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Reproductive biology of Hemitripterus villosus in the Bohai Strait,China

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Journal of Oceanology and Limnology 2024年第3期42卷 881-892页

作者： Ping SUN song qin Zhengyi LIU Longchuan ZHUANG Key Laboratory of Coastal Biology and Biological Resource Utilization Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China University of Chinese Academy of Sciences Beijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

To understand the reproductive biology of Hemitripterus villosus in the Bohai Strait,and fill the key knowledge gap in verifying reproductive seasonality and documenting gonadotropin dependent reproductive cycle of this species,a year-round detail study was conducted for the first *** total,263 individuals were randomly sampled off the coasts of the Bohai *** show that and the overall female-to-male ratio(1.35:1)did not differ significantly from the 1:1 sex *** length and weight relationship for females and males were regressed,depicting an isometric growth for both *** reproductive phases of the complete gonadotropin dependent reproductive cycle in both sexes were *** monthly variations in the gonadosomatic and hepatosomatic indexes for both sexes further indicated that this species spawns a single batch of eggs per year and the peak spawning period is from October to *** average diameter of eggs ranged from 2.10 to 3.57 *** length at first sexual maturity was 224.87 mm for females and 241.26 mm for *** positive relationships between absolute fecundity and fish size,and also gonadal weight were *** from the Bohai Strait exhibited smaller body size,smaller egg diameter,lower gonadosomatic index,lower absolute fecundity,and higher population extinction risk than the other populations’studied *** findings contribute to understanding the status of this isolated westernmost population,and we emphasize that more efficient protection measures for the species and control measures are urgently required to improve the coastal environment in the Bohai Strait.

关键词： Hemitripterus villosus Bohai Strait fecundity length at first maturity reproductive seasonality

Monotropein Induced Apoptosis and Suppressed Cell Cycle Progression in Colorectal Cancer Cells

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Chinese Journal of Integrative Medicine 2024年第1期30卷 25-33页

作者： GAO Quan LI Lin ZHANG Qi-man SHENG qin-song ZHANG Ji-liang JIN Li-jun SHANG Rui-yan School of Pharmacy and Department of Medical Oncology the Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Department of Colorectal Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Beijing Tong Ren Tang Chinese Medicine Co. Ltd.Beijing(100000)China Department of Traditional Chinese Medicine Hangzhou Shangcheng District People's HospitalHangzhou(310006)China Department of Gynecology Hangzhou Women's HospitalHangzhou(310008)China

Objective: To determine whether monotropein has an anticancer effect and explore its potential mechanisms against colorectal cancer(CRC) through network pharmacology and molecular docking combined with experimental verification. Methods: Network pharmacology and molecular docking were used to predict potential targets of monotropein against CRC. Cell counting kit assay, plate monoclonal assay and microscopic observation were used to investigate the antiproliferative effects of monotropein on CRC cells HCT116, HT29 and LoVo. Flow cytometry and scratch assay were used to analyze apoptosis and cell cycle, as well as cell migration, respectively in HCT116, HT29, and LoVo cells. Western blotting was used to detect the expression of proteins related to apoptosis, cell cycle, and cell migration, and the expression of proteins key to the Akt pathway. Results: The Gene Ontology and Reactome enrichment analyses indicated that the anticancer potential of monotropein against CRC might be involved in multiple cancer-related signaling pathways. Among these pathways, RAC-beta serine/threonine-protein kinase(Akt1, Akt2), cyclin-dependent kinase 6(CDK6), matrix metalloproteinase-9(MMP9), epidermal growth factor receptor(EGFR), cell division control protein 42 homolog(CDC42) were shown as the potential anticancer targets of monotropein against CRC. Molecular docking suggested that monotropein may interact with the 6 targets(Akt1, Akt2, CDK6, MMP9, EGFR, CDC42). Subsequently, cell activity of HCT116, HT29 and LoVo cell lines were significantly suppressed by monotropein(P<0.05). Furthermore, our research revealed that monotropein induced cell apoptosis by inhibiting Bcl-2 and increasing Bax, induced G_1–S cycle arrest in colorectal cancer by decreasing the expressions of CyclinD1, CDK4 and CDK6, inhibited cell migration by suppressing the expressions of CDC42 and MMP9(P<0.05), and might play an anticancer role through Akt signaling pathway. Conclusions: Monotropein exerts its antitumor

关键词： monotropein Chinese medicine anticancer activity colorectal cancer cells network pharmacology

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu Siying Kang song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China

