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Fully resolved simulations of viscoelastic suspensions by an efficient immersed boundary-lattice Boltzmann method

Particuology 2023年第4期75卷 26-49页

作者： Shenxu qin Maoqiang Jiang kuang Ma Jin Su Zhaohui Liu State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan430074China School of Science Xian Polytechnic UniversityXi'an710048China

An efficient immersed boundary-lattice Boltzmann method(IB-LBM)is proposed for fully resolved simulations of suspended solid particles in viscoelastic flows.Stress LBM based on Giesekus and Oldroyd-B constitutive equation are used to model the viscoelastic stress tensor.A boundary thickening-based direct forcing IB method is adopted to solve the particle-fluid interactions with high accuracy for non-slip boundary conditions.A universal law is proposed to determine the diffusivity constant in a viscoelastic LBM model to balance the numerical accuracy and stability over a wide range of computa-tional parameters.An asynchronous calculation strategy is adopted to further improve the computing efficiency.The method was firstly applicated to the simulation of sedimentation of a single particle and a pair of particles after good validations in cases of the flow past a fixed cylinder and particle migration in a Couette flow against FEM and FVM methods.The determination of the asynchronous calculation strategy and the effect of viscoelastic stress distribution on the settling behaviors of one and two particles are revealed.Subsequently,504 particles settling in a closed cavity was simulated and the phenomenon that the viscoelastic stress stabilizing the Rayleigh-Taylor instabilities was observed.At last,simulations of a dense flow involving 11001 particles,the largest number of particles to date,were performed to investigate the instability behavior induced by elastic effect under hydrodynamic interactions in a viscoelastic fluid.The elasticity-induced ordering of the particle structures and fluid bubble structures in this dense flow is revealed for the first time.These simulations demonstrate the capability and prospects of the present method for aid in understanding the complex behaviors of viscoelastic particle suspensions.

关键词： Fullyresolved simulation Lattice Boltzmann method Immersed boundary method Viscoelastic suspension Particle sedimentation

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Origin of symmetry breaking in the seed-mediated growth of bi-metal nano-heterostructures

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Science Bulletin 2018年第14期63卷 892-899页

作者： Guifen Du Jun Pei Zhiyuan Jiang Qiaoli Chen Zhenming Cao Qin Kuang Zhaoxiong Xie Lansun Zheng State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsDepartment of ChemistryCollege of Chemistry and Chemical EngineeringXiamen University Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen University

Seed-mediated growth is the most general way to controllably synthesize bimetal nano-heterostructures.Despite successful instances through trial and error were reported, the way for second metal depositing on the seed, namely whether the symmetry of resulted nano-heterostructure follows the original crystal symmetry of seed metal, remains an unpredictable issue to date. In this work, we propose that the thermodynamic factor, i.e., the difference of equilibrium electrochemical potentials(corresponding to their Fermi levels) of two metals in the growth solution, plays a key role for the symmetry breaking of bimetal nano-heterostructures during the seed-mediated growth. As a proof-of-principle experiment, by reversing the relative position of Fermi levels of the Pd nanocube seeds and the second metal Au with changing the concentration of reductant(L-ascorbic acid) in the growth solution, the structure of as-prepared products successfully evolved from centrosymmetric Pd@Au core-shell trisoctahedra to asymmetric Pd-Au hetero-dimers. The idea was further demonstrated by the growth of Ag on the Pd seeds. The present work intends to reveal the origin of symmetry breaking in the seed-mediated growth of nano-heterostructures from the viewpoint of thermodynamics, and these new insights will in turn help to achieve rational construction of bimetal nano-heterostructures with specific functions.

关键词：中心对称金属片生长期膨胀率种子起源电气化学相对位置

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The deubiquitinating enzyme 13 retards non-alcoholic steatohepatitis via blocking inactive rhomboid protein 2-dependent pathway

