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Selenium nanoparticles in aquaculture:Unique advantages in the production of Se-enriched grass carp(Ctenopharyngodon idella)

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Animal Nutrition 2024年第1期16卷 189-201页

作者： Chao Zhu Zifang Wu qimin liu Xiaolin Wang Lijuan Zheng Shuyang He Fangxia Yang Hong Ji Wuzi Dong College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi712100China College of Forestry Northwest A&F UniversityYanglingShaanxi712100China Biology Research Centre of Qin Mountains Wildlife Northwest A&F UniversityYanglingShaanxi712100China

The production of selenium-enriched fish can contribute to alleviating selenium deficiency in human ***,it is still unclear which selenium source,as an additive,can efficiently and costeffectively produce high-quality selenium-enriched *** study evaluated the effects of selenium nanoparticles(SeNP),selenite,and selenomethionine(SeMet)on the growth,antioxidant capacity,selenium content,selenium speciation,and meat quality of grass *** diets were prepared,including a basal diet(BD)and three concentrations(0.1,0.3,and 0.9 mg/kg)of SeNP,selenite,and SeMet.A total of600 fish(250.79±1.57 g)were randomly assigned to 30 tanks(3 tanks/group).Fish were fed the experimental diet three times daily for 60 *** this study,SeNP most significantly promoted the growth and antioxidant capacity of grass carp,with 0.3 mg/kg SeNP identified as the optimal additive ***,SeNP demonstrated equally excellent bioavailability as SeMet and significantly increased the content of SeMet in grass carp(Ctenopharyngodon idella)***,compared to SeMet and selenite,dietary SeNP could more significantly enhance the content of selenocysteine(SeCys2)and methylselenocysteine(MeSeCys)in grass carp muscle *** addition,we have demonstrated that SeCys2and MeSeCys promote apoptosis of cancer cells(HeLa)through the mitochondrial apoptotic pathway(involving Bax and Bcl-2).Furthermore,as an additive,0.3 mg/kg SeNP significantly improved the flesh quality of grass carp by reducing crude fat and heavy metal content,as well as increasing the levels of eicosapentaenoic acid(EPA)and docosahexaenoic acid(DHA)and the ratio of n-3/n-6 polyunsaturated fatty acid(PUFA).In summary,SeNP is the most suitable additive for producing selenium-enriched fish.

关键词： Selenium nanoparticle Speciation analysis Grass carp Selenium additive

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聚合物中Case Ⅱ扩散与材料溶胀变形的耦合行为分析

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固体力学学报 2024年第4期45卷 496-507页

作者：罗焱李能李旭刘齐民武汉理工大学理学院新材料理论与应用湖北省重点实验室武汉430070 武汉理工大学土木工程与建筑学院道路桥梁与结构工程湖北省重点实验室武汉430070

立足于连续介质力学理论,建立了一套描述聚合物中CaseⅡ扩散与材料溶胀变形耦合行为的理论模型,其控制方程包括力-化学平衡状态方程、溶剂扩散方程和分子数守恒方程,以及反映聚合物力学行为时间依赖性的粘-超弹本构方程.将该理论方法用... 详细信息

立足于连续介质力学理论,建立了一套描述聚合物中CaseⅡ扩散与材料溶胀变形耦合行为的理论模型,其控制方程包括力-化学平衡状态方程、溶剂扩散方程和分子数守恒方程,以及反映聚合物力学行为时间依赖性的粘-超弹本构方程.将该理论方法用于分析两种材料体系的瞬态自由溶胀过程,探讨无约束情况下柱状和板状聚合物试样中发生单向CaseⅡ扩散的行为特征.结合适当的边界条件和初始条件,直接求解单向扩散的浓度场和应力/变形场函数,并将其分布、演变规律与实测结果进行对比,较充分验证了本文建立的聚合物溶胀耦合分析框架的有效性和适应性.这些结果丰富了CaseⅡ扩散相关的表征理论,可望为后续的薄膜设计、药物输送等实际应用场景提供重要支撑.

