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Numerical Study of the Biomechanical Behavior of a 3D Printed Polymer Esophageal Stent in the Esophagus by BP Neural Network Algorithm

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2709-2725页

作者： Guilin wu Shenghua Huang Tingting Liu Zhuoni Yang Yuesong wu Guihong Wei Peng Yu qilin Zhang Jun Feng Bo Zeng College of Civil Engineering and Architecture Key Laboratory of Disaster Prevention and Structural Safety of Ministry of EducationGuangxi Key Laboratory of Disaster Prevention and Structural SafetyScientific Research Center of Engineering MechanicsGuangxi UniversityNanning530004China Anaesthesiology Department of the 923th The 923th Hospital of PLA Joint Logistic Support ForceNanning530021China Biomedical Materials Engineering Research Center Tsinghua Innovation Center in DongguanDongguan523808China Research Centre Guangxi Nanning Ruifeng Medical Devices Co.Ltd.Nanning530000China Department of Thoracic Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China

Esophageal disease is a common disorder of the digestive system that can severely affect the quality of life andprognosis of patients. Esophageal stenting is an effective treatment that has been widely used in clinical practice.However, esophageal stents of different types and parameters have varying adaptability and effectiveness forpatients, and they need to be individually selected according to the patient’s specific situation. The purposeof this study was to provide a reference for clinical doctors to choose suitable esophageal stents. We used 3Dprinting technology to fabricate esophageal stents with different ratios of thermoplastic polyurethane (TPU)/(Poly-ε-caprolactone) PCL polymer, and established an artificial neural network model that could predict the radial forceof esophageal stents based on the content of TPU, PCL and print parameter. We selected three optimal ratios formechanical performance tests and evaluated the biomechanical effects of different ratios of stents on esophagealimplantation, swallowing, and stent migration processes through finite element numerical simulation and in vitrosimulation tests. The results showed that different ratios of polymer stents had different mechanical properties,affecting the effectiveness of stent expansion treatment and the possibility of postoperative complications of stentimplantation.

关键词： Finite element method 3D printing polymer esophageal stent artificial neural network

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Construction of NiCo_(2)O_(4) nanoflake arrays on cellulose-derived carbon nanofibers as a freestanding electrode for high-performance supercapacitors

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Frontiers of Chemical Science and Engineering 2023年第6期17卷 691-703页

作者： Xuepeng Ni Kunming Li Changlei Li Qianqian wu Chenglin Liu Huifang Chen qilin wu Anqi Ju College of Materials Science and Engineering&State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua UniversityShanghai 201620China Key Laboratory of High-Performance Fibers&Products Ministry of EducationDonghua UniversityShanghai 201620China Weifang Xinlong Biomaterial Co. Ltd.Weifang 261000China

Cellulose has a wide range of applications in many fields due to their naturally degradable and low-cost characteristics,but few studies can achieve cellulose-nanofibers by conventional electrospinning.Herein,we demonstrate that the freestanding cellulose-based carbon nanofibers are successfully obtained by a special design of electrospinning firstly,pre-oxidation and high-temperature carbonization(1600℃),which display a superior electrical conductivity of 31.2 S·cm^(-1)and larger specific surface area of 35.61 m^(2)·g^(-1)than that of the polyacrylonitrile-based carbon nanofibers(electrical conductivity of 18.5 S·cm^(-1),specific surface area of 12 m^(2)·g^(-1).The NiCo_(2)O_(4)nanoflake arrays are grown uniformly on the cellulose-based carbon nanofibers successfully by a facile one-step solvothermal and calcination method.The as-prepared cellulose-based carbon nanofibers/NiCo_(2)O_(4)nanoflake arrays are directly used as electrodes to achieve a high specific capacitance of 1010 F·g^(-1)at 1 A·g^(-1)and a good cycling stability with 90.84%capacitance retention after 3000 times at 10 A·g^(-1).Furthermore,the all-solid-state symmetric supercapacitors assembled from the cellulose-based carbon nanofibers/NiCo_(2)O_(4)deliver a high energy density of 62 W·h·kg(-1) at a power density of 1200 W·kg^(-1).Six all-solid-state symmetric supercapacitors in series can also power a‘DHU’logo consisted of 36 light emitting diodes,confirming that the cellulose-based carbon nanofiber is a promising carbon matrix material for energy storage devices.

