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Pre-operative enhanced magnetic resonance imaging combined with clinical features predict early recurrence of hepatocellular carcinoma after radical resection

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1192-1203页

作者： jian-ping Chen Ri-Hui Yang Tian-Hui Zhang Li-An Liao Yu-Ting Guan Hai-Yang Dai Department of Intervention Meizhou People’s HospitalMeizhou 514031Guangdong ProvinceChina Department of Medical Imaging Meizhou People’s HospitalMeizhou 514031Guangdong ProvinceChina Department of Medical Imaging Huizhou Municipal Central HospitalHuizhou 516001Guangdong ProvinceChina

BACKGROUND Indentifying predictive factors for postoperative recurrence of hepatocellular carcinoma(HCC)has great significance for patient *** To explore the value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)enhanced magnetic resonance imaging(MRI)combined with clinical features in predicting early recurrence of HCC after *** A total of 161 patients with pathologically confirmed HCC were *** patients were divided into early recurrence and non-early recurrence group based on the follow-up *** clinical,laboratory,pathological results and Gd-EOB-DTPA enhanced MRI imaging features were *** Of 161 patients,73 had early recurrence and 88 were had non-early *** analysis showed that patient age,gender,serum alpha-fetoprotein level,the Barcelona Clinic Liver Cancer stage,China liver cancer(CNLC)stage,microvascular invasion(MVI),pathological satellite focus,tumor size,tumor number,tumor boundary,tumor capsule,intratumoral necrosis,portal vein tumor thrombus,large vessel invasion,nonperipheral washout,peritumoral enhancement,hepatobiliary phase(HBP)/tumor signal intensity(SI)/peritumoral SI,HBP peritumoral low signal and peritumoral delay enhancement were significantly associated with early recurrence of HCC after *** logistic regression analysis showed that patient age,MVI,CNLC stage,tumor boundary and large vessel invasion were independent predictive *** data validation indicated that the area under the curve of the combined predictors was 0.861,suggesting that multivariate logistic regression was a reasonable predictive model for early recurrence of *** Gd-EOB-DTPA enhanced MRI combined with clinical features would help predicting the early recurrence of HCC after operation.

关键词： Hepatocellular carcinoma Enhanced magnetic resonance imaging Microvascular invasion Hepatobiliary phase Recurrence

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Roles of the tumor microenvironment in the resistance to programmed cell death protein 1 inhibitors in patients with gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3820-3831页

作者： Ren-Jie Xia Xiao-Yu Du Li-Wen Shen jian-Guo Ma Shu-Mei Xu Rui-Fang Fan jian-Wei qin Long Yan Department of General Surgery The 940^(th)Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Medicine Northwest Minzu UniversityLanzhou 730050Gansu ProvinceChina Department of Medical Support Center The 940^(th)Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina

Despite the continuous developments and advancements in the treatment of gastric cancer(GC),which is one of the most prevalent types of cancer in China,the overall survival is still poor for most patients with advanced *** recent years,with the progress in tumor immunology research,attention has shifted toward immunotherapy as a therapeutic approach for *** cell death protein 1(PD-1)inhibitors,as novel immunosuppressive medications,have been widely utilized in the treatment of ***,many patients are still resistant to PD-1 inhibitors and experience recurrence in the advanced stages of PD-1 *** reduce the occurrence of drug resistance and recurrence in GC patients receiving PD-1 immunotherapy,to maximize the clinical activity of immunosuppressive drugs,and to elicit a lasting immune response,it is essential to research the tumor microenvironment mechanisms leading to PD-1 inhibitor resistance in GC *** article reviews the progress in studying the factors influencing the resistance to PD-1 inhibitors in the GC tumor microenvironment,aiming to provide insights and a basis for reducing resistance to PD-1 inhibitors for GC patients in the future.

