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ATP6AP2,a regulator of LRP6/β-catenin protein trafficking,promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner

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Bone Research 2024年第2期12卷 453-468页

作者： Lei xiong Hao-Han Guo Jin-Xiu Pan Xiao Ren Daehoon Lee Li Chen Lin Mei Wen-Cheng xiong Department of Neurosciences School of MedicineCase Western Reserve UniversityClevelandOH 44106USA Louis Stoke VA Medical Center ClevelandOH 44106USA

Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types,including osteoblast(OB)differentiation and *** how Wnt/β-catenin signaling is regulated in OBs remain ***6AP2,an accessory subunit of V-ATPase,plays important roles in multiple cell types/organs and multiple signaling ***,little is known whether and how ATP6AP2 in OBs regulates Wnt/β-catenin signaling and bone *** we provide evidence for ATP6AP2 in the OB-lineage cells to promote OB-mediated bone formation and bone homeostasis selectively in the trabecular bone *** knocking out(CKO)ATP6AP2 in the OB-lineage cells(Atp6ap2^(Ocn-Cre))reduced trabecular,but not cortical,bone formation and bone *** and cellular biochemical studies revealed that LRP6 and N-cadherin were reduced in ATP6AP2-KO BMSCs and OBs,but not *** in vitro and in vivo studies revealed impairedβ-catenin signaling in ATP6AP2-KO BMSCs and OBs,but not osteocytes,under both basal and Wnt stimulated conditions,although LRP5 was decreased in ATP6AP2-KO osteocytes,but not *** cell biological studies uncovered that osteoblastic ATP6AP2 is not required for Wnt3a suppression ofβ-catenin phosphorylation,but necessary for LRP6/β-catenin and N-cadherin/β-catenin protein complex distribution at the cell membrane,thus preventing their *** of activeβ-catenin diminished the OB differentiation deficit in ATP6AP2-KO *** together,these results support the view for ATP6AP2 as a critical regulator of both LRP6 and N-cadherin protein trafficking and stability,and thus regulatingβ-catenin levels,demonstrating an un-recognized function of osteoblastic ATP6AP2 in promoting Wnt/LRP6/β-catenin signaling and trabecular bone formation.

关键词： LRP6 impaired organs

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New Upper Bounds for the Inverse of H-Matrices Including S-SDD Matrices and Linear Complementarity Problems

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Journal of Mathematical Research with Applications 2024年第2期44卷 170-186页

作者： Yebo xiong Department of Mathematics and Statistics Hunan First Normal University

A partition reduction method is used to obtain new upper bounds for the inverses of H-matrices and S-strictly diagonally dominant(S-SDD) matrices. The estimates are expressed via the determinants of third order matrices. Numerical experiments with various random matrices show that they are stable and better than the estimates presented in literatures. We use these upper bounds to improve known error estimates for linear complementarity problems with H-matrices and S-SDD matrices.

关键词： linear complementarity problem error bound upper bound S-SDD matrices H-matrice

Performance Characterization of CR/PU Asphalt for Potential Application in Assembled Fast-Repairing Engineering

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Fluid Dynamics & Materials Processing 2024年第5期20卷 1063-1074页

作者： Hong Pang Ao Lu Ming xiong Chen Chen Xian Cao xiong Xu Jing Wang Hubei Regional Management Headquarters CCCC Asset Management Co.Ltd.Beijing101399China School of Civil Engineering and Architecture Wuhan Institute of TechnologyWuhan430073China Hubei Provincial Engineering Research Center for Green Civil Engineering Materials and Structures Wuhan Institute of TechnologyWuhan430073China

Conventional repairing methods for asphalt pavement have some inconveniences,such as insufficient strength,and are typically *** address these issues,this study proposes a new technological method to design and prepare a high-performance assembled asphalt concrete block for fast repair of the potholes.A series of composite modified asphalt binders with 10%crumb rubber(CR)and different dosages(0%,1%,3%,5%)of polyurethane(PU)are examined to determine the optimized ***,the corresponding asphalt mixtures are prepared for further comparison and assessment of engineering properties,such as moistureinduced damage,high-temperature deformation,and low-temperature cracking *** test results show that PU can significantly improve the high-temperature performance and hardness of(crumb rubber modified asphalt)CRMA binder;3%PU contributes allowing the resistance of CRMA mixture to moisture-induced damage at higher levels,particularly under water whole immersion;as 3%PU is added,the high-temperature rutting deformation resistance of the CRMA mixture increases significantly,and the low-temperature anti-cracking properties are also improved ***,the innovatively designed high-quality assembled fast-repairing asphalt concrete block is recommended as an appropriate option for highway maintenance.

