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杜仲叶黄酮纯化及其抗炎活性研究

应用化工 2024年第8期53卷 1823-1826页

作者：杨兴变陈震陈伟苏娇娇何珺欧琴贵州大学生化工程中心贵州贵阳550025 贵州贝因特生物技术有限公司贵州贵阳550025 武汉武药制药有限公司湖北武汉430000

对杜仲叶总黄酮提取物及其4种单体进行纯化,并对其抗炎作用进行初步研究。含量65.19%总黄酮杜仲叶提取物通过液-质联用确定其活性组分,经95%乙醇萃取,萃取料液比为1 g∶10 mL,萃取次数为1次,得到80.35%总黄酮含量杜仲叶提取物,通过半制... 详细信息

对杜仲叶总黄酮提取物及其4种单体进行纯化,并对其抗炎作用进行初步研究。含量65.19%总黄酮杜仲叶提取物通过液-质联用确定其活性组分,经95%乙醇萃取,萃取料液比为1 g∶10 mL,萃取次数为1次,得到80.35%总黄酮含量杜仲叶提取物,通过半制备液相色谱分离,得到槲皮素-3-O-桑布双糖苷、异槲皮苷、芦丁、紫云英苷4种单体黄酮化合物;经测定,4种杜仲叶单体黄酮化合物和杜仲叶18.14%总黄酮提取物及其78.78%总黄酮提取物均有一氧化氮致炎抗炎活性,其中含量为78.78%的总黄酮提取物抗炎活性最好,而单体化合物的一氧化氮生成抑制率为紫云英苷>芦丁>槲皮素-3-O-桑布双糖苷>异槲皮苷。

关键词：杜仲叶黄酮提取物黄酮纯化抗炎活性测试

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格式塔原则下的建筑群空间分布智能理解

浙江师范大学学报（自然科学版） 2024年第1期47卷 64-71页

作者：张凯业汪逸梁勤欧浙江师范大学地理与环境科学学院浙江金华321004

在格式塔原则下对建筑群进行聚类是计算机理解建筑群空间分布特征并实现地图自动综合的基础.在格式塔原则约束下,首先,利用最小生成树的阈值聚类及参数聚类,实现了对集中和分散均匀排列建筑群空间分布特征的挖掘,并利用C_(v)^(-)值定量... 详细信息

在格式塔原则下对建筑群进行聚类是计算机理解建筑群空间分布特征并实现地图自动综合的基础.在格式塔原则约束下,首先,利用最小生成树的阈值聚类及参数聚类,实现了对集中和分散均匀排列建筑群空间分布特征的挖掘,并利用C_(v)^(-)值定量评价了挖掘质量;其次,提出了阈值聚类和参数聚类的异同,以及阈值聚类具有局限性的原因;最后,根据建筑物语义特征获得最终聚类结果.试验表明:1)传统的MST阈值聚类不能维持分散均匀排列建筑群的空间分布特征;2)MST参数聚类的适应性要高于阈值聚类,更加符合人类的视觉认知.该方法更有助于提高计算机对建筑群空间分布的智能理解能力.

关键词：建筑群空间分布特征格式塔原则最小生成树参数聚类阈值聚类

Effects of Scutellaria Baicalensis on Activity and Biofilm Formation of Klebsiella Pneumoniae

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Chinese Medical Sciences Journal 2016年第3期31卷 180-184页

作者： Wei Chen Bei Li Shuai Li Yi-wen ou qin ou The First School of Clinical Medicine Hubei University of Medicine Department of Medical Microbiology Hubei University of Medicine

