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六味地黄丸调节肠道微生物组平衡抑制卵巢早衰小鼠的氧化应激

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中国组织工程研究 2025年第11期29卷 2285-2293页

作者：仲佳雯姜波张文燕李晓荣秦岭高婷宁夏医科大学中医学院宁夏回族自治区银川市750004 宁夏医科大学生育力保持重点实验室宁夏回族自治区银川市750004 宁夏医科大学少数民族医药现代化教育部重点实验室宁夏回族自治区银川市750004 宁夏医科大学总医院宁夏回族自治区银川市750000

背景:研究表明,卵巢早衰患者肠道菌群结构发生变化,肠道菌群失调可能是卵巢早衰发生的重要机制之一。目的:探讨六味地黄丸对环磷酰胺诱导卵巢早衰小鼠氧化应激和肠道微生物群的影响。方法:45只雌性ICR小鼠随机分为3组:空白组(正常小鼠)... 详细信息

背景:研究表明,卵巢早衰患者肠道菌群结构发生变化,肠道菌群失调可能是卵巢早衰发生的重要机制之一。目的:探讨六味地黄丸对环磷酰胺诱导卵巢早衰小鼠氧化应激和肠道微生物群的影响。方法:45只雌性ICR小鼠随机分为3组:空白组(正常小鼠)、模型组(卵巢早衰小鼠)、六味地黄丸组,后2组小鼠一次性腹腔注射环磷酰胺(120 mg/kg)制备卵巢早衰小鼠模型,造模成功后六味地黄丸组小鼠连续灌胃六味地黄丸(1.56 g/kg)28 d,其余2组灌胃等量生理盐水28 d,灌胃结束后取材。每周记录小鼠体质量,计算卵巢指数,苏木精-伊红染色观察小鼠卵泡的发育情况,EliSA法检测血清抗苗勒管激素、雌二醇、促卵泡激素、超氧化物歧化酶、谷胱甘肽过氧化物酶和丙二醛水平,并通过16S rDNA测序检测所有小鼠的肠道微生物组。结果与结论:(1)模型组小鼠的毛发疏松,活力及抓力下降,体质量几乎无增长,卵巢指数下降;六味地黄丸治疗后小鼠的体质量高于模型组,卵巢指数也随之升高(P<0.05)。(2)模型组小鼠动情周期紊乱;六味地黄丸能恢复卵巢早衰小鼠的发情周期,减少闭锁卵泡数量。(3)模型组小鼠血清中促卵泡激素、丙二醛水平显著升高(P<0.01),血清雌二醇、抗苗勒管激素、超氧化物歧化酶和谷胱甘肽过氧化物酶水平显著下降(P<0.01);六味地黄丸组小鼠血清促卵泡激素、丙二醛水平显著降低(P<0.01),雌二醇、抗苗勒管激素、超氧化物歧化酶、谷胱甘肽过氧化物酶水平升高。(4)根据16S rDNA测序结果,六味地黄丸可调控肠道微生物群的丰度和多样性,可增加有益菌的相对丰度,KEGG通路分析显示,肠道微生物群与代谢途径、次生代谢产物的生物合成、不同环境中的微生物代谢、氨基酸的生物合成等通路受六味地黄丸的调控。(5)结论:肠道微生物组的改变可能是六味地黄丸治疗卵巢早衰的潜在机制之一。六味地黄丸能调节肠道微生物组结构,增加有益菌数量,减少有害菌数量,从而改善肠道微生态平衡。这种调节作用有助于降低氧化应激水平,进一步抑制卵巢早衰小鼠卵巢氧化应激。

关键词：六味地黄丸卵巢早衰肠道微生物组氧化应激

Genetic Diversity： Geographical Distribution and Toxin Profiles of Microcystis Strains （Cyanobacteria） in China

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Journal of Integrative Plant Biology 2007年第3期49卷 262-269页

作者： zhong-Xing Wu Nan-qin Gan li-Rong Song State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology the Chinese Academy of Sciences Wuhan 430072 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China

Twenty strains of Microcystis Kütz were isolated from different freshwater bodies in China to analyze the diversity, geographical distribution and toxin profiles. Based on whole-cell polymerase chain reaction of cpcBA-IGS nucleotlde sequence, the derived neighbor-joining （NJ） and maximum parsimony （MP） trees Indicate that these strains of Microcystis can be divided into four clusters. The strains from south, middle and north region of China formed distinct lineages, suggesting high diversity and a geographical distribution from south to north locations. Moreover, the results being indicating high variable genotypes of the strains of the Microcystis strains from the same lake show that there Is high diversity of Microcystis within a water bloom population. Comparing the results of the present study with those reported for compared with 43 strains of Microcystis from other locations, also reveals Chinese strains have high similarity with those from regions in the North Hemispherical. This suggests that the Microcystis strains In the world might have a geographical distribution. Analysis of 30 strains using the primers MCF/TER and TOX2P/TOX2M showed that there was no correlation between the gene of cpcBA-IGS and the presence of racy. Toxic strains were founded to be predominant in different water bodies throughout China.

