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BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： qin wang qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu Mao-Ju Tang Man Luo Xiao-Wu Zhong Qiang Ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

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Homologous temperature of olivine: Implications for creep of the upper mantle and fabric transitions in olivine

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Science China Earth Sciences 2016年第6期59卷 1138-1156页

作者： wang qin State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering Nanjing University

The homologues temperature of a crystalline material is defined as T/Tm, where T is temperature and Tm is the melting （solidus） temperature in Kelvin. It has been widely used to compare the creep strength of crystalline materials. The melting temperature of olivine system, （Mg,Fe）2SiO4, decreases with increasing iron content and water content, and increases with confining pressure. At high pressure, phase transition will lead to a sharp change in the melting curve of olivine. After calibrating previous melting experiments on fayalite （Fe2SiO4）, the triple point of fayalite-Fe2SiO4 spinel-liquid is determined to be at 6.4 GPa and 1793 K. Using the generalized means, the solidus and liquidus of dry olivine are described as a function of iron content and pressure up to 6.4 GPa. The change of T/Tm of olivine with depth allows us to compare the strength of the up- per mantle with different thermal states and olivine composition. The transition from semi-brittle to ductile deformation in the upper mantle occurs at a depth where T/Tm of olivine equals 0.5. The lithospheric mantle beneath cratons shows much smaller T/Tm of olivine than orogens and extensional basins until the lithosphere-asthenosphere boundary where T/Tm 〉 0.66, suggesting a stronger lithosphere beneath cratons. In addition, T/Tm is used to analyze deformation experiments on olivine. The results indicate that the effect of water on fabric transitions in olivine is closely related with pressure. The hydrogen-weakening effect and its relationship with T/Tm of olivine need further investigation. Below 6.4 GPa （〈200 kin）, T/TIn of olivine controls the transition of dislocation glide from [100] slip to [001] slip. Under the strain rate of 10-12-10-15 s-1 and low stress in the upper mantle, the [100]（010） slip system （A-type fabric） becomes dominant when T/TIn〉 0.55-0.60. When T/Tm〈 0.55-0.60, [001] slip is easier and low T/Tm favors the operation of [001]（100） slip system （C-type fabric）. This is consistent with

关键词： Olivine Homologous temperature Lattice preferred orientation Water Seismic anisotropy Upper mantle

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The Coarse l^(p)-Novikov Conjecture and Banach Spaces with Property(H)

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 193-220页

作者： Huan wang qin wang Research Center for Operator Algebras School of Mathematical SciencesEast China Normal UniversityShanghai 200241China Key Laboratory of MEA Ministry of Educationand Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai 200241China

In this paper,for 1

关键词： The coarse l^(p)-Novikov conjecture Banach spaces with Property(H) Coarse geometry K-Theory

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Persistence Approximation Property for Maximal Roe Algebras

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Chinese Annals of Mathematics,Series B 2020年第1期41卷 1-26页

作者： qin wang Zhen wang Research Center for Operator Algebras School of Mathematical SciencesShanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal UniversityShanghai 200241China Research Center for Operator Algebras School of Mathematical SciencesEast China Normal UniversityShanghai 200241China

Persistence approximation property was introduced by Hervé Oyono-Oyono and Guoliang Yu. This property provides a geometric obstruction to Baum-Connes conjecture. In this paper, the authors mainly discuss the persistence approximation property for maximal Roe algebras. They show that persistence approximation property of maximal Roe algebras follows from maximal coarse Baum-Connes conjecture. In particular, let X be a discrete metric space with bounded geometry, assume that X admits a fibred coarse embedding into Hilbert space and X is coarsely uniformly contractible, then Cmax*(X) has persistence approximation property. The authors also give an application of the quantitative K-theory to the maximal coarse Baum-Connes conjecture.

关键词： Quantitative K-theory Persistence approximation property Maximal coarse Baum-Connes conjecture Maximal Roe algebras

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p-adic Transcendence and p-adic Transcendence Measures for the Values of Mahler Type Functions

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Acta Mathematica Sinica,English Series 2006年第1期22卷 187-194页

作者： Tian qin wang Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 P. R. China College of Computer Sciences Henan University Kaifeng 475001 P. R. China

We prove the p-adic transcendence and p-adic transcendence measures for the values of some Mahler type functions.

关键词： p-adic transcendence p-adic transcendence measure Mahler type function

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Lightweight and Manageable Digital Evidence Preservation System on Bitcoin

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Journal of Computer Science & Technology 2018年第3期33卷 568-586页

作者： Mingming wang Qianhong Wu Bo qin qin wang Jianwei Liu Zhenyu Guan School of Electronic and Information Engineering Beihang University Beijing 100191 China School of Information Renmin University of China Beijing 100872 China

An effective and secure system used for evidence preservation is essential to possess the properties of anti- loss, anti-forgery, anti-tamper and perfect verifiability. Traditional architecture which relies on centralized cloud storage is depressingly beset by the security problems such as incomplete confidence and unreliable regulation. Moreover, an expensive, inefficient and incompatible design impedes the effort of evidence preservation. In contrast, the decentralized blockchain network is qualified as a perfect replacement for its secure anonymity, irrevocable commitment, and transparent traceability. Combining with subliminal channels in blockchain, we have weaved the transaction network with newly designed evidence audit network. In this paper, we have presented and implemented a lightweight digital evidence-preservation architecture which possesses the features of privacy-anonymity, audit-transparency, function-scalability and operation-lightweight. The anonymity is naturally formed from the cryptographic design, since the cipher evidence under encrypted cryptosystem and hash-based functions leakages nothing to the public. Covert channels are efficiently excavated to optimize the cost, connectivity and security of the framework, transforming the great computation power of Bitcoin network to the value of credit. The transparency used for audit, which relates to the proof of existence, comes from instant timestamps and irreversible hash functions in mature blockchain network. The scalability is represented by the evidence chain interacted with the original blockchain, and the extended chains on top of mainchain will cover the most of auditors in different institutions. And the lightweight, which is equal to low-cost, is derived from our fine-grained hierarchical services. At last, analyses of efficiency, security, and availability have shown the complete accomplishment of our system.