Objective To explore the effects of Scutellaria baicalensis on activity and biofilm formation of Klebsiella pneumonia(Kp).Methods The broth and agar dilution methods were carried out to determine minimum inhibitory concentration and minimum bactericidal concentration of Scutellaria baicalensis for ***-32 system was used to assay TW518 susceptibility to *** biofilms were formed in vitro and stained with Bac Light Live/Dead *** class integron geneⅠ1 m RNA expression was analyzed with *** The minimum inhibitory concentration of Scutellaria baicalensis on TW518 identified as a Kp colony was 32 mg/ml,and minimum bactericidal concentration was 64 mg/*** baicalensis and broad-spectrum penicillin,cephalosporin,quinolones,or beta-lactamase had synergistic bactericidal *** formation activity of Kp treated with Scutellaria baicalensis was significantly lower than that of the control *** class integron geneⅠ1 m RNA expression of TW518 was significantly inhibited by Scutellaria *** Scutellaria baicalensis has sterilization effect on Kp,and Scutellaria baicalensis could effectively inhibit Kp biofilm formation with prolonged *** baicalensis might inhibit Kp biofilm formation through down-regulating integron geneⅠ1 expression.

关键词： Scutellaria baicalensis klebsiella pneumoniae biofilm formation integron geneⅠ1

LiFePO_4 doped with magnesium prepared by hydrothermal reaction in glucose solution

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Chinese Chemical Letters 2008年第3期19卷 345-349页

作者： Xiu qin ou Guang Chuan Liang Jin Sheng Liang Sheng Zhao Xu Xia Zhao Institute of Power Source ＆ Ecomaterials Science Box 1055 Hebei University of Technology Tianjin 300130 China

Lithium iron phosphate （LiFePO4） doped with magnesium was hydrothermally synthesized from commercial LiOH, FeSO4, H3PO4 and MgSO4 with glucose as carbon precursor in aqueous solution. The samples were characterized by X-ray powder diffraction, scanning electron microscopy and constant charge-discharge cycling. The results show that the synthesized powders have been in situ coated with carbon precursor produced from caramel reaction of glucose. At ambient temperature （28±2℃）, the electrochemical performances of LiFePO4 prepared exhibit the high discharge capacity of 135 mAh g^-1 at 5C and good capacity retention of 98% over 90 cycles. The excellent electrochemical performances should be correlated with the intimate contact between carbon and LiFePO4 primary and secondary particles, resulting from the in situ formation of carbon precursor/carbon, leading to the increase in conductivity of LiFePO4.

关键词： Lithium iron phosphate Mg doping Hydrothermal reaction Glucose Carbon coated

The Influence of SelW on GSH and GPx after Post-Transcriptional Gene Silencing in Mouse Skeletal Muscle Cells

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畜牧兽医学报 2009年第S1期40卷 62-66页

作者： WANG Xiao-long XU Kai qin ou-ju CHEN Xiao-feng YANG Chuan-ping Wildlife Medicine Dept. Wildlife Resource CollegeNortheast Forestry University Key Laboratory of Forest Tree Genetic Improvement and Biotechnology of Ministry of Education Northeast Forestry University

The expression of Selenoprotein W(SelW)in C2C12 skeletal muscle cells was specifically decreased to examine its influence on the amount of glutathione(GSH)and the activity of glutathione peroxidase(GPx).SelW knock-down was performed by RNA interference(RNAi)in cultured muscle cells and verified by Real-time PCR and Western *** addition,cell viability,GSH content and GPx activity were *** results showed that the mRNA level and protein expression of SelW were decreased successfully by 71.9%and 68.8%relative to control values,cell viability decreased by 21.5%,GSH increased by 29.76%,and GPx increased by 47.58%.WST assay showed that compared with blank control,the value of positive group dropped 21.5%;In GSH and GPx assay,compared with blank control the positive group increased29.76%and 47.58%*** conclusion,SelW knock-down by RNAi caused significant cytotoxity in skeletal muscle cells and led to compensatory increases in GSH content and GPx *** findings are consistent with the suggestions from bioinformatics indicating an antioxidative role for SelW in skeletal muscle cells.

