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Scale offers the possibility of identifying adherence to lifestyle interventions in patients with non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第25期30卷 3179-3181页

作者： Cen-qin liu Bing Hu Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology and Hepatology/Medical Engineering Integration Laboratory of Digestive Endoscopy West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disorder,and dietary and lifestyle interventions remain the mainstays of NAFLD *** et al established a prediction system to evaluate adherence to lifestyle interventions in patients with NAFLD and choose optimal ***,we discuss the application scenarios of the scale and the areas warranting further attention,aiming to provide a possible reference for clinical recommend-ations.

关键词： Nonalcoholic fatty liver disease Dietary and lifestyle interventions Scale Adherence Exercise

Single-Component Color-Tunable Smart Organic Emitters with Simultaneous Multistage Stimuli-Responsiveness and Multimode Emissions

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Research 2024年第2期2023卷 719-728页

作者： Yu Yan Chengfang liu Jianzhong Fan Yusheng Li Huanling liu Qian Wang Xiangchun Lil Junfeng Li Wen-Yong lai State Key Laboratory of Organic Electronics and Information Displays(SKLOEID) Institute of Advanced Materials(IAM)School of Chemistry and Life SciencesNanjing University of Posts&Telecommunications9 Wenyuan RoadNanjng 210023China Shandong Province Key Laboratory of Medical Physics and Image Processing Technology School of Physics and ElectronicsShandong Normal UniversityJinan 250358China

Achieving color-tunable emission in single-component organic emitters with multistage stimuli-responsiveness is of vital significance for intelligent optoelectronic applications,but remains enormously ***,we present an unprecedented example of a color-tunable single-component smart organic emitter(DDOP)that simultaneously exhibits multistage stimuli-responsiveness and multimode *** based on a highly twisted amide-bridged donor-tcceptor-donor structure has been found to facilitate intersystem crossing,form multimode emissions,and generate multiple emissive species with multistage *** pristine crystalline powders exhibit abnormal excitation-dependent emissions from a monomer-dominated blue emission centered at 470 nm to a dimer-dominated yellow emission centered at 550 nm through decreasing the ultraviolet(UV)excitation wavelengths,whereas DDOP single crystals show a wide emission band with a main emission peak at 585 nm when excited at different *** emission behaviors of pristine crystalline powders and single crystals are different,demonstrating emission features that are closely related to the aggregation *** work has developed color-tunable single-component organic emitters with simultaneous multistage stimuli-responsiveness and multimode emissions,which is vital for expanding intelligent optoelectronic applications,including multilevel information encryption,multicolor emissive patterns,and visual monitoring of UV wavelengths.

关键词： donor excitation Smart

Effect of Preload Force on Heat Generation of Li(Ni_(0.8)Co_(0.1)Mn_(0.1))O_(2)/SiO_(x)-C System Batteries:The Discharge Process

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Journal of Thermal Science 2024年第5期33卷 1809-1825页

作者： LIN Chunjing lai Zhenxing BAI Guangli MA Biao WEI Zhen QI Chuang liu Shiqiang Key Laboratory of Advanced Manufacturing Technology for Automobile Parts Ministry of EducationChongqing University of TechnologyChongqing 400054China China Auto Research New Energy Vehicle Inspection Center(Tianjin)Co Tianjin 300300China

Lithium-ion batteries(LIBs)undergo various degradation phenomena such as material decomposition,structural change and uneven lithium ion distribution during long-term cycles,which would affect their performance and *** order to improve the performance of the LIBs during their life cycle,preload force is preset when the batteries are *** preload forces will in turn affect the cycle life and heat generation of the *** order to address this issue,this work carries out charge/discharge cycle tests on a NCM811 battery under different preload *** calorimetry tests are performed to investigate the battery heat generation under different states of health(SOHs)and preload *** on the test results,an empirical prediction model for heat generation power as a function of SOH is *** show that when the preload force is 5 N·m,the battery capacity decreases in the slowest rate and the average heat generation power is the *** in peaks of the incremental capacity curve can be used to characterize the loss of lithium at the electrode,which in turn characterizes the change of heat generation power of the *** average heat generation power is mainly affected by the SOH,going through a period of trough with the decrease of the SOH and continuing to increase after crossing the critical *** general,these findings emphasize the relationship between preload force,SOH and heat generation power,which is helpful for the judgment of optimal preload to improve the efficiency of LIBs.

