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ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury

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Neural Regeneration Research 2021年第8期16卷 1598-1605页

作者： shi-qin Lv Wutian Wu Guangdong-Hong Kong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Re-Stem Biotechnology Co. Ltd.SuzhouJiangsu ProvinceChina

Both intracellular sigma peptide(ISP) and phosphatase and tensin homolog agonist protein(PAP4) promote nerve regeneration and motor functional recovery after spinal cord injury. However, the role of these two small peptides in peripheral nerve injury remains unclear. A rat model of brachial plexus injury was established by crush of the C6 ventral root. The rats were then treated with subcutaneous injection of PAP4(497 μg/d, twice per day) or ISP(11 μg/d, once per day) near the injury site for 21 successive days. After ISP and PAP treatment, the survival of motoneurons was increased, the number of regenerated axons and neuromuscular junctions was increased, muscle atrophy was reduced, the electrical response of the motor units was enhanced and the motor function of the injured upper limbs was greatly improved in rats with brachial plexus injury. These findings suggest that ISP and PAP4 promote the recovery of motor function after peripheral nerve injury in rats. The animal care and experimental procedures were approved by the Laboratory Animal Ethics Committee of Jinan University of China(approval No. 20111008001) in 2011.

关键词： axon brachial plexus injury crush injury intracellular sigma peptide motor function PAP4 peripheral nerve protection regeneration repair

Chemical constituents and biological activities of lycophytes and ferns

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Chinese Journal of Natural Medicines 2019年第12期17卷 887-891页

作者： ZHU qin-Feng ZHAO qin-shi State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

Lycophytes and ferns are unique and charismatic members of many terrestrial ecosystems and occupy the pivotal position in land plant origin and *** Chinese lycophytes and ferns flora,with approximately 2000 species,contributes a substantial component to the global lycophytes and ferns diversity,with estimates of 12000 *** them,about 433 species are medicinally recorded and researches based on their phytochemical properties are important topics in natural *** paper reviewed the research history and current status of chemical constituents and biological activities of lycophytes and ferns,which had highlighted the research progress of our group.

关键词： Lycophytes Ferns Chemical constituents Biological activities Lycopodium alkaloids

Do large-scale farmers use more pesticides? Empirical evidence from rice farmers in five Chinese provinces

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Journal of Integrative Agriculture 2020年第2期19卷 590-599页

作者： qin shi-le LU Xin-ye Institute of Agricultural Economics and Development Chinese Academy of Agricultural Sciences

It is of great theoretical and practical significance to understand the rules of the differences in pesticide use behaviors between large-scale and small-scale farmers,so as to regulate the behavior of farmers differently and improve the quality and safety of *** overall pesticide use behavior of large-scale farmers was characterized by large doses and high application frequency,while that of small-scale farmers was characterized by small doses and low application *** econometric test showed that(i)the proportion of staple food ration has a significant negative impact on the single dose exceeding the standard and pesticide application frequency of small-scale farmers,and the increase of the proportion of staple food ration will reduce the demand among small-scale farmers for pesticides;(ii)yield effect has a greater impact on the frequency of pesticide application by large-scale farmers,and the large yield effect will increase the frequency of pesticide application among large-scale ***,in pesticide use behaviors,large-scale farmers should reduce pesticide quantity and increase efficiency,while small-scale farmers improve the level of plant protection.

关键词： pesticide use behavior rice farmers scale management

DIRECT DIGITAL DESIGN AND SIMULATION OF MEshiNG IN WORM-GEAR DRIVE

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Chinese Journal of Mechanical Engineering 2006年第3期19卷 428-433页

作者： XU Wujiao qin Datong shi Wankai State Key Laboratory of Mechanical Transmission Chongqing University Chongqing 400044 China

A direct digital design method （DDDM） of worm-gear drive is proposed. It is directly based on the simulation of manufacturing process and completely different from the conventional modeling method. The loaded tooth contact analysis （LTCA） method is analyzed, in which the advanced surface to surface searching technique is included. The influence of misalignment errors and contact deformations on contact zone and transmission error （TE） is discussed. Combined modification approach on worm tooth surface is presented. By means of DDDM and LTCA, it is very conven- ient to verify the effect of worm-gear drive＇s modification approach. The analysis results show that, the modification in profile direction reduces the sensitivity of worm-gear drive to misalignment errors and the modification in longitudinal direction decreases the TE. Thus the optimization design of worm-gear drive can be achieved prior to the actual manufacturing process.

关键词： Direct digital design Loaded tooth contact analysis Combined modification approach Worm-gear drive

Introduction of a Reliable Method for Determination of Intrinsic Viscosity for Any Polymer with High Precision

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Chinese Journal of Polymer Science 2014年第2期32卷 209-217页

作者：熊晓鹏 Qi-rong Ke shi-qin Zhu Department of Materials Science and Engineering College of Materials Xiamen University Fujian Provincial Key Laboratory of Polymer Materials Fujian Normal University Institut für Physikalische Chemie der Johannes Gutenberg-Universit t Mainz

Intrinsic viscosities for a given polyelectrolyte in salt free and low-salt solvents reported in literatures are normally not comparable, because of inadequate valuation procedures. This article describes a theoretically justified reliable method, which is free of any model assumptions： The so called Wolf plot （logarithm of the relative viscosity as a function of polymer concentration） enables the unequivocal determination of intrinsic viscosities for all kinds of macromolecules, irrespective of whether they are chain molecules of different architecture or globular polymers, whether they are charged or uncharged. The validation of the method was examined by evaluation of the viscosities of a polyelectrolyte, some uncharged polymers of different architectures, uncharged polymer blends, and some literature data.

