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Chinese Journal of Clinical Oncology 2008年第4期5卷 273-276页

作者： qilian liang Saihong Chen Dachao Pan Jierong Xie liangzhen Cai Shujun Li Center of Oncology Affiliated Hospital ofGuangdong Medical College Zhanjiang524001 Guangdong Province China.

OBJECTIVE To examine the therapeutic effects and toxicity of high-dose-folinic acid plus a 5-fluorouracil(5-FU)bolus and continuous infusion with 5-FU combined with locally produced oxaliplatin(L-HOP)in treating advanced gastric carcinoma patients. METHODS Sixty-five patients with advanced gastric carcinoma were treated with high-dose-folinic acid plus a 5-FU bolus and a 48-h continuous infusion of 5-FU combined with *** effects of treatment and toxicity were observed. RESULTS There were 4 complete responses,26 partial responses, 30 with no change and 5 with progressive *** overall effective response rate was 46.2%(30/65).The median duration was 7 months,with the main side effects including nausea and vomiting,peripheral phlebitis,alopecia,leukopenia,dental ulcers, peripheral neuritis and *** the side effects were tolerated and minimal. CONCLUSION The results showed that high-dose folinic acid plus a 5-FU bolus and continuous infusion of 5-FU combined with oxaliplatin appears to be a safe and effective therapy for patients with advanced gastric *** therapeutic regimen is of value for these patients.

关键词：胃癌叶酸 5-氟尿嘧啶治疗方法

基于无线信道信息的5G与TSN联合调度机制研究

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通信学报 2021年第12期42卷 65-75页

作者：孙雷王健全林尚静马彰超李卫 qilian liang 黄蓉北京科技大学自动化学院北京100083 北京邮电大学电子工程学院北京100876 北京科技大学计算机与通信工程学院北京100083 美国得克萨斯大学阿灵顿分校电子工程系得克萨斯76019 中国联通研究院北京100048

针对具备周期性及时间触发特征的工业业务在无线环境下的确定性传输问题,提出了一种基于空口信道质量信息的5G与时间敏感网络联合优化机制。在时间敏感网络中,改进了时间敏感网络业务流处理架构,优先处理承载于较差质量无线信道的工业... 详细信息

针对具备周期性及时间触发特征的工业业务在无线环境下的确定性传输问题,提出了一种基于空口信道质量信息的5G与时间敏感网络联合优化机制。在时间敏感网络中,改进了时间敏感网络业务流处理架构,优先处理承载于较差质量无线信道的工业业务流;在5G网络中,分析了5G系统传输时延影响因素,对无线信道质量、无线资源数量与空口最大传输次数的关系进行建模,基于该模型可得到满足数据传输可靠度要求的最大重传次数,从而可动态设置重传因子以动态规划承载于不同无线资源上的工业业务的5G系统传输时延预算。仿真结果表明,所提联合调度机制能降低承载于较差信道质量的工业业务的时间敏感网络域传输时延,并能有效消除5G空口随机变化导致的重传对传输时延造成的抖动,实现工业业务端到端确定性时延保障。

关键词： 5G与时间敏感网络联合调度工业业务跨网确定性传输端到端确定性时延

基于机器学习预测新诊断喉癌患者的淋巴结转移

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中国肿瘤 2023年第12期32卷 956-964页

作者：申帆王永存马万瑞丁海峰梁启廉万崇华广东医科大学附属东莞第一医院广东东莞523808 广东医科大学生命质量与应用心理研究中心/生命质量与心理测评干预重点实验室广东东莞523808 广东医科大学附属医院广东湛江524023

[目的]建立一个机器学习预测模型,可用于预测新诊断喉癌患者的淋巴结转移。[方法]回顾性分析2018—2020年美国国立癌症研究所监测、流行病学和最终结果数据库(SEER)中新诊断喉癌患者的人口统计学变量和临床病理变量,开发基于机器学习的... 详细信息