关键词： cellulose carbon nanofibers NiCo_(2)O_(4) supercapacitors

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Enhanced bioavailability and biosafety of cannabidiol nanomicelles for effective anti-inflammatory therapy

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Particuology 2022年第10期20卷 1-9页

作者： Yuan Rao Runwei Li Saixing Liu Linchao Meng qilin wu Qipeng Yuan Hao Liang Meng Qin College of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China StarHealth Botanical Technology Corporation Beijing 100005China

Cannabidiol(CBD)shows great anti-inflammatory potential;however,the hydrophobicity and strong first-pass effect of CBD leads to its extremely low oral bioavailability.Poloxamer 407(P407)is a tri-block copolymer composed of(poly)ethylene oxide(PEO)and(poly)propylene oxide(PPO)sections.It has a PEO-PPO-PEO structure,which is widely used in the preparation of drug delivery systems that are highly biocompatible.When it reaches a certain concentration in water,P407 can self-assemble into a micelle structure containing a hydrophobic core and a hydrophilic shell.A potential approach to enhanc-ing the oral bioavailability of hydrophobic drugs incorporating them into the hydrophilic carrier.We prepared CBD nanomicelles with a drug loading of 14.29%by a cosolvent evaporation method using P407 with appropriate antioxidants.Cell experiments indicated that anti-inflammatory markers(IL-4 and IL-10)increased,while inflammatory markers(TNF-αand IL-6)decreased.Moreover,animal experiments showed that inflammatory cells were inhibited by CBD nanomicelles,and the anti-inflammatory effect of micelles was better than that of CBD,while no obvious evidence indicated toxicity to the liver and kidney.

关键词： CBD Poloxamer 407 Polymeric micelle Anti-inflammatory Cytotoxicity

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Maternal zinc alleviates tert-butyl hydroperoxide-induced mitochondrial oxidative stress on embryonic development involving the activation of Nrf2/PGC-1αpathway

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1730-1743页

作者： Liang Huang Wei Gao Xuri He Tong Yuan Huaqi Zhang Xiufen Zhang Wenxuan Zheng qilin wu Ju Liu Wence Wang Lin Yang Yongwen Zhu State Key Laboratory of Livestock and Poultry Breeding South China Agricultural UniversityGuangzhou 510000China Tongren Polytechnic College Tongren 554000China Enping Long Industrial Co.Ltd Enping 529400China

Background Mitochondrial dysfunction induced by excessive mitochondrial reactive oxygen species(ROS)damages embryonic development and leads to growth arrest.Objective The purpose of this study is to elucidate whether maternal zinc(Zn)exert protective effect on oxidative stress targeting mitochondrial function using an avian model.Result In ovo injected tert-butyl hydroperoxide(BHP)increases(P<0.05)hepatic mitochondrial ROS,malondialdehyde(MDA)and 8-hydroxy-2-deoxyguanosine(8-OHdG),and decreases(P<0.05)mitochondrial membrane potential(MMP),mitochondrial DNA(mtDNA)copy number and adenosine triphosphate(ATP)content,contributing to mitochondrial dysfunction.In vivo and in vitro studies revealed that Zn addition enhances(P<0.05)ATP synthesis and metallothionein 4(MT4)content and expression as well as alleviates(P<0.05)the BHP-induced mitochondrial ROS generation,oxidative damage and dysfunction,exerting a protective effect on mitochondrial function by enhancing antioxidant capacity and upregulating the mRNA and protein expressions of Nrf2 and PGC-1α.Conclusions The present study provides a new way to protect offspring against oxidative damage by maternal Zn supplementation through the process of targeting mitochondria involving the activation of Nrf2/PGC-1αsignaling.

关键词： Embryonic development Maternal zinc Mitochondrial function Oxidative stress

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A TEMPOL and rapamycin loaded nanofiber-covered stent favors endothelialization and mitigates neointimal hyperplasia and local inflammation

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Bioactive Materials 2023年第1期19卷 666-677页

作者： Rui Wang Jian Lu Jiasheng Yin Han Chen Hongmei Liu Fei Xu Tongtong Zang Rende Xu Chenguang Li Yizhe wu qilin wu Xiang Fei Meifang Zhu Li Shen Junbo Ge Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesNational Clinical Research Center for Interventional MedicineShanghaiChina State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInternational Joint Laboratory for Advanced Fiber and Low-dimension MaterialsDonghua UniversityShanghai201620China Research Unit of Cardiovascular Techniques and Devices Chinese Academy of Medical SciencesShanghaiChina Shanghai Engineering Research Center of Interventional Medicine ShanghaiChina

