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Anthropogenic Influence on Decadal Changes in Concurrent Hot and Dry Events over China around the Mid-1990s

Advances in Atmospheric Sciences 2024年第2期41卷 233-246页

作者： Qin Su Buwen DONG Fangxing TIAN Nicholas P.KLINGAMAN Yunnan Key Laboratory of Meteorological Disasters and Climate Resources in the Great Mekong subregion Yunnan UniversityKunming 650500China Department of Atmospheric Sciences Yunnan UniversityKunming 650500China National Centre for Atmospheric Science Department of MeteorologyUniversity of ReadingReadingRG66BBUK Geofysisk Institut University of BergenBergen 5007Norway Citadel Investment Group Moor House120 London WallLondonRG66BBUK

The frequency and duration of observed concurrent hot and dry events(HDEs) over China during the growing season(April–September) exhibit significant decadal changes across the mid-1990s. These changes are characterized by increases in HDE frequency and duration over most of China, with relatively large increases over southeastern China(SEC), northern China(NC), and northeastern China(NEC). The frequency of HDEs averaged over China in the present day(PD,1994–2011) is double that in the early period(EP, 1964–81);the duration of HDEs increases by 60%. Climate experiments with the Met Office Unified Model(MetUM-GOML2) are used to estimate the contributions of anthropogenic forcing to HDE decadal changes over China. Anthropogenic forcing changes can explain 60%–70% of the observed decadal changes,suggesting an important anthropogenic influence on HDE changes over China across the mid-1990s. Single-forcing experiments indicate that the increase in greenhouse gas(GHG) concentrations dominates the simulated decadal changes,increasing the frequency and duration of HDEs throughout China. The change in anthropogenic aerosol(AA) emissions significantly decreases the frequency and duration of HDEs over SEC and NC, but the magnitude of the decrease is much smaller than the increase induced by GHGs. The changes in HDEs in response to anthropogenic forcing are mainly due to the response of climatological mean surface air temperatures. The contributions from changes in variability and changes in climatological mean soil moisture and evapotranspiration are relatively small. The physical processes associated with the response of HDEs to GHG and AA changes are also revealed.

关键词： concurrent hot and dry events decadal variation greenhouse gases aerosol emissions

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Functional characterization of piggyBac-like elements from Nilaparvata lugens(St?l)(Hemiptera:Delphacidae)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第6期23卷 515-527页

作者： Jun LYU Qin Su Jinhui LIU Lin CHEN Jiawei suN Wenqing ZHANG State Key Laboratory of Biocontrol School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China

Piggy Bac is a transposable DNA element originally discovered in the cabbage looper moth(Trichoplusia ni).The T.ni piggyBac transposon can introduce exogenous fragments into a genome,constructing a transgenic organism.Nevertheless,the comprehensive analysis of endogenous piggyBac-like elements(PLEs)is important before using piggyBac,because they may influence the genetic stability of transgenic lines.Herein,we conducted a genome-wide analysis of PLEs in the brown planthopper(BPH)Nilaparvata lugens(St?l)(Hemiptera:Delphacidae),and identified a total of 28 PLE sequences.All N.lugens piggy Bac-like elements(NlPLEs)were present as multiple copies in the genome of BPH.Among the identified NlPLEs,NlPLE25 had the highest copy number and it was distributed on five chromosomes.The full length of NlPLE25 consisted of terminal inverted repeats and sub-terminal inverted repeats at both terminals,as well as a single open reading frame transposase encoding546 amino acids.Furthermore,NlPLE25 transposase caused precise excision and transposition in cultured insect cells and also restored the original TTAA target sequence after excision.A cross-recognition between the NlPLE25 transposon and the piggy Bac transposon was also revealed in this study.These findings provide useful information for the construction of transgenic insect lines.

