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尼龙6/SiO_2纳米复合材料的制备及其力学性能和热稳定性

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化学研究 2015年第2期26卷 196-200页

作者：徐启杰赵崇镇陈方飞蔡天聪董立玉李小红张治军河南大学特种功能材料重点实验室河南开封475004 黄淮学院化学化工系河南驻马店463000 中国石油化工股份有限公司勘探开发事业部北京100028 北京化工大学材料科学与工程系北京100029

以表面含有氨基的可反应性纳米SiO2(RNS-A)和表面含有烷基碳链的可分散性纳米SiO2(DNS-3)作为填料,利用原位聚合法制备了尼龙6/SiO2纳米复合材料(相应的复合材料分别简记为RPA和DP3);采用透射电子显微镜观察了复合材料中纳米SiO2的表面... 详细信息

以表面含有氨基的可反应性纳米SiO2(RNS-A)和表面含有烷基碳链的可分散性纳米SiO2(DNS-3)作为填料,利用原位聚合法制备了尼龙6/SiO2纳米复合材料(相应的复合材料分别简记为RPA和DP3);采用透射电子显微镜观察了复合材料中纳米SiO2的表面形貌,并利用热失重分析仪测定了复合材料的热稳定性,进而考察了纳米SiO2表面功能基团对尼龙6力学性能和热稳定性的影响.结果显示,纳米SiO2能够很好地分散在尼龙6基体中,并使尼龙6的热分解温度提高10℃左右.与此同时,RPA的最大拉伸强度和冲击强度较纯尼龙6的分别提高34.5%和12.5%,DP3的最大拉伸强度和冲击强度分别提高18.2%和45.7%.这表明两种纳米SiO2均可以有效地提高尼龙6的力学性能和热稳定性;可以推测,纳米SiO2的增强效应与其在尼龙6基体材料中的分散和界面作用有关.

关键词：原位聚合法纳米SiO2 尼龙6 纳米复合材料力学性能热稳定性

Evolution of melt convection in a liquid metal driven by a pulsed electric current

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Chinese Physics B 2021年第8期30卷 424-432页

作者： Yanyi xu Yunhu Zhang Tianqing Zheng Yongyong Gong Changjiang Song Hongxing Zheng qijie Zhai Center for Advanced Solidification Technology Shanghai UniversityShanghai 200072China College of Science Shanghai UniversityShanghai 200444China

Gain refinement in metal alloy can be achieved by applying an electric current pulse(ECP)in solidification *** flow inside the melt has been proved to be a key role in grain *** this paper,the fluid flow inside Ga 20 wt%-In 12 wt%-Sn alloy induced by a damping sinusoidal ECP flowing through two parallel electrodes into the cylindrical melt was investigated by both experimental measurements and numerical *** results showed that a strong descending jet was induced beneath the bottom of electrodes under the application of ***,it was found that flow intensity increases with the increase of amplitude,frequency,and pulse width,*** order to unlock the formation mechanism of flow pattern and the relevance of flow intensity varied with electrical parameters,a three-dimensional numerical model under the application of ECP was ***,a comparative study was conducted by numerical simulations to reveal the distributions of electromagnetic fields and forced *** results showed that the downward Lorentz force induced by ECP was concentrated beneath the bottom of *** downward Lorentz force induces a descending jet and provokes a global forced *** to numerical simulations,the evolution of flow intensity with electrical parameters under the application of ECP can be understood by the time averaged impulse of Lorentz force.

关键词： pulsed electric current flow measurement numerical simulation magnetohydrodynamics

Bone-targeted pH-responsive cerium nanoparticles for anabolic therapy in osteoporosis

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Bioactive Materials 2021年第12期6卷 4697-4706页

作者： Ce Dou Jianmei Li Jian He Fei Luo Tao Yu qijie Dai Yueqi Chen Jianzhong xu Xiaochao Yang Shiwu Dong Department of Orthopedics Southwest HospitalThird Military Medical University(Army Medical University)Chongqing400038China Department of Biomedical Materials Science Third Military Medical University(Army Medical University)Chongqing400038China State Key Laboratory of Trauma Burns and Combined InjuryThird Military Medical University(Army Medical University)Chongqing400038China

