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Experimental study on bed-load sediment transport under irregular wave and current combined flow

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Acta Oceanologica Sinica 2001年第2期20卷 271-280页

作者： Wu Yongsheng,qin chongren (1. Department of Hydraulic Engineering, Tsinghua University, Beijing 100084, China 2. School of Civil Engineering, Tianjin University, Tianjin 300072, China) Department of Hydraulic Engineering Tsinghua University Beijing 100084 China

Using an irregularly oscillating tray and flume, a series of experiments are completed to evaluate bed-load sediment transport rate under irregular wave -current coexistent field. Testing conditions include three interaction angles 0', 45', 90' and two kinds of median sizes (0.38 and 1.10 mm). The results of transport rate show that the net sediment transport rate can be expressed approximately as the function of the maximum bottom shear stress of waves, mean shear stress of current and the grain size.

关键词： Irregular wave-current bed-load transport rate

底浮箱式防波堤消浪性能、锚链张力及运动轨迹的试验研究

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港工技术 2008年第6期45卷 10-13页

作者：胡嵋李大鸣秦崇仁天津大学建筑工程学院天津300072

通过物理模型试验，底浮箱式防波堤在定水深和锚碇固位，受规则波、水流作用下，对浮堤的运动状态进行试验研究。对在波浪单独作用和波、流共同作用时，浮堤的消浪性能和锚链张力进行比较性试验，并对浮堤在波浪单独作用下的运动轨迹进... 详细信息

通过物理模型试验，底浮箱式防波堤在定水深和锚碇固位，受规则波、水流作用下，对浮堤的运动状态进行试验研究。对在波浪单独作用和波、流共同作用时，浮堤的消浪性能和锚链张力进行比较性试验，并对浮堤在波浪单独作用下的运动轨迹进行描述。试验结果表明，波浪单独作用的浮堤消浪效果好于波、流共同存在时；锚链张力的变化趋势基本相同；由于浮堤的堤宽与波长相比仅是1／6～1／3，浮堤两弦之间的相位差仅为（1／3～1／1．6）π，因此，浮堤的摇摆角度并不大。

关键词：浮式防波堤规则波水流波浪透射系数锚链张力浮堤的运动轨迹

DKP-SLAM:A Visual SLAM for Dynamic Indoor Scenes Based on Object Detection and Region Probability

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Computers, Materials & Continua 2025年第1期82卷 1329-1347页

作者： Menglin Yin Yong qin Jiansheng Peng College of Automation Guangxi University of Science and TechnologyLiuzhou545000China Department of Artificial Intelligence and Manufacturing Hechi UniversityHechi546300China Key Laboratory of AI and Information Processing Education Department of Guangxi Zhuang Autonomous RegionHechi546300China Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology School of Chemistry and BioengineeringHechi UniversityHechi546300China

In dynamic scenarios,visual simultaneous localization and mapping(SLAM)algorithms often incorrectly incorporate dynamic points during camera pose computation,leading to reduced accuracy and *** paper presents a dynamic SLAM algorithm that leverages object detection and regional dynamic ***,a parallel thread employs the YOLOX object detectionmodel to gather 2D semantic information and compensate for missed ***,an improved K-means++clustering algorithm clusters bounding box regions,adaptively determining the threshold for extracting dynamic object contours as dynamic points *** process divides the image into low dynamic,suspicious dynamic,and high dynamic *** the tracking thread,the dynamic point removal module assigns dynamic probability weights to the feature points in these *** with geometric methods,it detects and removes the dynamic *** final evaluation on the public TUM RGB-D dataset shows that the proposed dynamic SLAM algorithm surpasses most existing SLAM algorithms,providing better pose estimation accuracy and robustness in dynamic environments.

关键词： Visual SLAM dynamic scene YOLOX K-means++clustering dynamic probability

建设工程合同与索赔管理信息系统——工程施工中的合同管理计算机软件

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中国港湾建设 1999年第5期19卷 64-66页

作者：张伟刘海青秦崇仁天津大学建筑工程学院天津300072

本系统为工程施工中的合同与索赔管理的计算机软件，可以为业主、承包商和监理工程师在整个施工过程中的进度、资金和质量管理、控制以及索赔提供科学、快捷的手段。

关键词：合同管理施工过程索赔计算机软件

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian qin Yuxin Jin Yiming qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis

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Oncology Research 2025年第1期33卷 185-198页

作者： ZHOUYANG CHENG YUCHEN HUA YANG CAO JUN qin Department of General Surgery Affiliated Hospital of Nantong UniversityNantong226001China Department of Surgery Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Operation Affiliated Hospital of Nantong UniversityNantong226001China

