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Current Medical Science 2023年第6期43卷 1258-1259页

作者： Xin LUO Xue-kun HUANG Ya-na ZHANG qin-tai yang Department of Otolaryngology-Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China Department of Allergy The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China Naso-Orbital-Maxilla and Skull Base Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China

Chronic rhinosinusitis with nasal polyps(CRSw-NP)is a multifactorial and heterogeneous disorder of the sinonasal mucosa,characterized by a high relapse rate after medical and surgical treatments[1].Endoscopic sinus surgery(ESS)is the preferred treatment for CRSwNP in patients who have failed to respond to medical therapy[2].However,the postoperative complications will impair the recovery of patients,and accompanying post-operative outpatient visits may contribute to patient discomfort[3]Suppressing postoperative mucosa edema and improving mucosa recovery is critical to reducing the disease relapse after *** steroid-eluting sinus stent(SESS)represents a promising emerging therapy for CRSwNP.

关键词： Surgery operative treatment

Overexpression of mitogen-activated protein kinase phosphatase-1 in endothelial cells reduces blood-brain barrier injury in a mouse model of ischemic stroke

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Neural Regeneration Research 2023年第8期18卷 1743-1749页

作者： Xiu-De qin tai-qin yang Jing-Hui Zeng Hao-Bin Cai Shao-Hua Qi Jian-Jun Jiang Ying Cheng Long-Sheng Xu Fan Bu Department of Neurology&Psychology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhenGuangdong ProvinceChina Department of Cardiothoracic Surgery Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhenGuangdong ProvinceChina Department of Neurology The University of Texas Health Science Center at HoustonHoustonTXUSA Department of Nephrology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhenGuangdong ProvinceChina Department of Anesthesiology and Pain Medicine The Affiliated Hospital of Jiaxing UniversityJiaxingZhejiang ProvinceChina

Ischemic stroke can cause blood-brain barrier(BBB)injury,which worsens brain damage induced by *** expression of tight junction proteins in endothelial cells(ECs)can increase intracellular space and BBB *** inhibition of mitogen-activated protein kinase,the negative regulatory substrate of mitogen-activated protein kinase phosphatase(MKP)-1,improves tight junction protein function in ECs,and genetic deletion of MKP-1 aggravates ischemic brain ***,whether the latter affects BBB integrity,and the cell type-specific mechanism underlying this process,remain *** this study,we established an adult male mouse model of ischemic stroke by occluding the middle cerebral artery for 60 minutes and overexpressed MKP-1 in ECs on the injured side via lentiviral transfection before *** found that overexpression of MKP-1 in ECs reduced infarct volume,reduced the level of inflammatory factors interleukin-1β,interleukin-6,and chemokine C-C motif ligand-2,inhibited vascular injury,and promoted the recovery of sensorimotor and memory/cognitive *** of MKP-1 in ECs also inhibited the activation of cerebral ischemia-induced extracellular signal-regulated kinase(ERK)1/2 and the downregulation of occludin ***,to investigate the mechanism by which MKP-1 exerted these functions in ECs,we established an ischemic stroke model in vitro by depriving the primary endothelial cell of oxygen and glucose,and pharmacologically inhibited the activity of MKP-1 and ERK1/*** findings suggest that MKP-1 inhibition aggravates oxygen and glucose deprivation-induced cell death,cell monolayer leakage,and downregulation of occludin expression,and that inhibiting ERK1/2 can reverse these *** addition,co-inhibition of MKP-1 and ERK1/2 exhibited similar effects to inhibition of ERK1/*** findings suggest that overexpression of MKP-1 in ECs can prevent ischemia-induced occludin downregulation and cell death via deactivatin

关键词： blood-brain barrier brain injury cerebral ischemia endothelial cells extracellular signal-regulated kinase 1/2 functional recovery mitogenactivated protein kinase phosphatase 1 occludin oxygen and glucose deprivation transient middle cerebral artery occlusion

Enhanced recovery after surgery protocols in functional endoscopic sinus surgery for patients with chronic rhinosinusitis with nasal polyps: a randomized clinical trial

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Chinese Medical Journal 2019年第3期132卷 253-258页

作者： Xi-Fu Wu Wei-Feng Kong Wei-Hao Wang Lian-Xiong Yuan Hui-qing Xu Min Qi Shao-Li Zhou qin-tai yang Department of Otolaryngology Head and Neck Surgery the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Scientific Research the Third Affiliated Hospitai of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Anesthesiology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China

