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Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease

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Neural Regeneration Research 2024年第11期19卷 2467-2479页

作者： Yong Tang Jing Wei Xiao-Fang Wang Tao Long Xiaohong Xiang Liqun Qu Xingxia Wang Chonglin Yu Xingli Xiao xueyuan Hu Jing Zeng qin xu Anguo Wu Jianming Wu Dalian qin Xiaogang Zhou Betty Yuen-Kwan Law Dr.Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao Special Administrative RegionChina Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica Southwest Medical UniversityLuzhouSichuan ProvinceChina Eye School and Key Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection of Chengdu University of TCM ChengduSichuan ProvinceChina School of Basic Medical Sciences Southwest Medical UniversityLuzhouSichuan ProvinceChina Department of Ophthalmology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan ProvinceChina Department of Neurology The First People’s Hospital of NeijiangNeijiangSichuan ProvinceChina

Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer’s disease.Citri Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases,including Parkinson’s and Huntington’s diseases,however,the effect of Citri Reticulatae Semen on Alzheimer’s disease remains unelucidated.In the current study,the anti-apoptotic and autophagic roles of Citri Reticulatae Semen extract on amyloid-beta-induced apoptosis in PC12 cells were first investigated.Citri Reticulatae Semen extract protected PC12 cells from amyloid-beta-induced apoptosis by attenuating the Bax/Bcl-2 ratio via activation of autophagy.In addition,Citri Reticulatae Semen extract was confirmed to bind amyloid-beta as revealed by biolayer interferometry in vitro,and suppress amyloid-beta-induced pathology such as paralysis,in a transgenic Caenorhabditis elegans in vivo model.Moreover,genetically defective Caenorhabditis elegans further confirmed that the neuroprotective effect of Citri Reticulatae Semen extract was autophagy-dependent.Most importantly,Citri Reticulatae Semen extract was confirmed to improve cognitive impairment,neuronal injury and amyloid-beta burden in 3×Tg Alzheimer’s disease mice.As revealed by both in vitro and in vivo models,these results suggest that Citri Reticulatae Semen extract is a potential natural therapeutic agent for Alzheimer’s disease via its neuroprotective autophagic effects.

关键词： Alzheimer’s disease amyloid-beta apoptosis autophagy Caenorhabditis elegans Citri Reticulatae Semen

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Maternal Preconception Serum Alanine Aminotransferase Levels and Risk of Preterm Birth among Reproductive-Aged Women—China,2013-2017

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China CDC weekly 2024年第10期6卷 181-188,I0001页

作者： Chuanyu Zhao Jiajing Jia Hanbin Wu qin xu Xinyi Lyu Meiya Liu xuan Hu Jueming Lei Yuzhi Deng Yuan He Yuanyuan Wang Zuoqi Peng Ya Zhang Hongguang Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai Yan Ying Yang xu Ma National Research Institute for Family Planning BeijingChina National Human Genetic Resources Center BeijingChina Graduate School of Peking Union Medical College BeijingChina Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Summary What is already known about this topic?The significance of maternal liver health concerning preterm birth(PTB)is well recognized;however,there is a gap in understanding the precise influence of preconception s... 详细信息

关键词： Serum precise concerning

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Author correction to “Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy” [Acta Pharm Sin B (2022) 4224-4234]

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Acta Pharmaceutica Sinica B 2024年第2期14卷 897-899页

作者： Zekun Li Yongchun Pan Shiyu Du Yayao Li Chao Chen Hongxiu Song Yueyao Wu Xiaowei Luan qin xu Xiaoxiang Guan Yujun Song Xin Han Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of Medicine&Holistic Integrative MedicineJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative MedicineNanjing University of Chinese MedicineNanjing 210023China College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional MaterialsState Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The authors regret that there is an error in the article Fig.5E due to the mistake of copying and pasting in the process of assembling figures and negligence in the proofreading.Although it does not affect the conclusion,it is an obvious error.The authors have now modified as below.The authors apologize for any inconvenience caused to the journal and readers.

关键词： journal correction conclusion

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Capturability-based Fuzzy Footstep Planner for a Biped Robot with Centroidal Compliance

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Journal of Bionic Engineering 2024年第1期21卷 84-100页

作者： Zihan xu qin Fang Yong Ren Chengju Liu Robot and Artificial Intelligence Lab(RAIL) College of Electronic and Information EngineeringTongji UniversityShanghai 201804China Applied Technology College Soochow UniversitySuzhou 215000China

Compliance motion and footstep adjustment are active balance control strategies from learning human subconscious behaviors.The force estimation without direct end-actuator force measurement and the optimal footsteps based on complex analytical calculation are still challenging tasks for elementary and kid-size position-controlled robots.In this paper,an online compliant controller with Gravity Projection Observer(GPO),which can express the external force condition of perturbations by the estimated Projection of Gravity(PoG)with estimation covariance,is proposed for the realization of disturbance absorption,with which the robustness of the humanoid contact with environments can be maintained.The fuzzy footstep planner based on capturability analysis is proposed,and the Model Predictive Control(MPC)is applied to generate the desired steps.The fuzzification rules are well-designed and give the corresponding control output responding to complex and changeable external disturbances.To validate the presented methods,a series of experiments on a real humanoid robot are conducted.The results verify the effectiveness of the proposed balance control framework.

