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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao qin dong Dan Zou Zhijun Yang Lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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Preparation of nano-compounded polyolefin materials through in situ polymerization technique:status quo and future prospects

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Chinese Science Bulletin 2009年第1期54卷 38-45页

作者： qin YaWei dong JinYong CAS Key Laboratory of Engineering Plastics and Joint Laboratory of Polymer Science and Materials Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

Nano-compounding of polyolefins,an economical yet very effective route to high-performance poly-olefin materials,has received considerable attention in recent years. Unlike most of the other polymers,polyolefins are chemically inert,which dictates that nano-compounding of polyolefins has to be con-ducted via in situ polymerization. In this review,a technological progress of the nano-compounding of polyolefins via in situ polymerization technique was summarized thoroughly,with emphasis laid on the current research status of polyolefin/montmorillonite (MMT) nanocomposites. A clear perspective for future researches on this specific family of materials was envisaged.

关键词：聚烯烃纳米复合材料聚合反应蒙脱石

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Framing Silver Nanocrystals with a Second Metal to Enhance Shape Stability and Expand Functionality

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Accounts of Materials Research 2022年第3期3卷 391-402页

作者： dong qin School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGeorgia 30332United States

CONSPECTUS:Silver nanocrystals embrace fascinating properties for a wide variety of applications,but their performance tends to deteriorate because of shape instability arising from the dissolution of Ag atoms from high-energy sites such as edges and *** issue can be addressed by framing the particle with a more stable metal M for the generation of a Ag@M core-frame *** addition to the improvement in shape stability,the inclusion of metal M expands the functionality and capability of the Ag *** first part of this Account introduces two strategies for the rational synthesis of Ag-based core-frame nanocubes.

关键词： Silver rational frame

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The In-cell iR Compensation Using a Four-electrode System

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Chinese Chemical Letters 2006年第5期17卷 703-706页

作者： Xiang qin LIN Liang dong FENG University of Science and Technology of China Hefei 230026

A novel idea of in-cell iR compensation was proposed by using a four-electrode electrochemical system, which was consisted of two working electrodes, one reference electrode （RE） and one auxiliary electrode （AE）. One of the two working electrodes was called the auxiliary working electrode （AWE）, which was directly connected to the ground. Another working electrode was used as a regular working electrode （WE） for electrochemical testing. The reference electrode was set in a frit close to the AWE for potential sampling. The other electrodes, WE, RE and AE, were connected to a conventional potentiostat of three-electrode system for electrochemical measurements. A linear narrow electrochemical cell was designed for setting AE at one end and AWE with RE at another end, and setting WE in between AE and AWE. In this way, a positive feedback potential was generated at the working electrode from the solution resistance and the current flow in the solution. An formal iR compensation over 100%, as high as 500%, had been achieved without potential oscillation. The electrochemical cell design, the principle of the in-cell iR compensation, and the preliminary voltammetric characterization by using the redox reaction of ferrocyanide anions were reported.

关键词： In-cell iR compensation four-electrode system cell design cyclic voltammetry.

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Improving the real-time performance of Ethernet for plant automation(EPA) based industrial networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第6期14卷 433-448页

作者： Li LU dong-qin FENG Jian CHU Institute of Cyber-Systems and Control Zhejiang University State Key Laboratory of Industrial Control Technology Zhejiang University

Real-time Ethernet(RTE) control systems with critical real-time requirements are called fast real-time(FRT) *** improve the real-time performance of Ethernet for plant automation(EPA),we propose an EPA-FRT *** minimum macrocycle of EPA networks is reduced by redefining the EPA network frame format,and the synchronization process is modified to acquire higher accuracy.A multi-segmented topology with a scheduling scheme is introduced to increase effective bandwidth utilization and reduce protocol overheads,and thus to shorten the communication cycle *** analysis and practical tests on a prototype system show the effectiveness of the proposed scheme,which achieves the best performance at small periodic payload in large scale systems.

关键词： Ethernet for plant automation (EPA) Fast real-time (FRT) system Real-time Ethernet (RTE) Scheduling scheme171 ~ ~l ~nI~ ]Ui^umanf onrla* A ~| F numh~* TDg02

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Influence of RE elements on the performances of Ni-P coelectrodeposi-tion bath

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Rare Metals 2005年第4期24卷 341-344页

作者： SHAO Guangjie CHEN Ling qin Xiujuan dong Haifeng College of Environmental and Chemical Engineering Yanshan University Qinhuangdao 066004 China

Through adding the chlorides of La and Ce into Ni-P coelectrodeposition bath, the effects of rare earth （RE） elements on the performances of the bath have been investigated by hull cell tests, far and near cathodes tests, and so on. It is shown that the optimum contents of CeCl3, LaCl3 and their mixture are all 2 g/L. The bright zones of the Ni-P coelectrodeposition bath are greatly widened by the addition of RE, and this effect is more obvious in the low current density range. By the addition of RE, the current efficiency of the Ni-P coelectrodeposition bath is greatly increased. The results also show that RE elements can improve the dispersing capacity of the bath. It can be theoretically deduced that RE ions improve the cathodic polarization degree of Ni-P codeposition. This deduction has been confirmed by the cathodic polarization curves measured in the baths.