关键词： Gastric cancer Tumor microenvironment Programmed cell death protein 1 Immunotherapy Drug resistance

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Human pluripotent stem cell-derived kidney organoids:Current progress and challenges

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World Journal of Stem Cells 2024年第2期16卷 114-125页

作者： Hong-Yan Long Zu-ping Qian qin Lan Yong-Jie Xu Jing-Jing Da Fu-Xun Yu Yan Zha Graduate School Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Laboratory Medicine Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina Department of Nephrology Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina Key Laboratory of Diagnosis and Treatment of Pulmonary Immune Diseases National Health CommissionGuizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

Human pluripotent stem cell(hPSC)-derived kidney organoids share similarities with the fetal ***,the current hPSC-derived kidney organoids have some limitations,including the inability to perform nephrogenesis and lack of a corticomedullary definition,uniform vascular system,and coordinated exit path-way for urinary ***,further studies are required to produce hPSC-derived kidney organoids that accurately mimic human kidneys to facilitate research on kidney development,regeneration,disease modeling,and drug *** this review,we discussed recent advances in the generation of hPSC-derived kidney organoids,how these organoids contribute to the understanding of human kidney development and research in disease ***,the limitations,future research focus,and applications of hPSC-derived kidney organoids were highlighted.

关键词： Kidney Organoids Human pluripotent stem cell Development Vascular system Disease modeling

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论图书馆复制例外之扩大适用——兼论《著作权法》(修订草案送审稿)相关条款

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图书馆研究 2017年第5期47卷 1-6页

作者：秦建平中南财经政法大学知识产权研究中心湖北武汉430000

图书馆复制相关版权作品是图书馆的业务之一。现行《著作权法》只为图书馆设置了"保存"的例外,对于图书馆复制未发表的作品、图书馆应读者要求的复制行为、为其他图书馆提供复制件的行为以及通过网络实施上述复制行为,法律没有具体规定... 详细信息

图书馆复制相关版权作品是图书馆的业务之一。现行《著作权法》只为图书馆设置了"保存"的例外,对于图书馆复制未发表的作品、图书馆应读者要求的复制行为、为其他图书馆提供复制件的行为以及通过网络实施上述复制行为,法律没有具体规定,《著作权法》(修订草案送审稿)也保留了原先的法律规定,这给图书馆的运营带来了潜在的法律风险。在我国《著作权法》中设置图书馆合理使用的一般条款,完善图书馆的复制的具体情形,对维护社会公众、版权人和图书馆的利益,保障图书馆的保存和传播知识的功能,具有不可替代的意义。

关键词：图书馆复制权版权例外合理使用

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Aflibercept combined with triamcinolone acetonide in the treatment of diabetic macular edema:optical coherence tomography and optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 670-675页

作者： De-Shuang Li Hong-Xia Liao Chuan-He Zhang jian-Guo Huang Wei Chen Jing-Lin Zhang Bo qin Shenzhen Aier Eye Hospital Aier Eye HospitalJinan UniversityShenzhen 518031Guangdong ProvinceChina Department of Ophthalmology the University of Hong Kong-Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Guangzhou Aier Eye Hospital Jinan UniversityGuangzhou 510040Guangdong ProvinceChina

AIM:To analyze the relationship between optical coherence tomography(OCT)and OCT angiography(OCTA)imaging in patients with diabetic macular edema(DME)who are treated with a combination of aflibercept and triamcinolone acetonide(TA).METHODS:A total of 76 eyes newly diagnosed DME were included in this *** were randomly assigned to receive either aflibercept or a combination of aflibercept and *** once a month for a total of three *** macular thickness(CMT),number of hyperreflective foci(HRF),height of subretinal fluid(SRF),and area of foveal avascular zone(FAZ)were evaluated using OCT and OCTA at baseline and after each monthly ***:Both groups showed improvement in best corrected visual acuity(BCVA)and reduction in macular edema after treatment,and the difference in BCVA between the two groups was statistically significant after each treatment(P<0.05).The difference in CMT between the two groups was statistically significant after the first two injections(P<0.01),but not after the third injection(P=0.875).The number of HRF(1mo:7.41±8.25 vs 10.86±7.22,P=0.027;2mo:5.33±6.13 vs 9.12±8.61,P=0.034;3mo:3.58±3.00 vs 6.37±5.97,P=0.007)and height of SRF(1mo:82.39±39.12 vs 105.77±42.26μm,P=0.011;2mo:36.84±10.02 vs 83.59±37.78μm,P<0.01;3mo:11.57±3.29 vs 45.43±12.60μm,P<0.01)in combined group were statistically significant less than aflibercept group after each injection,while the area of FAZ showed no significant change before and after treatment in both ***:The combination therapy of aflibercept and TA shows more significant effects on DME eyes with decreased HRF and ***,both aflibercept and combination therapy show no significant change in the area of FAZ.

