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单细胞转录组测序在肿瘤浸润免疫细胞中的研究进展

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临床外科杂志 2024年第3期32卷 332-334页

作者：杜启联宋恩峰胡钦勇武汉大学人民医院肿瘤中心 430060 武汉大学人民医院中医科 430060

免疫细胞与肿瘤进展及治疗密切相关。单细胞转录组测序(single-cell RNA sequencing, scRNA-seq)已广泛应用于解析肿瘤浸润免疫细胞的生物学行为、机制及其与机体的关系。scRNA-seq能全面剖析肿瘤浸润免疫细胞并促进临床个体化精准治疗。

关键词：单细胞转录组技术免疫细胞肿瘤

Radioimmunotherapy-induced intratumoral changes in cervical squamous cell carcinoma at single-cell resolution

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Cancer Communications 2022年第12期42卷 1407-1411页

作者： Chao Liu Hao Yu Rui Huang Tianyu Lei Xiaohui Li Ming Liu Qingyu Huang qilian du Ligang Xing Jinming Yu Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117P.R.China Research Unit of Radiation Oncology Chinese Academy of Medical SciencesJinanShandong 250117P.R.China Department of Gynecologic Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117P.R.China Department of Oncology Renmin Hospital ofWuhan UniversityWuhanHubei 430060P.R.China

Dear Editor,Increasing numbers of studies have revealed the immunomodulating effects of radiotherapy when combined with immune checkpoint inhibitors,as radioimmunotherapy has proven to be a promising treatment[1].Radioimmunotherapy has shown significantly improved tumor responses than radiotherapy or immunotherapy alone in various malignant tumors[2–4].It has also been applied to cervical cancer in multiple ongoing clinical trials(NCT03612791[5]and NCT02635360[6]).However,tumor recurrence andmetastasis are often *** such,investigations into radioimmunotherapy-induced tumor ecosystem evolution are essential for guiding improvements in treatment strategies that achieve better long-term disease *** date,several studies have investigated radiochemotherapy-induced tumor ecosystem evolution using bulk RNA-sequencing and immune staining[7,8].However,these findings were limited owing to the cellular heterogeneity in ***-cell RNA-sequencing(scRNA-seq)enables the characterization of cell compositions and transcriptomic states in the tumor at single-cell resolution.

关键词： cervical chemotherapy treatment

Short communication:Extreme glacier mass loss triggered by high temperature and drought during hydrological year 2022/2023 in qilian Mountains

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Research in Cold and Arid Regions 2024年第1期16卷 1-4页

作者： JiZu Chen XingYu Xue WenTao du State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences(CAS)LanzhouGansu 730000China Gansu Provincial Industry Technology Center of Intelligent Equipment and Big Data for Disaster Prevention Northwest Institute of Eco-Environment and ResourcesChinese Academy of Science(CAS)LanzhouGansu 730000China Zhangye Meteorological Bureau ZhangyeGansu 734000China College of Resources and Environment University of Chinese Academy of Sciences(UCAS)Beijing 100049China

In the hydrological year 2022/2023,the glaciers in the qilian Mountains experienced unprecedented mass *** glacier-wide mass balance was-1,188 mm w.e.,in contrast to-350 mm of average mass balance since 1990 over the Bailanghe Glacier No.12 in the middle of qilian *** temperature during 2022–2023 reached the highest value ever recorded,second only to 2022,while at the same time the precipitation amount was less compared to other year since 2000,which together led to the strongest glacier mass loss during 2022–*** atmospheric circulation analysis shows that the high temperature in the qilian Mountains in 2023 was jointly caused by the Arctic air mass and East Asian monsoon.

关键词： Bailanghe Glacier No.21 Glacier mass loss Extreme high temperature Atmospheric circulation

Radial growth in Qinghai spruce is most sensitive to severe drought in the qilian Mountains of Northwest China

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Journal of Forestry Research 2024年第3期35卷 73-86页

作者： Xuge Wang Liang Jiao Ruhong Xue Peng Zhang Dashi du Mengyuan Wei Qian Li College of Geography and Environmental Science Northwest Normal UniversityNo.967Anning East RoadLanzhou 730070People's Republic of China Key Laboratory of Resource Environment and Sustainable Development of Oasis Northwest Normal UniversityLanzhou 730070Gansu ProvincePeople's Republicof China