关键词： Nilaparvata lugens piggyBac-like elements Transposon NlPLE25

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REEP1 Preserves Motor Function in SOD1^(G93A) Mice by Improving Mitochondrial Function via Interaction with NDUFA4

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Neuroscience Bulletin 2023年第6期39卷 929-946页

作者： Siyue qin Pan You Hui Yu Bo su Department of Cell Biology Shandong Provincial Key Laboratory of Mental DisordersSchool of Basic Medical SciencesShandong UniversityJinan250012China

A decline in the activities of oxidative phosphorylation(OXPHOS)complexes has been consistently reported in amyotrophic lateral sclerosis(ALS)patients and animal models of ALS,although the underlying molecular mechanisms are still elusive.Here,we report that receptor expression enhancing protein 1(REEP1)acts as an important regulator of complex IV assembly,which is pivotal to preserving motor neurons in SOD1^(G93A) mice.We found the expression of REEP1 was greatly reduced in transgenic SOD1^(G93A) mice with ALS.Moreover,forced expression of REEP1 in the spinal cord extended the lifespan,decelerated symptom progression,and improved the motor performance of SOD1^(G93A) mice.The neuromuscular synaptic loss,gliosis,and even motor neuron loss in SOD1^(G93A) mice were alleviated by increased REEP1 through augmentation of mitochondrial function.Mechanistically,REEP1 associates with NDUFA4,and plays an important role in preserving the integrity of mitochondrial complex IV.Our findings offer insights into the pathogenic mechanism of REEP1 deficiency in neurodegenerative diseases and suggest a new therapeutic target for ALS.

关键词： REEP1 Amyotrophic lateral sclerosis Mitochondria Complex IV assembly NDUFA4

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细雨绵绵母爱无边——杨巧云&粟琴母女的“闺蜜式”人生

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现代艺术 2023年第5期 20-23页

作者：杨巧云栗琴眉山市仁寿县文化馆童艺坊美术工作室四川省美术家协会眉山市美术家协会

陪伴式成长鼓励式教育在我看来,艺术是一种非常独特的表达方式。它能够将人类的情感和思想转化为不同的作品,比如绘画、音乐、舞蹈等。通过艺术,我可以感受到生命的美好和多彩;通过艺术,我可以表达自己的情感和思想。艺术是一种强大的工... 详细信息

陪伴式成长鼓励式教育在我看来,艺术是一种非常独特的表达方式。它能够将人类的情感和思想转化为不同的作品,比如绘画、音乐、舞蹈等。通过艺术,我可以感受到生命的美好和多彩;通过艺术,我可以表达自己的情感和思想。艺术是一种强大的工具,可以让人们感受到生命中真正的美好,让人们更好地了解自己。

关键词：思想转化鼓励式教育生命表达方式

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CRISPR-Based Genome-Editing Tools for Huntington’s Disease Research and Therapy

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Neuroscience Bulletin 2022年第11期38卷 1397-1408页

作者： Yiyang qin Shihua Li Xiao-Jiang Li su Yang Guangdong Key Laboratory of Non-human Primate Research Guangdong-Hongkong-Macao Institute of CNS RegenerationJinan UniversityGuangzhou 510632China

Huntington’s disease(HD)is an autosomal dominantly-inherited neurodegenerative disease,which is caused by CAG trinucleotide expansion in exon 1 of the Huntingtin(HTT)gene.Although HD is a rare disease,its monogenic nature makes it an ideal model in which to understand pathogenic mechanisms and to develop therapeutic strategies for neurodegenerative diseases.Clustered regularly-interspaced short palindromic repeats(CRISPR)is the latest technology for genome editing.Being simple to use and highly efficient,CRISPR-based genome-editing tools are rapidly gaining popularity in biomedical research and opening up new avenues for disease treatment.Here,we review the development of CRISPR-based genome-editing tools and their applications in HD research to offer a translational perspective on advancing the genome-editing technology to HD treatment.

关键词： Huntington’s disease CRISPR Animal models

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Clear cell hepatocellular carcinoma: origin,metabolic traits and fate of glycogenotic clear and ground glass cells

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 570-594页

作者： Peter Bannasch Silvia Ribback Qin Su Doris Mayer German Cancer Research Center HeidelbergGermany Institut fur Pathologie Universitatsmedizin Greifswald Greifswald Germany Cell Marque Millipore-Sigma Rocklin USA