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1071-1092页

作者： Minxuan Xu Jun Tan Liancai Zhu Chenxu Ge Wei Dong Xianling Dai Qin Kuang Shaoyu Zhong Lili Lai Chao Yi Qiang Li Deshuai Lou Linfeng Hu Xi Liu Gang kuang Jing Luo Jing Feng Bochu Wang Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region School of Biological and Chemical EngineeringChongqing University of EducationChongqing 400067China College of Modern Health Industry Chongqing University of EducationChongqing 400067China Key Laboratory of Biorheological Science and Technology(Chongqing University) Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400030China Shandong Cancer Hospital and Institute Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Nowadays potential preclinical drugs for the treatment of nonalcoholic steatohepatitis(NASH)have failed to achieve expected therapeutic efficacy because the pathogenic mechanisms are underestimated.Inactive rhomboid protein 2(IRHOM2),a promising target for treatment of inflammation-related diseases,contributes to deregulated hepatocyte metabolism-associated nonalcoholic steatohepatitis(NASH)progression.However,the molecular mechanism underlying Irhom2 regulation is still not completely understood.In this work,we identify the ubiquitin-specific protease 13(USP13)as a critical and novel endogenous blocker of IRHOM2,and we also indicate that USP13 is an IRHOM2-interacting protein that catalyzes deubiquitination of Irhom2 in hepatocytes.Hepatocyte-specific loss of the Usp13 disrupts liver metabolic homeostasis,followed by glycometabolic disorder,lipid deposition,increased inflammation,and markedly promotes NASH development.Conversely,transgenic mice with Usp13 overexpression,lentivirus(LV)-or adeno-associated virus(AAV)-driven Usp13 gene therapeutics mitigates NASH in 3 models of rodent.Mechanistically,in response to metabolic stresses,USP13 directly interacts with IRHOM2 and removes its K63-linked ubiquitination induced by ubiquitin-conjugating enzyme E2N(UBC13),a ubiquitin E2 conjugating enzyme,and thus prevents its activation of downstream cascade pathway.USP13 is a potential treatment target for NASH therapy by targeting the Irhom2 signaling pathway.

关键词： Usp13 Irhom2 NASH Hepatosteatosis Ubc13 NAFLD Ubiquitination Liver inflammation

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Celiomesenteric trunk: New classification based on multidetector computed tomography angiographic findings and probable embryological mechanisms

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World Journal of Clinical Cases 2019年第23期7卷 3980-3989页

作者： Wei Tang Jing Shi Lian-Qin Kuang Shuang-Yue Tang Yi Wang Department of Radiology Daping HospitalArmy Medical UniversityChongqing 400042China Sichuan Key Laboratory of Medical Imaging Department of RadiologyAffiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Nursing Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND In previous studies,celiomesenteric trunk(CMT)was narrowly defined as a hepato-gastro-spleno-mesenteric(HGSM)trunk,but other possible types were ignored.With the widespread use of multidetector computed tomography(MDCT)angiography,it is easy to collect a large sampling of data on arterial anatomy of the abdomen in daily radiological practice.A new classification system for CMT may be created based on its MDCT angiographic findings and variation patterns.AIM To identify the spectrum and prevalence of CMT according to a new classification based on MDCT angiographic findings,and discuss the probable embryological mechanisms to explain the CMT variants.METHODS A retrospective study was carried out on 5580 abdominal MDCT angiography images.CMT was defined as a single common trunk arising from the aorta and its branches including the superior mesenteric artery and at least two major branches of the celiac trunk.Various types of CMT were investigated.RESULTS Of the 5580 patients,171(3.06%)were identified as having CMT.According to the new definitions and classification,the CMT variants included five types:Ⅰ,Ⅱ,Ⅲ,Ⅳ and Ⅴ,which were found in 96(56.14%),57(33.33%),4(2.34%),3(1.75%)and 8(4.68%)patients,respectively.The CMT variants also were classified as long type(106 patients,61.99%)and short type(65 patients,38.01%)based on the length of single common trunk.Further CMT classification was based on the origin of the left gastric artery:Type a(92 patients,53.80%),type b(57 patients,33.33%),type c(11 patients,6.43%)and type d(8 patients,4.68%).CONCLUSION We systematically classified CMT variants according to our new classification system based on MDCT angiographic findings.Dislocation interruption,incomplete interruption and persistence of the longitudinal anastomosis could all be embryological mechanisms of various types of CMT variants.