An increased level of reactive oxygen species(ROS)plays a major role in endothelial dysfunction and vascular smooth muscle cell(VSMC)proliferation during in-stent thrombosis and restenosis after coronary artery stenting.Herein,we report an electrospun core-shell nanofiber coloaded with 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl(TEMPOL)and rapamycin(RAPA)that correspondingly serves as an ROS scavenger and VSMC inhibitor.This system has the potential to improve the biocompatibility of current drug-eluting stent(DES)coatings with the long-term and continuous release of TEMPOL and rapamycin.Moreover,the RAPA/TEMPOL-loaded membrane selectively inhibited the proliferation of VSMCs while sparing endothelial cells(ECs).This membrane demonstrated superior ROS-scavenging,anti-inflammatory and antithrombogenic effects in ECs.In addition,the membrane could maintain the contractile phenotype and mitigate platelet-derived growth factor BB(PDGF-BB)-induced proliferation of VSMCs.In vivo results further revealed that the RAPA/TEMPOL-loaded covered stents promoted rapid restoration of vascular endothelium compared with DES and persistently impeded inflammation and neointimal hyperplasia in porcine models.

关键词： Electrospun nanofiber membrane In-stent restenosis Re-endothelialization Reactive oxygen species

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Developmental changes in lipid and fatty acid metabolism and the inhibition by in ovo feeding oleic acid in Muscovy duck embryogenesis

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Animal Nutrition 2023年第1期12卷 321-333页

作者： Xiufen Zhang qilin wu Wenxuan Zheng Chuang Liu Liang Huang Xin Zuo Wenquan Xiao Xiaofeng Han Hui Ye Wence Wang Lin Yang Yongwen Zhu Guangdong Provincial Key Laboratory of Animal Nutrition and Regulation College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China Wen's Food Group Co. LtdYunfu 52740China

Hepatic lipid and fatty acid(FA)metabolism are critical for regulating energetic homeostasis during embryogenesis.At present,it remains unclear how an exogenous FA intervention affects embryonic development in an avian embryo model.In Exp.1,30 fertilized eggs were sampled on embryonic days(E)16,19,22,25,28,31 and the day of hatch(DOH)to determine the critical period of lipid metabolism.In Exp.2,a total of 120 fertilized eggs were divided into two groups(60 eggs/group)for in ovo feeding(IOF)procedures on E25.Eggs were injected into the yolk sac with PBS as the control group and with oleic acid(OA)as the IOF-OA treatment group.Samples were collected on E28 and E31.In Exp.1,hepatic triacylglycerol(TG)and cholesterol(CHO)contents increased while serum TG content decreased from E16 to DOH(P0.05).Maximal metabolic changes in lipid and FA metabolism occurred on E22-E28 in Muscovy duck embryogenesis,along with the altered target gene and protein expression related to lipogenesis and lipolysis.IOF-OA intervention on E25 could inhibit the target gene expression related to FA uptake,synthesis,and oxidation,which may influence the normal FA metabolism on E28 during embryogenesis.

关键词： Embryo Lipid Triacylglycerol Cholesterol Fatty acid Oleic acid

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Joint channel assignment and cross-layer routing protocol for multi-radio multi-channel Ad Hoc networks

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Journal of Systems Engineering and Electronics 2010年第6期21卷 1095-1102页

作者： Yang Lu Junming Guan Zhen Wei qilin wu School of Computer and Information Hefei University of Technology Heifei 230009 P. R. China Engineering Research Center of Safety Critical Industry Measure and Control Technology of Ministry of Education Hefei 230009 E R. China

To study multi-radio multi-channel （MR-MC） Ad Hoc networks based on 802.11, an efficient cross-layer routing protocol with the function of joint channel assignment, called joint channel assignment and cross-layer routing （JCACR）, is presented. Firstly, this paper introduces a new concept called channel utilization percentage （CUP）, which is for measuring the contention level of different channels in a node’s neighborhood, and deduces its optimal value for determining whether a channel is overloaded or not. Then, a metric parameter named channel selection metric （CSM） is designed, which actually reffects not only the channel status but also corresponding node’s capacity to seize it. JCACR evaluates channel assignment by CSM, performs a local optimization by assigning each node a channel with the smaller CSM value, and changes the working channel dynamically when the channel is overloaded. Therefore, the network load balancing can be achieved. In addition, simulation shows that, when compared with the protocol of weighted cumulative expected transfer time （WCETT）, the new protocol can improve the network throughput and reduce the end-to-end average delay with fewer overheads.

关键词： Ad Hoc network multi-radio multi-channel channel assignment routing protocol channel utilization percentage.

