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Chinese Journal of Clinical Oncology 2008年第4期5卷 273-276页

作者： qilian Liang Saihong Chen Dachao Pan Jierong Xie Liangzhen Cai Shujun Li Center of Oncology Affiliated Hospital ofGuangdong Medical College Zhanjiang524001 Guangdong Province China.

OBJECTIVE To examine the therapeutic effects and toxicity of high-dose-folinic acid plus a 5-fluorouracil(5-FU)bolus and continuous infusion with 5-FU combined with locally produced oxaliplatin(L-HOP)in treating advanced gastric carcinoma patients. METHODS Sixty-five patients with advanced gastric carcinoma were treated with high-dose-folinic acid plus a 5-FU bolus and a 48-h continuous infusion of 5-FU combined with *** effects of treatment and toxicity were observed. RESULTS There were 4 complete responses,26 partial responses, 30 with no change and 5 with progressive *** overall effective response rate was 46.2%(30/65).The median duration was 7 months,with the main side effects including nausea and vomiting,peripheral phlebitis,alopecia,leukopenia,dental ulcers, peripheral neuritis and *** the side effects were tolerated and minimal. CONCLUSION The results showed that high-dose folinic acid plus a 5-FU bolus and continuous infusion of 5-FU combined with oxaliplatin appears to be a safe and effective therapy for patients with advanced gastric *** therapeutic regimen is of value for these patients.

关键词： advanced gastric carinoma calcium folinate 5-fluorouracil oxaliplatin chemotherapy.

Changes of glacier area in the Xiying River Basin, East qilian Mountain, China

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Research in Cold and Arid Regions 2017年第5期9卷 432-437页

作者： YuShuo Liu Xiang Qin WenTao du State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Lanzhou Gansu 730000 China qilian Shan Station of Glaciology and Ecologic Environment Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Lanzhou Gansu 730000 China

The Xiying River,one of eight tributaries of the Shiyang River,located at Lenglongling,east qilian Mountain,is formed by the confluence of Luotuo,Qingyang,Ningchan,and Shuiguan *** the Xiying River Basin,where have 42 glaciers which toward NE in the *** this study,three Landsat images and two topographic maps were used to extract boundaries by artificial vector *** show that glacier area in Xiying Basin increased slightly around 1987,since then,has been reduced *** 1956/1972 to 2008,glacier area in Xiying River Basin was reduced by20.76%,nine glaciers have disappeared,and below 4,100 m a.s.l.,there is no ice *** tendency of glacier retreat was obviously controlled by *** increase especially after 1987 is the main reason of glacier shrinkage,where glaciers in the Xiying River Basin are more sensitive to climate change.

关键词： glacier shrink qilian Mountain Xiying River remote sense

基于无线信道信息的5G与TSN联合调度机制研究

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通信学报 2021年第12期42卷 65-75页

作者：孙雷王健全林尚静马彰超李卫 qilian Liang 黄蓉北京科技大学自动化学院北京100083 北京邮电大学电子工程学院北京100876 北京科技大学计算机与通信工程学院北京100083 美国得克萨斯大学阿灵顿分校电子工程系得克萨斯76019 中国联通研究院北京100048

针对具备周期性及时间触发特征的工业业务在无线环境下的确定性传输问题,提出了一种基于空口信道质量信息的5G与时间敏感网络联合优化机制。在时间敏感网络中,改进了时间敏感网络业务流处理架构,优先处理承载于较差质量无线信道的工业... 详细信息

针对具备周期性及时间触发特征的工业业务在无线环境下的确定性传输问题,提出了一种基于空口信道质量信息的5G与时间敏感网络联合优化机制。在时间敏感网络中,改进了时间敏感网络业务流处理架构,优先处理承载于较差质量无线信道的工业业务流;在5G网络中,分析了5G系统传输时延影响因素,对无线信道质量、无线资源数量与空口最大传输次数的关系进行建模,基于该模型可得到满足数据传输可靠度要求的最大重传次数,从而可动态设置重传因子以动态规划承载于不同无线资源上的工业业务的5G系统传输时延预算。仿真结果表明,所提联合调度机制能降低承载于较差信道质量的工业业务的时间敏感网络域传输时延,并能有效消除5G空口随机变化导致的重传对传输时延造成的抖动,实现工业业务端到端确定性时延保障。

关键词： 5G与时间敏感网络联合调度工业业务跨网确定性传输端到端确定性时延

Geochemistry and Zircon U-Pb Geochronology of Early Paleozoic S-type Granites in the Eastern qilian Block,Northwest China

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Acta Geologica Sinica(English Edition) 2021年第2期95卷 439-458页

作者： LIU Xiuting LI Binkai HAN Jilong REN Erfeng GAO Donglin du Yongsheng REN Qianhui ZHANG Yan Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt LakesChinese Academy of SciencesXining 810008China Key Laboratory of Salt Lake Geology and Environment of Qinghai Province Qinghai Institute ofSalt LakesChinese Academy of SciencesXining 810008China University ofChinese Academy of Sciences Beijing 100049China College of Chemical and Pharmaceutical Engineering(Hebei) University of Science and TechnologyShijiazhuang 050018China Department of Geological Engineering Qinghai UniversityXining 810016China Department of Water Conservancy and Electric Power Qinghai UniversityXining 810016China Qinghai Province Nonferrous Metals Third Geological Exploration Institute Xining 810012China

The qilian Block(QB)is a Precambrian micro-continent located in the northeastern Qinghai–Tibet *** Lower Paleozoic granitic magmatic rocks crop out in the QB.A new integrated study of zircon U-Pb ages and systematic whole-rock geochemical data for the Xindian,Dongjiazhuang and Xiaogaoling granites in the eastern segment of the QB constrains their emplacement ages,petrogenesis,and regional evolutionary history.U-Pb dating reveals that the Xindian granite was emplaced 454 Ma,and both the Dongjiazhuang and Xiaogaoling granites were emplaced ca.440 *** study shows that all granites belong to the high-K calc-alkaline to shoshonitic series and are S-type granites formed by partial melting of continental crust,mainly *** infer that these ca.454–445 Ma granites formed in a syn-collisional setting during the continental collisional between the Qaidam and qilian blocks.

关键词： geochemistry geochronology petrogenesis syn-collision qilian Block NW China

Origin of the Gas Hydrate and Free Gas in the qilian Permafrost,Northwest China:Evidence from Molecular Composition and Carbon Isotopes

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Acta Geologica Sinica(English Edition) 2021年第2期95卷 602-616页

作者： TAN Furong LI Yang du Fangpeng LIU Shiming CUI Weixiong LIU Zhiwu GENG Qingming LU Ping State Key Laboratoiy of Continental Dynamics Department of GeologyNorthwest UniversityXi'an 710069China State Key Laboratory of Organic Geochemistty Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China China National Administration of Coal Geology Beijing 10038China Shaanxi Mineral Resources and Geological Survey Xi'an 71006SChina Xi'an Research Institute of China Coal Technology&Engineering Group Corp. Xi'an 710077China College of Earth Science and Resources Chang'an UniversityXi'an 710054China

