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A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes

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Natural Products and Bioprospecting 2015年第3期5卷 159-166页

作者： Ji-huan qin Jun-Zeng Ma Xing-Wei Yang Ying-Jie Hu Juan Zhou Lin-Chun Fu Ru-hua Tian Shan Liu Gang Xu Xiao-Ling Shen Laboratory of Chinese Herbal Drug Discovery Tropical Medicine InstituteGuangzhou University of Chinese MedicineGuangzhou 510405People’s Republic of China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China

6a-Hydroxylup-20(29)-en-3-on-28-oic acid(1),a natural triterpenoid,was found to possess the ability in a dose-dependent manner inhibiting hormone-induced adipocyte differentiation in 3T3-L1 preadipocytes,and restoring glucose consuming ability in dexamethasone(DXM)-induced insulin resistant 3T3-L1 *** 1 was also found to ameliorate DXM-induced adipocyte dysfunction in lipolysis and adipokine *** studies revealed that 1 inhibited adipocyte differentiation in 3T3-L1 preadipocytes via down-regulating hormone-stimulated gene transcription of peroxisome proliferator-activated receptor c and CCAAT-enhancer-binding protein alpha which are key factors in lipogenesis,and restored DXM-impaired glucose consuming ability in differentiated 3T3-L1 adipocytes via repairing insulin signaling pathway and activating down-stream signaling transduction by phosphorylation of signaling molecules PI3K/p85,Akt2 and AS160,thus leading to increased translocation of glucose transporter type 4 and transportation of glucose.

关键词： 6a-Hydroxylup-20(29)-en-3-on-28-oic acid 3T3-L1 Adipocyte differentiation Dexamethasone induced insulin resistance Adipocyte dysfunction PI3K/Akt2 signaling

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西湖凹陷断裂系统特征及其控藏机制

天然气工业 2014年第10期34卷 18-26页

作者：蔡华张建培唐贤君中海石油(中国)有限公司上海分公司

东海陆架盆地西湖凹陷断裂系统复杂,断裂组合样式多样,前人较少涉及凹陷整体断裂系统及其对油气成藏控制作用的研究。为此,基于地震资料解释成果,系统研究了该区断裂的展布特征和活动特征,探讨了断裂系统对油气成藏的控制作用。结果表... 详细信息

东海陆架盆地西湖凹陷断裂系统复杂,断裂组合样式多样,前人较少涉及凹陷整体断裂系统及其对油气成藏控制作用的研究。为此,基于地震资料解释成果,系统研究了该区断裂的展布特征和活动特征,探讨了断裂系统对油气成藏的控制作用。结果表明:1以渐新统花港组底界和上中新统柳浪组底界为界,可将断裂系统垂向上分为下部(张性)、中部(压性)和上部(张剪性)3套断裂系统;2下部张性断裂系统主要有断阶型、多米诺型、地堑、地垒等多种断裂组合样式,主要形成于凹陷裂陷发育阶段,断裂对沉积地层的控制(或改造)作用显著;3中部压性断裂系统主要有正"Y"、反"Y"字形和简单后冲型断裂组合样式,形成于凹陷反转期,上盘地层存在不同程度的剥蚀;4上部张剪性断裂系统剖面上为悬挂断裂,平面上呈带状和雁行状组合,形成于凹陷区域沉降阶段,对地层控制作用微弱。结论认为:断裂系统中不同性质的断裂对油气聚集的控制作用存在显著差异,深大断裂宏观上控制油气田的分布,裂陷期断裂是油气运移的主要通道,而反转期断裂形成有效圈闭,区域沉降期断裂则改造原生油气藏。

关键词：东海陆架盆地西湖凹陷断裂系统控藏机制垂向运聚晚期断裂断裂组合样式油气运移

Detection of bacterial endotoxin in paclitaxel liposome

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Journal of Chinese Pharmaceutical Sciences 2018年第6期27卷 436-441页

作者： Yusheng Pei Tong cai Guolai Zhang Chen Chen hua Gao National Institutes for Food and Drug Control Beijing 102629China

Based on current research, there are three technologies during the test of bacterial endotoxin of liposomes：（1） extraction of bacterial endotoxin from liposomes;（2） addition of bacterial endotoxin in the process of recovery test; and（3） elimination of the interference factors from drugs and excipients. In the present study, we pointed out that the key technologies to test bacterial endotoxin from paclitaxel liposome included following steps： extraction of bacterial endotoxins from ethanol-dissolved liposomes; preparation of positive control of recovery solution by adding 0.01 m L standard endotoxins in 1 m L liposome ethanol solution; and the use of 0.5% human albumin to eliminate the interference from detection, and accurate detection of the bacterial endotoxin of liposomes.

关键词： Bacterial endotoxin test Paclitaxel Liposome Drug delivery system

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3K型行星轮系的单元分析法

机械设计与研究 2009年第6期25卷 22-24页

作者：卢存光段钦华西南交通大学机械工程学院成都610031 成都大学工业制造学院成都610106

将3K型行星轮系分解为3个简单的K-H型轮系单元,然后对这些单元进行运动分析和受力分析,列出方程组并求解。这种方法不仅可以求出每个构件的角速度和所受的力矩,整个轮系的功率流向也随之确定,而且还得到一个通用的效率公式。根据功率流... 详细信息

将3K型行星轮系分解为3个简单的K-H型轮系单元,然后对这些单元进行运动分析和受力分析,列出方程组并求解。这种方法不仅可以求出每个构件的角速度和所受的力矩,整个轮系的功率流向也随之确定,而且还得到一个通用的效率公式。根据功率流向,发现轮系中存在的循环功率流就是这类轮系效率较低、甚至发生自锁的原因。同时,举例证明通过减小循环功率与输出功率的比值可以适当提高这种轮系的啮合效率,从而为这类轮系的改进和设计提出了一种新方法。

关键词：行星轮系周转轮系循环功率啮合效率自锁

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轿车-行人事故中人体损伤来源与相关性分析

汽车工程 2017年第7期39卷 748-753,747页

作者：邹铁方肖璟胡林李华蔡铭长沙理工大学汽车与机械工程学院长沙410004 湖南省工程车辆安全性设计与可靠性技术重点实验室长沙410004 中山大学工学院广东省智能交通系统重点实验室广州510275

为更好地了解车-人碰撞事故中人体不同部位的损伤来源及其相关性,从大量事故案例中选取64例附着弹出类型车-人碰撞事故,用PC-Crash对事故进行再现后读取相关数据,经验证,数据可靠。然后借助做图和相关性分析等技术对数据进行分析。结果... 详细信息

为更好地了解车-人碰撞事故中人体不同部位的损伤来源及其相关性,从大量事故案例中选取64例附着弹出类型车-人碰撞事故,用PC-Crash对事故进行再现后读取相关数据,经验证,数据可靠。然后借助做图和相关性分析等技术对数据进行分析。结果表明,头部损伤和大腿部位的损伤主要来源于人与车碰撞的过程中;胸部由加速度引起的损伤主要来源于与车碰撞过程中,而由碰撞力引起的损伤则主要来源于与地面碰撞过程中;小腿部位的损伤来源,则须具体问题具体分析。通过相关性分析表明,行人头部HIC15与胸部3ms加速度值之间的相关系数最高,具有显著统计学意义,表明行人头部损伤与胸部损伤之间具有高度相关性。

关键词：轿车行人碰撞事故人体损伤相关性来源

Design and achievement of cloud geodatabase for a sponge city

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Journal of Central South University 2018年第10期25卷 2423-2437页

作者： HOU Jing-wei SUN Shi-qin LIU Ren-tao LI Jian-hua ZHANG Ming-xin School of Resources and Environment Ningxia UniversityYinchuan 750021China Ningxia(China-Arab)Key Laboratory of Resource Assessment and Environment Regulation in Arid Region Yinchuan 750021China Key Laboratory for Restoration and Reconstruction of Degraded Ecosystem in Northwestern China of Ministry of Education Ningxia UniversityYinchuan 750021China

Building a cloud geodatabase for a sponge city is crucial to integrate the geospatial information dispersed in various departments for multi-user high concurrent access and retrieval,high scalability and availability,efficient storage and *** this study,Hadoop distributed computing framework,including Hadoop distributed file system and MapReduce(mapper and reducer),is firstly designed with a parallel computing framework to process massive spatial ***,access control with a series of standard application programming interfaces for different functions is designed,including spatial data storage layer,cloud geodatabase access layer,spatial data access layer and spatial data analysis ***,a retrieval model is designed,including direct addressing via file name,three-level concurrent retrieval and block data retrieval *** functions are realised,including real-time concurrent access,high-performance computing,communication,massive data storage,efficient retrieval and scheduling decisions on the multi-scale,multi-source and massive spatial ***,the performance of Hadoop cloud geodatabases is validated and compared with that of the Oracle *** cloud geodatabase for the sponge city can avoid redundant configuration of personnel,hardware and software,support the data transfer,model debugging and application development,and provide accurate,real-time,virtual,intelligent,reliable,elastically scalable,dynamic and on-demand cloud services of the basic and thematic geographic information for the construction and management of the sponge city.

关键词： cloud geodatabase sponge city Hadoop concurrent retrieval access

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聚己内酯与聚羟基丁酸戊酸酯的脱氮性能对比

环境科学 2019年第9期40卷 4143-4151页

作者：易成豪秦伟陈湛文湘华清华大学环境学院环境模拟与污染控制国家重点联合实验室

以可生物降解聚合物聚己内酯(PCL)和聚羟基丁酸戊酸酯(PHBV)作为反硝化缓释碳源和微生物载体,利用清水释碳和批式反硝化试验选出适用于再生水反硝化深度脱氮生物滤池的可生物降解碳源滤料,通过比较与分析碳源滤料的表面形态及物质特性... 详细信息

以可生物降解聚合物聚己内酯(PCL)和聚羟基丁酸戊酸酯(PHBV)作为反硝化缓释碳源和微生物载体,利用清水释碳和批式反硝化试验选出适用于再生水反硝化深度脱氮生物滤池的可生物降解碳源滤料,通过比较与分析碳源滤料的表面形态及物质特性和附着微生物的群落特征揭示其性能优越的原因.结果表明,PHBV反硝化启动时间短,反硝化速率高,剩余有机物浓度低,相比PCL具有更稳定持续的反硝化效果.原因是其表面粗糙,且含有大量C—O和C=O等亲水性基团,易于微生物附着和降解利用;其表面附着的微生物种类多样,其中发硫菌属(Thiothrix)、假单胞属(Pseudomonas)、菌胶团属(Zoogloea)、黄杆菌属(Flavobacterium)和脱氯菌属(Dechloromonas)等优势菌属均具有异养反硝化功能.因此,PHBV更适合作为再生水反硝化深度脱氮生物滤池的碳源滤料.

关键词：固相反硝化碳源滤料可生物降解聚合物聚羟基丁酸戊酸酯(PHBV) 聚己内酯(PCL) 反硝化菌群落结构

选煤厂主要生产设备的计算机集控自动化的应用

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煤炭技术 2014年第10期33卷 254-256页

作者：蔡春华蔡昊牡丹江师范学院黑龙江牡丹江157011 中国矿业大学(北京) 北京100083

我国多数选煤厂采用计算机控制系统,推动了选煤工业的进步。实现全厂主要生产设备的集控自动化。主要阐述了选煤厂自动化的目标、构成与功能,计算机系统在控制和管理中的应用等技术问题。

关键词：计算机技术选煤厂自动化

A nuclear-localized cysteine desulfhydrase plays a role in fruit ripening in tomato

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Horticulture Research 2020年第1期7卷 40-52页

作者： Kang-Di Hu Xiao-Yue Zhang Gai-Fang Yao Yu-Lei Rong Chen Ding Jun Tang Feng Yang Zhong-qin huang Zi-Mu Xu Xiao-Yan Chen Yan-Hong Li Lan-Ying Hu hua Zhang School of Food and Biological Engineering Hefei University of Technology230009 HefeiChina Xuzhou Institute of Agricultural Sciences of the Xuhuai District of Jiangsu Province 221131 XuzhouChina School of Resources and Environmental Engineering Hefei University of Technology230009 HefeiChina

Hydrogen sulfide(H_(2)S)is a gaseous signaling molecule that plays multiple roles in plant ***,whether endogenous H_(2)S plays a role in fruit ripening in tomato is still *** this study,we show that the H_(2)S-producing enzyme L-cysteine desulfhydrase SILCD1 localizes to the *** constructing mutated forms of SILCD1,we show that the amino acid residue K24 of SILCD1 is the key amino acid that determines nuclear *** of SILCD1 by TRV-SILCD1 accelerated fruit ripening and reduced H_(2)S production compared with the control.A SILCD1 gene-edited mutant obtained through CRISPR/Cas9 modification displayed a slightly dwarfed phenotype and accelerated fruit *** mutant also showed increased cysteine content and produced less H_(2)S,suggesting a role of SILCD1 in H_(2)S *** degradation and carotenoid accumulation were enhanced in the SILCD1 *** ripening-related genes that play roles in chlorophyll degradation,carotenoid biosynthesis,cell wall degradation,ethylene biosynthesis,and the ethylene signaling pathway were enhanced at the transcriptional level in the lcd1 *** RNA was sequenced from unripe tomato fruit treated with exogenous H_(2)S,and transcriptome analysis showed that ripening-related gene expression was *** on the results for a SILCD1 gene-edited mutant and exogenous H_(2)S application,we propose that the nuclear-localized cysteine desulfhydrase SILCD1 is required for endogenous H_(2)S generation and participates in the regulation of tomato fruit ripening.

关键词： CRISPR/Cas9 dwarf endogenous