[目的]建立一个机器学习预测模型,可用于预测新诊断喉癌患者的淋巴结转移。[方法]回顾性分析2018—2020年美国国立癌症研究所监测、流行病学和最终结果数据库(SEER)中新诊断喉癌患者的人口统计学变量和临床病理变量,开发基于机器学习的淋巴结转移预测模型。利用ROC曲线下面积大小(AUC)、准确率、召回率、精确率和特异度来评估和比较各机器学习模型的预测性能。[结果]共纳入4462例喉癌患者,其中1444例发生淋巴结转移。年龄、原发部位、临床分级和T分期可以作为独立的风险因素。原发部位、T分期、年龄在淋巴结转移的重要性评估中排前3位。在所有的机器学习模型中,除KNN模型预测效果较差外,Random Forest、Boost、GLM、Neuralnet、Decision Tree这5种模型对于新诊断喉癌患者是否发生淋巴结转移都有较好的预测效果且分类能力近乎相同(在测试集中AUC值均在0.83左右),而准确率、召回率、特异度和精确率则在较小范围内各有优劣。[结论]本研究构建的机器学习模型可以较好地预测新诊断喉癌患者是否发生淋巴结转移,为临床医生的临床决策提供帮助。机器学习技术有可能帮助喉癌患者淋巴结转移预测模型的开发。

关键词：淋巴结转移机器学习喉癌

Radial growth in Qinghai spruce is most sensitive to severe drought in the qilian Mountains of Northwest China

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Journal of Forestry Research 2024年第3期35卷 73-86页

作者： Xuge Wang liang Jiao Ruhong Xue Peng Zhang Dashi Du Mengyuan Wei Qian Li College of Geography and Environmental Science Northwest Normal UniversityNo.967Anning East RoadLanzhou 730070People's Republic of China Key Laboratory of Resource Environment and Sustainable Development of Oasis Northwest Normal UniversityLanzhou 730070Gansu ProvincePeople's Republicof China

Global warming and frequent extreme drought events lead to tree death and extensive forest decline,but the underlying mechanism is not *** drought years,cambial development is more sensitive to climate change,but in different phenological stages,the response rela-tionship is ***,the dynamic relationship between tree radial growth and climatic/environmental fac-tors needs to be *** thus continuously monitored radial growth of Qinghai spruce(Picea crassifolia Kom.)and environmental factors from January 2021 to November 2022 using point dendrometers and portable meteorological weather stations in the central area of the qilian *** relationship and stability between the radial growth of Qinghai spruce and environmental factors were compared for different levels of drought in 2021 and *** year 2022 had higher temperatures and less precipitation and was drier than *** with 2021,the growing period in 2022 for Qinghai spruce was 10 days shorter,maximum growth rate(Grmax)was 4.5μm·d^(-1) slower,and the initiation of growth was 6 days *** of Qinghai spruce was always restricted by drought,and the stem radial increment(SRI)was more sensitive to precipitation and air relative *** changes in cumulative radial growth were divided into four phenological stages according to the time of growth onset,cessation,and maximum growth rate(Grmax)of Qinghai *** responses of SRI to climate change were stronger in Stage 3 and Stage 4 of 2021 and stronger in Stage 1(initiation growth stage)and Stage 3 of *** results provide important information on the growth of the trees in response to drought and for specific managing forests as the climate warms.

关键词： Picea crassifolia Radial growth dynamics Severe drought Response stability Point dendrometer

Elevation response of above-ground net primary productivity for Picea crassifolia to climate change in qilian Mountains of Northwest China based on tree rings

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Journal of Geographical Sciences 2024年第1期34卷 146-164页

作者： WU Xuan JIAO liang DU Dashi XUE Ruhong WEI Mengyuan ZHANG Peng College of Geography and Environment Science Northwest Normal UniversityLanzhou 730070China Key Laboratory of Resource Environment and Sustainable Development of Oasis Northwest Normal UniversityLanzhou 730070China

Current ecosystem models used to simulate global terrestrial carbon balance generally suggest that terrestrial landscapes are stable and mature,but terrestrial net primary productivity(NPP)data estimated without accounting for disturbances in species composition,environment,structure,and ecological characteristics will reduce the accuracy of the global carbon ***,the steady-state assumption and neglect of elevation-related changes in forest NPP is a *** qilian Mountains are located in continental climate zone,and vegetation is highly sensitive to climate *** quantified aboveground biomass(AGB)and aboveground net primary productivity(ANPP)sequences at three elevations using field-collected tree rings of Picea crassifolia in qilian Mountains of Northwest *** results showed that(1)There were significant differences between AGB and ANPP at the three elevations,and the growth rate of AGB was the highest at the low elevation(55.99 t ha^(–1)10a^(–1)).(2)There are differences in the response relationship between the ANPP and climate factors at the three elevations,and drought stress is the main climate signal affecting the change of ANPP.(3)Under the future climate scenario,drought stress intensifies,and the predicted decline trend of ANPP at the three elevations from mid-century to the end of this century is–0.025 t ha^(–1)10a^(–1),respectively;–0.022 t ha^(–1)10a^(–1);At–0.246 t ha^(–1)10a^(–1),the level of forest productivity was significantly *** results reveal the elevation gradient differences in forest productivity levels and provide key information for studying the carbon sink potential of boreal forests.

