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Next-generation sequencing and its clinical application

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Cancer Biology & Medicine 2019年第1期16卷 4-10页

作者： Dahui qin Molecular Diagnostic Laboratory Department of Pathology Moffitt Cancer Center

Next-generation sequencing (NGS) is a new technology used for DNA and RNA sequencing and variant/mutation detection. NGS can sequence hundreds and thousands of genes or whole genome in a short period of time. The sequence variants/mutations detected by NGS have been widely used for disease diagnosis, prognosis, therapeutic decision, and follow up of patients. The capacity of its massive parallel sequencing offers new opportunities for personalized precision medicine.

关键词： NGS DNA capacity

Decision-making under uncertainty for buildings exposed to environmental hazards

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Journal of Safety Science and Resilience 2022年第1期3卷 1-14页

作者： Hao qin School of Engineering The University of NewcastleNewcastleNSW 2308Australia School of Civil Engineering The University of QueenslandBrisbaneQld 4072Australia

Buildings are exposed to risks from environmental hazards such as earthquakes,windstorms and ***-stantial uncertainties from various sources are inevitably involved in the risk estimation and decision-making for activities such as design and disaster risk mitigation for *** makers seek to achieve economic efficiency while ensure building safety by managing the extreme tail risk that is typically a concern when facing low-probability,high-consequence ***,risk preferences and tolerances play an important role in the decision process,which often vary among different decision *** conventionally used minimum expected life-cycle cost criterion(MELC)fails to adequately cope with large uncertainty and risk *** this end,this paper presents the application of a set of decision models beyond the MELC to support decision-making under uncertainty for buildings exposed to environmental *** objective is to provide risk-informed de-cision support for decision-makers with a wide range of risk appetites while taking into account uncertainties involved in the life-cycle *** features,strengths and weaknesses of these decision models are discussed from a practical point of *** application and selection of the decision models are demonstrated by two practical decision problems:(i)seismic design of a high-rise commercial building,and(ii)wind hazard mitigation for a low-rise residential *** examples illustrate how the decisions for choosing seismic design levels and wind mitigation measures vary when different decision models and model settings are applied.

关键词： Decision-making Life-cycle cost Environmental hazards Uncertainty Risk preferences

Osteopontin is a promoter for hepatocellular carcinoma metastasis： a summary of 10 years of studies

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Frontiers of Medicine 2014年第1期8卷 24-32页

作者： Lunxiu qin Department of Surgery Huashan Hospital Fudan University Shanghai 200040 China

In this review, we summarize the novel findings from our series of studies on the leading metastasis- related gene, osteopontin （OPN）. In our previous gene expression profiling study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma （HCC）. We focused on OPN to evaluate its prognostic values and important roles in HCC metastasis. A retrospective study of large cohorts of HCC patients demonstrated that plasma OPN level was one of the leading independent prognostic factors for HCC patients, even in the early stage of HCC, and could serve as a surrogate serologic biomarker for monitoring the treatment response and tumor recurrence after HCC resection. Using both in vitro and in vivo investigations, we found that OPN has an important role in metastasis and tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis. We also found that OPNx HCC cells have much more amplifications at chromosomal regions, and promoter polymorphisms are important in the regulation of OPN expression and tumor growth and lung metastasis of HCC.

关键词： osteopontin (OPN) hepatocellular carcinoma metastasis prognosis therapeutic target biomarker geneticpolymorphism

8-Ranks of Class Groups of Quadratic Number Fields and Their Densities

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Acta Mathematica Sinica,English Series 2011年第7期27卷 1419-1434页

作者： qin YUE Department of Mathematics Nanjing University of Aeronautics and Astronautics Nanjing 210016 P. R. China

For F = Q（√εpq）, ε∈ {±1,±2}, primes -p ≡ q ≡ 1 mod 4, we give the necessary and sufficient conditions for 8-ranks of narrow class groups of F equal to 1 or 2 such that we can calculate their densities. All results are stated in terms of congruence relations of p, q modulo 2^n, the quartic residue symbol （1/q）4 and binary quadratic forms such as q^h（-2p）/^4 = x^2 ＋ 2py^2 where h（-2p） is the class number of Q（√-2p）. The results are very useful for numerical computations.

关键词： Class group unramified extension quartic residue

Knowledge-Based Multifaceted Modeling Methodology for Open Complex Giant Systems

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Journal of Systems Engineering and Electronics 1997年第3期8卷 34-42页

作者： qin, Shiyin Xi'an Jiaotong Univ China

In this paper, the structure characteristics of open complex giant systems are concretely analysed in depth, thus the view and its significance to support the meta synthesis engineering with manifold knowledge models are clarified. Furthermore, the knowledge based multifaceted modeling methodology for open complex giant systems is emphatically studied. The major points are as follows: (1) nonlinear mechanism and general information partition law; (2) from the symmetry and similarity to the acquisition of construction knowledge; (3) structures for hierarchical and nonhierarchical organizations; (4) the integration of manifold knowledge models; (5) the methodology of knowledge based multifaceted modeling.

关键词： Knowledge based multifaceted modeling Open complex giant systems Metasynthesis engineering Interpretive structural modeling.