关键词： lithium ion battery cyclic aging preload force heat generation characteristic

Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway

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Journal of Traditional Chinese Medicine 2024年第2期44卷 268-276页

作者： ZHENG Xueying GUO Liang lai Siyi LI Fengyue LIANG Mingli liu Wanting MENG Chun liu Guanghui Department of Bioengineering College of Biological Science and BiotechnologyFuzhou UniversityFuzhou 350104China Eye Institute of Integrated Chinese and Western Medicine Fujian University of Traditional Chinese MedicineFuzhou 350004China Department of Ophthalmology Affiliated People's Hospital(Fujian Provincial People's Hospital)Fujian University of Traditional Chinese MedicineFuzhou 350004China

OBJECTIVE:To investigate the effects of emodin on alkali burn-induced corneal inflammation and ***:The ability of emodin to target vascular endothelial growth factor receptor 2(VEGFR2)was predicted by molecular *** effects of emodin on the invasion,migration,and proliferation of human umbilical vein endothelial cells(HUVEC)were determined by cell counting kit-8,Transwell,and tube formation *** of apoptosis was performed by flow ***31 levels were examined by *** abundance and phosphorylation state of VEGFR2,protein kinase B(Akt),signal transducer and activator of transcription 3(STAT3),and P38 were examined by immunoblot *** alkali burn was performed on 40 *** were divided randomly into two groups,and the alkali-burned eyes were then treated with drops of either 10μM emodin or phosphate buffered saline(PBS)four times a *** microscopy was used to evaluate inflammation and corneal neovascularization(CNV)in all eyes on Days 0,7,10,and *** mice were killed humanely 14 d after the alkali burn,and their corneas were removed and preserved at-80℃ until histological study or protein ***:Molecular docking confirmed that emodin was able to target *** findings revealed that emodin decreased the invasion,migration,angiogenesis,and proliferation of HUVEC in a dose-dependent *** mice,emodin suppressed corneal inflammatory cell infiltration and inhibited the development of corneal neovascularization induced by alkali *** to those of the PBS-treated group,lower VEGFR2 expression and CD31 levels were found in the emodintreated *** dramatically decreased the expression of VEGFR2,p-VEGFR2,p-Akt,p-STAT3,and p-P38 in VEGF-treated ***:This study provides a new avenue for evaluating the molecular mechanisms underlying corneal inflammation and *** might be a promising new therapeutic option for corneal alkal

关键词： alkali burn emodin corneal inflammation corneal neovascularisation vascular endothelial growth factor receptor-2 signal transduction

Risk Assessment and Defense Resource Allocation of Cyber-physical Distribution Systems Under Denial-of-service Attacks

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CSEE Journal of Power and Energy Systems 2024年第5期10卷 2197-2207页

作者： Han qin Jiaming Weng Dong liu Donglian Qi Yufei Wang School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Electrical Engineering Zhejiang UniversityHangzhou 310027China China Electric Power Research Institute Beijing 102209China

With the help of advanced information technology,real-time monitoring and control levels of cyber-physical distribution systems(CPDS)have been significantly *** due to the deep integration of cyber and physical systems,attackers could still threaten the stable operation of CPDS by launching cyber-attacks,such as denial-of-service(DoS)***,it is necessary to study the CPDS risk assessment and defense resource allocation methods under DoS *** paper analyzes the impact of DoS attacks on the physical system based on the CPDS fault self-healing ***,considering attacker and defender strategies and attack damage,a CPDS risk assessment framework is ***,risk assessment and defense resource allocation methods,based on the Stackelberg dynamic game model,are proposed under conditions in which the cyber and physical systems are launched ***,a simulation based on an actual CPDS is performed,and the calculation results verify the effectiveness of the algorithm.

关键词： Cyber physical distribution system defense resource allocation denial-of-service attack risk assessment Stackelberg dynamic game model

Kaempferol ameliorated levodopa-induced dyskinesia in experimental rats: A role of brain monoamines, cFOS, FosB, Parkin, Pdyn, TH, and p-JNK

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BIOCELL 2024年第3期48卷 513-523页

作者： PEI qin MIAO liu XIN WANG JIANHUA MA Geriatrics Department Chengde Central HospitalChengde067000China

Background:L-dopa(Levodopa)is well known for managing PD(Parkinson’s disease);however,its prolonged use caused dyskinesia(LID).Due to the varied presentation of LID,effective treatment options are *** reported their neuroprotective activity by ameliorating acetylcholinesterase,monoamine oxidase,and neuroinﬂ*** is anotherﬂavonoid bearing these ***:To evaluate neuroprotective activity of kaempferol in dyskinetic ***:PD was developed in Sprague-Dawley rats by injecting combination of L-ascorbic acid(10µL)+6-OHDA(12µg)in medial forebrain bundle to induce neuronal damage in substantial nigra(SNr).LID was induced by administrating combination of L-dopa(20 mg/kg)+benserazide HCl(5 mg/kg)for 42 *** were concomitantly treated with amantadine(40 mg/kg)or kaempferol(25,50,and 100 mg/kg,p.o.).Results:Kaempferol(50 and 100 mg/kg)markedly(p<0.05)inhibited LID-induced abnormal involuntary movements(AIMs)and alternation in motor *** administration considerably(p<0.05)inhibited reduced mitochondrial complex activities,serotonin and dopamine levels,Bcl-2,and Tyrosine hydroxylase protein expressions in ***,kaempferol considerably(p<0.05)attenuated increased cFOS,FosB,Parkin,and Pdyn mRNAs expressions,Bax,cleaved caspase-3,caspase-3,and pJNK proteins levels;DOPAC and 5-HIAA levels in SNr.A positive correlation was reported between cFOS,FosB,Parkin,Pdyn,apoptosis,and TH with ***:Kaempferol effectively attenuated L-dopa-induced AIMs and dyskinesia via amelioration of alterations in cFOS,FosB,Parkin,Pdyn,Tyrosine hydroxylase,and apoptosis in the brain SNr.