关键词：聚合物 CaseⅡ扩散溶胀变形本构方程耦合分析

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构想当代的“江湖” 田耳《秘要》读记

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上海文化 2024年第7期 37-44页

作者：刘启民不详

来自湘西的实力作家田耳,过去喜欢把他奇崛的想象力投放在城市与乡村的当代故事中,剔骨刀一般地勾勒出人性人世,和主人公令人心惊的残酷命运,在文坛留下一派凌厉的印象。而在新近的长篇小说《秘要》中,他似乎对于人存在的那个世界更多... 详细信息

来自湘西的实力作家田耳,过去喜欢把他奇崛的想象力投放在城市与乡村的当代故事中,剔骨刀一般地勾勒出人性人世,和主人公令人心惊的残酷命运,在文坛留下一派凌厉的印象。而在新近的长篇小说《秘要》中,他似乎对于人存在的那个世界更多了一点感慨观照,通过武侠黑书,牵连起上世纪五六十年代至新世纪的黑书市场,构拟出一个跨越两岸三地的当代“江湖”世界。

关键词：城市与乡村田耳黑书两岸三地新世纪武侠江湖想象力

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地下水观测井水位自动化监测及优化措施研究

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自动化应用 2024年第S01期65卷 204-206页

作者：刘启民山东省煤田地质局第一勘探队山东青岛266000

随着社会的不断发展和城市化的推进,地下水资源的管理和监测变得愈加重要。地下水观测井是地下水监测的关键手段,其水位的自动化监测及优化措施的研究对地下水资源的科学管理具有重要意义。旨在探讨地下水观测井水位自动化监测的技术方... 详细信息

随着社会的不断发展和城市化的推进,地下水资源的管理和监测变得愈加重要。地下水观测井是地下水监测的关键手段,其水位的自动化监测及优化措施的研究对地下水资源的科学管理具有重要意义。旨在探讨地下水观测井水位自动化监测的技术方法,分析存在的问题,并提出相应的优化措施,以提高地下水监测的精准性和效率。

关键词：地下水观测井水位自动化监测

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Crustal structure of northeastern margin of the Tibetan Plateau by receiver function inversion

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Science China Earth Sciences 2014年第4期57卷 741-750页

作者： liu qimin ZHAO JunMeng LU Fang liu HongBing Key Laboratory of Continental Collision and Plateau Uplift Institute of Tibetan Plateau ResearchChinese Academy of Sciences University of Chinese Academy of Sciences Seismological Bureau of Hubei Province

Using seismic data of about one year recorded by 18 broadband stations of ASCENT project, we obtained 2547 receiver func- tions in the northeastern Tibetan Plateau. The Moho depths under 14 stations were calculated by applying the H-x domain search algorithm. The Moho depths under the stations with lower signal-noise ratio （SNR） were estimated by the time delay of the PS conversion. Results show that the Moho depth varies in a range of -40--60 kin. The Moho near the Haiyuan fault is vague, and its depth is larger than those on its two sides. In the Qinling-Qilian Block, the Moho becomes shallower gradually from west to east. To the east of 105~E, the average depth of the Moho is 45 km, whereas the west is 50 km or even deeper. Combining our results with surface wave research, we suggest a boundary between the Qinling and the Qilian Mountains at around 105~E. S wave velocities beneath 15 stations have been obtained through a linear inversion by using Crust2.0 as an ini- tial model, and the crustal thickness that was derived by H-x domain search algorithm was also taken into account. The results are very similar to the results of previous active source studies. The resulting figure indicates that low velocity layers devel- oped in the middle and lower crust beneath the transition zone of the Tibet Block and western Qinling, which may be related to regional faults and deep earth dynamics. The velocity of the middle and lower crust increases from the Songpan Block to the northeastern margin of Tibetan Plateau. Based on the velocity of the crust, the distribution of the low velocity zone and the composition of the curst （Poisson＇s ratio）, we infer that the crust thickening results from the crust shortening along the direc- tion of compression.

关键词： northeastern margin of Tibetan Plateau receiver function crustal structure crust flow

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Mechano-responsive hydrogel for direct stem cell manufacturing to therapy

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Bioactive Materials 2023年第6期24卷 387-400页

作者： Yufeng Shou Ling liu qimin liu Zhicheng Le Khang Leng Lee Hua Li Xianlei Li Dion Zhanyun Koh Yuwen Wang Tong Ming liu Zheng Yang Chwee Teck Lim Christine Cheung Andy Tay Department of Biomedical Engineering National University of Singapore117583Singapore Institute for Health Innovation&Technology National University of Singapore117599Singapore School of Civil Engineering and Architecture Wuhan University of Technology430070WuhanChina NUS Tissue Engineering Program National University of Singapore117510Singapore Lee Kong Chian School of Medicine Nanyang Technological University636921Singapore School of Mechanical and Aerospace Engineering Nanyang Technological University639798Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)138648Singapore Department of Orthopaedic Surgery Yong Loo Lin School of MedicineNational University of Singapore119288Singapore Mechanobiology Institute National University of Singapore117411Singapore