Clear cell hepatocellular carcinoma(CCHCC)has hitherto been considered an uncommon, highly differentiated variant of hepatocellular carcinoma(HCC) with a relatively favorable prognosis. CCHCC is composed of mixtures of clear and/or acidophilic ground glass hepatocytes with excessive glycogen and/or fat and shares histology, clinical features and etiology with common HCCs. Studies in animal models of chemical, hormonal and viral hepatocarcinogenesis and observations in patients with chronic liver diseases prone to develop HCC have shown that the majority of HCCs are preceded by, or associated with, focal or diffuse excessive storage of glycogen(glycogenosis) which later may be replaced by fat(lipidosis/steatosis). In ground glass cells, the glycogenosis is accompanied by proliferation of the smooth endoplasmic reticulum, which is closely related to glycogen particles and frequently harbors the hepatitis B surface antigen(HBs Ag).From the findings in animal models a sequence of changes has been established, commencing with preneoplastic glycogenotic liver lesions, often containing ground glass cells, and progressing to glycogen-poor neoplasms via various intermediate stages, including glycogenotic/lipidotic clear cell foci, clear cell hepatocellular adenomas(CCHCA) rich in glycogen and/or fat, and CCHCC. A similar process seems to take place in humans, with clear cells frequently persisting in CCHCC and steatohepatitic HCC, which presumably represent intermediate stages in the development rather than particular variants of HCC. During the progression of the preneoplastic lesions,the clear and ground glass cells transform into cells characteristic of common HCC. The sequential cellular changes are associated with metabolic aberrations, which start with an activation of the insulin signaling cascade resulting in preneoplastic hepatic glycogenosis. The molecular and metabolic changes underlying the glycogenosis/lipidosis are apparently responsible for the dramatic metabolic shift from gluconeogenesis to the pentose ph

关键词： clear cell hepatocellular carcinoma phenotypic heterogeneity glycogenosis lipidosis preneoplastic glycogenosis progression metabolic aberrations

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Revisiting the Second EOF Mode of Interannual Variation in summer Rainfall over East China

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Advances in Atmospheric Sciences 2016年第1期33卷 121-134页

作者： Zhongda LIN Qin Su Riyu LU State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of Sciences Department of Atmospheric Sciences Yunnan University

The second EOF（EOF2） mode of interannual variation in summer rainfall over East China is characterized by inverse rainfall changes between South China（SC） and the Yellow River-Huaihe River valleys（YH）.However,understanding of the EOF2 mode is still limited.In this study,the authors identify that the EOF2 mode physically depicts the latitudinal variation of the climatological summer-mean rainy belt along the Yangtze River valley（YRRB）,based on a 160-station rainfall dataset in China for the period 1951-2011.The latitudinal variation of the YRRB is mostly attributed to two different rainfall patterns：one reflects the seesaw（SS） rainfall changes between the YH and SC（SS pattern）,and the other features rainfall anomalies concentrated in SC only（SC pattern）.Corresponding to a southward shift of the YRRB,the SS pattern,with above-normal rainfall in SC and below-normal rainfall in the YH,is related to a cyclonic anomaly centered over the SC-East China Sea region,with a northerly anomaly blowing from the YH to SC;while the SC pattern,with above-normal rainfall in SC,is related to an anticyclonic anomaly over the western North Pacific（WNP）,corresponding to an enhanced southwest monsoon over SC.The cyclonic anomaly,related to the SS pattern,is induced by a near-barotropic eastward propagating wave train along the Asian upper-tropospheric westerly jet,originating from the mid-high latitudes of the North Atlantic.The anticyclonic anomaly,for the SC pattern,is related to suppressed rainfall in the WNP.

关键词： Yangtze River rainy belt,East China summer rainfall,seesaw pattern,South China pattern,western North Pacific subtropical high,extratropical wave train

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Chinese Herb Formulae Inhibit the Proliferation of Human Colon Cancer SW480 Cells by Inducing Cell Apoptosis

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World Journal of Traditional Chinese Medicine 2023年第3期9卷 348-354页

作者： su Fu Shao-Lin qin Wolf-Dieter Rausch Department for Internal Medicine of Traditional Chinese Medicine Eye Hospital China Academy of Chinese Medical SciencesBeijingChina Department for Biomedical Sciences Institute for Chemistry and BiochemistryUniversity of Veterinary Medicine ViennaViennaAustria