关键词： AIMs cFOS Kaempferol Levodopa-induced dyskinesia Pdyn

A Mass-Preserving Characteristic Finite Difference Method For Miscible Displacement Problem

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Advances in Applied Mathematics and Mechanics 2024年第1期16卷 164-180页

作者： Jiansong Zhang Yue Yu Rong qin Zhaohui liu Department of Applied Mathematics China University of PetroleumQingdaoShandong 266580China

In this article,a new characteristic finite difference method is developed for solving miscible displacement problem in porous *** new method combines the characteristic technique with mass-preserving interpolation,not only keeps mass balance but also is of second-order accuracy both in time and *** results are presented to confirm the convergence and the accuracy in time and space.

关键词： The method of characteristics mass-preserving finite difference miscible displacement problem

Electrically-driven ultrafast out-of-equilibrium light emission from hot electrons in suspended graphene/hBN heterostructures

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International Journal of Extreme Manufacturing 2024年第1期6卷 328-338页

作者： Qiang liu Wei Xu Xiaoxi Li Tongyao Zhang Chengbing qin Fang Luo Zhihong Zhu Shiqiao qin Mengjian Zhu Kostya S Novoselov College of Advanced Interdisciplinary Studies&Hunan Provincial Key Laboratory of Novel Nano-optoelectronic Information Materials and Devices National University of Defense TechnologyChangshaHunan 410073People’s Republic of China Nanhu Laser Laboratory National University of Defense TechnologyChangshaHunan 410073People’s Republic of China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006People’s Republic of China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006People’s Republic of China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006People’s Republic of China Institute for Functional Intelligent Materials National University of SingaporeSingapore 117544Singapore Department of Materials Science and Engineering National University of SingaporeSingapore 117575Singapore

Nanoscale light sources with high speed of electrical modulation and low energy consumption are key components for nanophotonics and *** record-high carrier mobility and ultrafast carrier dynamics of graphene make it promising as an atomically thin light emitter which can be further integrated into arbitrary platforms by van der Waals ***,due to the zero bandgap,graphene is difficult to emit light through the interband recombination of carriers like conventional ***,we demonstrate ultrafast thermal light emitters based on suspended graphene/hexagonal boron nitride(Gr/hBN)*** in biased graphene are significantly heated up to 2800 K at modest electric fields,emitting bright photons from the near-infrared to the visible spectral *** eliminating the heat dissipation channel of the substrate,the radiation efficiency of the suspended Gr/hBN device is about two orders of magnitude greater than that of graphene devices supported on SiO2or *** demonstrate that hot electrons and low-energy acoustic phonons in graphene are weakly coupled to each other and are not in full thermal *** cooling ofhigh-temperature hot electrons to low-temperature acoustic phonons is enabled by the significant near-field heat transfer at the highly localized Gr/hBN interface,resulting in ultrafast thermal emission with up to 1 GHz bandwidth under electrical *** is found thatsuspending the Gr/hBN heterostructures on the SiO2trenches significantly modifies the light emission due to the formation of the optical cavity and showed a~440%enhancement inintensity at the peak wavelength of 940 nm compared to the black-body thermal *** demonstration of electrically driven ultrafast light emission from suspended Gr/hBNheterostructures sheds the light on applications of graphene heterostructures in photonicintegrated circuits,such as broadband light sources and ultrafast thermo-optic phase modulat

关键词： suspended graphene ultrafast light emitter van der Waals heterostructures thermal radiation electron–phonon interaction

An investigation on topologies of hybrid manifold,impinging-jet nozzle and micro-pin-fin heat sinks

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Science China(Technological Sciences) 2024年第4期67卷 1061-1076页

作者： SHI QianLei YAO XiaoLe liu Qian qin Le JU Xing XU Chao Key Laboratory of Power Station Energy Transfer Conversion and System of MOE North China Electric Power UniversityBeijing 102206China

The hybrid manifold micro-pin-fin(MMPF)heat sink combined nozzle jets is an option for large-scale integrated circuits(LSI).The demond for uniform and ultra-high heat flux removal by MMPF heat sink has not been adequately *** work aims to solve the problem of fluid *** proposed basic tiling topologies,including square,regular hexagon,30°rhombus,and 60°rhombus topologies,provide different organized fluid flows and heat transfer *** present study focuses on comparing these topologies according to independent porous medium parameters,such as nozzle pore size D_(Z),flow pore size D_(X,Y),and porosityε.The results show that the square topology achieves the smallest total thermal resistance R_(tot)value of0.0975×10^(-4)K m^2/W,while the hexagon topology achieved the highest value of COP/?T,which was 2033.9 K^(-1).According to the sensitivity analysis results,the optimal total thermal resistance can be obtained by balancing the influences of nozzle pore size,flow pore size,and *** optimal pressure drop can be obtained by maximizing the porosity.

关键词： heat sink ultra-high heat flux manifold micro-pin-fin impinging-jet topology