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Inhibitory Effect of LPS on the Proliferation of Oligodendrocyte Precursor Cells through the Notch Signaling Pathway inIntrauterine Infection-induced Rats

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Current Medical Science 2018年第5期38卷 840-846页

作者： yan-qin YING Xue-qin yan Sheng-juan JIN yan LIANG Ling HOU Wan-ting NIU Xiao-ping LUO Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Children Healthcare Zhongshan Boai Hospital Affiliated to Southern Medical UniversityZhongshan 528403China VA Boston Healthcare System Department of OrthopedicsBrigham and Women's HospitalHarvard Medical SchoolBoston 02130USA

Periventricular white matter injury (PWMI)is very common in survivors of premature birth,and the final outcomes are a reduction in myelinated neurons leading to white matter *** and (or) why the oligodendrocyte lineage develops abnormally and myelination is reduced is a hot topic in the *** study focuses on the effect of intrauterine inflammation on the proliferation of oligodendrocyte lineage cells and the underlying *** (LPS)(300μg/kg)was intraperitoneally injected into pregnant Sprague-Dawley rats at embryonic days 19 and 20 to establish a rat model of intrauterine infection-induced white matter *** callosum tissues were collected at postnatal day 14(P14)to quantify the number of oligodendrocytes,the number and proliferation of oligodendrocyte precursor cells (OPCs), and the expression of myelin proteins (MBP and PLP).Furthermore,the expression of Writ and Notch signaling-related proteins was *** results showed that the number of oligodendrocytes in the corpus callosum tissues of LPS-treated rats was reduced,and the expression levels of myelinating proteins were *** analysis showed that the Notch signaling pathway was down-regulated in the LPS-treated *** results indicate that intrauterine LPS may inhibit the proliferation of OPCs by down-regulating the Notch rather than the Writ signaling pathway,leading to hypomyelination of white matter.

关键词： oligodendrocyte precursor cells intrauterine infection hypomyelination lipopolysaccharide signaling pathway

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Synthesis of cage-like octa(trimethylsiloxy)silsesquioxane

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Chinese Science Bulletin 1999年第22期44卷 2044-2047页

作者： Chunye Hu yan qin Changyou Yuan Chinese Acad Sci Inst Chem Beijing 100080 Peoples R China

Cage-like octa(trimethylsiloxy)silsesquioxane [(Me3SiO)SiO1.5]8 has been synthesized via the trimethylsilylation of cubic tetramethylammonium silicate octamer [(Me4NO)-SiO1.5]8 with chlorotrimethylsilane. The silicate octamer can be selectively formed by the reaction of tetraethoxysilane Si(OEt)4 with aqueous tetramethylammonium hydroxide in equal

关键词： cage-like silsesquioxane silicate Detainer trimethylsilylation.

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On-line optical determination of floc size of Fe(Ⅲ) coagulants

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Journal of Environmental Sciences 2005年第6期17卷 921-925页

作者： WANG yan GAO Bao-yu YUE qin-yan ZHOU Wei-zhi CHU Yong-bao School of Environmental Science and Engineering Shandong University Jinan 250100 China

This study investigated the floc aggregation, average floc size, floc size variance and floc growth velocity when ferric chloride （FeCl3） and polyferric chloride （PFC） were used to treat the simulated water samples. The factors including coagulant dose, ionic strength and solution pH, which affect the floc aggregation, were studied. Experiments were carried out in a bench-scale reactor using photometric dispersion analyzer （ PDA）. Results showed that there were great differences between the floc aggregation of PFC and FeCl3. The average floc size and fioc growth velocity of PFC were much larger than those of FeCl3. Compared with FeCl3, PFC gave a better coagulation performance in wider range of pH, dosage and ionic strength. It was also found that the coagulation efficiency of PFC did not depend on average floc size but on floc growth velocity.

