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TRAP1 Shows Clinical Significance and Promotes Cellular Migration and Invasion through STAT3/MMP2 Pathway in Human Esophageal Squamous Cell Cancer

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Journal of Genetics and Genomics 2014年第10期41卷 529-537页

作者： Yunwei Ou Lingyan liu Liyan Xue Wei Zhou Zitong Zhao Bainan Xu Yongmei Song qimin Zhan Department of Neurosurgery Chinese PLA General Hospital State Key Laboratory of Molecular Oncology Cancer Institute and Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Tumor necrosis factor receptor-associated protein 1 （TRAP1）, an important member of mitochondrial heat shock protein 90 family, is involved in multiple biological processes in several types of tumors. However, its pathological role in esophageal squamous cell cancer （ESCC） remains unknown. Herein, we demonstrated the clinical value of TRAP1, and its role in apoptosis and motility in ESCC. The clinical potential of TRAP1 was investigated through immunohistochemical analysis in 328 ESCC samples, which revealed that strong TRAP1 expression was associated with increased risk of lymph node metastasis, while high TRAP1 expression correlated with poor prognosis. Expression of TRAP1 was found to be an independent prognostic factor for patients with ESCC. Additionally, the upregulation of TRAP1 antagonized cisplatin-induced apoptosis while its downregulation sensitized cells to cisplatin-induced apoptosis. As revealed by the transwell assay, TRAP1 overexpression promoted cellular migration and invasion as compared to the control groups. In contrast, silencing of endogenous TRAP1 expression attenuated the ability of migration and invasion. Finally, the molecular mechanism investigated in the present study demonstrated that TRAP1-mediated migration and invasion occurred through STAT3/MMP2 signaling pathway. In conclusion, TRAP1 may be considered as a molecular predictive marker for prognosis and a novel molecular candidate for therapeutic target in ESCC.

关键词： TRAP1 Clinical Migration Invasion ESCC

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Changes of the F-wave in the acute phase of permanent spinal cord ischaemic injury predict spinal cord function in animal models of rabbits

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Journal of Translational Neuroscience 2020年第3期5卷 15-24页

作者： Yunfei Zhou Shuchao Zhao Yuanyuan Jiang Xingming liu Xueyuan Heng Jian Zhang qimin Song Clinical Medicine Department Binzhou Medical UniversityYantaiShandong 264033China Department of Pathology Affiliated Hospital of Qingdao UniversityQingdaoShandong 266000China Oncology Gynecology Qingdao Central(Tumor)HospitalQingdaoShandong 266042China Department of Neurosurgery Linyi Central HospitalLinyiShandong 276400China Department of Neurosurgery Linyi People’s HospitalLinyiShandong 276003China

Objective:to explore the changes of the F-wave in the posterior tibial nerve of rabbits after different levels of lumbar spinal cord ischaemic injury and its correlation with motor function and the extent of lumbar spinal cord pathological ***:thirty New Zealand rabbits were randomly divided into 6 *** control group(n=5)was used to exclude the influence of anaesthesia and surgery on the *** levels of lumbar arteries were ligated in the five experimental groups(n=5).The F-wave was recorded to observe the changes in the acute phase of spinal cord *** correlation between the changes of the F-wave in the acute reversible phase and the motor function of the spinal cord was *** functions were assessed after surgery and 2 d after vascular *** specimens were taken 2 d after ligation for histopathologic ***:the results for the control group indicated that anaesthesia and surgery did not affect the F-wave *** was no statistically significant difference in the F-wave amplitudes and latency before and after ligation in the 1 and 2 level ligation *** F-wave changed immediately after ligation in the 3,4 and 5 ligation *** latency of the F-wave gradually extended,the amplitude of the F-wave gradually *** amplitude variations of the F-wave were positively correlated with the motor function 2 d after ligation,there was a statistically significant *** the increase in the number of vascular ligation,the degree of destruction of the motor neurons in the anterior horn of the spinal cord in the pathological specimens ***:the F-waves in the posterior tibial nerve of rabbits were found to be sensitive to the lumbar spinal cord ischaemic injury and specific to predict motor function.

关键词： F-wave spinal cord ischaemic injury animal models

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Regional characteristics of ultrasonic structural scattering in liver

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Chinese Journal of Acoustics 1996年第2期15卷 97-105页

作者： CHEN qimin ZHANG Xiaofei liu Binsheng YAN Bige and liu Chunrong(Applied Acoustics Institute, Shaanxi Teachers University Xi’an, 710062)(Technical College of the Chinese People’s Armed Police Force, Xi’an, 710086)

In this paper, the ultrasonic spectra of liver's structural scattering wave obtained by autoregressive model and the spectral characteristics were analyzed statisticaJly The experimellt and analysis results show that a liver can be divided into three distingulshed scattering regions. The top layer region shows approkimate Rayleigh scattering characteristic, the central region shows diffosion scattering, and the region between the top layer and centre shows random scattering. These distribution characteristics correlate with the distribution of the microstructure characteristics of liver. The experiment results provide possibilities for tissue recognition using spectrum characteristics of the regional structure scattering.

