检索结果-南通市图书馆

A Hu sheep genome with the first ovine Y chromosome reveal introgression history after sheep domestication

Science China(Life Sciences) 2021年第7期64卷 1116-1130页

作者： Ran Li Peng yang Ming Li Wenwen Fang Xiangpeng Yue Hojjat Asadollahpour Nanaei Shangquan Gan Duo Du Yudong Cai Xuelei Dai qimeng yang Chunna Cao Weidong Deng Sangang He Wenrong Li Runlin Ma Mingjun Liu Yu Jiang Key Laboratory ofAnimal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China State Key Laboratory of Grassland Agro-ecosystems Key Laboratory of Grassland Livestock Industry InnovationMinistry of Agriculture and Rural AffairsEngineering Research Center of Grassland IndustryMinistry of EducationCollege of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou 730020China State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China Faculty of Animal Science and Technology Yunan Agricultural UniversityKunming 650201China Key Laboratory of Genetics Breeding and Reproduction of Grass feeding Livestock Ministry of AgricultureAnimal Biotechnology Research InstituteXinjiang Academy of Animal ScienceUrumqi 830026China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

The Y chromosome plays key roles in male fertility and reflects the evolutionary history of paternal lineages.Here,we present a de novo genome assembly of the Hu sheep with the first draft assembly of ovine Y chromosome(o MSY),using nanopore sequencing and Hi-C technologies.The o MSY that we generated spans 10.6 Mb from which 775 Y-SNPs were identified by applying a large panel of whole genome sequences from worldwide sheep and wild Iranian mouflons.Three major paternal lineages(HY1a,HY1b and HY2)were defined across domestic sheep,of which HY2 was newly detected.Surprisingly,HY2 forms a monophyletic clade with the Iranian mouflons and is highly divergent from both HY1a and HY1b.Demographic analysis of Y chromosomes,mitochondrial and nuclear genomes confirmed that HY2 and the maternal counterpart of lineage C represented a distinct wild mouflon population in Iran that diverge from the direct ancestor of domestic sheep,the wild mouflons in Southeastern Anatolia.Our results suggest that wild Iranian mouflons had introgressed into domestic sheep and thereby introduced this Iranian mouflon specific lineage carrying HY2 to both East Asian and Africa sheep populations.

关键词： Y chromosome sheep paternal lineage introgression de novo assembly

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Xenopus GLP-1-based glycopeptides as dual glucagon-like peptide 1 receptor/glucagon receptor agonists with improved in vivo stability for treating diabetes and obesity

引用

Chinese Journal of Natural Medicines 2022年第11期20卷 863-872页

作者： LI Qiang yang qimeng HAN Jing LIU Xiaohan FU Junjie YIN Jian Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhou 221116China Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor Ministry of EducationGuangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorGuangxi Medical UniversityNanning 530021China

Peptide dual agonists toward both glucagon-like peptide 1 receptor(GLP-1R)and glucagon receptor(GCGR)are emerging as novel therapeutics for the treatment of type 2 diabetes mellitus(T2DM)patients with obesity.Our previous work identified a Xenopus GLP-1-based dual GLP-1R/GCGR agonist termed xGLP/GCG-13,which showed decent hypoglycemic and body weight lowering activity.However,the clinical utility of xGLP/GCG-13 is limited due to its short in vivo half-life.Inspired by the fact that O-GlcNAcylation of intracellular proteins leads to increased stability of secreted proteins,we rationally designed a panel of O-GlcNAcylated xGLP/GCG-13 analogs as potential long-acting GLP-1R/GCGR dual agonists.One of the synthesized glycopeptides 1f was found to be equipotent to xGLP/GCG-13 in cell-based receptor activation assays.As expected,O-GlcNAcylation effectively improved the stability of xGLP/GCG-13 in vivo.Importantly,chronic administration of 1f potently induced body weight loss and hypoglycemic effects,improved glucose tolerance,and normalized lipid metabolism and adiposity in both db/db and diet induced obesity(DIO)mice models.These results supported the hypothesis that glycosylation is a useful strategy for improving the in vivo stability of GLP-1-based peptides and promoted the development of dual GLP-1R/GCGR agonists as antidiabetic/antiobesity drugs.

