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Ginger polysaccharide UGP1 suppressed human colon cancer growth via p53,Bax/Bcl-2,caspase-3 pathways and immunomodulation

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Food Science and Human Wellness 2023年第2期12卷 467-476页

作者： Yanfang Qian chenying Shi chen cheng Dengwei Liao Junping Liu Guitang chen College of Engineering/National R&D Center for Chinese Herbal Medicine Processing China Pharmaceutical UniversityNanjing 211198China

In previous study,we got a purified ginger polysaccharide UGP1 and verified its significant antitumor activities on colon cancer HCT116 *** this article,we aimed to illustrate the underlying mechanism of UGP1 exerted antitumor activities on colon cancer by using in vitro cell models and in vivo animal *** results demonstrated that UGP1 could induce S-phase cell cycle arrest,up-regulate the expression of Bax and p53,down-regulate the expression of Bcl-2,and activate the downstream protein caspase-9 and caspase-3,which was related to intrinsic apoptosis pathway on HCT116 ***,UGP1 significantly stimulated RAW264.7 cell proliferation and secretion ***,UGP1 inhibited tumor proliferation on tumor-bearing mice,increased the expression of p53 and the ratio of Bax/Bcl-2,enhanced the secretion of pro-inflammatory cytokines TNF-α,IL-2,IL-6 and decreased the secretion of pro-tumor cytokines TGF-βand b FGF in *** conclusion,it indicated that the UGP 1 could sup press human colon cancer growth by inducing apoptosis via the regulation of p53,caspase-3,and Bax/Bcl-2 ratio-dependent pathway and regulating immune system *** s investigation provided basic theoretical mechanism of ginger polysaccharideexerted antitumor activities,and contributed to develop a possible functional food or adjuvant agent for prevention or treatment of colon cancer.

关键词： Ginger polysaccharide Apoptosis p53 Bcl-2 Immunomodulation

Global Stability in a Competition Model of Plankton Allelopathy with Infinite Delay

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Journal of Systems Science & Complexity 2015年第5期28卷 1070-1079页

作者： chen Fengde XIE Xiangdong WANG Haina Department of Mathematics Ningde Teachers College College of Mathematics and Computer Science Fuzhou University

A competition model of plankton allelopathy with infinite delay is considered in this *** using an iterative method, the global stability of the interior equilibrium point of the system is investigated. The result shows that for this system, delay and toxic substances are harmless for the stability of the interior equilibrium point.

关键词： Equilibrium global stability infinite delay iterative method plankton allelopathy

Mesh deformation on 3D complex configurations using multistep radial basis functions interpolation

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Chinese Journal of Aeronautics 2018年第4期31卷 660-671页

作者： Gang WANG Xin chen Zhikan LIU School of Aeronautics Northwestern Polytechnical University

The Radial Basis Function（RBF） method with data reduction is an effective way to perform mesh deformation. However, for large deformations on meshes of complex aerodynamic configurations, the efficiency of the RBF mesh deformation method still needs to be further improved to fulfill the demand of practical application. To achieve this goal, a multistep RBF method based on a multilevel subspace RBF algorithm is presented to further improve the efficiency of the mesh deformation method in this research. A whole deformation is divided into a series of steps, and the supporting radius is adjusted in accordance with the maximal displacement error. Furthermore, parallel computing is applied to the interpolation to enhance the efficiency. Typical deformation problems of the NASA Common Research Model（CRM） configuration, the DLR-F6 wing-body-nacellepylon configuration, and the DLR-F11 high-lift configuration are tested to verify the feasibility of this method. Test results show that the presented multistep RBF mesh deformation method is efficient and robust in dealing with large deformation problems over complex geometries.

关键词： Data reduction Greedy method Mesh deformation Radial basis function Unstructured mesh

New method for determining central axial orientation of flux rope embedded within current sheet using multipoint measurements

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Science China Earth Sciences 2016年第10期59卷 2037-2052页

作者： LI ZhaoYu chen Tao YAN GuangQing State Key Laboratory of Space Weather National Space Science Center Chinese Academy of Sciences Beijing 100190 China College of Earth Sciences University of Chinese Academy of Sciences Beijing 100049 China

A new method for determining the central axial orientation of a two-dimensional coherent magnetic flux rope(MFR)via multipoint analysis of the magnetic-field structure is developed. The method is devised under the following geometrical assumptions:(1) on its cross section, the structure is left-right symmetric;(2) the projected structure velocity is vertical to the line of symmetry. The two conditions can be naturally satisfied for cylindrical MFRs and are expected to be satisfied for MFRs that are flattened within current sheets. The model test demonstrates that, for determining the axial orientation of such structures, the new method is more efficient and reliable than traditional techniques such as minimum-variance analysis of the magnetic field,Grad-Shafranov(GS) reconstruction, and the more recent method based on the cylindrically symmetric assumption. A total of five flux transfer events observed by Cluster are studied using the proposed approach, and the application results indicate that the observed structures, regardless of their actual physical properties, fit the assumed geometrical model well. For these events, the inferred axial orientations are all in excellent agreement with those obtained using the multi-GS reconstruction technique.

关键词： Flux rope Flux rope orientation Current sheet Transfer events Magnetopause Cluster data

Application of Internet of Things Micropower Smart Switch in Temperature Monitoring

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Journal of Electronic Science and Technology 2022年第3期20卷 319-330页

作者： Yeong-Chin chen Hao-cheng Yang Long-chen Hung cheng-Jung Ku the Department of Computer Science and Information Engineering Asia UniversityTaichung 41354 the Department of Electronic Engineering Lungh-Wa University of Science and TechnologyTaoyuan 333326

This study uses the smart phone with the Android system to construct a cloud-side smart switch system in the client-server architecture with the Android open platform system, using microprocessors(MCU 16F690) as the thermostat controller and combined with Raspberry Pi. The computing technology extends the control of the constant temperature from the local to the cloud, allowing the user to view the temperature status recorded by the cloud server using the smart phone application(App) or web browser. It can even remotely control the heating power of the smart switch for the heating device in the Internet control environment and use the proportional-integral-derivative(PID) control and the pulse-width modulation(PWM) technology to achieve intelligent constant temperature *** proposed control system uses the expert PID control as the core to calculate the duty cycle of the PWM signal to control the power output of the smart switch for the constant temperature water tank. The experiment results verify the effectiveness of the proposed system.

关键词： Proportional-integral-derivative(PID) pulse-width modulation(PWM) Raspberry Pi smart switch

Full-field dynamic strain reconstruction of an aero-engine blade from limited displacement responses

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Frontiers of Mechanical Engineering 2023年第1期18卷 235-251页

作者： Chunyan AO Baijie QIAO Kai ZHOU Lei chen Shunguo FU Xuefeng chen School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China The State Key Laboratory for Manufacturing Systems Engineering Xi’an 710061China AECC Sichuan Gas Turbine Establishment Chengdu 610500China

Blade strain distribution and its change with time are crucial for reliability analysis and residual life evaluation in blade vibration *** strain measurements are achieved by strain gauges(SGs)in a contact manner at discrete positions on the *** study proposes a method of full-field and real-time strain reconstruction of an aero-engine blade based on limited displacement *** optical measured displacement responses are utilized to reconstruct the full-field *** full-field strain distribution is in-time visualized.A displacement-to-strain transformation matrix is derived on the basis of the blade mode shapes in the modal *** proposed method is validated on an aero-engine blade in numerical and experimental *** discrete vibrational displacement responses measured by laser triangulation sensors are used to reconstruct the full-field strain over the whole operating *** reconstructed strain responses are compared with the results measured by SGs and numerical *** high consistency between the reconstructed and measured results demonstrates the accurate strain reconstructed by the *** paper provides a low-cost,real-time,and visualized measurement of blade full-field dynamic strain using displacement response,where the traditional SGs would fail.

关键词： aero-engine blade displacement response dynamic strain reconstruction mode shape strain gauge

Flat band localization due to self-localized orbital

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Frontiers of physics 2023年第6期18卷 203-209页

作者： Zhen Ma Wei-Jin chen Yuntian chen Jin-Hua Gao XCXie School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and TechnologyWuhan 430074China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China

We discover a new wave localization mechanism in a periodic wave system,which can produce a novel type of flat band and is distinct from the known localization mechanisms,i.e.,Anderson localization and flat band *** first example we give is a designed electron waveguide(EWG)on 2DEG with special periodic confinement *** calculations show that,with proper confinement geometry,electrons can be completely localized in an open *** interpret this flat band localization(FBL)phenomenon by introducing the concept of self-localized ***,each unit cell of the waveguide is equivalent to an artificial atom,where the self-localized orbital is a special eigenstate with unique spatial *** self-localized orbitals form the flat bands in the *** self-localized orbital induced FBL is a general phenomenon of wave motion,which can arise in any wave systems with carefully engineered boundary *** then design a metallic waveguide(MWG)array to illustrate that similar FBL can be readily realized and observed with electromagnetic waves.

关键词： flat band localization self-localized orbital electron waveguide

Effects of nitrogen application on beetle communities in tea plantations

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Insect Science 2009年第2期16卷 185-192页

作者： Shao-Bo chen Zhi-Juan Wei Zhao-Hua Zeng Li-Lin chen Hui-Tao chen Min-Sheng You Institute of Appfied Ecology Fujian Agriculture and Forestry University Fuzhou China

In contrast to grassland and forest ecosystems, little is known about insect response to nitrogen deposition in agricultural ecosystems. This study was carried out to investigate the effects of short-term （1-2 years） nitrogen application （0, 172.5, 345.0, 690.0, and 1035.0 kg · N ha^-1 · y^-1） on beetle communities in tea plantations. A collection of 34 families, 89 species of beetles, was obtained from a tea plantation in Wuyishan, China. Among them, herbivores, predators and detritivores had 52, 29, and eight species, respectively. Species richness, effective diversity and abundance （measured as the number of individuals and insect biomass） of the beetle community were not significantly related to the rate of nitrogen application. However, nitrogen application changed the species distribution and weakly increased the evenness of species distribution, while this did not significantly change the species evenness. Species richness and abundance of herbivores and predators were not significantly related to the rate of nitrogen application. However, there were some variations in trophic responses to nitrogen. Species richness and abundance of detritivores increased with increasing nitrogen application.

关键词： beetle community diversity abundance nitrogen application

Hierarchical Sponge-Hydrogel Hybrid Structures with Robust Interfaces

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Chinese Journal of Chemistry 2023年第20期41卷 2635-2640页

作者： Pei Zhang Guangda chen Xingmei chen Junfei Xing Yue Tao Ji Liu Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhenGuangdong518055 China Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems Department of Mechanical and Energy EngineeringSouthern University of Science and TechnologyShenzhenGuangdong518055 China Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities Southern University of Science and TechnologyShenzhenGuangdong518055 China

Soft materials including elastomers and hydrogels are playing critical roles in a variety of fields,including bioelectrodes,batteries,supercapacitors,biomedical scaffolds,and solar vapor *** hydrophobic sponges(i.e.,mechanical robustness,elasticity and macroscopic porous structure)and hydrophilic hydrogels(i.e.,autonomous water absorption and transportation,biocompatibility)within one unit could readily combine the complementary characters from each component,making a number of future research directions and applications *** propose a simple yet effective strategy to construct sponge-hydrogel hybrid structures with robust hydrophobic-hydrophilic *** sponge scaffold imparts the sponges-hydrogel hybrids with desirable mechanical robustness,elasticity and macroscopic *** the other hand,the incorporated hydrogel component endows the hybrids with high water content(98 wt%hydrogel and 2 wt%sponge),superior compatibility,and nanoscale pores allowing for storage and transportation of various chemical and biological *** further demonstrate that the introduction of hydrophilic hydrogel components could effectively improve the liquid absorption capability,blood coagulation rate,hemostatic capacity and hemocompatibility,thus promising as hemostatic agents.

关键词： Sponge-hydrogel hybrid Interface Hierarchical Robustness Liquid absorption Gels Polymer Composites Materials Science