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World Journal of Gastroenterology 2024年第10期30卷 1346-1357页

作者： Jing-Feng Chen Zhuo-qing Wu Hao-Shuang Liu Su Yan You-Xiang Wang Miao Xing Xiao-qin song Su-Ying Ding Health Management Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Institute of Systems Engineering Dalian University of TechnologyDalian 116024Liaoning ProvinceChina College of Public Health Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medicine and Forensic Medicine Henan University of Science and TechnologyLuoyang 471003Henan ProvinceChina

BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD *** A cohort of 3553 participants followed for four consecutive health examinations over 4 years was *** incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were *** proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset *** A total of 83.13%of participants with MAFLD had normal ALT *** incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT *** with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,*** Most participants with MAFLD had normal ALT ***-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.

关键词： Metabolic dysfunction-associated fatty liver disease High-normal alanine aminotransferase level Cumulative effect Cox proportional hazards regression Cohort study

Accidental placement of venous return catheter in the superior vena cava during venovenous extracorporeal membrane oxygenation for severe pneumonia: A case report

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World Journal of Clinical Cases 2024年第4期12卷 782-786页

作者： Xiao-qin song Yun-Long Jiang Xian-Bao Zou Shi-Chao Chen Ai-Jun Qu Ling-Ling Guo Emergency Department Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina

BACKGROUND Venovenous extracorporeal membrane oxygenation(V-V ECMO)has become an important treatment for severe pneumonia,but there are various complications during the *** article describes a case with severe pneumonia success-fully treated by V-V ECMO,but during treatment,the retrovenous catheter,which was supposed to be in the right internal vein,entered the superior vena cava directly in the *** ECMO was safely withdrawn after multidiscip-linary *** experience with this case is expected to provide a reference for colleagues who will encounter similar *** SUMMARY A 64-year-old man had severe pulmonary infection and respiratory *** was admitted to our hospital and was given ventilation support(fraction of inspired oxygen 100%).The respiratory failure was not improved and he was treated by V-V ECMO,during which the venous return catheter,which was supposed to be in the right internal vein,entered the superior vena cava directly in the *** was a risk of massive mediastinal bleeding if the catheter was removed directly when the ECMO was ***,the patient underwent vena cava angiography+balloon attachment+ECMO with-drawal in the operating room(prepared for conversion to thoracotomy for vascular exploration and repair at any time during surgery)after multidiscip-linary *** was safely withdrawn,and the patient recovered and was *** Patients may have different vascular *** cooperation can ensure patient *** experience will provide a reference for similar cases.

关键词： Severe pneumonia Extracorporeal membrane oxygenation Complications Superior vena cava Multidisciplinary consultation Case report

Temporal-spatial Generation of Astrocytes in the Developing Diencephalon

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Neuroscience Bulletin 2024年第1期40卷 1-16页

作者： Wentong Hong Pifang Gong Xinjie Pan Zhonggan Ren Yitong Liu Guibo Qi Jun-Liszt Li Wenzhi Sun Woo-Ping Ge Chun-Li Zhang Shumin Duan song qin Department of Anatomy Histology and EmbryologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China School of Basic Medical Sciences Capital Medical UniversityBeijing 100069China Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTexas 75390-9148USA Department of Neurobiology Key Laboratory of Medical Neurobiology of Ministry of Health of ChinaZhejiang University School of MedicineHangzhou 310058China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200032China

tAstrocytes are the largest glial population in the mammalian ***,we have a minimal understanding of astrocyte development,especially fate specification in different regions of the *** lineage tracing of the progenitors of the third ventricle(3V)wall via in-utero electroporation in the embryonic mouse brain,we show the fate specification and migration pattern of astrocytes derived from radial glia along the 3V ***,radial glia located in different regions along the 3V wall of the diencephalon produce distinct cell types:radial glia in the upper region produce astrocytes and those in the lower region produce neurons in the *** genetic fate mapping analysis,we reveal that the first population of astrocytes appears along the zona incerta in the *** occurs at an early time point in the dorsal region relative to that in the ventral region of the developing *** transcriptomic analysis of the region-specific 3V wall and lateral ventricle(LV)wall,we identified cohorts of differentially-expressed genes in the dorsal 3V wall compared to the ventral 3V wall and LV wall that may regulate astrogenesis in the dorsal ***,these results demonstrate that the generation of astrocytes shows a spatiotemporal pattern in the developing mouse diencephalon.