关键词： Glucagon-like peptide-1 Glucagon Diabetes Obesity O-GlcNAcylation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

刑行衔接视角下罪错未成年人专门教育矫治之体系性建构

引用

预防青少年犯罪研究 2024年第2期 86-92页

作者：王化宏张雪戴兴栋杨启孟贵州省毕节市威宁县人民检察院贵州毕节553199

为了明确《刑法》中的刑罚适用和《预防未成年人犯罪法》中的教育处罚和行政处罚之间的差别,我们需要建立一套全新的诉讼制度,同时适用于犯罪和预防犯罪,明确刑罚、教育处罚和行政处罚之间的区别。这一制度应从明确性质、遵循原则和建... 详细信息

为了明确《刑法》中的刑罚适用和《预防未成年人犯罪法》中的教育处罚和行政处罚之间的差别,我们需要建立一套全新的诉讼制度,同时适用于犯罪和预防犯罪,明确刑罚、教育处罚和行政处罚之间的区别。这一制度应从明确性质、遵循原则和建立衔接机制出发,提高效率,引导未成年人违法行为的教育矫正工作。必须准确分类不同情形下的犯罪行为,遵循公平、公正、人道原则,保障未成年人权益。与相关部门和社会资源有效衔接,形成完整的教育矫正体系,确保连续性和有效性,引导未成年人走向正确道路,预防减少犯罪行为,为社会稳定做出积极贡献。

关键词：专门教育专门矫治教育预防未成年人犯罪法衔接

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Functional gastrointestinal disorders, mental health, genetic susceptibility, and incident chronic kidney disease

引用

中华医学杂志(英文版) 2024年第9期137卷 1088-1094页

作者： Liu Mengyi He Panpan Ye Ziliang yang Sisi Zhang Yanjun Wu qimeng Zhou Chun Zhang Yuanyuan Hou Fan Fan Qin Xianhui Division of Nephrology Nanfang Hospital Southern Medical University National Clinical Research Center for Kidney Disease State Key Laboratory of Organ Failure Research Guangdong Provincial Institute of Nephrology Guangdong Provincial Key Laboratory of Renal Failure Research Guangzhou Guangdong China

Background: Whether functional gastrointestinal disorders (FGIDs) are associated with the long-term risk of chronic kidney disease (CKD) remains unclear. We aimed to investigate the prospective association of FGIDs with CKD and examine whether mental health mediated the association.Methods: About 416,258 participants without a prior CKD diagnosis enrolled in the UK Biobank between 2006 and 2010 were included. Participants with FGIDs (including irritable bowel syndrome [IBS], dyspepsia, and other functional intestinal disorders [FIDs; mainly composed of constipation]) were the exposure group, and non-FGID participants were the non-exposure group. The primary outcome was incident CKD, ascertained from hospital admission and death registry records. A Cox proportional hazard regression model was used to investigate the association between FGIDs and CKD, and the mediation analysis was performed to investigate the mediation proportions of mental health.Results: At baseline, 33,156 (8.0%) participants were diagnosed with FGIDs, including 21,060 (5.1%), 8262 (2.0%), and 6437 (1.6%) cases of IBS, dyspepsia, and other FIDs, respectively. During a mean follow-up period of 12.1 years, 11,001 (2.6%) participants developed CKD. FGIDs were significantly associated with a higher risk of incident CKD compared to the absence of FGIDs (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.28–1.44). Similar results were observed for IBS (HR, 1.27; 95% CI, 1.17–1.38), dyspepsia (HR, 1.30; 95% CI, 1.17–1.44), and other FIDs (HR, 1.60; 95% CI, 1.43–1.79). Mediation analyses suggested that the mental health score significantly mediated 9.05% of the association of FGIDs with incident CKD and 5.63–13.97% of the associations of FGID subtypes with CKD. Specifically, the positive associations of FGIDs and FGID subtypes with CKD were more pronounced in participants with a high genetic risk of CKD.Conclusion: Participants with FGIDs had a higher risk of incident CKD, which was partly explained by mental health scores and was more pronounced

关键词： Functional gastrointestinal disorders Chronic kidney diseases Genetic susceptibility Mental health

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Recess-free enhancement-mode AlGaN/GaN RF HEMTs on Si substrate

引用

Journal of Semiconductors 2024年第6期45卷 81-86页

作者： Tiantian Luan Sen Huang Guanjun Jing Jie Fan Haibo Yin Xinguo Gao Sheng Zhang Ke Wei Yankui Li qimeng Jiang Xinhua Wang Bin Hou Ling yang Xiaohua Ma Xinyu Liu High-Frequency High-Voltage Device and Integrated Circuits R&D Center Institute of Microelectronics of Chinese Academy of SciencesBe i-jing 100029China School of integrated Circuits University of Chinese Academy of SciencesBeijing 100049China Faculty of integrated Circuits Xidian UniversityXi’an 710071China

Enhancement-mode(E-mode)GaN-on-Si radio-frequency(RF)high-electron-mobility transistors(HEMTs)were fabri-cated on an ultrathin-barrier(UTB)AlGaN(<6 nm)/GaN heterostructure featuring a naturally depleted 2-D electron gas(2DEG)channel.The fabricated E-mode HEMTs exhibit a relatively high threshold voltage(VTH)of+1.1 V with good uniformity.A maxi-mum current/power gain cut-off frequency(fT/fMAX)of 31.3/99.6 GHz with a power added efficiency(PAE)of 52.47%and an out-put power density(Pout)of 1.0 W/mm at 3.5 GHz were achieved on the fabricated E-mode HEMTs with 1-μm gate and Au-free ohmic contact.

关键词： AlGaN/GaN heterostructure ultrathin-barrier enhancement-mode radio-frequency power added efficiency silicon substrate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

白蜡树重大害虫—多孔横沟象主要发生规律研究

引用

山东林业科技 2024年第1期54卷 47-59,75页

作者：闫家河赵燕刘子业季英超夏明辉王涛王海咏郭宇豪宋晨语杨启萌乔玮梁玉婷商河县林业保护和发展中心山东商河251600 济南市园林和林业科学研究院山东济南250102 北京林业大学林学院北京100083 山东农业大学植物保护学院山东泰安271018 商河县孙集镇农业综合服务中心山东商河251600

记述了白蜡树毁灭性蛀干害虫——多孔横沟象Pimelocerus perforatus在商河县的生活史和发生危害等基本生物学、生态学特性。1a发生1~2代,10~11月以成虫在树干基部周围土中、以3~7龄幼虫在干基和根颈部蛀害处越冬。整个树木生长期均可见... 详细信息

记述了白蜡树毁灭性蛀干害虫——多孔横沟象Pimelocerus perforatus在商河县的生活史和发生危害等基本生物学、生态学特性。1a发生1~2代,10~11月以成虫在树干基部周围土中、以3~7龄幼虫在干基和根颈部蛀害处越冬。整个树木生长期均可见成虫和幼虫栖息危害。越冬成虫最早3月下旬,多4月上旬开始出蛰。成虫寿命长,大部分可存活100~400 d,部分个体超600~800 d。全年有3个成虫高峰期,分别为4月上中旬或中下旬的越冬成虫出蛰集中期、6月中下旬至7月上旬的越冬代新成虫羽化集中期、8月中下旬至9月上中旬的第1代成虫羽化集中期。成虫具上下树习性、假死性和一定趋光性,雌性比平均0.47。成虫喜阴暗潮湿环境,不耐高温干燥。成虫一生可交配数十次,1头雌成虫62 d内可产卵42 d次、88粒,29℃室温条件下卵历期平均7.9 d(6.2~11.5)。成虫主要产卵于根颈部皮层或干基表面的皮缝间或伤口处,产卵后用粪屑将卵粘连覆盖或半覆盖。初步测定幼虫有7龄,1~4龄幼虫在皮下和韧皮部及木质部浅层蛀害,5~7龄幼虫在木质部蛀害形成坑道。明确多孔横沟象的基本生物学、生态学特性对预测预报和综合防治具有重要意义。

关键词：多孔横沟象白蜡树生活史成虫寿命生活习性发生规律

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Allotetraploidization event of Coptis chinensis shared by all Ranunculales

引用

Horticultural Plant Journal 2024年第1期10卷 288-303页

作者： Yan Zhang Weina Ge Jia Teng Yanmei yang Jianyu Wang Zijian Yu Jiaqi Wang qimeng Xiao Junxin Zhao Shaoqi Shen Yishan Feng Shoutong Bao Yu Li Yuxian Li Tianyu Lei Yuxin Pan Lan Zhang Jinpeng Wang Department of Bioinformatics School of Life SciencesNorth China University of Science and TechnologyTangshanHebei 063000China School of Life Sciences North China University of Science and TechnologyTangshanHebei 063000China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of ScienceBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China