Bone marrow-derived mesenchymal stem cell(MSC)is one of the most actively studied cell types due to its regenerative potential and immunomodulatory *** cell expansion methods using 2D tissue culture plates and 2.5D microcarriers in bioreactors can generate large cell numbers,but they compromise stem cell potency and lack mechanical preconditioning to prepare MSC for physiological loading expected in *** overcome these challenges,in this work,we describe a 3D dynamic hydrogel using magneto-stimulation for direct MSC manufacturing to *** our technology,we found that dynamic mechanical stimulation(DMS)enhanced matrix-integrinβ1 interactions which induced MSCs spreading and *** addition,DMS could modulate MSC biofunctions including directing MSC differentiation into specific lineages and boosting paracrine activities(e.g.,growth factor secretion)through YAP nuclear localization and FAK-ERK *** our magnetic hydrogel,complex procedures from MSC manufacturing to final clinical use,can be integrated into one single platform,and we believe this‘all-in-one’technology could offer a paradigm shift to existing standards in MSC therapy.

关键词： Mesenchymal stem cell Dynamic mechanical stimulation Magnetic hydrogel Stem cell manufacturing Cell therapy

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Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway

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Science China(Life Sciences) 2024年第4期67卷 663-679页

作者： Yanfang liu Yan Wang Bing liu Wenzhong liu Yuanyuan Ma Yiren Cao Shi Yan Panpan Zhang Lixin Zhou qimin Zhan Nan Wu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic Surgery IIPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic Oncology IIPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of PathologyPeking University Cancer Hospital and InstituteBeijing 100142China Peking University International Cancer Institute Beijing 100191China Institute of Cancer Research Shenzhen Bay LaboratoryShenzhen 518132China

Chemoresistance is a significant barrier to effective cancer *** mechanisms for chemoresistance include reactive oxygen species(ROS)accumulation and expression of chemoresistance-promoting ***,we report a novel function of lncRNA16 in the inhibition of ROS generation and the progression of *** analyzing the serum levels of lncRNA16 in a cohort of 35 patients with non-small cell lung cancer(NSCLC)and paired serum samples pre-and post-treatment from 10 NSCLC patients receiving neoadjuvant platinum-based chemotherapy,performing immunohistochemistry(IHC)assays on 188 NSCLC tumor samples,using comprehensive identification of RNA-binding proteins by mass spectrometry(ChIRP-MS)assays,as well as RNA immunoprecipitation(RIP)and RNA pull-down analyses,we discovered that patients with increased serum levels of lncRNA16 exhibited a poor response to platinum-based *** expression of hemoglobin subunit beta(HBB)and NDUFAF5 significantly increases with the development of ***16 binds to HBB and promotes HBB accumulation by inhibiting ***16 can also inhibit ROS generation via the HBB/NDUFAF5 axis and function as a scaffold to facilitate the colocalization of HBB and NDUFAF5 in the ***,preclinical studies in mouse models of chemo-resistant NSCLC have suggested that lncRNA16 targeting by trivalent N-acetylgalactosamine(GalNAc)-conjugated siRNA restores chemosensitivity and results in tumor growth inhibition with no detectable toxicity in ***,lncRNA16 is a promising therapeutic target for overcoming chemoresistance,and the combination of first-line platinum-based chemotherapy with lncRNA16 intervention can substantially enhance anti-tumor efficacy.

关键词： chemoresistance lncRNARNA interference ROs chemosensitizer

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Series 190 Diesel Engines Used in China's Oil Drilling

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China Oil & Gas 1996年第2期3卷 104-105页

作者： $$$$liu qimin(Chief Engineer,Jinan Diesel Engine Works) ChiefEngineer Jinan Diesel Engine Works

Ｓｅｒｉｅｓ１９０ＤｉｅｓｅｌＥｎｇｉｎｅｓＵｓｅｄｉｎＣｈｉｎａ＇ｓＯｉｌＤｒｉｌｌｉｎｇ￥／／ＬｉｕＱｉｍｉｎ（ＣｈｉｅｆＥｎｇｉｎｅｅｒ．ＪｉｎａｎＤｉｅｓｅｌＥｎｇｉｎｅＷｏｒｋｓ）ＪｉｎａｎＤｉｅｓｅｌＥｎ... 详细信息