关键词： Celiac artery Mesenteric artery superior Anatomic variation Classification Computed tomography angiography

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Fe-N-C nanostick derived from 1D Fe-ZIFs for electrocatalytic oxygen reduction

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Chinese Journal of Structural Chemistry 2023年第10期42卷 21-27页

作者： Jiayu Huang Kuan Chang Qi Liu Yameng Xie Zhijia Song Zhiping Zheng Qin Kuang State Key Laboratory of Physical Chemistry of Solid Surfaces&Department of Chemistry College of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian361005PR China

The slow oxygen reduction process at the cathode and the scarcity of platinum-based metals lead to limited applications in fuel cells and metal-air cells.Recently,transition metal and nitrogen co-doped carbon-based catalysts(M–N–C)are regarded as the most prospective non-precious metal catalysts for future fuel cell applications.It is verified theoretically and experimentally that the metal and nitrogen coordination structure is the main catalytic activity center of oxygen reduction reaction(ORR),so constructing M–N–C materials with high available surface area and structural stability is an effective way to accelerate ORR.Herein,we deliberately synthesize a one-dimensional ZIF structure to fabricate one-dimensional porous Fe–N–C nanostick via two-step pyrolysis.Excitingly,the as-synthesized exhibited an outstanding ORR activity in alkaline medium(E_(1/2)of 0.928 V),as well as superior stability(only changed 7 mV after 10,000 cycles in alkaline medium).Our results show that the reduction of electrocatalyst dimensionality can promote mass transport and increase the accessibility of active sites,thus optimizing their performance in ORR.This work is a good demonstration of the importance of a rational design of catalyst structure for efficient ORR.

关键词： Oxygen reduction reaction Metal-organic frameworks M-N-C catalysts Electrocatalysts

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Structure of plant photosystem I−light harvesting complex I supercomplex at 2.4Å resolution

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Journal of Integrative Plant Biology 2021年第7期63卷 1367-1381页

作者： Jie Wang Long-Jiang Yu Wenda Wang Qiujing Yan Tingyun kuang Xiaochun qin Jian-Ren Shen Photosynthesis Research Center Key Laboratory of PhotobiologyInstitute of BotanyChinese Academy of SciencesBeijing100093 China University of Chinese Academy of Sciences Beijing100049 China School of Biological Science and Technology University of JinanJinan250022 China

Photosystem I(PSI)is one of the two photosystems in photosynthesis,and performs a series of electron transfer reactions leading to the reduction of ferredoxin.In higher plants,PSI is surrounded by four light-harvesting complex I(LHCI)subunits,which harvest and transfer energy efficiently to the PSI core.The crystal structure of PSI-LHCI supercomplex has been analyzed up to 2.6Åresolution,providing much information on the arrangement of proteins and cofactors in this complicated supercomplex.Here we have optimized crystallization conditions,and analyzed the crystal structure of PSI-LHCI at 2.4Åresolution.Our structure showed some shift of the LHCI,especially the Lhca4 subunit,away from the PSI core,suggesting the indirect connection and inefficiency of energy transfer from this Lhca subunit to the PSI core.We identified five new lipids in the structure,most of them are located in the gap region between the Lhca subunits and the PSI core.These lipid molecules may play important roles in binding of the Lhca subunits to the core,as well as in the assembly of the supercomplex.The present results thus provide novel information for the elucidation of the mechanisms for the light-energy harvesting,transfer and assembly of this supercomplex.

关键词： crystal structure Lhca LHCI light-harvesting pea photosynthesis photosystem I

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Quantum parametric amplification of phonon-mediated magnon-spin interaction

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中国科学:物理学、力学、天文学英文版 2023年第11期66卷 92-105页

作者： Yan Wang Hui-Lai Zhang Jin-Lei Wu Jie Song Kun Yang Wei qin Hui Jing Le-Man kuang School of Electronics and Information Zhengzhou University of Light IndustryZhengzhou450001China Academy for Quantum Science and Technology Zhengzhou University of Light IndustryZhengzhou450001China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou450001China School of Physics Harbin Institute of TechnologyHarbin150001China Theoretical Quantum Physics Laboratory RIKEN Cluster for Pioneering ResearchWako-shiSaitama351-0198Japan Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha410081China

The recently developed hybrid magnonics provides new opportunities for advances in both the study of magnetism and the development of quantum information processing.However,engineering coherent quantum state transfer between magnons and specific information carriers,in particular,mechanical oscillators and solid-state spins,remains challenging due to the intrinsically weak interactions and the frequency mismatch between different components.Here,we show how to strongly couple the magnon modes in a nanomagnet to the quantized mechanical motion(phonons)of a micromechanical cantilever in a hybrid tripartite system.The coherent and enhanced magnon-phonon coupling is engineered by introducing the quantum parametric amplification of the mechanical motion.With experimentally feasible parameters,we show that the mechanical parametric drive can be adjusted to drive the system into the strong-coupling regime and even the ultrastrong-coupling regime.Furthermore,we show the coherent state transfer between the nanomagnet and a nitrogen-vacancy center in the dispersive-coupling regime,with the magnon-spin interaction mediated by the virtually-excited squeezed phonons.The amplified mechanical noise can hardly interrupt the coherent dynamics of the system even for low mechanical quality factors,which removes the requirement of applying additional engineered-reservoir techniques.Our work opens up prospects for developing novel quantum transducers,quantum memories and high-precision measurements.

