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Two New Abietane Quinones from Isodon lophanthoides var. Micranthus

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Chinese Chemical Letters 2003年第6期14卷 591-593页

作者： Ai Hua zhao Sheng Hong LI Yong Wei LI Quan Bin HUAN qin shi zhao Zhong Wen LIN Han Dong SUN State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650204

The structures of two new abietane quinones, named micranthins A and B, were determined to be 7a-methoxy-14, 16-epoxy-8, 13-abietadiene-11, 12-dione (1) and 16-acetoxy-6, 7-dehydroroyleanone (2) respectively, which we... 详细信息

关键词： Isodon lophanthoides var. micranthus Labiatae abietane quinones micranthin A miranthin B.

Isolation,Structural Assignment of Isoselagintamarlin A from Selaginella tamariscina and Its Biomimetic Synthesis

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Natural Products and Bioprospecting 2019年第1期9卷 69-74页

作者： qin-Feng Zhu Li-Dong Shao Xing-De Wu Jiang-Xin Liu qin-shi zhao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Isoselagintamarlin A(1),a selaginellin analogue featured a rare benzofuran unit,was isolated from Selaginella *** complete structural assignment was established through a combination of high-feld NMR technique and biomimetic ***,isoselagintamarlin A(1)was successfully synthesized via sequential oxidations and intramolecular cyclization.

关键词： Selaginella tamariscina Selaginellin Biomimetic synthesis Isoselagintamarlin A

Two New ent-Kaurane Diterpenoids from Isodon xerophilus

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Chinese Chemical Letters 2000年第9期11卷 795-798页

作者： Ai Jun HOU Hui YANG Bei JIANG qin shi zhao Yan Ze LIU Zhong Wen LIN Han Dong SUN Laboratory of Phytochemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650204 Department of Phytochemistry Henan College of Traditional Chinese MedicineZhengzhou 450003

Two new ent-kaurane diterpenoids, xerophilusin E (1) and xerophilusin F (2), were isolated from the leaves of Isodon xerophilus. Their structures were determined as 3, 20: 7, 20-diepoxy-ent-kaur-16-en-15-one and 7 beta, 14 beta, 20 (R)-trihydroxy-11 beta-acetoxy-7,20-cyclo-ent-kaur-16-en-6, 15-dione, respectively, by spectral methods and X-ray crystallographic analysis.

关键词： Isodon xerophilus Labiatae ent-kaurane diterpenoids xerophilusin E xerophilusin F

Exploring of drug leads from diversity-oriented Michael-acceptor library derived from natural products

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Natural Products and Bioprospecting 2012年第5期2卷 210-216页

作者： Xu DENG Ling-Mei KONG Yu zhao Juan HE Li-Yan PENG Yan LI qin-shi zhao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Graduate University of Chinese Academy of Sciences Beijing 100049China

A potential strategy for drug lead identification and in-active natural products re-discovery is *** from fifteen structurally diverse natural products,a focused library featured by Michael acceptors is constructed with IBX mediated *** assay on five tumor cell lines indicates that four Michael acceptors,8a,11a,12a,14a,are with improved cytotoxicity(3-10 folds more potent than the parent compounds),which merit further *** thiol-sensitive assay of the active hit 8a revealed that it was an irreversible Michael *** results suggest that the strategy is not only effective and relatively high discovery rate(28%),but also resource saving.

关键词： drug leads identification in-active natural products re-discovery Michael acceptors anti-tumor activity

Clerodane-type Diterpene Glycosides from Dicranopteris pedata

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Natural Products and Bioprospecting 2021年第5期11卷 557-564页

作者： Bei‑Bei Gao Yu‑Fei Ou qin‑Feng Zhu Zhi‑Ping Zhou Zhen‑Tao Deng Meng Li qin‑shi zhao Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationSchool of Chemical Science and TechnologyYunnan UniversityYunnan650091 KunmingPeople’s Republic of China State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China College of Pharmacy Guizhou Medical UniversityGuian New AreaGuizhou 550025China

Three new clerodane-type diterpene glycosides,(5R,6S,8R,9S,10R)-6-O-[β-d-glucopyranosyl-(1→4)-α-l-rhamnopyranosyl]cleroda-3,13(16),14-diene(1),(5R,6S,8R,9S,10R,13S)-6-O-[β-d-glucopyranosyl-(1→4)-α-l-rhamnopyranosyl]-2-ox-oneocleroda-3,13-dien-15-ol(2),(5R,6S,8R,9S,10R)-6-O-[β-d-glucopyranosyl-(1→4)-α-l-rhamnopyranosyl]-(13E)-2-oxoneocleroda-3,14-dien-13-ol(3),together with two known compounds 4 and 5 were isolated from Dicranopteris *** structures of these compounds were elucidated by detailed spectroscopic analysis,and the absolute configuration of compound 2 was determined by ECD *** addition,compound 1 exhibited weak inhibitory activities against SMMC-7721,MCF-7 and SW480.