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基于碳材料的多维度柔性应变/压力传感器的研究进展

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材料导报 2024年第4期38卷 220-228页

作者：刘玉慧柳仕林吴聪影吴琪琳东华大学纤维材料改性国家重点实验室上海201620 东华大学材料科学与工程学院上海201620

近年来,基于碳材料的柔性应变/压力传感器发展迅速,在临床疾病诊断、健康监测、电子皮肤和软机器人等智能可穿戴领域内具有广阔的应用前景。本文综述了基于碳纳米材料和生物衍生碳材料的柔性应变/压力传感器的制备方法和性能特征。根据... 详细信息

近年来,基于碳材料的柔性应变/压力传感器发展迅速,在临床疾病诊断、健康监测、电子皮肤和软机器人等智能可穿戴领域内具有广阔的应用前景。本文综述了基于碳纳米材料和生物衍生碳材料的柔性应变/压力传感器的制备方法和性能特征。根据碳材料的维度和结构特点,可将传感器划分为三大类型:一维纤维/纱线型、二维薄膜/织物型和三维多孔/网络型。本文还重点评述了不同维度碳基柔性传感器的研究进展和存在的问题。未来柔性传感器的发展重点将聚焦于新型结构设计、综合性能提升和多模式功能化应用。

关键词：碳材料柔性传感器多维度多功能

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基于多尺度上下文的英文作文自动评分研究

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计算机工程 2024年第3期50卷 259-266页

作者：于明诚党亚固吴奇林吉旭毕可鑫四川大学化学工程学院四川成都610041

目前作文自动评分模型缺乏对不同尺度上下文语义特征的提取,未能从句子级别计算与作文主题关联程度的特征。提出基于多尺度上下文的英文作文自动评分研究方法MSC。采用XLNet英文预训练模型提取原始作文文本单词嵌入和句嵌入,避免在处理... 详细信息

目前作文自动评分模型缺乏对不同尺度上下文语义特征的提取,未能从句子级别计算与作文主题关联程度的特征。提出基于多尺度上下文的英文作文自动评分研究方法MSC。采用XLNet英文预训练模型提取原始作文文本单词嵌入和句嵌入,避免在处理长序列文本时无法准确捕捉到符合上下文语境的向量嵌入,提升动态向量语义表征质量,解决一词多义问题,并通过一维卷积模块提取不同尺度的短语级别嵌入。多尺度上下文网络通过结合内置自注意力简单循环单元和全局注意力机制,分别捕捉单词、短语和句子级别的作文高维潜在上下文语义关联关系,利用句向量与作文主题计算语义相似度提取篇章主题层次特征,将所有特征输入融合层通过线性层得到自动评分结果。在公开的标准英文作文评分数据集ASAP上的实验结果表明,MSC模型平均二次加权的Kappa值达到了80.5%,且在多个子集上取得了最佳效果,优于实验对比的深度学习自动评分模型,证明了MSC在英文作文自动评分任务上的有效性。

关键词：英文作文自动评分预训练模型多尺度上下文全局注意力主题层次特征

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Hollow multi-nanochannel carbon nanofiber/MoS_(2)nanoflower composites as binder-free lithium-ion battery anodes with high capacity and ultralong-cycle life at large current density

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Journal of Materials Science & Technology 2021年第18期77卷 169-177页

作者： Xuepeng Ni Zhe Cui Ning Jiang Huifang Chen qilin wu Anqi Ju Meifang Zhu College of Materials Science and Engineering&Shanghai Collaborative Innovation Center for High Performance Fiber Composites Donghua UniversityShanghai201620China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials.Donghua University Shanghai201620China Key Laboratory of High Performance Fibers&Products Ministry of EducationDonghua UniversityShanghai201620China

The electrode materials with high pseudocapacitance can enhance the rate capability and cycling stability of lithium-ion storage devices.Herein,we fabricated MoS_(2)nanoflowers with ultra-large interlayer spacing on N-doped hollow multi-nanochannel carbon nanofibers(F_(2)-MoS_(2)/NHMCFs)as freestanding binder-free anodes for lithium-ion batteries(LIBs).The ultra-large interlayer spacing(0.78~1.11 nm)of MoS_(2)nanoflowers can not only reduce the internal resistance,but also increase accessible active surface area,which ensures the fast Li+intercalation and deintercalation.The NHMCFs with hollow and multi-nanochannel structure can accommodate the large internal strain and volume change during lithiation/delithiation process,it is beneficial to improving the cycling stability of LIBs.Benefiting from the above combined structure merits,the F_(2)-MoS_(2)/NHMCFs electrodes deliver a high rate capability 832 mA h g^(-1)at 10 A g^(-1)and ultralong cycling stability with 99.29 and 91.60%capacity retention at 10 A g^(-1)after 1000 and 2000 cycles,respectively.It is one of the largest capacities and best cycling stability at10 A g^(-1)ever reported to date,indicating the freestanding F2-MoS_(2)/NHMCFs electrodes have potential applications in high power density LIBs.

关键词： Carbon nanofibers Electrospinning MoS_(2) Freestanding Lithium ion batteries

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