关键词： diversity geographical distribution microcystin Microcystis

灰色-IAHP模型在煤矿冲击地压评价中的应用

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煤炭技术 2018年第8期37卷 126-129页

作者：秦忠诚李谭陈光波孙伟付彪山东科技大学矿业与安全工程学院山东青岛266590

由于煤矿冲击地压评价指标具有不确定性和模糊性等特点,所以从冲击倾向性、地质因素、技术因素、组织管理因素4个方面建立评价指标体系,利用改进型中心点三角白化权函数解决灰类多重交叉问题,通过区间层次分析法确定指标的权重,构建灰色... 详细信息

由于煤矿冲击地压评价指标具有不确定性和模糊性等特点,所以从冲击倾向性、地质因素、技术因素、组织管理因素4个方面建立评价指标体系,利用改进型中心点三角白化权函数解决灰类多重交叉问题,通过区间层次分析法确定指标的权重,构建灰色-IAHP评价模型,利用该评价模型对新安煤矿的5条巷道进行评价。

关键词：冲击地压灰色理论-区间层次分析法安全评价改进型中心点三角白化权函数

AZIDE-ALKYNE CliCK POLYMERIZATION:AN UPDATE

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Chinese Journal of Polymer Science 2012年第1期30卷 1-15页

作者： Hong-kun li Jing-zhi Sun An-jun qin Ben zhong Tang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China Department of Chemistry Institute of Molecular Functional Materials The Hong Kong University of Science ＆ Technology Clear Water Bay Kowloon Hong Kong China

The great achievements of click chemistry have encouraged polymer scientists to use this reaction in their field. This review assembles an update of the advances of using azide-alkyne click polymerization to prepare functional polytriazoles（PTAs） with linear and hyperbranched *** Cu（I）-mediated click polymerization furnishes 1,4-regioregular PTAs,whereas,the metal-free click polymerization of propiolates and azides produces PTAs with 1,4-regioisomer contents up to 90%.The PTAs display advanced functions,such as aggregation-induced emission,thermal stability,biocompatibility and optical nonlinearity.

关键词： Click polymerization Azide Alkyne Polytriazole Functionality

Integrated medical resource consumption stratification in hospitalized patients:an Auto Triage Management model based on accurate risk,cost and length of stay prediction

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Science China(life Sciences) 2022年第5期65卷 988-999页

作者： qin zhong Zongren li Wenjun Wang Lei Zhang Kunlun He Medical Big Data Research Center Chinese PLA General HospitalBeijing 100853China Medical Artificial Intelligence Research Center Chinese PLA General HospitalBeijing 100853China Bio-engineering Research Center Chinese PLA General HospitalBeijing 100039China Department of Cardiology Fourth Medical Center of Chinese PLA General HospitalBeijing 100048China Key Laboratory of Ministry of Industry and Information Technology of Biomedical Engineering and Translational Medicine Chinese PLA General HospitalBeijing 100048China China-Australia Joint Research Center for Infectious Diseases School of Public HealthXi’an Jiaotong University Health Science CenterXi’an 710061China

Triage management plays important roles in hospitalized patients for disease severity stratification and medical burden *** progression risks have been extensively researched for numbers of diseases,other crucial indicators that reflect patients’economic and time costs have not been systematically *** address the problems,we developed an automatic deep learning based Auto Triage Management(ATM)Framework capable of accurately modelling patients’disease progression risk and health economic *** on them,we can first discover the relationship between disease progression and medical system cost,find potential features that can more precisely aid patient triage in resource allocation,and allow treatment plan searching that has cured *** ATM in COVID-19,we built a joint model to predict patients’risk,the total length of stay(Lo S)and cost when at-admission,and remaining Lo S and cost at a given hospitalized time point,with C-index0.930 and 0.869 for risk prediction,mean absolute error(MAE)of 5.61 and 5.90 days for total Lo S prediction in internal and external validation data.