Background:Enhanced recovery after surgery (ERAS) protocols are a series of perioperative care to optimize preoperative preparation, prevent postoperative complications, minimize stress, and speed up recovery. This study aimed to assess the impact of ERAS protocols for functional endoscopic sinus surgery (FESS) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).Methods:One hundred and two patients with CRSwNP undergoing FESS were randomly divided into the ERAS group and the control group. The outcomes of the Self-Rating Anxiety Scale (SAS), Visual Analogue Scale (VAS), Medical Outcomes Study Sleep Scale (MOS-SS) and Kolcaba Comfort Scale Questionnaire (GCQ) were determined in both groups. The serum levels of C-reactive protein (CRP) were compared preoperatively and 24 hours ***:The ERAS group had a significantly better SAS scores than did the control group (28 [24, 35] vs. 43 [42, 47], Z=5.968, P 0.05);However, the CRP level in 24 hours postoperatively was significantly lower in the ERAS group than that in the control group (2.5 [1.4, 3.9] vs. 6.6 [3.8, 9.0], Z = 5.027, P 0.05), hemorrhage, aspiration and tumble, were not increased in the ERAS group compared with those in the control group. The ERAS group had a significantly shorter length of hospital stay (5 [4, 5] days vs. 8 [8,9] days, Z=8.939, P<0.001) and hospitalization expenses ($ 2670 [2375, 2740] vs. $3129 [311

关键词： Enhanced recovery after surgery Chronic rhinosinusitis Perioperative period Quality of life

Using the internet search data to investigate symptom characteristics of COVID-19: A big data study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第S1期6卷 S40-S48页

作者： Hui-Jun Qiu Lian-Xiong Yuan qing-Wu Wu Yu-Qi Zhou Rui Zheng Xue-Kun Huang qin-tai yang Department of Otolaryngology-Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-senUniversityGuangzhou510630China Department of Science and Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China Department of Pulmonary and Critical Care Medicine The Third Affiliated Hospital of Sun Yat-senUniversityGuangzhou510630China Department of Allergy The Third Affiliated Hospital of Sun Yat-senUniversityGuangzhou510630China

Objective:Analyzing the symptom characteristics of Coronavirus Disease 2019(COVID-19)to improve control and ***:Using the Baidu Index Platform(http://***)and the website of Chinese Center for Disease Control and Prevention as data resources to obtain the search volume(SV)of keywords for symptoms associated with COVID-19 from January 1 to February 20 in each year from 2017 to 2020 and the epidemic data in Hubei province and the other top 9 impacted provinces in *** of 2020 were compared with those of the previous three *** of Hubei province were compared with those of the other 9 *** differences and characteristics of the SV of COVID-19-related symptoms,and the correlations between the SV of COVID-19 and the number of newly confirmed/suspected cases were *** lag ef-fects were ***:Comparing the SV from January 1,2020 to February 20,2020 with those for the same period of the previous three years,Hubei’s SV for cough,fever,diarrhea,chest tightness,dys-pnea,and other symptoms were significantly *** total SV of lower respiratory symptoms was significantly higher than that of upper respiratory symptoms(P<0.001).The SV of COVID-19 in Hubei province was significantly correlated with the number of newly confirmed/suspected cases(rconfirmed Z 0.723,rsuspected Z 0.863,both p<0.001).The results of the distributed lag model suggested that the patients who searched relevant symptoms on the Internet may begin to see doctors in 2e3 days later and be confirmed in 3e4 days ***:The total SV of lower respiratory symptoms was higher than that of upper respira-tory symptoms,and the SV of diarrhea also increased *** warned us to pay atten-tion to not only the symptoms of the lower respiratory tract but also the gastrointestinal symptoms,especially diarrhea in patients with *** search behavior had a pos-itive correlation with the number of newly confirmed/suspected cas

关键词： SARS-CoV-2 COVID-19 Baidu index Big data Internet

种植密度及施肥对王不留行生长指标及干物质积累影响的研究

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中药材 2016年第11期39卷 2437-2440页

作者：刘晓清高钦杨太新河北农业大学农学院河北保定071001

目的:研究王不留行种植密度、施肥种类对其生长发育、干物质积累和质量的影响。方法:采用随机区组设计,定期进行调查测定王不留行株高、一级分级枝数、一级分枝总长度、干物质积累、总灰分、浸出物、王不留行黄酮苷以及单株籽粒干重和... 详细信息

