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地源热泵系统低负荷运行状态下能效分析及效益潜力评价研究

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山东国土资源 2023年第3期39卷 44-50页

作者：孔凡杜邵银川邹双英刘柱刘启民马亚弟梁兴光李庆林山东省煤田地质局第一勘探队低碳能源和碳中和工程研究中心山东青岛266500

为给地源热泵系统管理和维护、浅层地热能开发利用工程节能减排效果评价及浅层地热能开发利用的推广提供依据,以山东省东昌府区妇幼保健院嘉明分院为例,利用监测的地源热泵系统能效监测系统,对地源热泵系统低负荷运行状态下能效进行了分... 详细信息

为给地源热泵系统管理和维护、浅层地热能开发利用工程节能减排效果评价及浅层地热能开发利用的推广提供依据,以山东省东昌府区妇幼保健院嘉明分院为例,利用监测的地源热泵系统能效监测系统,对地源热泵系统低负荷运行状态下能效进行了分析,对效益潜力进行了评价。该套系统机组、系统名义能效均达到了1级标准,根据其2022年制冷季能效监测,该套系统机组、系统制冷能效比与系统负荷存在正相关关系,由于建筑物室内用户侧使用率较低,系统负荷不高,实际的机组和系统制冷能效比较低,系统实际使用效益不佳。按照典型年采用温频法计算了系统的制冷季效益潜力,即制冷季常规能源代替量94403kgce,热源价值84971元,节能的热源价值制冷季一次能源节能率40.90%,供冷期二氧化碳减排量233175kg,二氧化硫减排量1888kg,粉尘减排量944kg。

关键词：浅层地热能地源热泵系统低负荷效益潜力

血培养仪阳性病原菌报警时间在临床早期用药中的应用价值

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右江医学 2017年第3期45卷 299-302页

作者：王燕钱跃先周光莉陈俊侯祺敏吴世木刘锋贵州省兴义市人民医院检验科黔西南州人民医院骨科兴义562400

目的探讨血培养仪阳性病原菌报警时间在临床早期用药中的应用价值。方法采用回顾性调查分析,收集2015年6~12月住院及门诊患者送检的血培养阳性标本,统计分析不同病原菌阳性报警时间。结果不同菌属病原菌在血培养仪报警时间中位数不同,... 详细信息

目的探讨血培养仪阳性病原菌报警时间在临床早期用药中的应用价值。方法采用回顾性调查分析,收集2015年6~12月住院及门诊患者送检的血培养阳性标本,统计分析不同病原菌阳性报警时间。结果不同菌属病原菌在血培养仪报警时间中位数不同,报警速度从快到慢中位数依次是链球菌属(11.8 h)<非发酵菌(12.2 h)<肠杆菌科(13.5 h)<肠球菌属(15.8 h)<葡萄球菌属(21.3 h)<阳性杆菌(30.5 h)<厌氧菌(32.6 h)<真菌(46.3 h),且与肠杆菌科(中位数)比较,有统计学意义的菌属是真菌(P<0.001)、阳性杆菌(P=0.001)、葡萄球菌(P=0.007)、厌氧菌(P=0.037),无统计学意义的是肠球菌属(P=0.702)、非发酵菌(P=0.845)、链球菌属(P=0.859)。结论不同病原菌菌属在血培养仪中报警时间存在差异,依据该特点,结合报阳曲线或涂片染色,可初步推断血流感染病原菌菌属,为临床早期合理用药提供初步依据。

关键词：血培养报警时间病原菌

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文登西洋参的质量特征与产地自然条件

时珍国医国药 2001年第7期12卷 669-670页

作者：孙守祥王晓光刘其民中国人民解放军济南军区总医院山东济南250031 山东省文登市医药公司 264400

目的 :探讨自然条件对文登西洋参质量特征的影响。方法 :对文登西洋参种植情况 ,药材质量特征及该地区自然条件所产生的影响进行调研。结果与结论 :在吸收国外、国内种植西洋参先进经验的前提下 ,该地区地球纬度、地理、气候与西洋参原... 详细信息

目的 :探讨自然条件对文登西洋参质量特征的影响。方法 :对文登西洋参种植情况 ,药材质量特征及该地区自然条件所产生的影响进行调研。结果与结论 :在吸收国外、国内种植西洋参先进经验的前提下 ,该地区地球纬度、地理、气候与西洋参原产地相近 ,其受海洋性气候调节的温带湿润地区的温度和湿度 ,以及土壤等自然条件十分适宜西洋参生长 ,是形成西洋参特色药材的先决条件。

关键词：西洋参自然条件温带湿润地区中药

Quantum anomalous Hall effect in two-dimensional magnetic insulator heterojunctions

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npj Computational Materials 2020年第1期6卷 405-412页