关键词： Biped walking Centroidal compliance Gravity projection observer Fuzzy footstep planner

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The Monsky Matrices and Non-congruent Numbers

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Algebra Colloquium 2024年第2期31卷 239-262页

作者： Guilin Li Hourong qin Fei xu Department of Mathematics Nanjing UniversityNanjing 210093China 不详

We give some sufficient conditions for non-congruent numbers in terms of the Monsky matrices.Many known criteria for non-congruent numbers can be viewed as special cases of our results.

关键词： congruent elliptic curve Selmer group Monsky matrix non-congruent number

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Estimation of free core nutation parameters and availability of computing options

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Geodesy and Geodynamics 2024年第1期15卷 61-74页

作者： Weiwei Yang Xiaoming Cui Jianqiao xu qingchao Liu Ming qin State Key Laboratory of Geodesy and Earth's Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China University of Chinese Academy of Sciences Beijing 100049China Hubei Luojia Laboratory Wuhan 430079China

The Earth’s Free Core Nutation(FCN) causes Earth tides and forced nutation with frequencies close to the FCN that exhibit resonance effects.High-precision superconducting gravimeter(SG) and very long baseline interferometry(VLBI) provide good observation techniques for detecting the FCN parameters.However,some choices in data processing and solution procedures increase the uncertainty of the FCN parameters.In this study,we analyzed the differences and the effectiveness of weight function and ocean tide corrections in the FCN parameter detection using synthetic data,SG data from thirty-one stations,and the 10 celestial pole offset(CPO) series.The results show that significant discrepancies are caused by different computing options for a single SG station.The stacking method,which results in a variation of0.24-5 sidereal days(SDs) in the FCN period(T) and 10^(3)-10^(4) in the quality factor(Q) due to the selection of the weighting function and the ocean tide model(OTM),can effectively suppress this influence.The statistical analysis results of synthetic data shows that although different weight choices,while adjusting the proportion of diurnal tidal waves involved,do not significantly improve the accuracy of fitted FCN parameters from gravity observations.The study evaluated a series of OTMs using the loading correction efficiency.The fitting of FCN parameters can be improved by selecting the mean of appropriate OTMs based on the evaluation results.Through the estimation of the FCN parameters based on the forced nutation,it was found that the weight function P_(1) is more suitable than others,and different CPO series(after 2009) resulted in a difference of 0.4 SDs in the T and of 103 in the Q.We estimated the FCN parameters for SG(T=430.4±1.5 SDs and Q=1.52×10^(4)±2.5×10^(3)) and for VLBI(T=429.8±0.7 SDs,Q=1.88×10^(4)±2.1×10^(3)).

关键词： Free core nutation Superconducting gravimeter Very long baseline interferometry Weight function Ocean tide model

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Enhanced bright green luminescence from GdOF:Ho^(3+) up-conversion phosphor via Yb^(3+) doping

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Journal of Rare Earths 2024年第2期42卷 263-269,I0002页

作者： Linjun qin Yue Guo Jing xu Lixi Wang Qitu Zhang College of Materials Science and Engineering Nanjing Tech UniversityNanjing211816China

In this paper,a series of GdOF-based green phosphors doped with Ho^(3+) and Yb^(3+) ions was prepared by a simple co-precipitation method.The crystal structure s and optical prope rties were investigated in detail.The intensity of the emission of GdOF:Yb^(3+),Ho^(3+) phosphors is enhanced by the effective energy transfer from Yb^(3+) to Ho^(3+),and the optimal luminescence is achieved with the Ho^(3+)doping amount of 0.1 mol%as well as Yb^(3+) doping amount of 5 mol%.Tunable UC emission of samples is achieved by adjusting the doping concentration of Ho^(3+) or Yb^(3+).The purity of the green UC emission is further improved by enhancing the excitation pumping power.In addition,logarithmic functions of green,red and nearinfrared radiation intensities were calculated versus logarithmic function of pump power for further study.A possible UC luminescence mechanism between Yb^(3+) and Ho^(3+) is discussed based on powerdependent UC luminescence spectrum and decay lifetimes.These results suggest that GdOF:Yb^(3+),Ho^(3+)phosphors with bright and high-purity green UC emission have potential applications in the fields of bioimaging,display and illumination.