关键词： Radial glia Astrocyte specification Lineage tracing Diencephalon Third ventricle

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非定向近水平钻孔轨迹参数的解算及应用

采矿与安全工程学报 2024年第2期41卷 341-351页

作者：高杰秦松张佳乐常乐乐中国矿业大学煤炭精细勘探与智能开发全国重点实验室江苏徐州221116 西安科技大学安全科学与工程学院陕西西安710054 江苏东科安全研究院有限公司江苏徐州221100 中国矿业大学安全工程学院江苏徐州221116

为解决目前井下瓦斯抽采短钻孔、探放水钻孔及地质勘探钻孔等非受控近水平钻孔轨迹随钻测量发展缓慢问题,开展了非定向近水平钻孔轨迹参数解算及现场应用。对近水平钻孔轨迹的5种解算方法进行对比分析,选择平均角法并植入Visual C++6.0... 详细信息

为解决目前井下瓦斯抽采短钻孔、探放水钻孔及地质勘探钻孔等非受控近水平钻孔轨迹随钻测量发展缓慢问题,开展了非定向近水平钻孔轨迹参数解算及现场应用。对近水平钻孔轨迹的5种解算方法进行对比分析,选择平均角法并植入Visual C++6.0软件,开发了随钻轨迹测量数据处理及钻孔轨迹图展示软件,研发了抗地磁场干扰的随钻测量装置。该软件通过对钻孔数据进行解算,展示了钻孔二维及三维形态轨迹图;将钻孔轨迹与矿井生产图结合,形成利于管理的轨迹跟踪底图,并根据偏差量划分出瓦斯抽采空白条带区域或勘探盲区。在贺西煤矿进行工业性试验,获取了11个钻孔的钻孔轨迹,结合工作面抽采系统图对瓦斯抽采空白条带进行分析识别,绘制了钻孔轨迹图和瓦斯抽采空白区域分布图,取得了较好的现场应用效果。

关键词：近水平钻孔随钻测量偏差量钻孔轨迹瓦斯抽采空白带

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脓毒症急性肺损伤治疗的研究进展

中华医院感染学杂志 2024年第1期34卷 149-155页

作者：李林邢福席付全有宋勤琴李双汝刘继松蚌埠医学院附属蚌埠市第三人民医院烧伤整形科安徽蚌埠233000 蚌埠医学院研究生院安徽蚌埠233030

脓毒症常继发于创伤、烧伤和感染、休克等情况,如果治疗不及时,将进一步发展为多器官衰竭而死亡。脓毒症可激活肺内大量巨噬细胞,释放大量炎症因子,引起急性肺损伤(ALI),作为脓毒症的严重并发症,急性呼吸窘迫综合征(ARDS)具有较高的发... 详细信息

脓毒症常继发于创伤、烧伤和感染、休克等情况,如果治疗不及时,将进一步发展为多器官衰竭而死亡。脓毒症可激活肺内大量巨噬细胞,释放大量炎症因子,引起急性肺损伤(ALI),作为脓毒症的严重并发症,急性呼吸窘迫综合征(ARDS)具有较高的发病率和病死率。ALI/ARDS患者由于肺泡上皮细胞和肺毛细血管内皮细胞的弥漫性损伤可以导致肺泡毛细血管通透性增加,导致肺水肿,临床表现为难治性低氧血症和致命性呼吸衰竭,目前尚无可靠的方法如生物学标志物等预测其发生、发展,临床以支持治疗为主。本文主要就脓毒症相关的肺损伤发病机制及其治疗的最新进展综述如下。

关键词：脓毒症急性肺损伤急性呼吸窘迫综合征机械通气干细胞外泌体

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建材行业智能化发展现状及展望

新型工业化 2024年第2期14卷 5-9页

作者：秦松沈雪中国建筑材料联合会北京100083 建筑材料工业信息中心北京100083

智能制造是制造强国建设的主攻方向,是新型工业化的重要特征。本文总体介绍了近年来建材行业智能化发展取得的积极进展,重点分析了水泥、玻璃、陶瓷领域推进智能制造取得的成效,从智能装备、技术创新和推广应用等方面分析了建材行业智... 详细信息

智能制造是制造强国建设的主攻方向,是新型工业化的重要特征。本文总体介绍了近年来建材行业智能化发展取得的积极进展,重点分析了水泥、玻璃、陶瓷领域推进智能制造取得的成效,从智能装备、技术创新和推广应用等方面分析了建材行业智能化发展的趋势,指出了建材行业智能化发展存在的不足,并提出相关建议。

关键词：智能制造零一线员工工业互联网发展趋势