Coptis chinensis Franch.,also named Chinese goldthread is a member of Ranunculaceae in the order Ranunculales and represents an important lineage of early eudicots with traditional medicinal value.In our study,by using syntenic analysis combined with phylogenomic analysis of C.chinensis and four other representative genomes from basal and core eudicots,we confirmed that the WGD event in C.chinensis was shared by Aquilegia coerulea and Papaver somniferum L.and quickly occurred after Ranunculales diverged from other eudicots,likely a Ranunculales common tetraploidization(RCT).The synonymous nucleotide substitutions at synonymous sites distribution of syntenic blocks across these genomes showed that the evolutionary rate of the P.somniferum genome is faster than that of the C.chinensis genome by approximately 13.7%,possibly due to Papaveraceaes having an additional special tetraploidization event(PST).After Ks correction,the RCT dated to 115—130 million years ago(MYA),which was close to the divergence of Ranunculaceaes and Papaveraceaes approximately115.45—130.51 MYA.Moreover,we identified homologous genes related to polyploidization and speciation and constructed multiple sequence alignments with different reference genomes.Notably,the event-related subgenomes in the basal genomes all showed genomic fractionation bias,suggesting a likely allopolyploid nature of the RCT,PST and T-Alpha and T-Beta events in Tetracentron sinense.In addition,we detected that the sixteen P450 subfamilies were markedly expanded in the genomes of Ranunculales,and most of them were related to the RCT and PST events.We constructed a new platform for Early Eudicot Comparative Genomic Research(http://www.***.top/index.html)to store more information.In summary,our findings support the WGD of C.chinensis shared by Ranunculales,which is likely an allotetraploidization event.This present effort offered new insights into the evolution of key polyploidization events and the genes related to secondary metabolites during the diversification of ea

关键词： Coptis chinensis Ranunculales Polyploidization Genomic fractionation P450 genes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

我国建筑零碳化研究及实践进展

引用

建筑科学 2024年第4期40卷 75-86,141页

作者：刘衍刘冬杨柳曹其梦杨怡牛兵兵绿色建筑全国重点实验室西安710055 西安建筑科技大学建筑学院西安710055 西安建筑科技大学交叉创新研究院西安710055

建筑领域减碳是我国实现全社会双碳目标的重要一环,然而现阶段研究基础不足以支撑建筑领域碳中和目标的达成。本文从建筑零碳化路径、建筑零碳化设计、建筑零碳化标准体系等几个方面,对国内相关研究进展进行了梳理,对比分析了我国建筑... 详细信息

建筑领域减碳是我国实现全社会双碳目标的重要一环,然而现阶段研究基础不足以支撑建筑领域碳中和目标的达成。本文从建筑零碳化路径、建筑零碳化设计、建筑零碳化标准体系等几个方面,对国内相关研究进展进行了梳理,对比分析了我国建筑零碳化路径,总结出了今后的研究方向;梳理了建筑零碳化设计基础、理论与工程试验,提炼出了建筑零碳化设计方法;研判了标准体系的建设方向,辨析了建筑零碳化与节能的联系和区别;初步论证了在太阳能富集条件下建筑零碳化先行先试的可行性。最后,提出了我国建筑零碳化的若干研究建议。

关键词：建筑零碳化发展路径建筑设计标准体系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

北京市城市公园绿地土壤种子库特征及其更新潜力

引用

北京林业大学学报 2023年第10期45卷 1-15页

作者：薛雅文赵丁洁孙明琦杨启盟刘宝华许行张志强北京林业大学水土保持学院北京100083 山西吉县森林生态系统国家野外科学观测研究站山西吉县042200 水土保持国家林业和草原局重点实验室北京100083

【目的】作为潜在的植物群落,土壤种子库在一定程度上代表地上植被的更新演替潜力,研究城市公园绿地土壤种子库特征及其对地上植被和土壤因子的响应,为近自然城市公园的营造提供理论依据。【方法】以北京市六环内公园绿地为对象,将其划... 详细信息