The qilian permafrost of the South qilian Basin(SQB)has become a research focus since gas hydrates were discovered in *** many works from different perspectives have been conducted in this area,the origin of gas from gas hydrate is still *** composition and carbon isotope of 190 samples related to gas hydrates collected from 11 boreholes allowed exploration of genetic type,thermal maturity,biodegradation,as well as gas-source correlation of alkane gases from gas hydrates and free *** indicate that alkane gases biodegraded after the formation of natural *** to differences in carbon isotopes of methane and their congeners(CH4,C2H6,C3H8),the thermal maturity(vitrinite reflectance,VRo)of most alkane gases ranges from 0.6%to 1.5%,indicating a mature to high mature *** thermal maturity VRo of a small part of alkane gas(in boreholes DK5 and DK6)is higher than 1.3%,indicating a high mature *** gases were mainly produced by secondary cracking,consisting of crude oilcracking gases and wet gases cracking to dry *** types of alkane gases are primarily oil-type gases generated from shales and mudstones in the upper Yaojie Formation of Jurassic,with less coal-type gases originated from the mudstones in the Triassic Galedesi Formation and the lower Yaojie Formation of *** dioxides associated with alkanes from gas hydrates and free gases indicate the thermal decomposition and biodegradation of organic *** origins of natural gases from gas hydrates and free gases shed light on the evaluation of petroleum resource potential,deeply buried sediments,and petroleum resource exploration in the SQB.

关键词： uunconventional energy gas hydrate carbon isotope alkane gas origin thermal maturity South qilian Basin

Inhibitor RNA blocks the protein translation mediated by hepatitis C virus internal ribosome entry site in vivo

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World Journal of Gastroenterology 2004年第5期10卷 664-667页

作者： Xue-SongLiang Jian-qilian Yong-XingZhou Mo-BinWan DepartmentofInfectiousDiseases ChanghaiHospitalSecondMilitaryMedicalUniversityShanghaiChina DepartmentofInfectiousDiseases TangduHospitalFourthMilitaryMedicalUniversityXi'an710038ShaanxiProvinceChina

AIM:To investigate the inhibitory effect of hepatitis C virus internal ribosome entry site (HCV IRES) specific inhibitor RNA(IRNA) on gene expression mediated by HCV IRES in ***:By using G418 screening system, hepatoma cells constitutively expressing IRNA or mutant IRNA (mIRNA) were established and characterized, and HCV replicons containing the 5′ untranslated region (5′UTR) were constructed by using the same method. Cotransfection of pCMVNCRluc containing HCV 5′UTR-Iuc fusion genes and eukaryotic vector of IRNA into human hepatic carcinoma cells (HepG2) was performed and the eukaryotic expression plasmid of IRNA was transfected transiently into HCV replicons, pCMVNCRluc or pCDNA-luc was cotransfected with pSV40-β Gal into IRNA expressing hepatoma cells by using lipofectamine 2000 in vitro. Then the reporting gene expression level was examined at 48h after transfection by using a luminometer and the expressing level of HCV C antigen was analysed with a confocal ***: Transient expression of IRES specific IRNA could significantly inhibit the expression of reporter gene and viral antigen mediated by HCV IRES by 50% to 90% in vivo, but mIRNA lost its inhibitory activity completely. The luciferase gene expression mediated by HCV IRES was blocked in the HHCC constitutively expressing IRNA. At 48h after transfection, the expression level of reportor gene descreased by 20%, but cap-dependent luciferase gene expression was not affected. IRNA could inhibit the HCV replicon expression 24h after transfection and the highest inhibitory activity was 80% by 72h, and the inhibitory activity was not increased until 7d after ***:IRNA can inhibit HCV IRES mediated gene expression in vivo.

关键词： RNA干扰丙型肝炎病毒核糖体真核表达载体细胞培养

Comparative Nursing Study of Patients Undergoing Coronary Intervention Therapy in Different Ways

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Journal of Biosciences and Medicines 2019年第5期7卷 203-212页

作者： qilian He Yuquan Luan Yanfen Fu Jun Tang School of Nursing Dali University Dali China

Purpose: To compare the surgical indicators, perioperative complications and postoperative psychological status of patients with coronary interventional therapy (CIT) by radical artery and femoral artery puncture approaches. Methods: 120 patients with CIT were divided into femoral artery group (FAG) and radial artery group (RAG) according to the operation ways. The interventional operation was performed by the same surgeon team and methods. Data of surgical indicators and perioperative complications were recorded and collected. The psychological questionare survey was made within 48 hours the after surgery by the hospital anxiety and depression scale (HAD), and the results were scored by the psychiatrist. Results: The age, sex, ethnicity, education level, disease type, and combined diseases of the two groups had homogeneity without statistical difference. There was no obvious difference in X-ray exposure time, contrast agent usage and operation time in two ways (P > 0.05). The success rate of one-time catheterization was higher in FAG than in RAG (P Conclusion: CIT via radial artery can reduce the incidence of postoperative complications, postoperative physical discomfort and psychological problems such as anxiety and depression of patients.

关键词： Nursing Coronary Interventional Therapy (CIT) Coronary Arterial Angiography (CAG) Percutaneous Coronary Intervention (PCI) Radical Artery Femoral Artery The Hospital Anxiety and Depression Scale (HAD)

铝土矿及伴生关键金属矿床的岩石(矿石)组成、成矿序列及成矿机理

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古地理学报 2024年第5期26卷 1152-1166页

作者：杜远生余文超翁申富雷志远李沛刚覃英邓克勇卢树藩罗香建符宏斌张嘉玮吴波邓旭升陈群郭尚宇张启连覃丰邹应中庞大卫周锦涛成龙中国地质大学(武汉)地球科学学院湖北武汉430074 自然资源部基岩区矿产资源勘查工程技术创新中心贵州贵阳550081 贵州省地质矿产勘查开发局106地质大队贵州遵义563003 贵州省地质矿产勘查开发局贵州贵阳550004 贵州省地质调查院贵州贵阳550018 贵州省地质矿产勘查开发局115地质队贵州贵阳551400 广西壮族自治区矿产资源储量评审中心广西南宁530028 广西壮族自治区地质调查院广西南宁530023 广西壮族自治区274地质队广西北海536005 广西壮族自治区第六地质队广西贵港537100

大陆风化是地球表层系统中的关键过程,涉及多种能量形式(太阳能、风能、化学能和重力势能)和物理化学过程,是地球化学元素在地球不同层面(如岩石圈、水圈、生物圈和大气圈)之间迁移和重新分配的基础。在此过程中,异常的元素富集可形成... 详细信息

大陆风化是地球表层系统中的关键过程,涉及多种能量形式(太阳能、风能、化学能和重力势能)和物理化学过程,是地球化学元素在地球不同层面(如岩石圈、水圈、生物圈和大气圈)之间迁移和重新分配的基础。在此过程中,异常的元素富集可形成工业级的风化淋滤矿床。风化淋滤矿床可进一步区分出风化矿床和沉积—淋滤型矿床2种类型。传统的矿床学和沉积学研究方法在理解风化淋滤矿床形成过程中存在局限性,特别是在解析成矿阶段和动态成矿过程方面仍不甚明晰,导致该类型矿床在基础研究和勘查方面长期存在亟待解决的一批问题。本研究在厘清大陆风化作用、风化壳(古风化壳)、土壤(古土壤)等概念的基础之上,对现代风化淋滤剖面(如广西贵港三水铝石矿床)和古老风化淋滤型矿床(如中国华南地区早石炭世—晚二叠世铝土矿床及沉积淋滤型稀土矿床)开展了系统的沉积学分析与对比工作。研究发现,风化淋滤矿床的结构组分主要包括碎屑、团粒与包粒、块状黏土等结构类型,分别对应碎屑状、包粒状、致密状矿石的形成。成岩过程主要依赖于氧化物矿物及黏土质的胶结与填隙作用。基于上述认识,提出了风化淋滤矿床的淋滤序列和剖面结构划分方案。该方案以风化剖面中渗流带与潜流带作为基本的划分依据,进一步区分出风化矿床序列与沉积—淋滤型矿床序列,两者主要以是否出现沉积单位作为主要识别标志。以古气候为主线分析了风化淋滤矿床的成因机理,并结合近年来质量平衡计算相关成果,总结了淋滤过程中元素迁移规律,将风化淋滤型矿床的成矿过程概括为成矿母质形成、成矿物质风化和后期改造3个阶段。