关键词： diabetic macular edema optical coherence tomography optical coherence tomography angiography hyperreflective foci subretinal fluid foveal avascular zone aflibercept

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Short-term displacement prediction for newly established monitoring slopes based on transfer learning

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China Geology 2024年第2期7卷 351-364页

作者： Yuan Tian Yang-landuo Deng Ming-zhi Zhang Xiao Pang Rui-ping Ma jian-xue Zhang Institute of Remote Sensing and Geographical Information Systems Peking UniversityBeijing 100871China Beijing Key Laboratory of Spatial Information Integration and Its Applications Beijing 100871China Institute of Public Safety Research Department of Engineering PhysicsTsinghua UniversityBeijing 100084China China Institute of Geo-Environment Monitoring Beijing 100081China Technology Innovation Center for Geohazard Monitoring and Risk Early Warning Ministry of Natural ResourcesBeijing 100081China

This study makes a significant progress in addressing the challenges of short-term slope displacement prediction in the Universal Landslide Monitoring Program,an unprecedented disaster mitigation program in China,where lots of newly established monitoring slopes lack sufficient historical deformation data,making it difficult to extract deformation patterns and provide effective predictions which plays a crucial role in the early warning and forecasting of landslide hazards.A slope displacement prediction method based on transfer learning is therefore ***,the method transfers the deformation patterns learned from slopes with relatively rich deformation data by a pre-trained model based on a multi-slope integrated dataset to newly established monitoring slopes with limited or even no useful data,thus enabling rapid and efficient predictions for these ***,as time goes on and monitoring data accumulates,fine-tuning of the pre-trained model for individual slopes can further improve prediction accuracy,enabling continuous optimization of prediction results.A case study indicates that,after being trained on a multi-slope integrated dataset,the TCN-Transformer model can efficiently serve as a pretrained model for displacement prediction at newly established monitoring *** three-day average RMSE is significantly reduced by 34.6%compared to models trained only on individual slope data,and it also successfully predicts the majority of deformation *** fine-tuned model based on accumulated data on the target newly established monitoring slope further reduced the three-day RMSE by 37.2%,demonstrating a considerable predictive *** conclusion,taking advantage of transfer learning,the proposed slope displacement prediction method effectively utilizes the available data,which enables the rapid deployment and continual refinement of displacement predictions on newly established monitoring slopes.

关键词： Landslide Slope displacement prediction Transfer learning Integrated dataset Transformer Pre-trained model Universal Landslide Monitoring Program(ULMP) Geological hazards survey engineering

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Structure elucidation and sulfated derivatives preparation of a water extractable polysaccharide from Lonicerae japonica Thunb and their anti-Aβ aggregation bioactivity

Structure elucidation and sulfated derivatives preparation o...

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2008年全国糖生物学学术会议

作者： LIU qin FANG jian-ping DING Kan Glycobiology and Glycochemistry Lab,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China

Heparan sulfate(HS)and glycoaminoglycan analogues have some potential of treatment for AD(Alzheimer’s disease).They have been shown to inhibit the formation of Aβ(amyloid β-peptide)by directly interaction with BAC...

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Triple points and phase transitions of D-dimensional dyonic Ad S black holes with quasitopological electromagnetism in Einstein–Gauss–Bonnet gravity

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Chinese Physics B 2024年第6期33卷 272-287页

作者：牟平辉蒋青权何柯腱李国平 School of Physics and Astronomy China West Normal UniversityNanchong 637000China College of Physics Chongqing UniversityChongqing 401331China