Objective:Gastric cancer(GC)is a globally common cancer characterized by high incidence and mortality *** in the molecular understanding of GC provide promising targets for GC diagnosis and *** non-coding RNAs(lncRNAs)and their downstream regulators are regarded to be implicated in the progression of multiple types of *** have shown that the lncRNA small nucleolar RNA host gene 4(SNHG4)serves as a tumor promoter in various malignancies,while its function in GC has yet to be ***,our study aimed to explore the role and underlying mechanism of SNHG4 in ***:We used qRT-PCR to analyze SNHG4 expression in GC tissues and ***-Meier analysis was used to assess the correlation between SNHG4 expression and the survival rate of GC *** function experiments such as CCK-8,BrdU,colony formation,flow cytometry analysis,and transwell were performed to explore the effects of SNHG4 on GC cell proliferation,apoptosis,cell cycle,migration,and *** also established xenograft mouse models to explore the effect of SNHG4 on GC tumor ***,dual luciferase reporter assay was used to verify the interaction between SNHG4 and miR-409-3p and between miR-409-3p and cAMP responsive element binding protein 1(CREB1).Results:The results indicated that SNHG4 was overexpressed in GC tissues and cell lines,and was linked with poor survival rate of GC ***4 promoted GC cell proliferation,migration,and invasion while inhibiting cell apoptosis and cell cycle arrest in *** in vivo experiment indicated that SNHG4 facilitated GC tumor ***,SNHG4 was demonstrated to bind to ***,CREB1 was directly targeted by *** assays demonstrated that miR-409-3p deficiency reversed the suppressive impact of SNHG4 knockdown on GC cell ***,miR-409-3p was also revealed to inhibit GC cell proliferation,migration,and invasion by targeting CREB1

关键词： Gastric cancer Small nucleolar RNA host gene 4(SNHG4) MicroRNA-409-3p(miR-409-3p) cAMP responsive element binding protein 1(CREB1)

潮汐作用下重力式沉箱压载致倾调平的试验研究

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港工技术 2009年第6期46卷 1-3页

作者：胡嵋张兴无秦崇仁天津大学建筑工程学院天津300072

为避免沉箱在坐底时产生较大的倾斜,在受潮汐作用的条件下,针对在淤泥质海床上锚固定位后的沉箱进行压载致倾调平物理模型试验研究。试验中,根据地质勘察报告给出的现场分层地基的土层厚度及物理性质指标,将地基模型分成3层。通过本研究... 详细信息

为避免沉箱在坐底时产生较大的倾斜,在受潮汐作用的条件下,针对在淤泥质海床上锚固定位后的沉箱进行压载致倾调平物理模型试验研究。试验中,根据地质勘察报告给出的现场分层地基的土层厚度及物理性质指标,将地基模型分成3层。通过本研究,分析总结沉箱在饱和软粘土地基上临近压载坐底前的过程,试验结果可为工程施工提供参考。

关键词：模型试验锚固定位潮汐沉箱压载致倾调平饱和软粘土

Post-tunable salt gel electrolytes toward flexible supercapacitor switches

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Journal of Energy Chemistry 2025年第1期100卷 114-124页

作者： Hui Wang Shuang Chen Xuming Liu qin Zhang Xin Liu Polymeric and Soft Materials Laboratory School of Chemistry and Life Science and Advanced Institute of Materials Science Changchun University of Technology Polymeric and Soft Materials Laboratory School of Chemical Engineering and Advanced Institute of Materials Science Changchun University of Technology

Convertible hydrogel supercapacitors have emerged as promising energy storage devices in switches,diodes, and transistors. However, inherent weaknesses in ionic conductivity, mechanical properties,and water retention of hydrogel electrolytes seriously hinder their development. Inspired by the hardness conversion of sea cucumber skin, a conductivity and mechanics dual-tunable salt gel electrolyte is successfully designed. The salt gel presents a reversible switching of conductors-insulators and a mechanical regulation between softness and hardness via the dissolution-crystallization transition of sodium acetate trihydrate（SAT）. Meanwhile, the salt gels spontaneously grow a layer of “armor” through saturated phase-change salt crystals effectively reducing water evaporation of hydrogel ***, this phase-change soft-rigid conversion strategy will expand the capabilities of gel-based flexible supercapacitors(area capacitance: 258.6 mF cm-2), and the capacitance retention rate could still reach 86.9% after 3000 cycles at high temperatures. Moreover, the salt gel supercapacitor is potentially used in over-heat alarm systems. It is anticipated that the strategy of conductivity and mechanics of dual-tunable salt gel would provide a new perspective on the development of energy storage devices,wearable electronics, and flexible robots.

关键词： Capacitance

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte