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Syphilitic uveitis in HIV-positive patients: report of a case series, treatment outcomes, and comprehensive review of the literature

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1250-1259页

作者： Ning Xu Jia-Guo Yuan qin-jin dai Chao Yuan Yan He Ting-Shuai Jiang Jie Zhu Guangzhou Twelfth People’s Hospital Guangzhou Medical UniversityGuangzhou 510620Guangdong ProvinceChina Guangzhou Eighth People’s Hospital Guangzhou Medical UniversityGuangzhou 510440Guangdong ProvinceChina Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510623Guangdong ProvinceChina Xijing Hospital Fourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

AIM:To report the clinical characteristics,treatment and outcomes of active syphilitic uveitis in human immunodeficiency virus(HIV)positive patients and compare them with the previously published ***:Retrospective analysis of the case series from an infectious disease center in southern China was *** review of previously published cases of HIV positive syphilitic uveitis was conducted using the PubMed and Web of Science databases and the references listed in the identified ***:Twelve HIV positive patients with active syphilitic uveitis were *** were male,with age of 36.3y(range 27 to 53y).Five(41.7%)had a history of syphilis,and three of them had received anti-syphilis *** manifestations included corneal epithelial defect(13%),complicated cataract(17.4%),vitreous opacity(82.6%),optic disc edema(26.1%),macular edema(30.4%),neuro-retinitis(43.5%),and retinal hemorrhage(26.1%).After standardized syphilitic treatment,intraocular inflammation was reduced and vision improved in all *** literature review summarizes 105 previously reported cases of HIV positive syphilitic *** serum rapid plasma regain(RPR)titers may be associated with severe uveitis and poor *** with penicillin,ceftriaxone sodium,or penicillin plus benzylpenicillin instead of using benzylpenicillin alone can significantly improve bestcorrected visual acuity(BCVA)in HIV positive ocular syphilis ***:For HIV positive syphilitic uveitis patients,prompt diagnosis and appropriate treatment and follow-up are *** our series,the clinical manifestations are *** patients treated by penicillin G or long-acting penicillin before may still develop syphilitic *** who relapse after long-term penicillin treatment can still benefit from penicillin G.

关键词： syphilis uveitis human immunodeficiency virus neurosyphilis regimen literature review

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The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration

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Neural Regeneration Research 2025年第10期20卷 2741-2757页

作者： Qianzi jin Suyu Wang Yujia Yao qin Jiang Keran Li Department of Ophthalmology The Affiliated Eye Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina The Fourth School of Clinical Medicine Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts ***,the specific pathogenesis remains unclear,and effective early treatment options are consequently *** microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a *** intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other *** dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many *** recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the ***,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s ***,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular ***,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable *** such,the intestinal flora may play an important role in age-related macular *** the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic ***,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular ***-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the inte

关键词： age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora metabolite microecology neurodegenerative disease

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Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian qin Yuxin jin Yiming qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

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Impact of Drug Eluting Stents on the Progression of Coronary Artery Atherosclerotic Plaque

Impact of Drug Eluting Stents on the Progression of Coronary...

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第十三次全国心血管病学术会议

作者： qin Hua-jin,YUN dai-chen,LU Yue-gaiJUN Guo- JLng The Chinese People’s Liberation Army General Hospital,100853 Beijing,China

Objective The objective of this study was to evaluate whether the drug eluting stents can affect the progression of coronary artery atherosclerotic *** 410 patients,who had angiography follow up at more than 9 months after drug eluting stents implantation,were included in the *** the initial angiography immediately after stents there were 276

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Stepwise assembly to construct stable copper(I) cluster-based circularly polarized luminescent MOFs

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Science China Chemistry 2025年

作者： jing-Wen Xie Meng-Ting Wang Yan jin Si Li Jian-Hua qin Shuang-Quan Zang Tomas C.W.Mak College of Chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University College of Chemistry and Chemical Engineering Luoyang Normal University Department of Chemistry The Chinese University of Hong Kong

Circularly polarized luminescence （CPL） materials have been extensively studied in recent years owing to their widespread applications in 3D display,optical storage,optical anti-counterfeiting,and biological imaging,***（I） clusters have emerged as a promising candidate for CPL materials,driven by their cost-effectiveness,superior luminescent properties,precise structure,and low ***,the poor environmental stability of copper（I） clusters renders their synthesis and preservation challenging,thereby significantly impeding their ***,we have designed and synthesised a chiral double-coordinated ligand in order to construct copper（I） cluster nodes that can be further *** anticipated,by utilizing stepwise assembly strategy,a Cu4cluster node co-modified by chiral alkynyl ligands and triphenylphosphine was further assembled with Cd2+ions to obtain 2D layers structure,L/*** L/D-Cu4-Cd exhibits excellent stability and optical properties,including bright yellow emission,solvent-responsive luminescence,and CPL activity with a maximum glumup to 2.0×10-3,which shows potential applications in the WLED and *** interestingly,the material also exhibits deflection ability towards different wavelengths of linearly polarized light,showing certain potential in the preparation of circular polarizer.

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An improved Bag-of-Words framework for remote sensing image retrieval in large-scale image databases

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International Journal of Digital Earth 2015年第4期8卷 273-292页

作者： jin Yang Jianbo Liu qin dai Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences BeijingChina University of Chinese Academy of Sciences BeijingChina

Due to advances in satellite and sensor technology,the number and size of Remote Sensing(RS)images continue to grow at a rapid *** continuous stream of sensor data from satellites poses major challenges for the retrieval of relevant information from those satellite *** Bag-of-Words(BoW)framework is a leading image search approach and has been successfully applied in a broad range of computer vision problems and hence has received much attention from the RS ***,the recognition performance of a typical BoW framework becomes very poor when the framework is applied to application scenarios where the appearance and texture of images are very *** this paper,we propose a simple method to improve recognition performance of a typical BoW framework by representing images with local features extracted from base *** addition,we propose a similarity measure for RS images by counting the number of same words assigned to *** compare the performance of these methods with a typical BoW *** experiments show that the proposed method has better recognition performance than that of the BoW and requires less storage space for saving local invariant features.

关键词： remote sensing image retrieval base image Bag-of-Words visual word

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Location-based instant satellite image service: concept and system design

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International Journal of Digital Earth 2015年第2期8卷 91-101页

作者： Jianbo Liu jin Yang Fu Chen qin dai jing Zhang Institute of Remote Sensing and Digital Earth Chinese Academy of SciencesBeijingChina

This paper presents various limitations of the current remote sensing data distribution models and proposes a new concept called the location-based instant satellite image service for a new generation of remote sensing image distribution *** essential feature of the service is that customers can subscribe to data based on the location of interest and satellite image data received by antenna will be distributed to customer’s terminal devices instantly after imaging over the subscribed *** workflow,architecture,and key technologies of the new generation data distribution system are *** system is composed of four parts:data comprehensive processing component,data management component,product distribution component,and data display *** on this,a prototype system is developed,which demonstrates the promising service model with great potential for increased usage in many applications.

关键词： remote sensing data distribution model location-based service instant service

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An improved SVM model for relevance feedback in remote sensing image retrieval

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International Journal of Digital Earth 2014年第9期7卷 725-745页

作者： Caihong Ma qin dai Jianbo Liu Shibin Liu jin Yang Center for Earth Observation and Digital Earth Chinese Academy of SciencesBeijing 100094China

With the rapid development of satellite remote sensing technology and an ever-increasing number of Earth observation satellites being launched,the global volume of remotely sensed imagery has been growing *** the variety of remotely sensed data has increasingly been complex and *** is also hard to efficiently and intelligently retrieve what users need from a massive database of *** paper introduces an improved support vector machine(SVM)model,which optimizes the model parameters and selects the feature subset based on the particle swarm optimization(PSO)method and genetic algorithm(GA)for remote sensing image *** results from an image retrieval experiment show that our method outperforms traditional methods such as GRID,PSO,and GA in terms of consistency and stability.

关键词： content-based remote sensing image retrieval relevance feedback support vector machines particle swarm optimization genetic algorithm

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A Gradient-Domain Based Geometry Processing Framework for Point Clouds

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Journal of Computer Science & Technology 2018年第4期33卷 863-872页

作者： Hong-Xing qin jin-Long He Meng-Hui Wang Yu dai Zhi-Yong Ran College of Computer Science and Technology Chongqing University of Posts and Telecommunications Chongqing 400065 China

The use of point clouds is becoming increasingly popular. We present a general framework for performing geometry filtering on point-based surface through applying the meshless local Petrol-Galelkin （MLPG） to obtain the solution of a screened Poisson equation. The enhancement or smoothing of surfaces is controlled by a gradient scale parameter. Anisotropic filtering is supported by the adapted Riemannian metric. Contrary to the other approaches of partial differential equation for point-based surface, the proposed approach neither needs to construct local or global triangular meshes, nor needs global parameterization. It is only based on the local tangent space and local interpolated surfaces. Experiments demonstrate the efficiency of our approach.

关键词： point clouds processing partial differential equation meshless method gradient-domain

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Incorporation of Fluorescent Carbon Quantum Dots into Metal-Organic Frameworks with Peroxidase-Mimicking Activity for High-Performance Ratiometric Fluorescent Biosensing

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Journal of Analysis and Testing 2023年第1期7卷 16-24页

作者： Qiuyu Ye Tao dai jin Shen qin Xu Xiaoya Hu Yun Shu School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

A new ratiometric fluorescent sensor based on the bifunctional carbon quantum dots(CQDs)@metal-organic framework(MOF)nanocomposite possessing peroxidase-mimicking catalytic and luminescent characteristics was developed for hydrogen peroxide(H_(2)O_(2))and cholesterol *** incorporation of fluorescent CQDs into the cavities of MIL-101(Fe)MOF with peroxidase-like activities endows the nanocomposite with bifunctional *** CQDs@MOF can oxidize o-phenylene-diamine to 2,3-diaminophenolazine by H_(2)O_(2)with yellow fluorescence(556 nm).Meantime,the intrinsic fluorescence signal(455 nm)of CQDs@MOF is inhibited due to the inner filter ***,the ratio of the fluorescent intensity is employed as the signal output to construct the H_(2)O_(2)ratiometric *** addition,the cholesterol can be determined by the ratiometric sensor with high *** addition,the total cholesterol in human serum is determined with high accuracy using our ratiometric *** ratiometric fluorescent platform based on the bifunctional CQDs@MOF provides new insights in the field of bio-sensing.

关键词： Carbon quantum dots Metal-organic framework Peroxidase-like activity Ratiometric fluorescent detection

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