关键词： electrodeposition Ni-P alloys coelectrodeposition bath rare earth

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Surface Characterization and Tribology Behavior of PMMA Processed by Excimer Laser

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Chinese Journal of Mechanical Engineering 2023年第5期36卷 45-61页

作者： dong qin Juan Guo Ming Liang Ling Chen Weimin He Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610000China Ophthalmology Department The Third People’s Hospital of ChengduChengdu 610031China

Polyoxymethylene methacrylate (PMMA) is widely used in ophthalmic biomaterials. Misuse of PMMA in extreme environments is likely to damage the ocular surface and intraocular structures. The surface characterization and tribological behavior of PMMA processed using an excimer laser were investigated in this study by contrasting diferent lubrication conditions and friction cycles. The results show that the roughness of the material surface increases with laser processing, which changes its physical structure. Under lubrication, the laser-treated PMMA exhibits better hydrophilicity, especially during the use of eye drops. No obvious relationship exists between the laser-processing time and friction behavior. However, the laser treatment may contribute to the formation of friction and wear mechanisms of PMMA materials. Laser-treated PMMA in saline solution exhibits better abrasive resistance by showing a lower wear rate than that in eye drops, although it has a higher friction coefcient. In this study, the diferent friction stages in laser-treated PMMA were clarifed under two lubrication conditions. The wear rates of the laser-treated PMMA were found to decrease with the number of cycles, and the friction coefcient has a similar variation tendency. The wear behavior of the laser-treated PMMA is dominated by the main abrasive wear and secondary transferred flm formation. This study provides a theoretical basis for the development and application of ophthalmic biomaterials in complex environments by examining the material surface interface behavior and wear mechanism after laser processing using PMMA as the research matrix.

关键词： Biocompatible materials Poly(methyl methacrylate) Surface characterization Tribology behavior

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Engrafted newborn neurons could functionally integrate into the host neuronal network

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Zoological Research 2017年第1期38卷 5-6页

作者： Zheng-Bo Wang dong-dong qin Xin-Tian Hu Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Kunming Yunnan 650223 China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai 200031 China

The limited capability to regenerate new neurons following injuries of the central neural system（CNS）still remains a major challenge for basic and clinical *** stem cells（NSCs）could nearly have the potential to di... 详细信息

关键词： cell NSCs Engrafted newborn neurons could functionally integrate into the host neuronal network

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Design, Synthesis and Application of Multifunctional Chiral Aminophosphine Catalyst for Asymmetric Intermolecular Cross Rauhut-Currier Reaction

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Chinese Journal of Chemistry 2022年第17期40卷 2061-2066页

作者： Wu-Wei dong Kui Tian Xiu-qin dong Chun-Jiang Wang Engineering Research Center of Organosilicon Compounds&Materials Ministry of EducationCollege of Chemistry and Molecular SciencesWuhan UniversityWuhanHubei430072 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai230021 China Suzhou Institute of Wuhan University SuzhouJiangsu215123 China

A series of structurally novel multifunctional chiral aminophosphine catalysts were developed through a concise synthetic strategy from easily available starting *** highly enantioselective intermolecular cross Rauhut-Currier reactions of vinyl ketones with 3-acyl acrylates and 2-ene-1,4-diones catalyzed by(S,S)-5a were well realized,generating a wide range of the structurally important chiral multicarbonyl products in good to excellent yields with high stereocontrol(up to 97%yield,99%ee).In addition,a series of 31P NMR experiments were carried out to further investigate the catalytic process.

关键词： Asymmetric catalysis Chiral aminophosphine Intermolecular cross Rauhut-Currier reaction Chiral multicarbonyl molecules Enantioselectivity

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Facile access to chiral 1-pyrrolines through Rh-catalyzed enantioselective partial hydrogenation of unprotected simple pyrroles

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Chinese Chemical Letters 2022年第12期33卷 5092-5095页

作者： Kui Tian Gongyi Liu Xiu-qin dong Engineering Research Centre of Organosilicon Compounds&Materials Ministry of EducationCollege of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China Suzhou Institute of Wuhan University Suzhou 215123China

Highly enantioselective Rh-catalyzed partial hydrogenation of unprotected simple 2-alkyl-5-aryl-disubstituted pyrroles has been successfully developed,generating a series of chiral 1-pyrroline derivatives generally with excellent results(95%-99%yields,91%-96%ee).Moreover,2,5-aryl-1H-pyrroles were hydrogenated well in high yields and good *** efficient protocol features easily accessible substrates,wide substrate scope,well functional group compatibility,commercially available rhodium precursor and chiral *** provides a versatile route to access chiral 1-pyrroline derivatives that are of great importance in organic synthesis and pharmaceutical chemistry.

关键词： Chiral 1-pyrrolines Partial hydrogenation Unprotected simple pyrroles Regioselectivity Enantioselectivity

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