关键词： blockchain covert channel data auditing digital evidence

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Permanence of Metric Sparsification Property under Finite Decomposition Complexity

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Chinese Annals of Mathematics,Series B 2014年第5期35卷 751-760页

作者： qin wang Wenjing wang Xianjin wang Research Center for Operator Algebras Department of Mathematics East China Normal University Department of Applied Mathematics Donghua University College of Mathematics and Statistics Chongqing University

The notions of metric sparsification property and finite decomposition complexity are recently introduced in metric geometry to study the coarse Novikov conjecture and the stable Borel conjecture. In this paper, it is proved that a metric space X has finite decomposition complexity with respect to metric sparsification property if and only if X itself has metric sparsification property. As a consequence, the authors obtain an alternative proof of a very recent result by Guentner, Tessera and Yu that all countable linear groups have the metric sparsification property and hence the operator norm localization property.

关键词： Metric space Metric sparsification Asymptotic dimension Decomposi- tion complexity Permanence property

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Hyper-parameter optimization of multiple machine learning algorithms for molecular property prediction using hyperopt library

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Chinese Journal of Chemical Engineering 2022年第12期52卷 115-125页

作者： Jun Zhang qin wang Weifeng Shen School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China School of Chemistry and Chemical Engineering Chongqing University of Science&TechnologyChongqing 401331China Chongqing Key Laboratory of Theoretical and Computational Chemistry Chongqing 400044China

Due to outstanding performance in cheminformatics,machine learning algorithms have been increasingly used to mine molecular properties and biomedical big *** performance of machine learning models is known to critically depend on the selection of the hyper-parameter ***,many studies either explored the optimal hyper-parameters per the grid searching method or employed arbitrarily selected hyper-parameters,which can easily lead to achieving a suboptimal hyper-parameter *** this study,Hyperopt library embedding with the Bayesian optimization is employed to find optimal hyper-parameters for different machine learning *** drug discovery datasets,including solubility,probe-likeness,h ERG,Chagas disease,tuberculosis,and malaria,are used to compare different machine learning algorithms with ECFP6 *** contribution aims to evaluate whether the Bernoulli Na?ve Bayes,logistic linear regression,Ada Boost decision tree,random forest,support vector machine,and deep neural networks algorithms with optimized hyper-parameters can offer any improvement in testing as compared with the referenced models assessed by an array of metrics including AUC,F1-score,Cohen’s kappa,Matthews correlation coefficient,recall,precision,and *** on the rank normalized score approach,the Hyperopt models achieve better or comparable performance on 33 out 36 models for different drug discovery datasets,showing significant improvement achieved by employing the Hyperopt *** open-source code of all the 6 machine learning frameworks employed in the Hyperopt python package is provided to make this approach accessible to more scientists,who are not familiar with writing code.

关键词： Machine learning Prediction Optimal design Hyper-parameter optimization Hyperopt library

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Ideals in the Roe Algebras of Discrete Metric Spaces with Coefficients in B(H)

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Chinese Annals of Mathematics,Series B 2009年第2期30卷 139-144页

作者： Yingjie HU qin wang Department of Applied Mathematics Donghua University Shanghai 201620 China

The notion of an ideal family of weighted subspaces of a discrete metric space X with bounded geometry is introduced. It is shown that, if X has Yu’s property A, the ideal structure of the Roe algebra of X with coefficients in B(H) is completely characterized by the ideal families of weighted subspaces of X, where B(H) denotes the C*-algebra of bounded linear operators on a separable Hilbert space H.

关键词： Roe algebra Ideal Metric space Coarse geometry Band-dominatedoperator

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Nanomedicines for the treatment of rheumatoid arthritis:State of art and potential therapeutic strategies

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1158-1174页

作者： qin wang Xianyan qin Jiyu Fang Xun Sun Key Laboratory of Advanced Technologies of Materials Ministry of Education and School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Advanced Materials Processing and Analysis Center and Department of Materials Science and Engineering University of Central FloridaOrlandoFL 32816USA Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacySichuan UniversityChengdu 610041China

Increasing understanding of the pathogenesis of rheumatoid arthritis(RA)has remarkably promoted the development of effective therapeutic regimens of ***,the inadequate response to current therapies in a proportion of patients,the systemic toxicity accompanied by longterm administration or distribution in non-targeted sites and the comprised efficacy caused by undesirable bioavailability,are still unsettled problems lying across the full remission of *** far,these existing limitations have inspired comprehensive academic researches on nanomedicines for RA treatment.A variety of versatile nanocarriers with controllable physicochemical properties,tailorable drug release pattern or active targeting ability were fabricated to enhance the drug delivery efficiency in RA *** review aims to provide an up-to-date progress regarding to RA treatment using nanomedicines in the last 5 years and concisely discuss the potential application of several newly emerged therapeutic strategies such as inducing the antigen-specific tolerance,pro-resolving therapy or regulating the immunometabolism for RA treatments.

关键词： Nanomedicines Rheumatoid arthritis Targeted drug delivery Liposome Micelle Stimulus-responsive delivery systems Immune tolerance Inflammation resolution

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