作者： Jinbo Pan Jiabin Yu Yan-Fang Zhang Shixuan Du Anderson Janotti Chao-Xing liu qimin Yan Department of Physics Temple UniversityPhiladelphiaPA 19122USA Department of Physics The Pennsylvania State UniversityUniversity ParkPA 16802USA Condensed Matter Theory Center Department of PhysicsUniversity of MarylandCollege ParkMaryland 20742USA Institute of Physics Chinese Academy of ScienceBeijing 100190China Department of Materials Science and Engineering University of DelawareDE 19716 WilmingtonUSA

Recent years have witnessed tremendous success in the discovery of topological states of ***,sophisticated theoretical methods in time-reversal-invariant topological phases have been developed,leading to the comprehensive search of crystal database and the prediction of thousands of topological *** contrast,the discovery of magnetic topological phases that break time reversal is still limited to several exemplary materials because the coexistence of magnetism and topological electronic band structure is rare in a single *** overcome this challenge,we propose an alternative approach to realize the quantum anomalous Hall(QAH)effect,a typical example of magnetic topological phase,via engineering two-dimensional(2D)magnetic van der Waals heterojunctions.

关键词： magnetic anomalous effect

Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma

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Chinese Journal of Cancer Research 2023年第2期35卷 176-190页

作者： Xiangping Wu Qingnan Wu Yan Wang Yehai liu Zhenhao Li Qingchuan liu Zhengming Huang Mingyan Li Bin Zhang qimin Zhan Department of Otolaryngology-Head&Neck Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Zhejiang Shouxiangu Pharmaceutical Co.Ltd Jinhua 321200China Beijing Weijian Jiye Institute of Biotechnology Beijing 102488China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Head and Neck SurgeryPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: Ferroptosis is a novel cell death process which displays a promising role in cancer ***, clinically available drugs targeting ferroptosis are rarely used, and yet there are no studies reporting on inducing ferroptosis via Chinese herbal extracts. Here we explored the tumor inhibition effects of Ganoderma lucidum(G. lucidum) on oral squamous cell carcinoma(OSCC). Specifically, we aimed to clarify the biological mechanism of components in the dietary, aqueous-soluble sporoderm-removed G. lucidum spore powder(A-GSP).Methods: Preliminary transcriptome analysis revealed the significant enrichment of the ferroptosis *** Fe2+, glutathione(GSH), malondialdehyde(MDA), reactive oxygen species(ROS) and lipid peroxide levels were measured to identify ferroptosis occurrence. Western blotting was used to measure ferroptosis-related proteins. Changes in mitochondria morphology and function were observed with transmission electron microscopy(TEM) and ATP detection assays. Ferroptosis inhibitor ferrostatin-1 was then used to verify the anti-tumor effects of A-GSP. Finally, nude mice xenograft models of oral cancer confirmed that A-GSP inhibited tumor ***: A-GSP promoted ferroptosis in oral cancer cells by inducing Fe2+influx, GSH depletion, as well as lipid peroxide and ROS accumulation. Ferroptosis-related proteins exhibited corresponding changes, particularly Acylco A synthetase long chain family member 4(ACSL4) increase and glutathione peroxidase 4(GPX4) decrease. A-GSP considerably lowered mitochondrial volume and ridge number, while significantly decreasing ATP production. Ferrostatin-1 reversed all of these A-GSP-induced changes. In vivo, A-GSP exerted a ferroptosismediated tumor-suppressing effect without observable adverse ***: Our findings demonstrate the therapeutic potential of A-GSP for treating patients with OSCC by targeting ferroptosis.

关键词： Ganoderma lucidum spore powder OSCC ferroptosis ACSL4

On the structure of AP-4 responsive element in the LTR of Jembrana disease virus

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Chinese Science Bulletin 2003年第2期48卷 1247-1250页

作者： Zijing liu Hongyan Yin Gang Deng Yuhua Yuan Jinzhong Wang Yunqi Geng qimin Chen Nankai Univ Coll Life Sci Tianjin 300071 Peoples R China

Previous studies with deletion and sequence analysis of JDV LTR showed that there is a putative AP-4 responsive element in LTR. By antisense transient assay and gel shifting assay, we for the first time demonstrated that AP-4 modulated JDV gene expression by binding DNA di-rectly to bovine cells. The results, derived from site-directed mutagenesis experiments, suggest that the six base pairs of AP-4 binding site (CAGCTG) have different effects on JDV gene expression. When the first two base pairs changed to GC, JDV gene expression is severely decreased.

关键词： JDV cellular factor AP-4 trans-activator (Tat) LTR site-directed mutagenesis.