关键词： coagulants photometric dispersion analyzer(PDA) floc aggregation water treatment

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A simple method to extract glacier length based on Digital Elevation Model and glacier boundaries for simple basin type glacier

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Journal of Mountain Science 2017年第9期14卷 1776-1790页

作者： JI qin yanG Tai-bao HE Yi qin yan DONG Jun HU Fan-sheng Institute of Glaciology and Ecogeography College of Earth and Environmental Sciences Lanzhou University Lanzhou 73000 China Faculty of Geomatics Lanzhou Jiaotong University Lanzhou 730000 China Research Center for Arid Area and Desert College of Earth and Environmental Sciences Lanzhou University Lanzhou 730000 China

Glacier length is a key morphological element that has many glaciological applications; however, it is often difficult to determine, especially for glaciers that cover larger spatial areas or those that exhibit frequent temporal change. In this paper, we describe a new Arc GIS-based method that can derive glacier flow lines for determining glacier length based on digital elevation model and glacier outlines. This method involves(1) extraction of the highest and lowest points on a glacier,(2) calculation of 10-m contour lines on the glacier from 10 m to 100 m height, and(3) connection of the midpoints of each contour line with the highest and the lowest points in order to create a flow line, which is subsequently smoothed. In order to assess the reliability of this method, we tested the algorithm's results against flow lines calculated using field measurements, analysing data from the Chinese Glacier Inventory, and manual interpretation. These data showed that the new automated method is effective in deriving glacier flow lines when contour lines are relatively large; in particular, when they are between 70 m and 100 m. Nonetheless, a key limitation of the algorithm is the requirement to automatically delete repeated and closed curves in the pre-treatment processes. In addition to calculating glacier flow lines for derivation of glacier length, this method also can be used to effectively determine glacier terminus change.

关键词： Glacier length Flow lines Glacier boundary DEM Arc GIS

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Quantitative Study of Iron Metabolism-related Genes Expression in Rat

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Biomedical and Environmental Sciences 2013年第10期26卷 808-819页

作者： LI yan qin BAI Bin ZHENG Quan qing yan Hong ZHUANG Gui Hua Department of Public Health College of MedicineXi’an Jiaotong University Department of Orthopedics The First Affiliated Hospital of the College of MedicineXi’an Jiaotong University

Objective To investigate the multiple iron metabolism-related genes expression, its regulation by iron and the expression correlation among the genes in rat tissues. Methods Two groups （n=30） of Sprague-Dawley female weanling rats were fed with a control diet and an iron deficient diet respectively for 4 weeks. All rats were then sacrificed, and blood and tissue samples were collected. The routine blood examination was performed with a veterinary automatic blood cell analyzer. Elemental iron levels in liver, spleen and serum were determined by atomic absorption spectrophotometry. The mRNA expression of genes was detected by real-time fluorescence quantitative PCR. Results After 4 weeks, the hemoglobin （Hb） level and red blood cell （RBC） count were significantly lower in the iron deficient group compared with those in the control group. The iron levels in liver, spleen and serum in the iron deficient group were significantly lower than those in the control group. In reference to small intestine, the relative expression of each iron-related gene varied in the different tissues. Under the iron deficiency, the expression of these genes changed in a tissue-specific manner. The expression of most of the genes significantly correlated in intestine, spleen and lung, but few correlated in liver, heart and kidney. Conclusion Findings from our study provides new regulation by iron and correlation among the mRNA divalent metal transporter 1, ferritin, iron regulation protein, hepcidin, ferroportin 1 and hephaestin in intesti understandings about the relative expression, expressions of transferrin receptors 1 and 2, proteins 1 and 2, hereditary hemochromatosis ne, liver, spleen, kidney, heart, and lung of rat.