关键词： global climate change tree ring aboveground net primary productivity aboveground biomass drought stress qilian Mountains

膜联蛋白A2和锌指转录因子Snail在人脑胶质瘤组织中的表达及意义

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中华实验外科杂志 2015年第1期32卷 175-177页

作者：陈敢峰黄昕江亮梁卫明梁启廉浙江省东阳市人民医院神经外科 322100 广东医学院附属医院肿瘤中心

目的探讨膜联蛋白A2（Annexin A2）和锌指转录因子Snail在胶质瘤组织的表达水平及两者与胶质瘤病理学特征的关系.方法应用免疫组织化学法检测52例胶质瘤组织和22例正常脑组织中Annexin A2和Snail表达水平.结果 Annexin A2在胶质瘤组... 详细信息

目的探讨膜联蛋白A2（Annexin A2）和锌指转录因子Snail在胶质瘤组织的表达水平及两者与胶质瘤病理学特征的关系.方法应用免疫组织化学法检测52例胶质瘤组织和22例正常脑组织中Annexin A2和Snail表达水平.结果 Annexin A2在胶质瘤组织中阳性表达率明显高于正常脑组织（80.77％比9.09％,P＜0.01）,Snail在胶质瘤组织中阳性表达率明显高于正常脑组织（67.31％比13.64％,P＜0.01）;Annexin A2及Snail表达水平与胶质瘤组织学分级有关（P＜0.05）.结论 Annexin A2及Snail的过度表达与胶质瘤的发生发展和恶性程度有关,联合检测Annexin A2及Snail有助于判断胶质瘤患者预后.

关键词：膜联蛋白A2 Snail 胶质瘤

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路盖克治疗中度癌痛的临床观察

中国新药杂志 1999年第12期8卷 841-842页

作者：梁启廉徐轶广东医学院附属医院湛江524001 广东省农垦中心医院

目的：观察路盖克（双氢可待因／醋氨酚复方片）对中度癌痛的镇痛效果和不良反应。方法：路盖克每次2片，tid或qid，应用于150例中度癌痛患者。结果：路盖克治疗中度癌痛的显效率为84．7％，68．0％的患者提高了生活质量，不良反应低。... 详细信息

目的：观察路盖克（双氢可待因／醋氨酚复方片）对中度癌痛的镇痛效果和不良反应。方法：路盖克每次2片，tid或qid，应用于150例中度癌痛患者。结果：路盖克治疗中度癌痛的显效率为84．7％，68．0％的患者提高了生活质量，不良反应低。结论：此药可作为中度癌痛患者常规使用镇痛药物之一。

关键词：路盖克癌症中度疼痛镇痛

钙结合蛋白S100A4和zeste基因增强子同源物2在乳腺癌组织中的表达及临床意义

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中华实验外科杂志 2015年第7期32卷 1669-1671页

作者：刘佩姿黄犁江亮欧雯婷梁启廉深圳市妇幼保健院乳腺外科 518000 广东医学院附属医院肿瘤中心

目的探讨乳腺癌组织中钙结合蛋白S100A4和zeste基因增强子同源物2（EZH2）的表达水平及临床意义.方法应用免疫组织化学法检测79例乳腺癌患者手术切除的癌组织和癌旁组织中S100A4和EZH2表达水平.结果 S100A4在乳腺癌组织中表达率明显... 详细信息

目的探讨乳腺癌组织中钙结合蛋白S100A4和zeste基因增强子同源物2（EZH2）的表达水平及临床意义.方法应用免疫组织化学法检测79例乳腺癌患者手术切除的癌组织和癌旁组织中S100A4和EZH2表达水平.结果 S100A4在乳腺癌组织中表达率明显高于癌旁组织（62.03％比22.79％,P＜0.01）,EZH2在乳腺癌组织中表达率明显高于癌旁组织（70.89％比30.38％,P＜0.01）;S100A4表达水平与乳腺癌肿瘤大小、TNM分期和淋巴结转移明显相关（P＜0.05）,EZH2表达水平与乳腺癌TNM分期和淋巴结转移明显相关（P＜0.05）.结论 S100A4和EZH2在乳腺癌组织中呈高表达,检测S100A4和EZH2有助于判断乳腺癌生物学行为.