Ｓｅｒｉｅｓ１９０ＤｉｅｓｅｌＥｎｇｉｎｅｓＵｓｅｄｉｎＣｈｉｎａ＇ｓＯｉｌＤｒｉｌｌｉｎｇ￥／／ＬｉｕＱｉｍｉｎ（ＣｈｉｅｆＥｎｇｉｎｅｅｒ．ＪｉｎａｎＤｉｅｓｅｌＥｎｇｉｎｅＷｏｒｋｓ）ＪｉｎａｎＤｉｅｓｅｌＥｎｇｉｎｅＷｏｒｋｓ，ｌｏｃａｔｅｄ...

关键词： Series 190 Diesel Engines Used in China’s Oil Drilling

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Modulation doping of p-type Cu_(12)Sb_(4)S_(13)toward improving thermoelectric performance

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Journal of Materials Science & Technology 2024年第4期171卷 71-79页

作者： Khak Ho Lim Mingquan Li Yu Zhang Yue Wu qimin Zhou Qingyue Wang Xuan Yang Pingwei liu Wen-Jun Wang Ka Wai Wong Ka Ming Ng Yu liu Andreu Cabot Institute of Zhejiang University-Quzhou Quzhou 324000China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310007China School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Ostia Technologies Limited United Kingdom Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongChina ICREA Pg.Lluis Companys 23Barcelona 08010Spain Catalonia Energy Research Institute-IREC Sant Adria del BesosBarcelona 08930Spain

The commercial viability of thermoelectric(TE)devices relies heavily on two factors:cost reduction and efficiency *** this study,we first produce p-type Cu_(12)Sb_(4)S_(16-x)(x=0,3,4)using a low-temperature bottom-up approach and demonstrate Cu_(12)Sb_(4)S_(13)to show the best TE performance among the three tested ***,the TE energy conversion efficiency of Cu_(12)Sb_(4)S_(13)is further enhanced by optimizing its electronic band structure through the incorporation of small amounts of *** an optimal Te content of 5 mol%,more than a twofold increase in the TE figure of merit(zT)is *** gain insight into the mechanism of improvement on the transport properties of the mate-rial,we compare the interphase transport mechanism by incorporating nanodomains of different metals(Ag and Cu)into the Cu_(12)Sb_(4)S_(13)*** improved electrical conductivity obtained with Cu_(12)Sb_(4)S_(13)-Te nanocomposites is attributed to a charge flooding of the Cu_(12)Sb_(4)S_(13)*** contrast,excessive down-ward band-bending at the interphases of Ag/Cu metal-semiconductor drastically reduces the electrical ***,a weighted mobility(μw)analysis shows a dominant thermal activation of carri-ers in Cu_(12)Sb_(4)S_(13)-Te *** this material,a strong decrease in lattice thermal conductivity is also found,which is associated with a phonon-carrier scattering *** work shows the impor-tance of proper band-engineering in TE nanocomposites to decouple electrical and thermal transport to enhance TE performance,and the efficacy ofμw for electrical and thermal transport analysis.

关键词： Modulation doping Thermoelectric Interphase transport Charge flooding Phonon-carrier scattering

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作为“地方”的乡村：《马桥词典》的空间书写

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当代文坛 2020年第2期 49-56页

作者：刘启民北京大学中文系

本文试图通过"地方"概念打开乡村书写中一直被研究者们所忽视的空间面向,并以对韩少功《马桥词典》的再读来考察1990年代全球化语境为中国乡村带来的新的空间意涵。长久以来研究者们惯用"乡土文学"的概念来总称现代绵延至今的乡村书写传... 详细信息

本文试图通过"地方"概念打开乡村书写中一直被研究者们所忽视的空间面向,并以对韩少功《马桥词典》的再读来考察1990年代全球化语境为中国乡村带来的新的空间意涵。长久以来研究者们惯用"乡土文学"的概念来总称现代绵延至今的乡村书写传统,但"乡土文学"概念所遮蔽的是它本身作为"民族国家文学"的特性,即乡村总是作为民族国家的表征物而在文学中得到表达。《马桥词典》的重要性在于,作者在1990年代全球化的格局下率先察觉到乡村、国家、全球之间的空间关系错动,由此打破了乡村与国家的自然关联,在文本中构造出关于"地方"/"乡村"的"跨文化"空间关系。

关键词：《马桥词典》地方空间乡土文学

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