关键词： Iron Tfr Dmtl Hepcidin Ferroportin 1 Hephaestin

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Structure and Magnetic Properties of a Manganese Complex with 1-Carboxymethylpyridinium-3-carboxylate

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Chinese Journal of Structural Chemistry 2013年第12期32卷 1761-1766页

作者： WANG yan-qin LIU Zhi-Liang GAO En-qing College of Chemistry and Chemical Engineering Inner Mongolia University Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistryEast China Normal University

One complex with a zwitterionic dicarboxylate ligand, [Mn（L）（N3）]n 1 （L = 1-car- boxymethylpyridinium-3-carboxylate）, was synthesized and structurally characterized. Complex 1 crystallizes in triclinic, space group P1 with a = 7.570（2）, b = 7.808（2）, c = 9.232（3） A, β= 94.450（19）°, V= 489.0（3） A3, Z = 2, Mr = 277.11, Dc = 1.882 g/cm3, F（000） = 278,μ = 1.359 mm-1, S = 1.021, the final R = 0.0509 and wR = 0.1149 for 2236 observed reflections with 1 〉 2σ（I）. Complex 1 consists of two-dimensional coordination layers in which the anionic uniform chains with mixed triple bridges （one end-on （EO） azide and two syn-syn carboxylates） are cross-linked by the flexible cationic N-methylpyridinium spacers. Magnetic studies demonstrated that the triple bridge in 1 transmits antiferromagnetic coupling between the Mn（Ⅱ） ions.

关键词： zwitterionic ligand manganese complex,structure mixed bridges magnetic properties

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Revisiting the dichotomy of early-type galaxies

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Research in Astronomy and Astrophysics 2014年第2期14卷 144-158页

作者： yan-qin He Cai-Na Hao Xiao-yang Xia University of Chinese Academy of Sciences National Astronomical Observatories Chinese Academy of Sciences Tianjin Astrophysics Center Tianjin Normal University

We study the relationship between isophotal shapes, central light profiles and kinematic properties of early-type galaxies （ETGs） based on a compiled sample of 184 ETGs. These sample galaxies are included in Data Release 8 of the Sloan Digital Sky Survey and have central light profiles and kinematic properties available from the literature, which were compiled from observations by the Hubble Space Telescope and the ATLAS3D integral-field spectrograph, respectively. We find that there is only a weak correlation between the isophotal shape （a4/a） and the central light profile （within 1 kpc） of ETGs. About two-fifths of ＂core＂ galaxies have disky isophotes, and one-third of ＂power-law＂ galaxies are boxy. Our statistical results also show that there are weak correlations between galaxy luminosity and dynamical mass with a4/a, but such correlations are tighter with a central light profile. Moreover, no clear link has been found between the isophotal shape and the Sersic index. Comparisons show that there are similar correlations between a4/a and ellipticity, and between a4/a and specific angular momentum ARo/2 for ＂power-law＂ ETGs, but there are no such correlations for ＂core＂ ETGs. Therefore, we speculate that the bimodal classifications of ETGs are not as simple as previously thought, though we also find that the disky ETGs with highest a4/a are more elongated and fast rotators.

关键词： galaxies: elliptical and lenticular cD -- galaxies: kinematics and dynamics -- galaxies: photometry -- galaxies: structure

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Curcumin protects against staurosporine toxicity in rat neurons

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Neuroscience Bulletin 2012年第5期28卷 606-610页

作者： Xiao-yan qin Ji-Hui Lv Jia Cui Xue Fang yan Zhang State Key Laboratory of Biomembrane and Membrane Biotechnology College of Life Sciences Peking University Beijing 100871 Laboratory of Biotechnology and State Key Laboratory of Chinese Ethnic Minority Traditional Medicine College of Life & Environmental Science Minzu University of China Beijing 100081 China Beijing Geriatric Hospital Beijing 100095 China

Objective Curcumin is extracted from the turmeric plant （Curcuma longa Linn.） and is widely used as a food additive and traditional medicine. The present study investigated the activity of curcumin against staurosporine （STS） toxicity in cell culture. Methods Rat hippocampal neurons in primary culture were exposed to STS （20 μmol/L） and treated with curcumin （20 μmol/L）. Cell viability was tested by MTT assay and reactive oxygen species （ROS） were measured using the MitoSOX red mitochondrial superoxide indicator. Western blot was used to assess changes in the levels of caspase-3 （Csp3）, heat shock protein 70 （Hsp70） and Akt. Results The results showed that curcumin protects against STS-induced cytotoxicity in rat hippocampal neurons. Csp3, Hsp70, Akt and ROS activation may be involved in this protection. Conclusion Curcumin could be a potential drug for combination with STS in cancer treatment to reduce the unwanted cytotoxicity of STS.

