表

引用

地球学报 2016年第5期37卷 528-534页

作者：任纪舜徐芹芹邓平肖黎微中国地质科学院地质所北京100037

构造旋回的划分是大地构造研究的基础之一。但板块学说兴起以来,一些学者基于均变论的哲学思想,却试图抛弃构造旋回的概念。然而,随着时间的推移,地球系统科学的提出,大规模、多学科地学观测,人们已认识到突变与灾变的重要性,认识到渐... 详细信息

构造旋回的划分是大地构造研究的基础之一。但板块学说兴起以来,一些学者基于均变论的哲学思想,却试图抛弃构造旋回的概念。然而,随着时间的推移,地球系统科学的提出,大规模、多学科地学观测,人们已认识到突变与灾变的重要性,认识到渐变与突变相结合的螺旋式向前发展的旋回演化论,才是更全面、更深刻地认识地质规律的有力武器。在大地构造研究中,一些学者常用地层年表,而不用构造旋回。然而,以生物地层学为主要依据的显生宙地层年表与构造旋回和构造岩浆事件并不完全耦合。这是因为,地层年表是在研究地球表生作用,即岩石圈、水圈、大气圈、生物圈之间相互作用的基础上建立的;而构造旋回则是地球内生作用,即壳、幔、核以及壳、幔、核不同层次间多层圈相互作用的历史记录。一些学者在研究大地构造时,只用同位素年龄表示的构造事件,不使用构造旋回。然而,"事件"只是单个现象的呈现,只是构造发展的片段,旋回则阐明过程,反映事物发展中各"事件"(片段)之间的内在联系,反映事物演化的本质。事实上,威尔逊旋回的建立,已为构造旋回和构造事件之间的联系赋予了全新的科学内涵,这也是地质科学发展过程中,正确处理继承与创新关系的一个光辉范例。一些学者由于对全球造山运动是否是同时性的质疑,认为建立全球统一构造年表是不可能的,也是不必要的。可是,地球作为一个整体,其动态活动应该基本上同时的,在受同一地球动力系统控制的一个大区域内,构造运动在各地虽然不是完全同时,但却大致是同时的。北美、欧洲、亚洲加里东、华力西旋回的各次构造运动基本上可以互相对比,就是证明。既然如此,我们就可以按照优先原则,将早古生代的构造旋回称为加里东旋回,将晚古生代的构造旋回称为华力西(海西)旋回。超大陆和超大陆旋回的提出,深化了构造旋回的研究,同时也为建立构造年表开辟了道路。目前已初步提出古元古代哥伦比亚、中元古代罗丁尼亚、新元古代冈瓦纳和显生宙潘吉亚等几个超大陆旋回,这样,我们便可以用超大陆旋回作为构造年表中最大一级的时间单位,每个超大陆旋回又可进一步分为几个旋回,如潘吉亚旋回可分为加里东、华力西两个旋回。我们相信,随着地质学、地球化学、地球物理学研究的深入,随着对固体地球系统和全球地质构造更加深入、全面、系统的观测研究,不久的将来我们将会像建立显生宙地层年表一样,建立起大区域以至全球的构造年表。

关键词：构造旋回构造年表超大陆旋回角度不整合造山运动

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Controllable chaos in the coupled waveguide-optomechanical system with phase shifter

引用

Science China(Physics,Mechanics & Astronomy) 2025年第04期Mechanics & Astronomy) .卷 30-38页

作者： deng-Wei Zhang Pei-Qi qin Li-Li Zheng Zhi-Ming Zhan Xin-You Lü Department of Mathematics and Physics Luoyang Institute of Science and Technology School of Computer and Information Engineering School of Software Luoyang Institute of Science and Technology School of Artificial Intelligence Jianghan University School of Physics Huazhong University of Science and Technology

We theoretically investigate chaotic dynamics in an optomechanical system composed of a whispering-gallery-mode(WGM) microresonator and a sensor. We find that tuning the optical phase using a phase shifter and modifying the coupling strength via a unidirectional waveguide(IWG) can induce chaotic motion. The underlying reason for this phenomenon is that adjusting the phase and coupling strength via the phase shifter and IWG bring the system close to an exceptional point(EP), where field localization dynamically enhances the optomechanical nonlinearity, leading to the generation of chaotic motion. In addition, due to the sensitivity of chaos to phase in the vicinity of the EP, we propose a theoretical scheme to measure the optical phase perturbations using chaos. Our work may offer an alternative approach to chaos generation with current experimental technology and provide theoretical guidance for optical signal processing and chaotic secure communication.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Effect of Railway Spacing on Aerodynamic Performance of 600 km/h Maglev Trains Passing Each Other