关键词： Up-conversion GdOF Lanthanide ions Rare earths

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An effective catalyst carrier SiO_(2):Enhancing catalytic and combustion properties of CuFe_(2)O_(4)on energetic components

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Defence Technology（防务技术） 2024年第2期32卷 383-392页

作者： Li Ding Chong Wan Suhang Chen Zhao qin Kangzhen xu School of Chemical Engineering/Xi'an Key Laboratory of Special Energy Materials Northwest UniversityXi'an710069China Xi’an Modern Chemistry Research Institute Xi'an710065China

To enhance the catalytic activity of copper ferrite(CuFe_(2)O_(4))nanoparticle and promote its application as combustion catalyst,a low-cost silicon dioxide(SiO_(2))carrier was employed to construct a novel CuFe_(2)O_(4)/SiO_(2)binary composites via solvothermal method.The phase structure,morphology and catalytic activity of CuFe_(2)O_(4)/SiO_(2)composites were studied firstly,and thermal decomposition,combustion and safety performance of ammonium perchlorate(AP)and 1,3,5-trinitroperhydro-1,3,5-triazine(RDX)with it affecting were then systematically analyzed.The results show that CuFe_(2)O_(4)/SiO_(2)composite can remarkably either advance the decomposition peak temperature of AP and RDX,or reduce the apparent activation energy at their main decomposition zone.Moreover,the flame propagation rate of RDX was promoted by about 2.73 times with SiO_(2)content of 3 wt%,and safety property of energetic component was also improved greatly,in which depressing the electrostatic discharge sensitivity of pure RDX by about 1.89 times.In addition,the effective range of SiO_(2)carrier content in the binary catalyst is found to be 3 to 5 wt%.Therefore,SiO_(2)opens a new insight on the design of combustion catalyst carrier and will promote the application of CuFe_(2)O_(4)catalyst in solid propellant.

关键词： Copper ferrite Silicon dioxide Combustion catalyst Thermal decomposition Laser ignition

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Cancer organoids:A platform in basic and translational research

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Genes & Diseases 2024年第2期11卷 614-632页

作者： Xin Ma qin Wang Guozheng Li Hui Li Shouping xu Da Pang Department of Breast Surgery Harbin Medical University Cancer HospitalHarbinHeilongjiang 150081China Sino-Russian Medical Research Center Harbin Medical University Cancer HospitalHarbinHeilongjiang 150081China Heilongjiang Academy of Medical Sciences HarbinHeilongjiang 150086China Department of Pharmacology (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China) College of Pharmacy of Harbin Medical UniversityHarbinHeilongjiang 150086China

An accumulation of previous work has established organoids as good preclinical models of human tumors,facilitating translation from basic research to clinical practice.They are changing the paradigm of preclinical cancer research because they can recapitulate the heterogeneity and pathophysiology of human cancers and more closely approximate the complex tissue environment and structure found in clinical tumors than in vitro cell lines and animal models.However,the potential applications of cancer organoids remain to be comprehensively summarized.In the review,we firstly describe what is currently known about cancer organoid culture and then discuss in depth the basic mechanisms,including tumorigenesis and tumor metastasis,and describe recent advances in patient-derived tumor organoids(PDOs)for drug screening and immunological studies.Finally,the present challenges faced by organoid technology in clinical practice and its prospects are discussed.This review highlights that organoids may offer a novel therapeutic strategy for cancer research.

关键词： Drug assays Immunotherapy Mechanism research Organoids Precision medicine

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Two-dimensional porous carbon derived from pollen with enlarged interlayer distance enhanced electrocatalytic oxidation of n-valeraldehyde to octane

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Nano Research 2024年第5期17卷 3455-3461页

作者： Meichun qin Chaolong Liu Shouhen xu Jianguo Tang Institute of Hybrid Materials National Center of International Joint Research for Hybrid Materials TechnologyNational Base of International Sci.and Tech.Cooperation on Hybrid MaterialsCollege of Materials Science and EngineeringQingdao UniversityQingdao266071China Department of Pharmaceutics School of PharmacyQingdao UniversityQingdao266071China

Electrocatalytic n-valeraldehyde oxidation reaction was an inexpensive and eco-friendly method to control n-valeraldehyde contamination and produce high value-added octane.However,low-cost and readily available electrocatalysts with high current efficiency were urgently needed.Herein,two-dimensional porous carbon derived from pollen with enlarged interlayer distance was built by alkali activation method,applying in electrocatalytic n-valeraldehyde oxidation reaction.The enlarged interlayer distance was verified by X-ray diffraction(XRD)and high-angle annular dark-field scanning transmission electron microscope(HAADF-STEM).Electrocatalytic experiments consequences showed activated biomass derived carbon possessed a higher electrocatalytic activity and octane selectivity than unactivated catalyst.Systematic tests and in situ infrared experiments demonstrated that enlarged interlayer distance was positively correlated with specific surface area of catalysts,large specific surface area provided abundant absorption sites,facilitated the adsorption for n-valeraldehyde,and further promoted the transformation of n-valeraldehyde to octane.This work also provides a new avenue for creating high-performance electrocatalysts in terms of lattice engineering.

关键词： biomass derived carbon lattice expansion high specific surface area upgrade of n-valeraldehyde

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