Global warming and frequent extreme drought events lead to tree death and extensive forest decline,but the underlying mechanism is not *** drought years,cambial development is more sensitive to climate change,but in different phenological stages,the response rela-tionship is ***,the dynamic relationship between tree radial growth and climatic/environmental fac-tors needs to be *** thus continuously monitored radial growth of Qinghai spruce(Picea crassifolia Kom.)and environmental factors from January 2021 to November 2022 using point dendrometers and portable meteorological weather stations in the central area of the qilian *** relationship and stability between the radial growth of Qinghai spruce and environmental factors were compared for different levels of drought in 2021 and *** year 2022 had higher temperatures and less precipitation and was drier than *** with 2021,the growing period in 2022 for Qinghai spruce was 10 days shorter,maximum growth rate(Grmax)was 4.5μm·d^(-1) slower,and the initiation of growth was 6 days *** of Qinghai spruce was always restricted by drought,and the stem radial increment(SRI)was more sensitive to precipitation and air relative *** changes in cumulative radial growth were divided into four phenological stages according to the time of growth onset,cessation,and maximum growth rate(Grmax)of Qinghai *** responses of SRI to climate change were stronger in Stage 3 and Stage 4 of 2021 and stronger in Stage 1(initiation growth stage)and Stage 3 of *** results provide important information on the growth of the trees in response to drought and for specific managing forests as the climate warms.

关键词： Picea crassifolia Radial growth dynamics Severe drought Response stability Point dendrometer

Elevation response of above-ground net primary productivity for Picea crassifolia to climate change in qilian Mountains of Northwest China based on tree rings

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Journal of Geographical Sciences 2024年第1期34卷 146-164页

作者： WU Xuan JIAO Liang du Dashi XUE Ruhong WEI Mengyuan ZHANG Peng College of Geography and Environment Science Northwest Normal UniversityLanzhou 730070China Key Laboratory of Resource Environment and Sustainable Development of Oasis Northwest Normal UniversityLanzhou 730070China

Current ecosystem models used to simulate global terrestrial carbon balance generally suggest that terrestrial landscapes are stable and mature,but terrestrial net primary productivity(NPP)data estimated without accounting for disturbances in species composition,environment,structure,and ecological characteristics will reduce the accuracy of the global carbon ***,the steady-state assumption and neglect of elevation-related changes in forest NPP is a *** qilian Mountains are located in continental climate zone,and vegetation is highly sensitive to climate *** quantified aboveground biomass(AGB)and aboveground net primary productivity(ANPP)sequences at three elevations using field-collected tree rings of Picea crassifolia in qilian Mountains of Northwest *** results showed that(1)There were significant differences between AGB and ANPP at the three elevations,and the growth rate of AGB was the highest at the low elevation(55.99 t ha^(–1)10a^(–1)).(2)There are differences in the response relationship between the ANPP and climate factors at the three elevations,and drought stress is the main climate signal affecting the change of ANPP.(3)Under the future climate scenario,drought stress intensifies,and the predicted decline trend of ANPP at the three elevations from mid-century to the end of this century is–0.025 t ha^(–1)10a^(–1),respectively;–0.022 t ha^(–1)10a^(–1);At–0.246 t ha^(–1)10a^(–1),the level of forest productivity was significantly *** results reveal the elevation gradient differences in forest productivity levels and provide key information for studying the carbon sink potential of boreal forests.

关键词： global climate change tree ring aboveground net primary productivity aboveground biomass drought stress qilian Mountains

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893例藏族人口腔修复病例的统计学分析

中国现代医生 2012年第28期50卷 4-5页

作者：杜启莲西藏自治区人民政府驻成都办事处医院口腔科四川成都610041

目的探讨藏族人口腔修复病例的规律性,为临床、科研、预防提供数据基础。方法回顾2007～2011年在我科进行口腔修复的藏族病例,在性别、年龄、缺牙位置、修复情况等方面进行统计学分析。结果性别分布无统计学意义;随着年龄增长,缺牙逐渐... 详细信息

目的探讨藏族人口腔修复病例的规律性,为临床、科研、预防提供数据基础。方法回顾2007～2011年在我科进行口腔修复的藏族病例,在性别、年龄、缺牙位置、修复情况等方面进行统计学分析。结果性别分布无统计学意义;随着年龄增长,缺牙逐渐增多,60岁以上组的牙列缺损、牙列缺失最多。缺牙牙位由多到少顺序是:第一磨牙>第二磨牙>第二双尖牙>第一双尖牙>中切牙>侧切呀>尖牙。修复类型以可摘局部义齿居多。结论随着经济和生活水平的提高,藏族人对口腔修复的需求越来越高。

关键词：藏族人口腔修复统计学分析

门诊1064例藏族人牙列缺损和修复情况调查分析

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口腔医学 2013年第3期33卷 185-187页

作者：杜启莲西藏政府驻成都办事处医院口腔科成都610041

目的调查藏族人的牙列缺损及修复状况。方法对2007年—2010年到我院口腔科就诊的初诊藏族患者进行问卷调查和临床检查。结果牙列缺损人数占总人数的78.8%,年龄越大缺牙率越高,可摘局部义齿修复率28.4%,固定桥修复率18.7%。结论门诊藏族... 详细信息