关键词： Composite modified asphalt crumb rubber polyurethane assembled fast-repairing asphalt concrete maintenance engineering

Activation of leukotriene B_(4)receptor 1 is a prerequisite for complement receptor 3-mediated antifungal responses of neutrophils

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Cellular & Molecular Immunology 2024年第3期21卷 245-259页

作者： Yan Xin Sihan xiong Linghong Zhou Xin Lin Institute for Immunology and School of Medicine Tsinghua University100084BeijingChina Tsinghua University-Peking University Center for Life Sciences 100084BeijingChina Department of Infectious Diseases Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency ResponseNational Medical Center for Infectious DiseasesHuashan HospitalFudan UniversityShanghai200040China

Invasive fungal infections are life-threatening,and neutrophils are vital cells of the innate immune system that defend against *** role of LTA4H-LTB_(4)-BLT1 axis in regulation of neutrophil responses to fungal infection remains poorly ***,we demonstrated that the LTA4H-LTB_(4)-BLT1 axis protects the host against Candida albicans and Aspergillus fumigatus,but not Cryptococcus neoformans infection,by regulating the antifungal activity of *** results show that deleting Lta4h or Blt1 substantially impairs the fungal-specific phagocytic capacity of ***,defective activation of the spleen tyrosine kinase(Syk)and extracellular signal-related kinase(ERK1/2)pathways in neutrophils accompanies this ***,BLT1 regulates CR3-mediated,β-1,3-glucan-induced neutrophil phagocytosis,while a physical interaction with CR3 with slight influence on its dynamics is *** findings thus demonstrate that the LTA4H-LTB_(4)-BLT1 axis is essential for the phagocytic function of neutrophils in host antifungal immune response against Candida albicans and Aspergillus fumigatus.

关键词： LTA4H BLT1 Phagocytosis Complement receptor 3 Fungi

A Survey of Knowledge Graph Construction Using Machine Learning

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 225-257页

作者： Zhigang Zhao xiong Luo Maojian Chen Ling Ma School of Computer and Communication Engineering University of Science and Technology BeijingBeijing100083China Shunde Innovation School University of Science and Technology BeijingFoshan528399China Beijing Key Laboratory of Knowledge Engineering for Materials Science Beijing100083China

Knowledge graph(KG)serves as a specialized semantic network that encapsulates intricate relationships among real-world entities within a structured *** framework facilitates a transformation in information retrieval,transitioning it from mere string matching to far more sophisticated entity *** this transformative process,the advancement of artificial intelligence and intelligent information services is ***,the role ofmachine learningmethod in the construction of KG is important,and these techniques have already achieved initial *** article embarks on a comprehensive journey through the last strides in the field of KG via machine *** a profound amalgamation of cutting-edge research in machine learning,this article undertakes a systematical exploration of KG construction methods in three distinct phases:entity learning,ontology learning,and knowledge ***,a meticulous dissection of machine learningdriven algorithms is conducted,spotlighting their contributions to critical facets such as entity extraction,relation extraction,entity linking,and link ***,this article also provides an analysis of the unresolved challenges and emerging trajectories that beckon within the expansive application of machine learning-fueled,large-scale KG construction.

关键词： Knowledge graph(KG) semantic network relation extraction entity linking knowledge reasoning

A Hierarchical LSTM-Based Vehicle Trajectory Prediction Method Considering Interaction Information

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Automotive Innovation 2024年第1期7卷 71-81页

作者： Haitao Min Xiaoyong xiong Pengyu Wang Zhaopu Zhang State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130012China

Trajectory prediction is an essential component in autonomous driving systems,as it can forecast the future movements of surrounding vehicles,thereby enhancing the decision-making and planning capabilities of autonomous driving *** models relying on constant acceleration and constant velocity often experience a reduction in prediction accu-racy as the forecasted timeframe *** limitation makes it challenging to meet the demands for medium to long-term trajectory ***,data-driven models,particularly those based on Long Short-Term Memory(LSTM)neural networks,have demonstrated superior performance in medium to long-term trajectory ***,this study introduces a hierarchical LSTM-based method for vehicle trajectory *** the difficulty of using a single LSTM model to predict trajectories for all driving intentions,the trajectory prediction task is decomposed into three sequential steps:driving intention prediction,lane change time prediction,and trajectory ***,given that the driving intent and trajectory of a vehicle are always subject to the influence of the surrounding traffic flow,the predictive model proposed in this paper incorporates the interactional information of neighboring vehicle movements into the model *** proposed method is trained and validated on the real vehicle trajectory dataset Next Generation *** results show that the proposed hierarchical LSTM method has a lower prediction error compared to the integral LSTM model.

关键词： Autonomous vehicles Trajectory prediction Long Short-Term Memory Driving intention prediction

Updated roles of the gut microbiota in exploring shrimp etiology, polymicrobial pathogens, and disease incidence

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Zoological Research 2024年第4期45卷 910-923页

作者： Jin-Bo xiong Hao-Nan Sha Jiong Chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products School of Marine SciencesNingbo UniversityNingboZhejiang 315211China Key Laboratory of Aquacultural Biotechnology Ministry of EducationSchool of Marine SciencesNingbo UniversityNingboZhejiang 315211China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesNingbo UniversityNingboZhejiang 315211China