关键词： SelW GSH GPx anti-oxidation skeletal muscle cell

A novel multi-channel CNN-LSTM and transformer-based network for diesel engine misfire diagnosis under different noise conditions

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Science China(Technological Sciences) 2024年第9期67卷 2965-2967页

作者： LI ou LEI JunBo qin ChengJin ZHANG ZhiNan TAO JianFeng LIU ChengLiang State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Misfire fault, as a major fault of diesel engines, usually occurs because of low fuel quality, insufficient compression, ignition system failure, *** engines may experience issues such as reduced power, increased fuel consumption, and increased noise when misfire happens. Therefore, timely detection and diagnosis of diesel engine misfire faults are of great significance in the industry [1].

关键词： Diesel diagnosis network

LOOKING FOR'DROMA'Seventy years of Tibetan stories behind“Droma”

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China Report ASEAN 2021年第6期6卷 42-45页

作者： Norbu Tsering Wang qin’ou 不详

“ou have the name of a flower,beautiful Droma *** have the smile of a flower,beautiful Droma La.”These lines are from Droma,a popular Tibetan song celebrating the beauty of Tibetan *** Tibet,women are often referred to as“Droma,”and many use it as a given *** word“Droma”has become *** who are Dromas?What are Dromas like?What forces shape them?We trekked across the vast Tibetan plateau in search of Dromas and found profound stories against a backdrop of changing times.

关键词： Tibetan beautiful plateau

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基于克隆选择算法的障碍布局分配问题研究

武汉大学学报（信息科学版） 2007年第8期32卷 744-747页

作者：梁勤欧武汉大学资源与环境科学学院武汉市珞喻路129号430079

应用克隆选择算法(clonal selection principle,CLONALG),结合其他模型算法,提出了一套解决障碍布局分配问题的简化流程,并用实验进行了验证,得到了满意的效果。

关键词：人工免疫系统克隆选择算法障碍布局分配问题

Association between inflammatory bowel disease and all-cause dementia:A two-sample Mendelian randomization study

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World Journal of Psychiatry 2024年第1期14卷 15-25页

作者： ou-Lan Liao Si-Yuan Xie Jun Ye qin Du Guo-Chun Lou Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Gastroenterology The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu 322000Zhejiang ProvinceChina

BACKGRouND Numerous observational studies have documented a correlation between inflammatory bowel disease(IBD)and an increased risk of ***,the causality of their associations remains *** To assess the causal relationship between IBD and the occurrence of all-cause dementia using the two-sample Mendelian randomization(MR)*** Genetic variants extracted from the large genome-wide association study(GWAS)for IBD(the International IBD Genetics Consortium,n=34652)were used to identify the causal link between IBD and dementia(FinnGen,n=306102).The results of the study were validated via another IBD GWAS(United Kingdom Biobank,n=463372).Moreover,MR egger intercept,MR pleiotropy residual sum and outlier,and Cochran's Q test were employed to evaluate pleiotropy and ***,multiple MR methods were performed to estimate the effects of genetically predicted IBD on dementia,with the inverse variance weighted approach adopted as the primary *** The results of the pleiotropy and heterogeneity tests revealed an absence of significant pleiotropic effects or heterogeneity across all genetic variants in outcome *** evidence of a causal effect between IBD and the risk of dementia was identified in the inverse variance weighted[odds ratio(OR)=0.980,95%CI:0.942-1.020,P value=0.325],weighted median(OR=0.964,95%CI:0.914-1.017,P value=0.180),and MR-Egger(OR=0.963,95%CI:0.867-1.070,P value=0.492)*** results were observed in validation *** MR analysis also showed no effect of dementia on the development of ***,MR analysis suggested that IBD and its subtypes did not causally affect allcause dementia and its four subtypes,including dementia in Alzheimer's disease,vascular dementia,dementia in other diseases classified elsewhere,and unspecified *** Taken together,our MR study signaled that IBD and its subentities were not genetically associated with all-cause dementia or its