关键词： Intrinsic viscosity Polyelectrolyte New method Wolf plot Introduction.

State of charge estimation by finite difference extended Kalman filter with HPPC parameters identification

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Science China(Technological Sciences) 2020年第3期63卷 410-421页

作者： HE Lin HU MinKang WEI YuJiang LIU BingJiao shi qin Automotive Research Institute Hefei University of TechnologyHefei 230009China School of Automotive and Transportation Engineering Hefei University of TechnologyHefei 230009China

State of charge(SOC) is a key parameter of lithium-ion battery. In this paper, a finite difference extended Kalman filter(FDEKF)with Hybrid Pulse Power Characterization(HPPC) parameters identification is proposed to estimate the SOC. The finite difference(FD) algorithm is benefit to compute the partial derivative of nonlinear function, which can reduce the linearization error generated by the extended Kalman filter(EKF). The FDEKF algorithm can reduce the computational load of controller in engineering practice without solving the Jacobian matrix. It is simple of dynamic model of lithium-ion battery to adopt a secondorder resistor-capacitor(2 RC) network, the parameters of which are identified by the HPPC. Two conditions, both constant current discharge(CCD) and urban dynamometer driving schedule(UDDS), are utilized to validate the FDEKF *** convergence rate and accuracy between the FDEKF and the EKF algorithm, it can be seen that the former is a better candidate to estimate the SOC.

关键词： state of charge lithium-ion battery parameters identification finite difference algorithm extended Kalman filter

Fluctuations of Single-Mode Laser Driven by Two Different Kinds of Colored Noise

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Communications in Theoretical Physics 2006年第4期45卷 630-636页

作者： WU Dan LUO Xiao-qin ZHU shi-Qun School of Physical Science and Technology Suzhou University Suzhou 215006 China

A single-mode laser with coupling between additive and multiplicative noise terms is investigated when the multiplicative noise and the coupling between two noise terms are colored fluctuations with finite correlation times T1 and T2. Combining the unified colored noise approximation （UCNA） and the functional analysis, the stationary probability distribution （SPD） and the variance of the laser intensity is derived. It is found that the colored nature of multiplicative noise and the coupling strength between two noise terms can affect both the structure and the height of the SPD, while the colored nature of the coupling between two noise terms can only affect the height of the SPD. The multiplicative noise can enhance the intensity fluctuations while the additive noise can reduce the fluctuations in a laser system. Numerical simulations are presented and consistent to the analytical results.

关键词： single-mode laser colored noise fluctuation coupling variance

Advances in coamorphous drug delivery systems

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Acta Pharmaceutica Sinica B 2019年第1期9卷 19-35页

作者： qin shi Sakib M.Moinuddin Ting Cai State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University

In recent years, the coamorphous drug delivery system has been established as a promising formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a single-phase system containing an active pharmaceutical ingredient(API) and other low molecular weight molecules that might be pharmacologically relevant APIs or excipients. These formulations exhibit considerable advantages over neat crystalline or amorphous material, including improved physical stability, dissolution profiles, and potentially enhanced therapeutic efficacy. This review provides a comprehensive overview of coamorphous drug delivery systems from the perspectives of preparation, physicochemical characteristics,physical stability, in vitro and in vivo performance. Furthermore, the challenges and strategies in developing robust coamorphous drug products of high quality and performance are briefly discussed.

关键词： Coamorphous Preparation Characterization Physical stability Dissolution Bioavailability

Anchor Self-Localization Algorithm Based on UWB Ranging and Inertial Measurements

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Tsinghua Science and Technology 2019年第6期24卷 728-737页

作者： qin shi Sihao Zhao Xiaowei Cui Mingquan Lu Mengdi Jia the Department of Electronic Engineering Tsinghua University

Localization systems utilizing Ultra-WideBand(UWB) have been widely used in dense urban and indoor environments. A moving UWB tag can be located by ranging to fixed UWB anchors whose positions are surveyed in advance. However, manually surveying the anchors is typically a dull and time-consuming process and prone to artificial errors. In this paper, we present an accurate and easy-to-use method for UWB anchor self-localization,using the UWB ranging measurements and readings from a low-cost Inertial Measurement Unit(IMU). The locations of the anchors are automatically estimated by freely moving the tag in the environment. The method is inspired by the Simultaneous Localization And Mapping(SLAM) technique used by the robotics community. A tightly-coupled Error-State Kalman Filter(ESKF) is utilized to fuse UWB and inertial measurements, producing UWB anchor position estimates and six Degrees of Freedom(6 DoF) tag pose estimates. Simulated experiments demonstrate that our proposed method enables accurate self-localization for UWB anchors and smooth tracking of the tag.

关键词： anchor self-localization error-state Kalman filter sensor fusion simultaneous localization and mapping