关键词： patient triage AutoML electronic medical records

FeCo alloy/N,S co-doped carbon aerogel derived from directionalcasting cellulose nanofibers for rechargeable liquid flow and flexible Zn–air batteries

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Nano Research 2023年第5期16卷 6870-6880页

作者： Yiwen Zhang Xifeng Zhang Yuting li Juan Wang Sibudjing Kawi qin zhong School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117582Singapore

Bifunctional oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)electrocatalysts with the advantages of excellent activity and stability are the vital components of air cathodes for rechargeable Zn–air batteries(ZABs).Herein,the carbon aerogel with honeycomb-like structure,N and S double doping and loaded with FeCo alloy nanoparticles(NSCA/FeCo)was prepared successfully as cathodes for rechargeable liquid flow and two-dimensional flexible ZABs by clever directional *** interaction between the bimetallic alloy and the double-doped carbon with specifical structure,large surface,great conductivity endows NSCA/FeCo with effective ORR/OER active sites and small charge/mass transport barrier,thus achieving outstanding bifunctional catalytic *** NSCA/FeCo displays a half-wave potential of+0.85 V(*** hydrogen electrode(RHE))for ORR and an overpotential of 335 mV at a current density of 10 mA·cm^(−2)for OER,which is even comparable to the performance of noble-metal catalysts in relevant fields(Pt/C for ORR and RuO_(2)for OER).Consequently,the rechargeable liquid flow ZABs assembled with NSCA/FeCo showed excellent performance(maximum power density:132.0 mW·cm^(−2),specific capacity:804.5 Wh·kg^(−1)at 10 mA·cm^(−2),charge and discharge cycle stability of more than 250 cycles).Furthermore,the flexible NSCA/FeCo-based ZABs have a maximum power density of 43.0 mW·cm^(−2),outstanding charging–discharge stability of more than 450 cycles,exhibit good flexibility under different bending ***,this work has provided an efficient bifunctional electrocatalyst for OER/ORR and a promising strategy of air cathodes for rechargeable and wearable ZABs.

关键词： carbon aerogel bifunctional electrocatalyst FeCo alloy directional freeze-casting rechargeable zinc–air batteries flexible batteries

Effects of Temperature and light on Growth Rate and Photosynthetic Characteristics of Sargassum horneri

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Journal of Ocean University of China 2021年第1期20卷 101-110页

作者： WANG Yong zhong Zhihai qin Song li Jialin li Jingjing liU Zhengyi Key Laboratory of Marine Hazards Forecasting Ministry of Natural ResourcesHohai UniversityNanjing 210098China Yantai Institute of Coastal Zone Research Chinese Academy of SciencesYantai 264003China

The changing environmental factors exerted great influences on coastal macroalgal *** study the responses of the brown seaweed Sargassum horneri to temperature and light,*** was cultured under three temperatures(20,25 and 30℃)and three light intensities(30,60,and 120μmol photons m-2 s-1)for seven *** growth rate,chlorophyll a(Chl a)and carotenoids(Car)contents,chlorophyll fluorescence,and photosynthetic oxygen evolution rate were *** results show that the highest relative growth rate(RGR),maximal electron transport rate(rETRmax);the net photosynthetic rate(Pn)were observed at the lowest temperature(20℃)and highest light intensity(120μmol photons m-2 s-1);and the RGR and Pn were significantly inhibited by the highest temperature(30℃),especially at the lowest light intensity(30μmol photons m-2 s-1)(Plight intensity enhanced the non-photochemical quenching(NPQ)even under the highest temperature(30℃),indicating that the higher light intensity could induce photo-protection reaction of *** results suggest that the higher temperature and lower light intensity exerted negative influences on ***.

关键词： chlorophyll fluorescence parameter ocean warming oxygen electrode photosynthetic activity Sargassum horneri transparency

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui liu Chao Fang Qiuxia Peng Wen qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Boosting low-temperature selective catalytic reduction of NO_(x)with NH_(3)of V_(2)O_(5)/TiO_(2)catalyst via B-doping

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Chinese Journal of Chemical Engineering 2022年第4期35卷 377-383页

作者： Hanghang li Wei Zhao licheng Wu Qian Wang Danhong Shang qin zhong School of Energy&Power Engineering Jiangsu UniversityZhenjiang 212013China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China

A series of B-doped V_(2)O_(5)/TiO_(2) catalysts has been prepared the by sol-gel and impregnation methods to investigate the influence of B-doping on the selective catalytic reduction(SCR)of NOxwith NH_(3).X-ray diffraction,Brunauer-Emmett-Teller specific surface area,scanning electron microscope,X-ray photoelectron spectroscopy,temperature-programmed reduction of H_(2) and temperature-programmed desorption of NH_(3)technology were used to study the effect of the B-doping on the structure and NH_(3)-SCR activity of V_(2)O_(5)/TiO_(2) *** experimental results demonstrated that the introduction of B not only improved the low-temperature SCR activity of the catalysts,but also broadened the activity temperature *** best SCR activity in the entire test temperature range is obtained for VTiB_(2.0) with 2.0%doping amount of B and the NO_(x) conversion rate is up to 94.3%at 210℃.The crystal phase,specific surface area,valence state reducibility and surface acidity of the active components for the as-prepared catalysts are significantly affected by the B-doping,resulting in an improved NH_(3)-SCR *** results suggest that the V_(2)O_(5)/TiO_(2) catalysts with an appropriate B content afford good candidates for SCR in the low temperature window.

关键词： B-doping Catalyst SCR NO_(x) Support