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杏鲍菇菌糠饲料化研究与应用进展

中国饲料 2024年第1期 149-154页

作者：徐启民帖余张鑫左志琼宋洪宁王风青李仲玄刘超兰四川轻化工大学生物工程学院四川宜宾644000 固态发酵资源利用四川省重点实验室四川宜宾644000 山东泰山生力源集团股份有限公司山东泰安271000 国家新抗生素菌种保藏管理中心药学院成都大学四川成都610106

杏鲍菇菌糠是用于栽培杏鲍菇,子实体采收之后残留的栽培基质,含有蛋白质、畜禽必需氨基酸、脂肪、纤维、钙、磷等多种营养因子,多糖、黄铜、低聚糖、漆酶、锰过氧化物酶等多种活性功能成分,同时其中的重金属、霉菌毒素、农药残留浓度及... 详细信息

杏鲍菇菌糠是用于栽培杏鲍菇,子实体采收之后残留的栽培基质,含有蛋白质、畜禽必需氨基酸、脂肪、纤维、钙、磷等多种营养因子,多糖、黄铜、低聚糖、漆酶、锰过氧化物酶等多种活性功能成分,同时其中的重金属、霉菌毒素、农药残留浓度及有害微生物数量均低于标准限定值。因此杏鲍菇菌糠作为非常规饲料原料,用于饲料的研究与开发,代替部分或全部的日粮组分,在一定程度上解决了饲料短缺问题,并降低了养殖成本,提升了养殖效益。为此本文就杏鲍菇菌糠营养成分、饲用安全性以及在牛、羊、猪、禽等动物养殖中的应用进行了综述,以期为杏鲍菇菌糠在饲料化资源利用研究及应用方面提供参考。

关键词：杏鲍菇菌糠营养安全性动物养殖

Analysis of microscopic pore structures of rocks before and after water absorption

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Mining Science and Technology 2011年第2期21卷 287-293页

作者： Li Dejian Wang Guilian Han Liqiang liu Peiyu He Manchao Yang Guoxing Tai qimin Chen Cheng State Key Laboratory of Geomechanics and Deep Underground Engineering Beijing 100083 China Institute of Geotechnical Engineering China University of Mining ＆ Technology Beijing 100083 China Sichuan Staff University of Science and Technology Sichuan 610101 China Engineering Research Institute of General Armament Department Beijing 100083 China

Hydrophilic characteristics of rocks are affected by their microscopic pore structures,which clearly change after water *** absorption tests and scanning electron microscopic（SEM） experiments on rock samples,located at a site in Tibet,China,were carried out Changes of rock pore structures before and after water absorption were studied with the distribution of pore sizes and fractal characteristics of *** results show that surface porosities,fractal dimensions of pores and the complexity of pore structures increased because the number of new small pores produced increased or the original macropore flow channels were expanded after rocks absorbed *** were points of inflection on their water absorption *** water absorption of other rocks,surface porosities and fractal dimensions of pores and complexity of pore structures decreased as the original pore flow channels became *** absorption curves did not *** porosity and the pore fractal dimensions of rocks have good linear relationships before and after water absorption.

关键词： Hydrophilic characteristics Pore structures Pore size distribution Pore fractal characteristics

Flotillin1 promotes EMT of human small cell lung cancer via TGF-β signaling pathway

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Cancer Biology & Medicine 2018年第4期15卷 400-414页

作者： Lianmei Zhao Jie Li Yueping liu Wei Zhou Yanan Shan Xinyi Fan Xinliang Zhou Baoen Shan Yongmei Song qimin Zhan State Key Laboratory of Molecular Oncology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences&Peking Union Medical College Research Center The Fourth Hospital of Hebei Medical University Pathology Department The Fourth Hospital of Hebei Medical University Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular Oncology Peking University Cancer Hospital &Institute

Objective:Small cell lung carcinoma(SCLC)is considered one of the most aggressive types of lung cancer due to its rapid growth and early *** tumor markers or therapeutic targets have been demonstrated to be specific or effective in SCLC to *** study aims to evaluate the potential of Flotillin1(Flot1)as a target of SCLC ***:Flot1 expression level in the tissue of SCLC and other tissue of lung disease was detected using immunohistochemical *** and Matrigel assays were employed to examine migration and invasion of cancer *** cytometry and xCELLigence system were used to evaluate cell apoptosis and cell viability,*** levels of Flot1,epithelialmesenchymal transition(EMT)marker E-cadherin,vimentin,cyclinD1,TGF-β-Smad2/3,and p-AKT were examined using Western ***,xenograft tumor in nude mice was used to evaluate the growth and metastasis of NCI-H446 cells in ***:Our results demonstrated that Flot1 is highly expressed in SCLC samples and that its expression correlates strongly with clinical stage,distant metastasis,and poor *** knockdown of Flot1 decreased the growth,migration,and invasiveness of SCLC cells and reversed EMT phenotype in vitro and in vivo,while enhanced Flot1 expression exhibited the opposite *** expression profile analysis demonstrated that Flot1-regulated genes frequently mapped to the AKT and TGF-β-Smad2/*** results further revealed that Flot1 affected the progression of SCLC via regulation of EMT ***:These findings indicated an oncogenic role of Flot1 via promoting EMT in SCLC and suggested its potential as a tumor marker and prognostic indicator.

关键词： Flotillin1 small cell lung cancer EMT TGF-β-smad2/3