Litopenaeus vannamei is the most extensively cultured shrimp species globally,recognized for its scale,production,and economic ***,its aquaculture is plagued by frequent disease outbreaks,resulting in rapid and massive *** research often lags behind the emergence of new diseases,leaving the causal agents of some shrimp diseases unidentified and leading to nomenclature based on symptomatic presentations,especially in cases involving co-and polymicrobial *** data on shrimp disease statuses remain *** this review,we summarize current knowledge on shrimp diseases and their effects on the gut ***,we also propose a workflow integrating primary colonizers,“driver”taxa in gut networks from healthy to diseased states,disease-discriminatory taxa,and virulence genes to identify potential polymicrobial *** examine both abiotic and biotic factors(e.g.,external and internal sources and specific-disease effects)that influence shrimp gut microbiota,with an emphasis on the“holobiome”concept and common features of gut microbiota response to diverse *** excluding the effects of confounding factors,we provide a diagnosis model for quantitatively predicting shrimp disease incidence using disease common-discriminatory taxa,irrespective of the causal *** to the conservation of functional genes used in designing specific primers,we propose a practical strategy applying qPCR-assayed abundances of disease common-discriminatory functional *** review updates the roles of the gut microbiota in exploring shrimp etiology,polymicrobial pathogens,and disease incidence,offering a refined perspective for advancing shrimp aquaculture health management.

关键词： Shrimp disease Gut microbiota Polymicrobial pathogens Diagnosis model Disease common-discriminatory taxa Disease prediction

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Thiazoloisoindigo-based Polymer Semiconductors: Synthesis,Structure-Property Relationship, Charge Carrier Polarity, and Field-Effect Transistor Performance

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Chinese Journal of Polymer Science 2024年第1期42卷 24-31,I0006页

作者： Bo-Wen Li Miao xiong Mei-Hua Liu Zhi-Gao Li Long Sang Zi-Han xiong Biao Xiao Jian Pei Xiao-Bo Wan Key Laboratory of Optoelectronic Chemical Materials and Devices Ministry of EducationSchoolofOptoelectronic Materials&TechnologyJianghan UniversityWuhan430056China Bejing National Laboratoryfor Molecular Sciences the Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Developing new polymeric semiconductors with excellent device performance is essential for organic electronics. Herein, we synthesized two new thiazoloisoindigo(Tz II)-based polymers, namely, P(Tz II-d Th-d Th) and P(Tz II-d Th-d Tz), by copolymerizing thiophene-flanked Tz II with bithiophene and bithiazole, respectively. Owing to the more electron-deficient nature of bithiazole than bithiophene, P(Tz II-d Th-d Tz)possesses deeper LUMO/HOMO levels of-3.45/-5.47 e V than P(Tz II-d Th-d Th)(-3.34/-5.32 e V). The organic field-effect transistor(OFET) devices based on P(Tz II-d Th-d Th) exhibited p-type behaviors with an average hole mobility value as high as 1.43 cm^(2)·V^(-1)·s^(-1), while P(Tz II-d Th-d Tz)showed typical ambipolar characteristics with average hole and electron mobilities of 0.38 and 0.56 cm^(2)·V^(-1)·s^(-1). In addition, we compared the performances of both polymers with other Tz II-based polymers reported in our previous work, and showed that the charge carrier polarity can be manipulated by adjusting the number of the thiophene units between the acceptor unit. As the increase of the number of thiophene rings,charge carrier polarity shifts from electron-dominated ambipolar transport to hole-dominated ambipolar transport and then to unipolar hole transport in OFETs, which provides an effective molecular design strategy for further optimization of polymer OFET performance.

关键词： Field-effect transistor Charge carrier polarity Thiazoloisoindigo

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MEMS reservoir computing system with stiffness modulation for multi-scene data processing at the edge

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Microsystems & Nanoengineering 2024年第3期10卷 421-432页

作者： Xiaowei Guo Wuhao Yang Xingyin xiong Zheng Wang Xudong Zou The State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijingChina School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijingChina QILU Aerospace Information Research Institute JinanChina

Reservoir computing(RC)is a bio-inspired neural network structure which can be implemented in hardware with *** has been applied across various fields such as memristors,and electrochemical reactions,among which the microelectro-mechanical systems(MEMS)is supposed to be the closest to sensing and computing *** previous MEMS RCs have demonstrated their potential as reservoirs,the amplitude modulation mode was found to be inadequate for computing directly upon *** achieve this objective,this paper introduces a novel MEMS reservoir computing system based on stiffness modulation,where natural signals directly influence the system stiffness as *** this innovative concept,information can be processed locally without the need for advanced data collection and *** present an integrated RC system characterized by small volume and low power consumption,eliminating complicated setups in traditional MEMS RC for data discretization and *** simulation and experiment were conducted on our *** performed nonlinearity tuning for the resonator and optimized the post-processing algorithm by introducing a digital mask ***,our MEMS RC is capable of both classification and forecasting,surpassing the capabilities of our previous non-delay-based *** method successfully processed word classification,with a 99.8%accuracy,and chaos forecasting,with a 0.0305 normalized mean square error(NMSE),demonstrating its adaptability for multi-scene data *** work is essential as it presents a novel MEMS RC with stiffness modulation,offering a simplified,efficient approach to integrate sensing and *** approach has initiated edge computing,enabling emergent applications in MEMS for local computations.

关键词： computing hardware stiffness