关键词： Liver Regional structure Scattering spectrum characteristics

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基于物料依赖矩阵的化工产品链空间布局优化研究

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生态经济 2010年第5期26卷 44-48页

作者：刘伟付启敏重庆大学经济与工商管理学院重庆400044 长江师范学院重庆涪陵408100

化工产品链的各产品项目之间存在很强的物料联系,优化其空间布局既可以节约投资,又可节约物料传输费用。将用于产品开发的设计结构矩阵(DSM)引入到化工产品链空间布局优化研究中,在构建体现物料联系的物料依赖矩阵(MRM)的基础上,通过聚... 详细信息

化工产品链的各产品项目之间存在很强的物料联系,优化其空间布局既可以节约投资,又可节约物料传输费用。将用于产品开发的设计结构矩阵(DSM)引入到化工产品链空间布局优化研究中,在构建体现物料联系的物料依赖矩阵(MRM)的基础上,通过聚类重构,提出了化工产品链空间布局优化策略,并通过案例验证了优化策略的有效性。

关键词：设计结构矩阵(DSM) 物料依赖矩阵(MRM) 化工产品链空间布局:优化策略

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基于交互多模型距离平滑的UWB/IMU因子图组合导航方法

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中国惯性技术学报 2022年第3期30卷 322-327页

作者：李旭孔鑫刘锡祥宋翔徐启敏东南大学仪器科学与工程学院南京210096 微惯性仪表与先进导航技术教育部重点实验室南京210096 南京晓庄学院电子工程学院南京211171

为了解决全球导航卫星系统(GNSS)拒止条件下车辆定位困难问题,提出了一种基于交互多模型距离平滑的超宽带/惯性测量单元(UWB/IMU)因子图组合导航方法。首先,针对超宽带信号由于反射或折射导致的非视距问题,分别建立视距与非视距情况下... 详细信息

为了解决全球导航卫星系统(GNSS)拒止条件下车辆定位困难问题,提出了一种基于交互多模型距离平滑的超宽带/惯性测量单元(UWB/IMU)因子图组合导航方法。首先,针对超宽带信号由于反射或折射导致的非视距问题,分别建立视距与非视距情况下超宽带基站与标签间距离的因子图模型,并利用交互式多模型算法进行原始距离的平滑;然后,对惯性导航系统、交互式多模型处理的超宽带距离信息等测量量进行建模,构建基于因子图的信息融合框架,并根据非线性优化理论与增量平滑算法实现变量节点的递推与更新。最后,采用因子图方法对融合数据进行处理,实现车辆多传感器高精度组合导航。实际测试结果表明,相比基于卡尔曼滤波的多传感器融合方法,所提出的基于交互多模型距离平滑的惯性/超宽带的因子图定位方法在非视距情况下位置估计精度(RMS)提高40%以上。

关键词：惯性/超宽带因子图交互式多模型组合导航非视距

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基于产品线规划的企业技改项目资源分配策略研究

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科技进步与对策 2008年第12期25卷 100-103页

作者：刘伟何伟付启敏重庆大学经济与工商管理学院重庆400044 长江师范学院重庆408100

通过对项目资源分配与企业战略的联合研究,指出产品线规划是企业技改项目资源分配的基础,同时对产品线规划与项目资源配置的关系作了较为详细的研究,最后提出了基于产品线规划的企业技改项目资源分配策略。

关键词：项目规划产品线规划资源分配技术改造项目

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基于多因素的产品平台衍生模型研究

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科技进步与对策 2009年第2期26卷 1-3页

作者：刘伟李杨付启敏重庆大学经济与工商管理学院重庆400044

在探讨区域创新系统(RIS)时,不得不首先面对一个现实而又极其重要的问题——RIS中的区域边界问题。正确认识和理解其边界及其与行政边界之间的关系,对于我们针对具体行政区域及其中心城市建立可行的RIS十分重要。从分析RIS的由来及内涵... 详细信息

在探讨区域创新系统(RIS)时,不得不首先面对一个现实而又极其重要的问题——RIS中的区域边界问题。正确认识和理解其边界及其与行政边界之间的关系,对于我们针对具体行政区域及其中心城市建立可行的RIS十分重要。从分析RIS的由来及内涵出发,从RIS的系统运行机制、运行目的以及运行过程来考察,发现RIS的区域边界应该与行政边界等同。通过进一步的分析,得出了RIS是一个开放系统,区域边界不应成为限制各要素流动的障碍。最后,提出构建RIS时既要强调地方政府的职责,同时也要强调区域间的分工与合作。

关键词：区域创新系统区域边界行政边界

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单分散聚苯乙烯胶体颗粒的界面电性质研究

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化学通报 2007年第8期70卷 641-644页

作者：刘丽严亚陈启明华东师范大学化学系上海200062

以过硫酸钾(KPS)为引发剂,以水为反应介质,采用无皂乳液聚合工艺,制备出粒径在500nm左右单分散(分散系数<5%)聚苯乙烯微球。所制备的聚苯乙烯微球为光滑的球形颗粒。研究发现:由无皂乳液聚合法制备的胶体颗粒其ζ电势在不同的离子强度下... 详细信息

以过硫酸钾(KPS)为引发剂,以水为反应介质,采用无皂乳液聚合工艺,制备出粒径在500nm左右单分散(分散系数<5%)聚苯乙烯微球。所制备的聚苯乙烯微球为光滑的球形颗粒。研究发现:由无皂乳液聚合法制备的胶体颗粒其ζ电势在不同的离子强度下随pH的变化曲线均出现平台pH6～10.5,说明在一定的离子强度和pH条件下,聚苯乙烯胶乳的ζ电势具有良好的稳定性。聚苯乙烯胶乳有望作为具有一定电势值的标准颗粒。

关键词：聚苯乙烯无皂乳液聚合界面电性质 ζ电势

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