关键词：乳腺癌 S100A4 zeste基因增强子同源物2

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南宁吴圩国际机场冬季鸟类组成与鸟击防范

野生动物学报 2015年第4期36卷 407-415页

作者：黄才斌李东余丽江梁启联广西大学动物科学技术学院南宁530004 南宁吴圩国际机场南宁530048

2014年12月~2015年2月,对南宁吴圩国际机场冬季鸟类进行了调查,在场内及周边4 km范围内共发现鸟类11目30科60种,留鸟有38种,占63.33%;冬候鸟22种,占36.67%。重要性值分析表明池鹭（Ardeola bacchus）、白鹡鸰（Motacilla alba）、红耳鹎... 详细信息

2014年12月~2015年2月,对南宁吴圩国际机场冬季鸟类进行了调查,在场内及周边4 km范围内共发现鸟类11目30科60种,留鸟有38种,占63.33%;冬候鸟22种,占36.67%。重要性值分析表明池鹭（Ardeola bacchus）、白鹡鸰（Motacilla alba）、红耳鹎（Pycnonotus jocosus）、白头鹎（Pycnonotus sinensis）、棕背伯劳（Lanius schach）等10种为机场冬季鸟类群落中最重要的种类。分布系数划分表明,广性分布型鸟类有19种,中性分布型有16种,狭性分布型25种。场内观察发现一天中7：00~8：00、17：00~18：00两个时段鸟类最活跃。根据数据分析和实际调查,机场冬季构成鸟撞隐患的主要为鹭科、鹰科、隼科、鸱鹗科、鹬科的鸟类。同时对机场及周边不同生境进行多样性分析,结合各生境的特点和高危鸟种初步提出生态治理对策和鸟击防范措施,以期减少鸟类和飞行器之间的相互影响。

关键词：鸟击群落结构鸟击防范吴圩机场

Ordovician integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 971-1004页

作者： Xiang FANG Yong Yi ZHEN Guangxu WANG Xin WEI Zhongyang CHEN Yan liang Xuejin WU Wenjie LI Chao LI Renbin ZHAN Yuandong ZHANG State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Geological Survey of New South Wales W.B.Clarke Geoscience CentreNSW 2753Australia University of Chinese Academy of Sciences Beijing 100049China

The Ordovician rocks on the Qinghai-Tibetan Plateau represent the oldest non-metamorphic strata,and are critical to understanding the history of regional geology and biotic evolution of the entire *** of Floian,Darriwilian,Sandbian,Katian and Hirnantian are represented in the plateau with a hiatus of variable duration occurring underneath the basal Ordovician across the *** stratigraphical regions,including the Himalaya,Gangdise-Zayu,Qiangtang-Qamdo,Songpan-Garze,and Karakoram-Kunlun-Altun,are differentiated for the Ordovician strata,which are correlated with their equivalents in the Sibumasu,Indochina,Qaidam-qilian,Tarim-Tianshan,and the Yangtze(western margin)stratigraphical *** the QinghaiTibetan Plateau,graptolites,conodonts,and cephalopods are the most common and useful fossils for the Ordovician *** Ordovician biotas of the Qinghai-Tibetan Plateau bear some distinguishable palaeobiogeographical signatures,among which the cephalopods are characterized by the flourishing actinocerids of North China affinity in the Early-Middle Ordovician,and by the thriving lituitids and orthocerids of South China affinity in the Middle-Late *** occurrences and their palaeobiogeographical evolution provide critical evidence bearing on the reconstruction of the geological history of the Qinghai-Tibetan Plateau and surrounding terranes in northeastern *** stratigraphical successions of the Cambrian-Ordovician transition in the Himalaya and Lhasa and nearby Sibumasu terranes were significantly affected by the Kurgiakh Orogeny,which resulted in the extensive unconformity between the Ordovician and the underlying rocks in most areas of the Qinghai-Tibetan *** southern Xizang,a warm-water biota of Middle Ordovician age was recovered from oolitic limestones,suggesting a likely palaeogeographical location in low-latitudes near the *** the Himalaya and Sibumasu regions,the Upper Ordovician was typified by t

关键词： Ordovician Chronostratigraphy Lithostratigraphy Biostratigraphy Palaeobiogeography Qinghai-Tibetan Plateau