关键词： mechanical parametric amplification strong-coupling regime hybrid quantum system

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Engineering the Surface Structure of Functional Nanocrystalline Materials and their Corresponding Applications

Engineering the Surface Structure of Functional Nanocrystall...

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第二届海峡两岸功能材料科技与产业峰会（2015）

作者： Qin Kuang Yaqi Jiang Zhiyuan Jiang Zhaoxiong Xie State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsCollege of Chemistry and Chemical EngineeringXiamen University

The physical and chemical properties of nanocrystalline materials depend on the surface structures.Nanocrystals with high-energy facets exposed usually show high physical and chemical activities,due to abundant unsaturated coordination atoms and atomic steps and ledges.However,in order to minimize the surface energy of the crystals,the high-energy facets quickly disappeared in the crystal growth process.Therefore,controllable synthesis of the nanocrystals exposed with high-energy facets is still a challenging topic.

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Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism

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Bioactive Materials 2020年第4期5卷 1113-1126页

作者： Zongshan Shen Shuhong kuang Yong Zhang Mingmei Yang Wei qin Xuetao Shi Zhengmei Lin Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhouGuangdongChina National Engineering Research Centre for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhouChina

Periodontitis is caused by host immune-inflammatory response to bacterial insult.A high proportion of proinflammatory macrophages to anti-inflammatory macrophages leads to the pathogenesis of periodontitis.As stem cell-derived exosomes can modulate macrophage phenotype,dental pulp stem cell-derived exosomes(DPSC-Exo)can effectively treat periodontitis.In this study,we demonstrated that DPSC-Exo-incorporated chitosan hydrogel(DPSC-Exo/CS)can accelerate the healing of alveolar bone and the periodontal epithelium in mice with periodontitis.Gene Ontology(GO)term enrichment analysis showed that treatment with DPSC-Exo/CS ameliorated periodontal lesion by suppressing periodontal inflammation and modulating the immune response.Specifically,DPSC-Exo/CS facilitated macrophages to convert from a pro-inflammatory phenotype to an anti-inflammatory phenotype in the periodontium of mice with periodontitis,the mechanism of which could be associated with miR-1246 in DPSC-Exo.These results not only shed light on the therapeutic mechanism of DPSCExo/CS but also provide the basis for developing an effective therapeutic approach for periodontitis.

关键词： Dental pulp stem cells Exosomes Chitosan hydrogel Periodontitis Macrophages

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Optomechanical Schrödinger cat states in a cavity Bose-Einstein condensate

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Fundamental Research 2023年第1期3卷 15-20页

作者： Baijun Li Wei qin Ya-Feng Jiao Cui-Lu Zhai Xun-Wei Xu Le-Man kuang Hui Jing Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China Theoretical Quantum Physics Laboratory RIKEN Cluster for Pioneering ResearchWako-shiSaitama 351-0198Japan Laboratory of Chemical Biology&Traditional Chinese Medicine Research Ministry of Education College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China

Schrödinger cat states,consisting of superpositions of macroscopically distinct states,provide key resources for a large number of emerging quantum technologies in quantum information processing.Here we propose how to generate and manipulate mechanical and optical Schrödinger cat states with distinguishable superposition components by exploiting the unique properties of cavity optomechanical systems based on Bose-Einstein condensate.Specifically,we show that in comparison with its solid-state counterparts,almost a 3 order of magnitude enhancement in the size of the mechanical Schrödinger cat state could be achieved,characterizing a much smaller overlap between its two superposed coherent-state components.By exploiting this generated cat state,we further show how to engineer the quadrature squeezing of the mechanical mode.Besides,we also provide an efficient method to create multicomponent optical Schrödinger cat states in our proposed scheme.Our work opens up a new way to achieve nonclassical states of massive objects,facilitating the development of fault-tolerant quantum processors and sensors.

关键词： Schrödinger cat state Cavity Optomechanics Bose-Einstein condensate Collective density excitation Squeezing

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