目的调查藏族人的牙列缺损及修复状况。方法对2007年—2010年到我院口腔科就诊的初诊藏族患者进行问卷调查和临床检查。结果牙列缺损人数占总人数的78.8%,年龄越大缺牙率越高,可摘局部义齿修复率28.4%,固定桥修复率18.7%。结论门诊藏族人牙列缺损较严重,修复率低,对义齿修复的认识不足,应加强口腔健康教育和规范的修复治疗。

关键词：牙列缺损修复藏族调查

不同海拔地区藏族和汉族牙周炎患者牙周微生物群落结构分析

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中国微生态学杂志 2023年第10期35卷 1164-1172页

作者：杜启莲袁星唐灿叶枫西藏自治区人民政府驻成都办事处医院四川成都610041

目的比较西藏高海拔地区和成都平原地区的藏族和汉族患者龈下微生物群落结构,初步探讨高海拔、民族和牙周炎症对龈下微生物群落结构的影响。方法纳入长期在西藏的藏族牙周炎患者38例和汉族牙周炎患者30例,长期在成都的汉族牙周炎患者31... 详细信息

目的比较西藏高海拔地区和成都平原地区的藏族和汉族患者龈下微生物群落结构,初步探讨高海拔、民族和牙周炎症对龈下微生物群落结构的影响。方法纳入长期在西藏的藏族牙周炎患者38例和汉族牙周炎患者30例,长期在成都的汉族牙周炎患者31例,并与健康组进行对比,使用Illumina MiSeq测序平台进行龈下菌斑16S rRNA基因测序,对比分析各组之间的微生物群落结构差异。结果牙周炎组较牙周健康组物种组成高。对于汉族牙周炎患者,海拔越高则龈下微生物alpha多样性越低(P=0.009),beta多样性差异也有统计学意义(P=0.003),但对汉族牙周健康者,海拔对于alpha多样性和beta多样性均无显著影响(P=0.071)。牙周健康组较牙周炎组龈下微生物群落alpha多样性高(P<0.001),二者beta多样性分析差异也有统计学意义(P=0.001)。藏族和汉族的龈下微生物beta多样性相似(P=0.431)。平原汉族牙周炎组的优势菌群有牙龈卟啉单胞菌、拟杆菌。高原汉族牙周炎组的优势菌群是普氏菌。平原汉族牙周炎组与高原汉族牙周炎组相比,卟啉单胞菌丰度显著升高。平原健康组的弯曲杆菌、梭菌属丰度较高原健康组高,而高原健康组的艾肯菌属丰度较高。在高原牙周炎中藏族与汉族人群的牙周常见菌群无显著差异。结论高海拔和牙周健康状况对龈下微生物群落结构有一定影响,相对而言民族之间差异较小。

关键词：牙周炎民族龈下微生物 16S rRNA 高原

藏族和汉族上颌第一恒磨牙近中颊根的CBCT对比研究

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口腔医学研究 2021年第3期37卷 218-221页

作者：杜启莲李紫嫣袁星唐灿西藏自治区人民政府驻成都办事处医院四川成都610041

目的:比较藏族和汉族上颌第一恒磨牙近中颊根数据,为临床提供参考。方法:随机收集藏族和汉族患者上颌第一恒磨牙近中颊根CBCT图像440例,测量根长、弯曲度、弯曲位置、是否有第二近颊根(MB2)、MB-MB2距离。结果:藏族第一恒磨牙近中颊根... 详细信息

目的:比较藏族和汉族上颌第一恒磨牙近中颊根数据,为临床提供参考。方法:随机收集藏族和汉族患者上颌第一恒磨牙近中颊根CBCT图像440例,测量根长、弯曲度、弯曲位置、是否有第二近颊根(MB2)、MB-MB2距离。结果:藏族第一恒磨牙近中颊根长度较汉族长,差异有统计学意义(P30°)也较汉族多。根管弯曲位置方面,汉族以根管中分的弯曲居多,而藏族不仅根管中分的弯曲较多,根管口和根尖弯曲也较多,差异有统计学意义(P<0.05)。藏汉族的MB2发生率、MB-MB2距离比较差异无统计学意义。结论:藏族和汉族上颌第一恒磨牙近中颊根的根长、根管弯曲度、根管弯曲位置有差别,藏族牙根更长,弯曲度更大,特别是根尖区弯曲度,值得临床注意。而MB2发生率和MB-MB2距离藏汉族无差异。

关键词： CBCT 上颌第一恒磨牙牙根长度 MB2 牙根弯曲度