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Differential metabolite analysis of the pharmacodynamic differences between different ratios of Dahuang(Radix Et Rhizoma Rhei Palmati)-Taoren(Semen Persicae) herb pair

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Journal of Traditional Chinese Medicine 2024年第3期44卷 515-523页

作者： WANG Xiang HUANG Jianping WANG Yupeng WANG qilong JING Yajiang ZHANG Gang PENG Liang gao Jing WANG Hongyan YAN Yonggang Department of Key Laboratory of "Qin Pharmaceutical" Research and Development Shaanxi University of Traditional Chinese Medicine Department of Yupeng Shaanxi Haitian Pharmaceutical Co. Ltd. Department of Acupuncture and Tuina Shaanxi University of Traditional Chinese Medicine

OBJECTIVE: To explore the material basis of the difference of efficacy of Dahuang(Radix Et Rhizoma Rhei Palmati)-Taoren(Semen Persicae)(DT) drugs with different proportions. METHODS: Samples of different ratios of Dahuang(Radix et Rhizoma Rhei Palnati, DH) to Taoren(Semen Persicae, TR)(Group A 1∶1, B 2∶3, C 3∶2) were analyzed based on gas chromatography time-of-flight mass spectrometry untargeted metabolomics technique. RESULTS: A total of 240 primary metabolites were detected. Forty-one differential metabolites involved nine differential metabolic pathways, of which four were closely related to the efficacy of DT in the treatment of heat and blood stasis syndrome. These pathways included the biosynthesis of amino acid(phenylalanine tyrosine and tryptophan), flavonoids, unsaturated fatty acids, and the glycolysis/glycogenesis pathway. CONCLUSION: There are significant differences in the efficacy of different ratios of DT drugs, and their optimal ratio for the treatment of heat and blood stasis syndrome should be 1∶1.

关键词： Dahuang () Taoren () differential metabolites kernel drug pairs metabolic networks and pathways metabolomics

Illuminating the negative thermal expansion mechanism of YFe(CN)_(6)via electronic structure and unusual phonon modes

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Journal of Rare Earths 2023年第8期41卷 1258-1264,I0006页

作者： Junzhe Liu Yixin Jiao qilong gao Qiang Sun Jun Chen Key Laboratory of Materials Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Beijing Advanced Innovation Center for Materials Genome Engineering Department of Physical ChemistryUniversity of Science and Technology BeijingBeijing 100083China

Understanding the negative thermal expansion(NTE)mechanism remains an important and challenging thing.In this work,we selected the case of YFe(CN)_(6)to investigate the structure-mechanism relation on the base of crystal structure,electro nic structure and lattice dynamics.We expanded the NTE of YFe(CN)_(6)to 150 K,and the temperature dependence of volume and lattice constants was determined by temperature-variable synchrotro n X-ray diffraction measure ments.A large NTE was found in the system.Our theoretical calculations indicate that the Y-N bond exhibits a strong ionic feature through the calculated electron localization function(ELF),which has a strong influence on the anisotropic vibration of the N atom.The detailed lattice dynamics simulations suggest that the NTE of YFe(CN)_(6)may be related to the presence of the unusual low-frequency modes of the YN_(6)triangular prism(tri-prism)units.The optical branches with low frequencies are mainly related to the distortion and twisting modes of the YN_(6)tri-prism units,which contribute most to the NTE effect in the crystal.

关键词： Negative thermal expansion Prussian blue analogues Electronic structure Low-frequency phonons Rareearths

A new isotropic negative thermal expansion material of CaSnF_(6)with facile and low-cost synthesis

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Nano Research 2023年第4期16卷 5964-5972页

作者： qilong gao Sen Zhang Yixin Jiao Yongqiang Qiao Andrea Sanson Qiang Sun Xinwei Shi Erjun Liang Jun Chen Key Laboratory of Materials Physics of Ministry of Education and School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Department of Physics and Astronomy University of PadovaPadova I-35131Italy Beijing Advanced Innovation Center for Materials Genome Engineering Department of Physical ChemistryUniversity of Science and Technology BeijingBeijing 100083China

Double ReO_(3)-type fluorides have a great interest in the field of negative thermal expansion(NTE)and luminescent materials.However,their application is limited by the scarcity of quantity,expensive raw materials,and harsh preparation conditions.In this work we have found a new NTE material,CaSnF_(6),by applying the concept of the average atomic volume.More importantly,different from the previous solid-phase sintering and direct fluorination methods,the nano CaSnF6 has been synthesized for the first time by solvothermal method.The results of X-ray diffraction(XRD)and Raman spectroscopy show that a phase transition occurs from rhombohedral(R3)to cubic(Fm3m)structure at about 200 K,and a strong isotropic NTE(αv=−15.78×10^(−6)K^(−1))appears in the cubic phase.Lattice dynamics calculations from first-principles illustrate that the NTE is due to the transverse vibration of fluorine atoms excited by low-frequency phonons.This work not only broadens the NTE family of fluorides,but also provides a new facile and low-cost fabricati on method for the preparation of NTE fluorides.

关键词： negative thermal expansion double ReO_(3)-type fluorides Grüneisen parameters lattice dynamics

Endothelial phosphodiesterase 4B inactivation ameliorates endothelial-to-mesenchymal transition and pulmonary hypertension

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1726-1741页

作者： Yanjiang Xing Yangfeng Hou Tianfei Fan Ran gao Xiaohang Feng Bolun Li Junling Pang Wenjun Guo Ting Shu Jinqiu Li Jie Yang qilong Mao Ya Luo Xianmei Qi Peiran Yang Chaoyang Liang Hongmei Zhao Wenhui Chen Jing Wang Chen Wang State Key Laboratory of Respiratory Health and Multimorbidity Institute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100005China Department of Lung Transplantation National Center for Respiratory MedicineNational Clinical Research Center for Respiratory DiseasesChina–Japan Friendship HospitalInstitute of Respiratory MedicineChinese Academy of Medical SciencesBeijing 100029China Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300051China The State Key Laboratory of Complex Severeand Rare DiseasesInstitute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of PathophysiologyPeking Union Medical CollegeBeijing 100005China Department of Pharmacy West China HospitalSichuan UniversityChengdu 610044China

Pulmonary hypertension (PH) is a fatal disorder characterized by pulmonary vascular remodeling and obstruction. The phosphodiesterase 4 (PDE4) family hydrolyzes cyclic AMP (cAMP) and is comprised of four subtypes (PDE4A–D). Previous studies have shown the beneficial effects of pan-PDE4 inhibitors in rodent PH;however, this class of drugs is associated with side effects owing to the broad inhibition of all four PDE4 isozymes. Here, we demonstrate that PDE4B is the predominant PDE isozyme in lungs and that it was upregulated in rodent and human PH lung tissues. We also confirmed that PDE4B is mainly expressed in the lung endothelial cells (ECs). Evaluation of PH in Pde4b wild type and knockout mice confirmed that Pde4b is important for the vascular remodeling associated with PH. In vivo EC lineage tracing demonstrated that Pde4b induces PH development by driving endothelial-to-mesenchymal transition (EndMT), and mechanistic studies showed that Pde4b regulates EndMT by antagonizing the cAMP-dependent PKA–CREB–BMPRII axis. Finally, treating PH rats with a PDE4B-specific inhibitor validated that PDE4B inhibition has a significant pharmacological effect in the alleviation of PH. Collectively, our findings indicate a critical role for PDE4B in EndMT and PH, prompting further studies of PDE4B-specific inhibitors as a therapeutic strategy for PH.

关键词： Phosphodiesterase 4B Pulmonary hypertension Endothelial-to-mesenchymal transition

Large negative thermal expansion in GdFe(CN)_(6) driven by unusual low-frequency modes

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Chinese Chemical Letters 2023年第5期34卷 557-560页

作者： qilong gao Yixin Jiao Andrea Sanson Erjun Liang Qiang Sun Key Laboratory of Materials Physics of Ministry of Education and School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Department of Physics and Astronomy University of PadovaPadova I-35131Italy

Understanding the negative thermal expansion(NTE)mechanism is of great importance.In this work,we consider the new NTE compound Gd Fe(CN)_(6)(α_(v)=-34.2×10^(-6)K^(-1))as a case study to investigate the NTE mechanism from the perspective of the lattice vibrational dynamics.The atomic mean-square displacements suggest that the NTE of Gd Fe(CN)_(6)comes from the strong tension effect induced by the transverse vibrations of the atomic-Fe-C≡N-Gd-linkages,with the largest contribution given by N atoms.Lattice dynamics calculations show that three low-frequency optical modes at about 50 cm^(-1)show the largest negative Grüneisen parameters thus providing the largest contribution to the NTE.The existence of these unusual low-frequency vibrational modes can be ascribed to the presence of GdN_(6)trigonal prisms in the framework structure of Gd Fe(CN)_(6).

关键词： Negative thermal expansion Prussian blue analogues Low frequency phonon Crystal structure Transverse vibration

医保政策对处方决策的影响及保障合理处方的思考

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卫生经济研究 2024年第5期41卷 45-47页

作者：高奇隆董恒进浙江省人民医院杭州医学院附属人民医院浙江杭州310014 浙江大学医学院卫生政策学研究中心浙江杭州310058

合理处方是具备资质的医师根据患者的实际健康需要,遵照诊疗、用药等相关临床规范与指南而开具的处方。医保支付政策、医保监管政策、供给侧改革等都会导致医疗机构收入发生变化,可能影响医师的处方决策。为保障合理处方,医疗机构需研... 详细信息

合理处方是具备资质的医师根据患者的实际健康需要,遵照诊疗、用药等相关临床规范与指南而开具的处方。医保支付政策、医保监管政策、供给侧改革等都会导致医疗机构收入发生变化,可能影响医师的处方决策。为保障合理处方,医疗机构需研制科学合理的绩效考核方案,避免唯效益论、唯指标论;医保支付、监管、考核等相关政策要与时俱进、不断调整。

关键词：医保政策处方决策合理处方

Negative thermal expansion: Mechanisms and materials

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Frontiers of physics 2021年第5期16卷 69-105页

作者： Erjun Liang Qiang Sun Huanli Yuan Jiaqi Wang gaojie Zeng qilong gao Key Laboratory of Materials Physics of Ministry of Education of China and School of Physics&MicroelectronicsZhengzhou UniversityZhengzhou450001China

Negative thermal expansion(NTE)of materials is an intriguing phenomenon challenging the concept of traditional lattice dynamics and of importance for a variety of applications.Progresses in this field develop markedly and update continuously our knowledge on the NTE behavior of materials.In this article,we review the most recent understandings on the underlying mechanisms(anharmonic phonon vibration,magnetovolume effect,ferroelectrorestriction and charge transfer)of thermal shrinkage and the development of NTE materials under each mechanism from both the theoretical and experimental aspects.Besides the low frequency optical phonons which are usually accepted as the origins of NTE in framework structures,NTE driven by acoustic phonons and the interplay between anisotropic elasticity and phonons are stressed.Based on the data documented,some problems affecting applications of NTE materials are discussed and strategies for discovering and design novel framework structured NET materials are also presented.

关键词： negative thermal expansion mechanisms of thermal contraction negative thermal expansion materials lattice thermal dynamics magnetovolume effect ferroelectrostriction charge transfer anisotropic elasticity

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侧喷铝卷退火炉气固传热过程研究

热加工工艺 2024年第8期53卷 59-62,68页

作者：秦明臣高玉峰李国华龚奇龙中航工程集成设备有限公司热能设备工程研究所北京102206

采用数值模拟和实验测试的方法,研究了侧喷铝卷退火炉内气固传热流场和铝卷温度场的分布规律,并讨论了铝卷表面传热系数的分布特性。结果表明:炉内喷口速度分布均匀,铝卷端面和外表面温度温度较高,且外表面和端面各点温度分布差别较大;... 详细信息

采用数值模拟和实验测试的方法,研究了侧喷铝卷退火炉内气固传热流场和铝卷温度场的分布规律,并讨论了铝卷表面传热系数的分布特性。结果表明:炉内喷口速度分布均匀,铝卷端面和外表面温度温度较高,且外表面和端面各点温度分布差别较大;计算得到铝卷外表面换热系数分布呈现两端高中间低的趋势,端面换热系数呈现边缘高中间低的特点,并拟合了各表面传热系数的加权系数计算公式。模拟结果同测试结果规律一致,流速计算误差约为±10%,铝卷温度偏差小于2℃。

关键词：铝卷退火炉气固传热数值模拟温度场

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一种面向催化材料领域的文献信息抽取方法

北京信息科技大学学报（自然科学版） 2024年第2期39卷 50-56页

作者：高强张仰森孙圆明贾启龙北京信息科技大学智能信息处理实验室北京100192

为有效利用PDF文献中的非结构化文本数据,面向费托合成催化材料领域文献,设计了关键信息抽取流水线从PDF文献中抽取表格及其相应注释等关键信息。以微分二值化网络(differentiable binarization network, DBNet)为基准模型,通过引入自... 详细信息

为有效利用PDF文献中的非结构化文本数据,面向费托合成催化材料领域文献,设计了关键信息抽取流水线从PDF文献中抽取表格及其相应注释等关键信息。以微分二值化网络(differentiable binarization network, DBNet)为基准模型,通过引入自适应空间注意力(adaptive spatial attention, ASA)模块,提出了DB-ASA文本检测模型,提高了检测精度。采用单视觉文本识别模型(scene text recognition with a single visual model, SVTR)进行文本识别,结合领域字典文件在自建数据集上对模型进行微调,文本识别准确率可达93.87%。

关键词：催化材料费托合成信息抽取文本识别