关键词：大陆风化铝土矿关键金属成矿序列成矿机制

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祁连山青海云杉林叶面积指数的空间异质性

山地学报 2024年第3期42卷 312-319页

作者：赵维俊牛赟杜军马雪娥张克海甘肃省祁连山水源涵养林研究院甘肃祁连山森林生态系统国家定位观测研究站淮阴师范学院地理科学与规划学院中国科学院西北生态环境资源研究院

叶面积指数（leaf area index,LAI）在山地森林具有高度的空间异质性。基于大样地尺度的山地森林叶面积空间异质性的研究较少，而且不涉及LAI对地形的响应研究。基于LAI的空间异质性和地形因子的相关性，确定取样尺度，可为提升区域尺度... 详细信息

叶面积指数（leaf area index,LAI）在山地森林具有高度的空间异质性。基于大样地尺度的山地森林叶面积空间异质性的研究较少，而且不涉及LAI对地形的响应研究。基于LAI的空间异质性和地形因子的相关性，确定取样尺度，可为提升区域尺度上LAI的空间遥感精度提供依据。本研究依托祁连山大野口流域10.2 ha(340 m×300 m)的青海云杉林动态监测样地，使用CID CI-110植物冠层数字图像分析仪对样地内255个20 m×20 m样方进行五点法LAI测定，分析LAI的空间异质性特征和空间分布格局及其与地形因子的相关性。研究结果表明：（1） LAI具有中等变异性，指数模型是变异函数的最佳理论模型，具有强烈的空间自相关，变程为16 m，南—北方向上是LAI分布的优势格局。（2） LAI的空间分布格局相对简单，具有一定的斑块性，LAI为0.56～1.43的斑块所占面积最大。（3） LAI与海拔和坡度均呈极显著负相关（P 0.05）。（4）青海云杉林的LAI空间异质性与尺度和方向有关，部分地形因子对LAI存在着显著影响。研究结果可为青海云杉林生态过程分析以及遥感技术反演LAI参数提供依据。

关键词：青海云杉林动态监测样地叶面积指数空间异质性

基于Sentinel-2的互助北山林场森林蓄积量反演研究

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青海科技 2024年第3期31卷 27-33页

作者：邓平顾天江杜凯青海师范大学地理科学学院青海省自然地理与环境过程重点实验室西宁810008 青海师范大学青藏高原地表过程与生态保育教育部重点实验室西宁810008 青海祁连山南坡森林生态系统国家定位观测研究站互助810500

森林蓄积量是评估森林健康和固碳能力的关键指标,利用遥感技术能够实现区域森林蓄积量的快速估测。本研究以青海省海东市互助北山林场为研究区域,基于森林样地调查数据和Sentinel-2影像,利用提取出的单波段反射率、植被指数、纹理因子... 详细信息

森林蓄积量是评估森林健康和固碳能力的关键指标,利用遥感技术能够实现区域森林蓄积量的快速估测。本研究以青海省海东市互助北山林场为研究区域,基于森林样地调查数据和Sentinel-2影像,利用提取出的单波段反射率、植被指数、纹理因子和地形因子等筛选出具有代表性的遥感特征,运用随机森林算法实现研究区森林蓄积量反演。主要结果如下:(1)基于皮尔逊相关性分析,确定B11、B10、B6、B7、EVI、SAVI、NIRv、ExGR、MNLI、B12为本研究森林蓄积量反演的遥感特征因子。(2)利用随机森林算法能够有效反演研究区森林蓄积量。反演结果的决定系数R2为0.73,均方根误差RMSE为1.65m^(3)/hm^(2)。(3)互助北山林场乔木林平均蓄积量为134.4m3/hm2,在空间分布上,中东部、东南部和北部部分区域森林蓄积量较高。

关键词：祁连山南麓 Sentinel-2 特征选择随机森林蓄积量反演