【目的】作为潜在的植物群落,土壤种子库在一定程度上代表地上植被的更新演替潜力,研究城市公园绿地土壤种子库特征及其对地上植被和土壤因子的响应,为近自然城市公园的营造提供理论依据。【方法】以北京市六环内公园绿地为对象,将其划分为综合公园、郊野公园、文化遗址公园、社区公园4种类型。在随机选取的75个公园内,采用样方法进行地上植被调查,随机法进行土壤采样,土壤种子库采用萌发试验确定,常规方法获取土壤理化指标。【结果】(1)北京城市公园土壤种子库共有77种植物,隶属34科74属,以草本植物为主(97.5%),其中菊科物种数最多(16种)。土壤种子库密度在352~899粒/m^(2)之间,其中菊科种子储量最高,其次为禾本科和豆科,密度最大的物种为马唐(147.11粒/m^(2)),其次为苜蓿(128.40粒/m^(2))、狗尾草(122.67粒/m^(2))等。4类城市公园均以一、二年生草本为主,郊野公园的多年生草本相对丰度要高于其他类型公园,其种子库密度显著大于其他类型公园(P<0.05)。(2)城市公园土壤种子库的ShannonWiener多样性指数范围在1.04~1.46,Simpson优势度指数范围在0.53~0.62,Patrick丰富度指数范围在4.79~8.41,Pielou均匀度指数范围在0.74~0.84,其中郊野公园种子库物种丰富度显著大于其他类型公园(P<0.05)。(3)相似系数(Sorensen指数)和非度量多维尺度排序分析表明,不同类型公园间土壤种子库、地上植被相似性系数较高,且群落结构差异不显著。4类城市公园土壤种子库与地上植被相似性偏低,相似系数为0.10~0.18,且土壤种子库与地上植被间群落构成存在明显差异。(4)土壤种子库密度与草本多样性指数、草本物种丰富度指数、土壤铵态氮和非毛管孔隙度呈显著正相关(P<0.05),与土壤全氮和硝态氮呈显著负相关;土壤种子库物种丰富度指数与土壤全氮和硝态氮呈显著正相关,与草本多样性指数和土壤铵态氮呈显著负相关。土壤种子库均匀度、优势度和多样性指数与灌木物种丰富度指数呈显著正相关,与草本物种丰富度指数呈显著负相关。其中,草本多样性指数和灌木物种丰富度指数对城市公园土壤种子库的密度和物种多样性影响较大。【结论】城市公园土壤种子库密度较小,与其对应地上植被间相似性也较低,且以草本植物种子为主;种子库密度和物种多样性主要受地上草本多样性指数和灌木物种丰富度指数影响较大。因此城市公园绿地土壤种子库更新潜力较低,采取人工促进木本植被更新,是营建近自然城市公园的关键。

关键词：城市公园土壤种子库植被更新地上植被群落土壤理化性质

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

洞庭湖区城市景观生态风险评价及驱动力分析——以常德市和益阳市为例

引用

城市学刊 2024年第1期45卷 23-31页

作者：杨华周辉汤静宁启蒙湖南省国土空间调查监测所长沙410000 湖南城市学院建筑与城市规划学院湖南益阳413000

以2000、2010和2020年的遥感影像作为主要数据源,构建景观生态风险评价模型,研究常德市和益阳市两个城市土地利用、景观生态风险的时空变化及其空间模式。结果表明:两个城市的土地利用类型以林地和耕地为主,近20年来两个城市的林地和耕... 详细信息

以2000、2010和2020年的遥感影像作为主要数据源,构建景观生态风险评价模型,研究常德市和益阳市两个城市土地利用、景观生态风险的时空变化及其空间模式。结果表明:两个城市的土地利用类型以林地和耕地为主,近20年来两个城市的林地和耕地面积均在减少,建设用地面积增加明显;景观指数方面,两个城市呈现出相似的变化,建设用地、草地和水域景观类型分离度指数始终保持较高状态,破碎度亦较高;耕地和林地景观类型分离度指数较低,破碎度也偏低;景观生态风险方面,两个城市的高和较高风险区均分布在临湖的平原区和城市建成区,低和较低风险区分布于林地景观,景观生态风险的空间分布存在较强的空间集聚效应。

关键词：土地利用景观生态风险评价景观格局景观指数洞庭湖区

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：