关键词： Dicranopteris pedata Clerodane-type diterpene glycosides ECD

Four new labdane-type diterpenoid glycosides from Diplopterygium laevissimum

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Natural Products and Bioprospecting 2013年第2期3卷 38-42页

作者： Ming-Ming LI Kou WANG Juan HE Li-Yan PENG Xuan-qin CHEN Xiao CHENG qin-shi zhao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

Four new labdane-type diterpenoid glycosides,laevissiosides A-D(1-4)were isolated from the 95%ethanol extract of Diplopterygium laevissimum(Christ)Nakai,along with two known analogues,18-b-D-glucopyranosyl ester-sclareol(5)and 18-hydroxy-sclareol(6).The structures of compounds 1-4 were elucidated by extensive 1D and 2D NMR spectroscopy as well as high-resolution MS *** isolated compounds were evaluated for their cytotoxic effects.

关键词： Diplopterygium laevissimum labdane-type diterpenoid glycosides laevissiosides

neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies

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Natural Products and Bioprospecting 2011年第2期1卷 81-86页

作者： Gang XU Fang zhao Xian-Wen YANG Juan ZHOU Li-Xin YANG Xiao-Ling SHEN Ying-Jie HU qin-shi zhao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Tropical Medicine Institute Guangzhou University of Chinese MedicineGuangzhou 510405China Key Laboratory of Marine Bioresources Sustainable Utilization South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China

Salvia dugesii is an invasive plant in Yunnan,*** tentatively explore its utilization,a systematic phytochemical investigation was carried out on this plant,which led to the isolation of five new neo-clerodane diterpenoids,dugesins C-G(1-5),together with six known *** structures were determined by comprehensive NMR and MS spectroscopic *** was noteworthy that the eleven isolates,composed of five different carbocyclic systems derived from the neo-clerodane diterpenoid skeleton,were reported from the same plant for the first *** anti-feedantial,cytotoxic,and antiviral activities of the isolates were *** F(4)was tested to be a non-toxic antiviral compound against influenza virus FM1.

关键词： Salvia dugesii neo-clerodane diterpenoids dugesins antivirus

A New Abietane Diterpenoid from Orthosiphon wulfenioides

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Chinese Chemical Letters 2002年第2期13卷 141-142页

作者： Wei XIANG Sheng Hong LI qin shi zhao Zhi NA Bei JIANG Hong Jie ZHANG Zhong Wen LIN Han Dong SUN Laboratory of Phytochemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650204

A new abietane diterpenoid, orthosiphonol (11-methoxy-12, 14-dihydroxy-8, 11, 13-abieta trien-7-one) (1) together with known 11-hydroxysugiol (2) were isolated from Orthosiphon wulfenioides. Their structures were det... 详细信息

关键词： Orthosiphon wulfenioides abietane diterpenoid orthosiphonol.

Discovery and Asymmetric Total Synthesis of Phlegmine A as a Selective Inhibitor of ASIC1a

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CCS Chemistry 2024年第10期6卷 2529-2536页

作者： Zai-Feng Yuan Fei Liu Yu-Fei Ou Wen-Yan Li Li-Yan Peng Xiao-Nian Li qin-shi zhao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201 School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137 University of Chinese Academy of Sciences Beijing 10049

Phlegmine A(1),a novel type of Lycopodium alkaloid with a unique skeleton,was isolated from the rare and endangered herbal medicinal plant,Phlegmariurus *** methods and X-ray diffraction analysis were employed to unambiguously elucidate the structure of phlegmine A(1).Furthermore,we realized the asymmetric total synthesis of the natural product phlegmine A(1)in 18 linear steps from commercial ingredients,achieving a 1.3%overall *** intramolecular carbene cyclization,dimethyldioxirane(DMDO)enamine oxidation,and Stevens rearrangement were exploited to establish the sterically congested vicinal quaternary centers,and an epimerization/aldol condensation/deacetylation reaction was utilized for the rapid assembly of enone at the final *** our semisynthesis attempts,a novel transformation was developed to constructα-aminoketone from enamine ***,the synthetic sample obtained from this work enabled the successful verification of phlegmine A(1)as a new type of highly selective acidsensing ion channel 1a(ASIC1a)inhibitor,which also exerted an in vivo analgesic effect,rendering it a promising lead compound.

关键词： Lycopodium alkaloids phlegmine A total synthesis ASIC1a inhibitor analgesic