目的:研究王不留行种植密度、施肥种类对其生长发育、干物质积累和质量的影响。方法:采用随机区组设计,定期进行调查测定王不留行株高、一级分级枝数、一级分枝总长度、干物质积累、总灰分、浸出物、王不留行黄酮苷以及单株籽粒干重和产量。结果:王不留行株高、一级分枝总长度及浸出物均随密度的减小而增加,获得高产的适宜种植密度为行株距20 cm×35 cm。单施有机肥的单株干物质积累量、单株籽粒干重及亩产量均最大。结论:行株距20 cm×35 cm为高产适宜种植密度,生产中应提倡底施有机肥100 kg/667 m^2。

关键词：王不留行种植密度施肥

A simple method to extract glacier length based on Digital Elevation Model and glacier boundaries for simple basin type glacier

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Journal of Mountain Science 2017年第9期14卷 1776-1790页

作者： JI qin yang tai-bao HE Yi qin Yan DONG Jun HU Fan-sheng Institute of Glaciology and Ecogeography College of Earth and Environmental Sciences Lanzhou University Lanzhou 73000 China Faculty of Geomatics Lanzhou Jiaotong University Lanzhou 730000 China Research Center for Arid Area and Desert College of Earth and Environmental Sciences Lanzhou University Lanzhou 730000 China

Glacier length is a key morphological element that has many glaciological applications; however, it is often difficult to determine, especially for glaciers that cover larger spatial areas or those that exhibit frequent temporal change. In this paper, we describe a new Arc GIS-based method that can derive glacier flow lines for determining glacier length based on digital elevation model and glacier outlines. This method involves(1) extraction of the highest and lowest points on a glacier,(2) calculation of 10-m contour lines on the glacier from 10 m to 100 m height, and(3) connection of the midpoints of each contour line with the highest and the lowest points in order to create a flow line, which is subsequently smoothed. In order to assess the reliability of this method, we tested the algorithm's results against flow lines calculated using field measurements, analysing data from the Chinese Glacier Inventory, and manual interpretation. These data showed that the new automated method is effective in deriving glacier flow lines when contour lines are relatively large; in particular, when they are between 70 m and 100 m. Nonetheless, a key limitation of the algorithm is the requirement to automatically delete repeated and closed curves in the pre-treatment processes. In addition to calculating glacier flow lines for derivation of glacier length, this method also can be used to effectively determine glacier terminus change.

关键词： Glacier length Flow lines Glacier boundary DEM Arc GIS

Glacier changes in the eastern Nyainqêntanglha Range of Tibetan Plateau from 1975 to 2013

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Journal of Mountain Science 2016年第4期13卷 682-692页

作者： JI qin yang tai-bao HE Yi CHEN Jie WANG Kai Institute of Glaciology and Ecogeography College of Earth and Environmental SciencesLanzhou University

Maritime-type glaciers in the eastern Nyainqêntanglha Range, located in the southeastern part of the Tibetan Plateau, are an important water source for downstream residents and ecological systems. To better understand the variability of glaciers in this region, we used the band ratio threshold（TM3/TM5 for the Landsat TM /ETM＋ and TM4/TM6 for Landsat OLI） to extract glacier outlines in ~1999 and ~2013. After that, we also generated a series of glacier boundaries and monitored glacier variations in the past 40 years with the help of the Chinese Glacier Inventory data（1975） and Landsat TM, ETM＋ and OLI data. The total glacier area decreased by 37.69 ± 2.84% from 1975 to 2013. The annual percentage area change（APAC） was ~1.32% a-1 and ~1.29% a-1 in the periods 1975-1999 and 1999-2013, respectively. According to the lag theory, the reaction time is probably about 10 years and we discuss the variations of temperature and precipitation between 1965 and 2011. Temperature and precipitation increased between 1965 and 2011 at a rate of 0.34°C /10 a and 15.4 mm/10 a, respectively. Extensive meteorological data show that the glacier shrinkage rate over the period may be mainly due to increasing air temperature, while the increasing precipitation partly made up for the mass loss of glacier ice resulting from increasing temperature may also lead to the low APAC between 1999 and 2013. The lag theory suggests that glacier shrinkage may accelerate in the next 10 years. Small glaciers were more sensitive to climate change, and there was a normal distribution between glacier area and elevation. Glaciers shrank in all aspects, and south aspects diminished faster than others.