Objective:This study aimed to reveal the antitumor effects of Chinese herbal formulae and the underlying mechanisms in treating colorectal cancer,with a focus on developing traditional Chinese medicine(TCM)as a supplement and alternative therapeutic method for cancers.Materials and Methods:Human colon cancer SW480 cells were treated with three Chinese herbal formulae,Bu Zhong Yi Qi Decoction,Fuzi Lizhong Decoction,and Pulsatilla Decoction at different concentrations(50–600μg/mL)for 24,36,and 48 h,respectively.Cell viability was determined using the resazurin reduction assay,and cell survival rate was evaluated using a colony formation assay.After treatment with different concentrations(50–600μg/mL)of these three formulae for 48 h,the effects of the Chinese herbal formulae on cell apoptosis were investigated using Hoechst/propidium iodide(PI)staining.The positive PI-stained cells were investigated using an EnSpire multilabel plate reader and the positive Hoechst-stained cells were observed under a fluorescence microscope for morphological changes.Results:Bu Zhong Yi Qi Decoction,Fuzi Lizhong Decoction,and Pulsatilla Decoction inhibited SW480 cell proliferation in a dose-and time-dependent manner and induced cell apoptosis.Conclusion:Chinese herbal formulae with a special prescription form of TCM with antitumor effects bring a new perspective in line with the principles of TCM in cancer treatment.

关键词： Apoptosis cell proliferation Chinese herbal formulae colorectal cancer SW480 cells

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Fully resolved simulations of viscoelastic suspensions by an efficient immersed boundary-lattice Boltzmann method

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Particuology 2023年第4期75卷 26-49页

作者： Shenxu qin Maoqiang Jiang Kuang Ma Jin su Zhaohui Liu State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan430074China School of Science Xian Polytechnic UniversityXi'an710048China

An efficient immersed boundary-lattice Boltzmann method(IB-LBM)is proposed for fully resolved simulations of suspended solid particles in viscoelastic flows.Stress LBM based on Giesekus and Oldroyd-B constitutive equation are used to model the viscoelastic stress tensor.A boundary thickening-based direct forcing IB method is adopted to solve the particle-fluid interactions with high accuracy for non-slip boundary conditions.A universal law is proposed to determine the diffusivity constant in a viscoelastic LBM model to balance the numerical accuracy and stability over a wide range of computa-tional parameters.An asynchronous calculation strategy is adopted to further improve the computing efficiency.The method was firstly applicated to the simulation of sedimentation of a single particle and a pair of particles after good validations in cases of the flow past a fixed cylinder and particle migration in a Couette flow against FEM and FVM methods.The determination of the asynchronous calculation strategy and the effect of viscoelastic stress distribution on the settling behaviors of one and two particles are revealed.subsequently,504 particles settling in a closed cavity was simulated and the phenomenon that the viscoelastic stress stabilizing the Rayleigh-Taylor instabilities was observed.At last,simulations of a dense flow involving 11001 particles,the largest number of particles to date,were performed to investigate the instability behavior induced by elastic effect under hydrodynamic interactions in a viscoelastic fluid.The elasticity-induced ordering of the particle structures and fluid bubble structures in this dense flow is revealed for the first time.These simulations demonstrate the capability and prospects of the present method for aid in understanding the complex behaviors of viscoelastic particle suspensions.

关键词： Fullyresolved simulation Lattice Boltzmann method Immersed boundary method Viscoelastic suspension Particle sedimentation

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Enhanced microwave absorption property of silver decorated biomass ordered porous carbon composite materials with frequency selective surface incorporation

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International Journal of Minerals,Metallurgy and Materials 2023年第3期30卷 525-535页

作者： Yi Liu Jingnan qin Linlin Lu Jie Xu Xiaolei su Xi’an Polytechnic University Xi’an 710048China

Porous carbon(PC)is a promising electromagnetic(EM)wave absorbing material thanks to its light weight,large specific surface area as well as good dissipating capacity.To further improve its microwave absorbing performance,silver coated porous carbon(Ag@PC)is synthesized by one-step hydro-thermal synthesis process making use of fir as a biomass formwork.Phase compositions,morphological structure,and microwave absorption capability of the Ag@PC has been explored.Research results show that the metallic Ag was successfully reduced and the particles are evenly distributed inward the pores of the carbon formwork,which accelerates graphitization process of the amorphous carbon.The Ag@PC composite without adding polyvinyl pyrrolidone(PVP)exhibits higher dielectric constant and better EM wave dissipating capability.This is because the larger particles of Ag give rise to higher electric conductivity.After combing with frequency selective surface(FSS),the EM wave absorbing performance is further improved and the frequency region below-10 d B is located in8.20-11.75 GHz,and the minimal reflection loss value is-22.5 dB.This work indicates that incorporating metallic Ag particles and FSS provides a valid way to strengthen EM wave absorbing capacity of PC material.

关键词： biomass carbon Ag@PC composite material frequency selective surface electromagnetic wave absorbing property

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