Antiresorptive drugs are widely used for treatment of osteoporosis and cancer bone metastasis,which function mainly through an overall inhibition of ***,not all osteoclasts are“bone eaters”;preosteoclasts(pOCs)play anabolic roles in bone formation and angiogenesis through coupling with osteoblasts and secreting platelet derived growth factor-BB(PDGF-BB).In this study,a bone-targeted pH-responsive nanomaterial was designed for selectively eliminating mature osteoclasts(mOCs)without affecting *** cerium nano-system(CNS)was guided to the acidic extracellular microenvironment created by mOCs and gained oxidative enzymatic *** CNS decreased the viability of mOCs through accumulating intracellular reactive oxygen species and enhancing calcium ***-acid secreting anabolic pOCs were thus preserved and kept producing PDGF-BB,which lead to mesenchymal stem cell osteogenesis and endothelial progenitor cell angiogenesis via PI3K-Akt activated focal adhesion *** treating osteoporotic ovariectomized mice,CNS showed better protective effects compare with the current first line antiresorptive drug due to the better anabolic effects marked by higher level of bone formation and *** provided a novel anabolic therapeutic strategy in treating bone disorders with excessive bone resorption.

关键词： pH-responsive Nanomedicine Bone Osteoclast Anabolic therapy

PREPARATION OF MESOPOROUS SILICA PILLARED LAYERED TITANONIOBATE WITH A HIGH INTERLAYER DISTANCE AND SPECIFIC SURFACE AREA

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南京大学学报(自然科学) 1999年第5期 631-633页

作者： xu Lin Hou Wenhua Yan qijie (Department of Chemistry,Nanjing University,210093, Nanjing, PRC)

Ｒｅｃｅｎｔｌｙ，ａｎｅｗｋｉｎｄｏｆｉｎｏｒｇａｎｉｃｐｏｒｏｕｓｍａｔｅｒｉａｌ—ｐｉｌｌａｒｅｄｌａｙｅｒｅｄｍｅｔａｌｏｘｉｄｅｗａｓｄｅｖｅｌｏｐｅｄ．Ｃｏｍｐａｒｅｄｗｉｔｈｔｒａｄｉｔｉｏｎａｌｐｉｌ... 详细信息

Ｒｅｃｅｎｔｌｙ，ａｎｅｗｋｉｎｄｏｆｉｎｏｒｇａｎｉｃｐｏｒｏｕｓｍａｔｅｒｉａｌ—ｐｉｌｌａｒｅｄｌａｙｅｒｅｄｍｅｔａｌｏｘｉｄｅｗａｓｄｅｖｅｌｏｐｅｄ．Ｃｏｍｐａｒｅｄｗｉｔｈｔｒａｄｉｔｉｏｎａｌｐｉｌｌａｒｅｄｃｌａｙｓａｎｄｍｅｔａｌｐｈｏｓｐｈａｔｅｓ［１，２］，ｔｈｉｓｋｉｎｄｏｆｐｉｌｌａｒｅｄｍａｔｅｒｉａｌｓｃａｎｐｒｏｖｉｄｅｍｏｒｅｖｅｒｓａｔｉｌｅｓｔｒｕｃｔｕｒａｌａｎｄｐｈｙｓｉｃａｌｐｒｏｐｅｒｔｉｅｓ，ｗｈｉｃｈｉｎｔｕｒｎｗｉｌｌｆｉｎｄｗｉｄｅａｐｐｌｉｃａｔｉｏｎｉｎｓｕｃｈａｒｅａｓａｓｃａｔａｌｙｓｉｓ，ｓｏｒｐｔｉｏｎａｎｄｓｏｏｎ．Ｂｕｔ，ｕｎｌｉｋｅｔｈｅｌａｙｅｒｅｄｃｌａｙ，ｔｈｅｌａｙｅｒｅｄｍｅｔａｌｏｘｉｄｅｓａｒｅｕｓｕａｌｌｙｎｏｔｓｗｅｌｌａｂｌｅｉｎａｑｕｅｏｕｓｓｏｌｕｔｉｏｎｄｕｅｔｏｔｈｅｉｒｈｉｇｈｌａｙｅｒｃｈａｒｇｅｄｅｎｓｉｔｙ，ｗｈｉｃｈｐｒｅｖｅｎｔｓｔｈｅｄｉｒｅｃｔｆａｃｉｌｅｉｏｎｅｘｃｈａｎｇｅｏｆｌａｒｇｅｉｎｏｒｇａｎｉｃｏｘｏｃａｔｉｏｎｓｔｏｇｅｔｔｈｅｒｍｏｓｔａｂｌｅｐｉｌｌａｒｅｄｍａｔｅｒ...