关键词： curcumin staurosporine-induced cytotoxicity hippocampal neurons caspase-3 Akt Hsp70 reactive oxygen species cancer treatment

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Heavy metal pollution in tidal zones of Bohai Bay using the dated sediment cores

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Journal of Environmental Sciences 2006年第3期18卷 610-615页

作者： qin yan-wen MENG Wei ZHENG Bing-hui SU Yi-bin River and Coastal Environment Research Center Chinese Research Academy of Environmental Sciences Beijing 100012 China

Three sediment cores were collected in November 2003 from Dagu estuary to Qikou estuary. The main polluted heavy metals in the sediment of tidal zones for the Bohai Bay have been found by analyzing the relationship among the contents of heavy metals, the contents of geochemical elements （Fe, AI and Mn） and the size of grain. The dominating contaminative elements in tidal sediments of Bohai Bay are Pb, Zn and Cd. Their contents are higher than the corresponding upper limit of environmental background values and they have very faint correlation with the corresponding contents of geochemical elements and the size of grain, indicating the anthropogenic enrichment. Especially, the preliminary study on the pollution sources and the history of heavy metals in the Dagu estuary has been done using the dated results. The contamination by Zn and Cd also started in the middle 1950s, while the contamination by Pb appeared in the early 1940s. The pollution by Zn and Cd mainly originate from sewage discharge, while the pollution by Pb has many sources, like atmosphere deposition and industrial discharRe.

关键词： Bohai Bay tidal zone the dated sediment core heavy metal pollution

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Effects of inclination angles of disc cutter on machining quality of Nomex honeycomb core in ultrasonic cutting

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Frontiers of Mechanical Engineering 2021年第2期16卷 285-297页

作者： Yidan WANG Renke KANG yan qin Qian MENG Zhigang DONG Key Laboratory for Precision and Non-traditional Machining Technology of Ministry of Education Dalian University of TechnologyDalian 116024China

Ultrasonic cutting with a disc cutter is an advanced machining method for the high-quality processing of Nomex honeycomb *** machining quality is influenced by ultrasonic cutting parameters,as well as tool orientations,which are determined by the multi-axis machining requirements and the angle control of the cutting ***,in existing research,the effect of the disc cutter orientation on the machining quality has not been studied in depth,and practical guidance for the use of disc cutters is *** this work,the inclined ultrasonic cutting process with a disc cutter was analyzed,and cutting experiments with different inclination angles were *** theoretical residual height models of the honeycomb core,as a result of the lead and tilt angles,were established and verified with the results obtained by a linear laser displacement *** shows that the residual height of the honeycomb core,as a result of the tilt angle,is much larger than that as a result of the lead ***,the tearing of the cell wall on the machined surface was observed,and the effects of the ultrasonic vibration,lead angle,and tilt angle on the tear rate and tear length of the cell wall were *** results revealed that ultrasonic vibration can effectively decrease the tearing of the cell wall and improve the machining *** in the tilt angle have less effect than changes in the lead angle on the tearing of the cell *** determination of inclination angles should consider the actual processing requirements for the residual height and the machining quality of the cell *** study investigates the influence of the inclination angles of a disc cutter on the machining quality of Nomex honeycomb core in ultrasonic cutting and provides guidelines for machining.

关键词： Nomex honeycomb core disc cutter inclined ultrasonic cutting machining quality

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