中国儿童青少年遗尿症患病率及影响因素的Meta分析

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中国全科医学 2025年第6期28卷 763-770,776页

作者：刘芹程敏江凤琼李小玉川北医学院护理学院四川省南充市637000 电子科技大学医学院附属绵阳医院绵阳市中心医院四川省绵阳市621000

背景遗尿症是儿科常见疾病之一,近年来,遗尿症对儿童青少年身心健康造成了极大的威胁,严重影响患儿的生活质量,给社会和家庭带来严重的负担。目前,关于儿童青少年遗尿症的影响因素还存在争议,且国内外鲜见相关的系统评价。目的利用Meta... 详细信息

背景遗尿症是儿科常见疾病之一,近年来,遗尿症对儿童青少年身心健康造成了极大的威胁,严重影响患儿的生活质量,给社会和家庭带来严重的负担。目前,关于儿童青少年遗尿症的影响因素还存在争议,且国内外鲜见相关的系统评价。目的利用Meta分析探讨国内儿童青少年遗尿症的患病率和影响因素。方法计算机检索中国知网(CNKI)、万方数据知识服务平台(Wanfang Data)、维普网(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Embase、Web of Science、Cochrane Library数据库中的相关研究,检索时间从建库至2024年5月。由2名研究者独立筛选并交叉核对,横断面研究采用美国医疗保健研究与质量机构进行评估,采用Stata17.0软件进行Meta分析。结果共纳入27篇文献,包括243530例患儿。Meta分析结果显示,中国儿童青少年遗尿症患病率为6.1%(95%CI=5.1%~7.2%),其中,男性(OR=1.52,95%CI=1.41~1.64)、遗尿症家族史(OR=3.46,95%CI=2.01~5.93)、便秘(OR=2.32,95%CI=1.59~3.40)、尿路感染史(OR=2.33,95%CI=1.81~3.01)、睡眠障碍(OR=2.01,95%CI=1.10~3.67)、尿频(OR=1.90,95%CI=1.43~2.52)、尿急(OR=1.67,95%CI=1.31~2.12)、尿失禁(OR=4.85,95%CI=2.78~8.45)是儿童青少年遗尿症的危险因素(P<0.05);排尿训练(OR=0.11,95%CI=0.02~0.46)是儿童青少年遗尿症的保护因素(P<0.05)。结论中国儿童青少年遗尿症患病率较高,性别、遗尿症家族史、便秘、尿路感染史、排尿训练、睡眠障碍、尿频、尿急、尿失禁是儿童青少年遗尿症的主要影响因素。因此,未来应对儿童青少年遗尿症进行早期识别和干预,提高家长对遗尿症的重视,做好疾病宣教普及,减少遗尿症患病率,提高患儿及家庭生活质量。

关键词：遗尿遗尿症儿童青少年患病率影响因素 Meta分析

Revised Iterative Solution of Ground State of Double-Well Potential

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Communications in Theoretical Physics 2005年第6期43卷 1009-1018页

作者： ZHAOWei-qin ChinaCenterofAdvancedScienceandTechnology（CCAST） P.O.Box8730Beijing100080China／／InstituteofHighEnergyPhysicstheChineseAcademyofSciencesP.O.Box918（4-1）Beijing100049China

The revised new iterative method for solving the ground state of Schroedingerequation is deduced. Based on Green functions defined by quadratures along a single trajectory thisiterative method is applied to solve the ground state of the double-well potential. The result iscompared to the one based on the original iterative method. The limitation of the asymptoticexpansion is also discussed.

关键词： iterative solution asymptotic expansion double-well potential

Representations of Inverse Covariances by Differential Operators

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Advances in Atmospheric Sciences 2005年第2期22卷 181-198页

作者： qin XU NationalOceanicandAtmosphericAdministration／NationalSevereStormsLaboratory NormanOklahoma73069

In the cost function of three- or four-dimensional variational dataassimilation, each term is weighted by the inverse of its associated error covariance matrix and thebackground error covariance matrix is usually much larger than the other covariance *** the background error covariances are traditionally normalized and parameterized by simplesmooth homogeneous correlation functions, the covariance matrices constructed from these correlationfunctions are often too large to be inverted or even manipulated. It is thus desirable to finddirect representations of the inverses of background error correlations. This problem is studied inthis paper. In particular, it is shown that the background term can be written into ∫ dx∣Dυ(x)∣~2, that is, a squared 1/2 norm of a vector differential operator D, called theD-operator, applied to the field of analysis increment υ(x). For autoregressive correlationfunctions, the D-operators are of finite orders. For Gaussian correlation functions, the D-operatorsare of infinite order. For practical applications, the Gaussian D-operators must be truncated tofinite orders. The truncation errors are found to be small even when the Gaussian D-operators aretruncated to low orders. With a truncated D-operator, the background term can be easily constructedwith neither inversion nor direct calculation of the covariance matrix. D-operators are also derivedfor non-Gaussian correlations and transformed into non-isotropic forms.

关键词： differential operator inverse background covariance data assimilation

Revised Iterative Solution for Groundstate of Schro^edinger Equation

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Communications in Theoretical Physics 2004年第1X期42卷 37-42页

作者： ZHAOWei-qin ChinaCenterofAdvancedScienceandTechnology(CCAST) (WorldLab.)P.O.Box8730Beijing100080China

A revised iterative method based on Green function defined by quadratures along a single trajectory is proposed to solve the low-lying quantum wave function for Schro^edinger equation. Specially a new expression of the perturbed energy is obtained, which is much simpler than the traditional one. The method is applied to solve the unharmonic oscillator potential. The revised iteration procedure gives exactly the same result as those based on the single trajectory quadrature method. A comparison of the revised iteration method to the old one is made using the example of Stark effect. The obtained results are consistent to each other after making power expansion.

关键词：量子力学格林函数修订迭代解薛定谔方程单轨道求积法