关键词： Mesoporous Layered titanoniobate Silica pillared Preparation

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浙北地区籼稻准低温储藏应用工艺研究

粮食储藏 2019年第4期48卷 7-13页

作者：闵炎芳张坚张学良王飞李孟泽周华付鹏程刘胜强许启杰周绪霞中央储备粮湖州直属库有限公司 313000 中储粮成都储藏研究院有限公司 610000 浙江工业大学食品工程与质量控制研究所 310014

浙北地区夏季高温时间长,稻谷储藏受环境影响大,为延缓稻谷储藏品质变化,中储粮湖州直属库开展了内环流均温、墙体'热皮'控温与储粮风管机空调补冷三结合的综合控温应用试验,研究工艺参数和运行效果,结果表明:三项技术综合应用,可以将... 详细信息

浙北地区夏季高温时间长,稻谷储藏受环境影响大,为延缓稻谷储藏品质变化,中储粮湖州直属库开展了内环流均温、墙体'热皮'控温与储粮风管机空调补冷三结合的综合控温应用试验,研究工艺参数和运行效果,结果表明:三项技术综合应用,可以将经隔热改造的高大平房仓的仓温和最高粮温均控制在25℃以下,在高温季节通过内环流控温结合空调控温技术,可以有效抑制'热皮'层稻谷粮温过快上升;开启内环流控温后,能够有效控制高温粮的产生,延缓粮食品质的变化,预期可达到保质增效的目的;与传统的专用空调相比,可进一步降低能耗,降本增效明显。

关键词：储粮专用风管墙体“热皮”控温内环流均温

基于单细胞转录组测序分析骨关节炎软骨细胞分化的分子机制

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生物骨科材料与临床研究 2024年第1期21卷 1-6,13页

作者：徐文飞梅其杰明春玉段戡袁长深郭锦荣胡琪曾超梁晓辉广西中医药大学第一附属医院四肢骨伤科广西南宁530023 广西中医药大学附属瑞康医院老年病科广西南宁530011 湖南中医药大学第二附属医院创伤骨科湖南长沙410005

目的深度分析骨关节炎(osteoarthritis,OA)软骨细胞分化的单细胞转录组数据,探究其关键性靶基因及分子机制,为临床靶向治疗骨关节炎提供分子理论依据。方法从GEO数据库下载数据集(GSE104782),包含10个骨关节炎样本及1464个软骨单细胞测... 详细信息

目的深度分析骨关节炎(osteoarthritis,OA)软骨细胞分化的单细胞转录组数据,探究其关键性靶基因及分子机制,为临床靶向治疗骨关节炎提供分子理论依据。方法从GEO数据库下载数据集(GSE104782),包含10个骨关节炎样本及1464个软骨单细胞测序结果,运用R语言分析软骨细胞分化中关键Marker基因,并采用质控和数据过滤、PCA、TSNE、细胞轨迹、GO、KEGG信号通路及蛋白互助网络分析揭示软骨细胞分化机制。结果该数据集共包含基因17380种、20个主成分、9种细胞类型、1886个Marker基因及6种分化途径,其中软骨祖细胞为软骨最早分化细胞。GO分析涉及软骨发育、结缔组织发育等生物过程;涉及含胶原蛋白细胞外基质、内质网内腔等细胞组分;涉及肝素结合、糖胺聚糖结合等分子功能。KEGG通路分析涉及蛋白质消化吸收、ECM受体相互作用、人乳头瘤病毒感染、补体与凝血级联反应、PI3K-Akt信号通路等信号通路。运用Cytoscape 3.7.2软件获得5个关键Marker基因(COL1A1、COL2A1、VEGFA、COL1A2、DCN)。结论运用单细胞转录组测序发现骨关节炎软骨细胞共有6种分化途径及多种Marker基因的潜在特征,进一步从单细胞角度阐述骨关节炎的发病机制。

关键词：骨关节炎软骨细胞单细胞转录组测序分子机制

Neural-Network-Based Model Reference Adaptive Control

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Neural-Network-Based Model Reference Adaptive Control

基于PVC基体的铵离子敏感膜制备及性能表征

计算机，通信，控制与电力工程国际会议

作者： xu Jianmin Zhou qijie T.P.Leung Dept.of Automation South China University of Technology Dept.of Mechanical & Marine Engineering Hong Kong Polytecnic

This paper presents the learning algorithm of neural network being applied to identification of the affine nonlinear system,and proposes a neural-network-based model reference adaptive control *** theorems on exponent... 详细信息

关键词： neural network BP algorithm affine nonlinear system model reference adaptive control

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电力科技与环保 2024年第4期40卷 416-426页