By considering the negative cosmological constant Λ as a thermodynamic pressure, we study the thermodynamics and phase transitions of the D-dimensional dyonic Ad S black holes(BHs) with quasitopological electromagnetism in Einstein–Gauss–Bonnet(EGB) gravity. The results indicate that the small/large BH phase transition that is similar to the van der Waals(vdW) liquid/gas phase transition always exists for any spacetime dimensions. Interestingly, we then find that this BH system exhibits a more complex phase structure in 6-dimensional case that is missed in other ***, it shows for D = 6 that we observed the small/intermediate/large BH phase transitions in a specific parameter region with the triple point naturally appeared. Moreover, when the magnetic charge turned off, we still observed the small/intermediate/large BH phase transitions and triple point only in 6-dimensional spacetime, which is consistent with the previous results. However, for the dyonic Ad S BHs with quasitopological electromagnetism in Einstein–Born–Infeld(EBI) gravity, the novel phase structure composed of two separate coexistence curves observed by Li et al. [Phys. Rev. D105 104048(2022)] disappeared in EGB gravity. This implies that this novel phase structure is closely related to gravity theories, and seems to have nothing to do with the effect of quasitopological electromagnetism. In addition, it is also true that the critical exponents calculated near the critical points possess identical values as mean field theory. Finally, we conclude that these findings shall provide some deep insights into the intriguing thermodynamic properties of the dyonic Ad S BHs with quasitopological electromagnetism in EGB gravity.

关键词： AdS black hole phase transition triple point

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Visible-light photoredox-catalyzed carboxylation of aryl epoxides with CO_(2)

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Chinese Chemical Letters 2024年第7期35卷 281-284页

作者： Tian-Yu Gao Xiao-Yan Mo Shu-Rong Zhang Yuan-Xu jiang Shu-ping Luo jian-Heng Ye Da-Gang Yu Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology Zhejiang University of TechnologyHangzhou 310014China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Herein, we report the first visible-light photoredox-catalyzed carboxylation of aryl epoxides with CO_(2)to synthesize hydroxy acid derivatives. A variety of valuable β-, γ-, δ-, ε–hydroxy acid derivatives are obtained in moderate to high yields under mild conditions. This protocol shows noteworthy functionalgroup compatibility, high chemo-and regioselectivities under transition-metal-free conditions with an inexpensive organo-dye as photosensitizer. Mechanistic studies indicate that the benzylic carbanion is generated as an intermediate via the sequential single electron transfer(SSET) process.

关键词： Carbon dioxide Epoxides Visible-light photoredox catalysis Hydroxy acid Sequential single electron transfer

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Inverse Calculation and Regularization Process for the Solar Aspect System(SAS) of HXI Payload on ASO-S Spacecraft

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Research in Astronomy and Astrophysics 2024年第4期24卷 13-34页

作者： Ji-Rui Yu ping Ruan Yang Su Ying-Hong He Jin-You Tao Zhe Zhang Song Guo Bin Xue jian-Feng Yang Xi'an Institute of Optics and Precision Mechanics of Chinese Academy of Sciences Xi'an 710119China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 20034China School ofAstronomy and Space Science Universityof Science and Technology of ChinaHefei 230026China

For the ASO-S/HXI payload, the accuracy of the flare reconstruction is reliant on important factors such as the alignment of the dual grating and the precise measurement of observation orientation. To guarantee optimal functionality of the instrument throughout its life cycle, the Solar Aspect System (SAS) is imperative to ensure that measurements are accurate and reliable. This is achieved by capturing the target motion and utilizing a physical model-based inversion algorithm. However, the SAS optical system’s inversion model is a typical ill-posed inverse problem due to its optical parameters, which results in small target sampling errors triggering unacceptable shifts in the solution. To enhance inversion accuracy and make it more robust against observation errors, we suggest dividing the inversion operation into two stages based on the SAS spot motion model. First, the as-rigid-aspossible (ARAP) transformation algorithm calculates the relative rotations and an intermediate variable between the substrates. Second, we solve an inversion linear equation for the relative translation of the substrates, the offset of the optical axes, and the observation orientation. To address the ill-posed challenge, the Tikhonov method grounded on the discrepancy criterion and the maximum a posteriori (MAP) method founded on the Bayesian framework are utilized. The simulation results exhibit that the ARAP method achieves a solution with a rotational error of roughly±3 5 (1/2-quantile);both regularization techniques are successful in enhancing the stability of the solution, the variance of error in the MAP method is even smaller—it achieves a translational error of approximately±18μm (1/2-quantile) in comparison to the Tikhonov method’s error of around±24μm (1/2-quantile). Furthermore, the SAS practical application data indicates the method’s usability in this study. Lastly, this paper discusses the intrinsic interconnections between the regularization methods.

关键词： methods:data analysis Sun:flares Sun:X-rays gamma rays

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