引用

Fluid Dynamics & Materials Processing 2025年第2期21卷 371-385页

作者： Bailong Sun Tian Li deng qin Yan Li State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu610031China Southwest Jiaotong University Chengdu Design Institute Co. Ltd.Southwest Jiaotong UniversityChengdu610031China

High-speed maglev trains(HSMTs)can run at high running speeds due to their unique *** pressure waves that these trains generate while passing each other are therefore very intense,and can even have safety *** order to reduce the transient impact of such waves,the standard k-ε turbulence model is used in this work to assess the effect of railway spacing on the aerodynamic loads,pressure and surrounding flow field of 600 km/h maglev trains passing each other in open *** sliding mesh technique is used to determine the relative motion between the considered *** results show that the surface pressure is approximately linearly correlated with the square of the speed while the amplitude of the pressure wave on the train surface,side force,and rolling moment all have negative exponential relationships with the railway spacing.

关键词： Railway spacing maglev train aerodynamic numerical simulation two trains passing each other

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

精神家园还是文化陷阱:《地下铁道》对黑人音乐的文化反思

引用

外语导刊 2025年第1期48卷 149-156,F0003页

作者：邓琴华中师范大学外国语学院湖北武汉430079

美国非裔作家科尔森·怀特黑德的小说《地下铁道》在重述美国奴隶制时期的历史时,对黑人音乐进行了深刻的文化反思。本文通过还原历史语境梳理小说中的黑人音乐书写,发现小说一方面肯定了黑人音乐作为美国非裔民族精神家园的文化意义,... 详细信息

美国非裔作家科尔森·怀特黑德的小说《地下铁道》在重述美国奴隶制时期的历史时,对黑人音乐进行了深刻的文化反思。本文通过还原历史语境梳理小说中的黑人音乐书写,发现小说一方面肯定了黑人音乐作为美国非裔民族精神家园的文化意义,另一方面也揭示了黑人音乐潜在的文化陷阱,即黑人音乐的现实逃逸性和白人操纵性。本文认为,小说对黑人音乐的文化反思,实际上也是基于21世纪历史高点对民族文化传统的反思,反映了小说对新世纪美国非裔批判地继承民族文化传统的文化立场。

关键词：科尔森·怀特黑德地下铁道美国小说非裔作家黑人音乐文化反思

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

引用

Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia qin Lingyan Liang Yichen Wei qingping Zhang Xiaocheng Li Haixia qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

17-β雌二醇和他莫昔芬对小鼠慢性高眼压模型的作用研究

引用

国际眼科杂志 2018年第6期18卷 994-998页

作者：马雪云邓琴琴沈吟邢怡桥武汉大学人民医院眼科中心中国湖北省武汉市430060

目的:探讨17-β雌二醇(17-β-estradiol,E2)和他莫昔芬(tamoxifen,TAM)在慢性高眼压小鼠模型中的调节作用。方法:通过前房注射磁珠堵塞房角构建小鼠慢性高眼压模型。将C57BL/6成年小鼠随机分为对照组、Beads组、E2组和E2+TAM组。采用眼... 详细信息

目的:探讨17-β雌二醇(17-β-estradiol,E2)和他莫昔芬(tamoxifen,TAM)在慢性高眼压小鼠模型中的调节作用。方法:通过前房注射磁珠堵塞房角构建小鼠慢性高眼压模型。将C57BL/6成年小鼠随机分为对照组、Beads组、E2组和E2+TAM组。采用眼压计监测各组眼内压(intraocular pressure,IOP)的变化;HE染色观察并测量中央视网膜厚度;Brn3a免疫组织化学染色观察并计数存活的视网膜神经节细胞(retinal ganglion cells,RGCs);Western blot法检测视网膜中胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)的表达。结果:造模后2wk内,Beads组小鼠平均眼压显著高于对照组,而E2组和E2+TAM组眼压均明显低于Beads组,差异均有统计学意义(P0.05)。Western blot结果显示,Beads组小鼠视网膜GFAP蛋白表达量升高,注射E2和E2+TAM后,GFAP蛋白表达量显著下降(P<0.05)。结论:皮下注射E2和E2+TAM均能降低慢性高眼压模型小鼠眼内压,增加RGCs存活数量,且降低视网膜GFAP蛋白表达量,表明E2和TAM在青光眼的发生发展过程中具有一定的保护作用。

关键词： 17-β雌二醇他莫昔芬高眼压视网膜神经节细胞神经保护

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：