作者：雒建中柏源韦飞周香刘田田梅蓉金奇杰徐海涛闫新龙林正根国家能源投资集团有限责任公司北京100011 国电环境保护研究院有限公司江苏南京210031 国家能源集团科学技术研究院有限公司江苏南京210023 南京工业大学环境科学与工程学院江苏南京211816 中国矿业大学化工学院江苏徐州221116

铵离子选择电极是电厂脱硫废水氨氮检测传感器的核心部件,而铵离子敏感膜是影响传感器电极性能的关键因素。为获得性能较好的铵离子敏感膜,本文以PVC为敏感膜基体,针对增塑剂、离子添加剂和离子载体的这3种添加剂的组合变化筛选最佳配... 详细信息

铵离子选择电极是电厂脱硫废水氨氮检测传感器的核心部件,而铵离子敏感膜是影响传感器电极性能的关键因素。为获得性能较好的铵离子敏感膜,本文以PVC为敏感膜基体,针对增塑剂、离子添加剂和离子载体的这3种添加剂的组合变化筛选最佳配方组合,并表征和分析其对电极响应性能的影响,以及敏感膜性能参数的变化规律,同时考察了Li^(+)、Na^(+)等9类干扰离子对电极选择性及抗干扰能力的影响。结果表明:敏感膜的最佳配方为50%邻苯二甲酸二丁酯+0.75%四(4-氯苯基)硼酸钾+1.20%无活菌素,基底PVC与邻苯二甲酸二丁酯的质量比为1:1,与溶剂四氢呋喃的质量比为1:20。该配方下敏感膜的探测下限为1.26×10^(-5)mol/L;当氯化铵溶液浓度大于0.001 mol/L时,响应时间为0.5~2.0s;浓度小于0.001 mol/L时,响应时间则延长至约5 s;重现性测试显示,相对标准偏差均小于2%;电极寿命超过90 d,性能良好。多种表征结果显示膜具有无定形的微观结构,各组分良好的相容性有利于强化NH+4的响应稳定性。加入增塑剂和离子添加剂后,离子载体的主要结构未发生明显改变,膜的完整性能够保持;9类离子选择性系数均小于0,干扰性均较小。其中K^(+)干扰最大,可以通过K+浓度修正方程解决,从而提高氨氮检测的准确性。

关键词：脱硫废水铵离子选择电极敏感膜增塑剂电极性能

Conditional reprogramming:next generation cell culture

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Acta Pharmaceutica Sinica B 2020年第8期10卷 1360-1381页

作者： Xiaoxiao Wu Shengpeng Wang Mingxing Li Jing Li Jing Shen Yueshui Zhao Jun Pang Qinglian Wen Meijuan Chen Bin Wei Parham Jabbarzadeh Kaboli Fukuan Du qijie Zhao Chi Hin Cho Yitao Wang Zhangang Xiao xu Wu Laboratory of Molecular Pharmacology Department of PharmacologySchool of PharmacySouthwest Medical UniversityLuzhou 646000China South Sichuan Institute of Translational Medicine Luzhou 646000China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoChina Department of Oncology and Hematology Hospital(T.C.M)Affiliated to Southwest Medical UniversityLuzhou 646000China Center of Radiation Oncology Hospital(T.C.M)Affiliated to Southwest Medical UniversityLuzhou 646000China Department of Oncology the Affiliated Hospital of Southwest Medical UniversitySouthwest Medical UniversityLuzhou 646000China College of Pharmaceutical Science&Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals Zhejiang University of TechnologyHangzhou 310014China School of Biomedical Sciences Faculty of Medicinethe Chinese University of Hong KongHong KongChina

Long-term primary culture of mammalian cells has been always difficult due to unavoidable senescence. Conventional methods for generating immortalized cell lines usually require manipulation of genome which leads to change of important biological and genetic characteristics. Recently, conditional reprogramming(CR) emerges as a novel next generation tool for long-term culture of primary epithelium cells derived from almost all origins without alteration of genetic background of primary cells. CR cocultures primary cells with inactivated mouse 3T3-J2 fibroblasts in the presence of RHO-related protein kinase(ROCK) inhibitor Y-27632, enabling primary cells to acquire stem-like characteristics while retain their ability to fully differentiate. With only a few years’ development, CR shows broad prospects in applications in varied areas including disease modeling, regenerative medicine, drug evaluation, drug discovery as well as precision medicine. This review is thus to comprehensively summarize and assess current progress in understanding mechanism of CR and its wide applications, highlighting the value of CR in both basic and translational researches and discussing the challenges faced with CR.

关键词： culture epithelium programming