关键词： Glacier variation Climate change Nyainqêntanglha Range Temperature Precipitation

Model Tests Research on A Float-Over Barge in Shallow Water Under the Undocking Conditions

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China Ocean Engineering 2021年第6期35卷 933-942页

作者： qin Li-cheng DING Hong-yan ZHANG Pu-yang LI Huai-liang YU Wen-tai State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China China Offshore Oil Engineering Company Limited Tianjin 300461China

In this study,the Jinzhou 9-3 CEPD float-over installation project was *** the undocking condition,the water depth of the motion path of the working barge gradually changed from 10.31 m to 9.41 *** undocking clearance of the HYSY 228 is smaller than 1 m;therefore,the barge shows highly nonlinear hydrodynamic characteristics,and it is difficult to be accurately simulated by numerical ***,it is necessary to obtain the hydrodynamic characteristics and laws of the float-over barge at different water depths by using tank model test,to provide some reference and guidance for float-over operations in shallow water.

关键词： float-over installation shallow water effect undocking conditions model test

The possible KK^(*)and D^(*)bound and resonance states by solving the Schrodinger equation

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Communications in Theoretical Physics 2024年第10期76卷 85-91页

作者： Bao-Xi Sun qin-qin Cao Ying-tai Sun School of Physics and Optoelectronic Engineering Beijing University of TechnologyBeijing 100124China School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China

The Schrodinger equation with a Yukawa type of potential is solved *** different boundary conditions are taken into account,a series of solutions are indicated as a Bessel function,the first kind of Hankel function and the second kind of Hankel function,***,the scattering processes of K^(*)and D^(*)are *** the K^(*)sector,the f_(1)(1285)particle is treated as a K^(*)bound state,therefore,the coupling constant in the K^(*)Yukawa potential can be fixed according to the binding energy of the f_(1)(1285)***,a K^(*)resonance state is generated by solving the Schrodinger equation with the outgoing wave condition,which lies at 1417-i18 MeV on the complex energy *** is reasonable to assume that the K^(*)resonance state at 1417-i18 MeV might correspond to the f_(1)(1420)particle in the review of the Particle Data *** the D^(*)sector,since the X(3872)particle is almost located at the D^(*)threshold,its binding energy is approximately equal to ***,the coupling constant in the D^(*)Yukawa potential is determined,which is related to the first zero point of the zero-order Bessel *** to the K^(*)case,four resonance states are produced as solutions of the Schrodinger equation with the outgoing wave *** is assumed that the resonance states at 3885~i1 MeV,4029-i108 MeV,4328-i191 MeV and 4772-i267 MeV might be associated with the Zc(3900),the X(3940),theχ_(c1)(4274)andχ_(c1)(4685)particles,*** is noted that all solutions are isospin degenerate.

关键词： non-Hermitian quantum mechanics Schrodinger equation meson-meson interaction one-pion exchanging potential resonance state bound state

Glacier Variation in Response to Climate Change in Chinese Tianshan Mountains from 1989 to 2012

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Journal of Mountain Science 2015年第5期12卷 1189-1202页

作者： HE Yi yang tai-bao JI qin CHEN Jie ZHAO Gang SHAO Wan-wan College of Earth and Environmental Sciences Lanzhou University

Based on the 1990, 2000 and 2011 Landsat TM/ETM+ remote sensing data, glacier information of three periods in the Chinese Tianshan Mountains were extracted by using ratio threshold method(TM3/TM5) and visual interpretation, combined with digital processing of satellite images and analysis in GIS. The climate data in the surrounding area were analyzed by using linear regression, Mann-Kendall abrupt test, and Morlet wavelet analysis. Study results showed that: over the 23 years investigation, the glacier areas have markedly decreased. In the last 12 years(2000 to 2011), the rate of retreat has begun to accelerate. The most dramatic glacier shrinkage occurred in the central region, the lowest in the eastern region. The mean summer temperature and warm precipitation in Chinese Tianshan Mountains had an increasing trend, with rates of 0.22°C /10 a and 5.1mm/10 a from 1960 to 2011, respectively. Mean summer temperature have experienced a strong increase in 1998. The analysis of the results showed that the rise of mean summer temperature was the main factor that contributed to glacier shrinkage. Regional differences of glacier area changes were investigated by analyzing glacier behavior in five study sub-regions; regional differences are related to local climate, to the relative proportion of glaciers in different size classes, altitudinal and aspect distribution of glaciated areas. In addition, the lag theory indicated that glaciers may accelerate the retreat in the next decade, considering climate trends recognized for the period 2000-2011.

关键词： Climate variation Glacier Remotesensing Tianshan