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Consensus on rapid screening for prodromal Alzheimer's disease in China

General Psychiatry 2024年第1期37卷 1-16页

作者： Lin Huang Qinjie Li Yao Lu Fengfeng Pan Liang Cui Ying Wang Ya Miao Tianlu Chen Yatian Li Jingnan Wu Xiaochun Chen Jianping Jia qihao guo Department of Gerontology Shanghai Sixth People's Hospital Afiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina shanghai BestCovered ShanghaiChina ADepartment of Neurology Fujan Medical University Union HospitalFuzhouChina Department of Neurology National Clinical Research Center for Geriatric DiseasesBeijingChina

Alzheimer's disease(AD)is a common cause of dementia,characterised by cerebral amyloid-βdeposition,pathological tau and *** prodromal stage of AD(pAD)refers to patients with mild cognitive impairment(MCl)and evidence of AD's *** this stage,disease-modifying interventions should be used to prevent the progression to *** the inherent heterogeneity of MCl,more specific biomarkers are needed to elucidate the underlying AD's *** the uses of cerebrospinal fluid and positron emission tomography are widely accepted methods for detecting AD's pathology,their clinical applications are limited by their high costs and invasiveness,particularly in low-income areas in ***,to improve the early detection of Alzheimer's disease(AD)pathology through cost-effective screening methods,a panel of 45neurologists,psychiatrists andgerontologistswas invited to establish a formal consensus on the screening of pAD in *** supportive evidence and grades of recommendations are based on a systematic literature review andfocus group *** meetings were held to allow participants to review,vote and provide their expert opinions to reach a consensus.A majority(two-thirds)decision was used for questions for which consensus could not be *** screening methods are presented in this publication,including neuropsychological assessment,peripheral biomarkers and brain *** addition,a general workflow for Screening pAD in China is established,which will help clinicians identify individuals at high risk and determine therapeutic targets.

关键词： Alzheimer income screening

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7T MRI在阿尔茨海默病中的研究进展

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中华神经医学杂志 2024年第4期23卷 417-420页

作者：张臻郭起浩上海交通大学医学院附属第六人民医院老年病科上海200233

阿尔茨海默病(AD)是机体认知功能障碍最常见的病因。除临床诊断之外,AD的病理改变也被认为是其发病机制研究及新药开发研究的"金标准"。根据AD研究框架,神经退行性变发生在β-淀粉样蛋白和Tau蛋白沉积之后、认知功能下降之前。但因中低... 详细信息

阿尔茨海默病(AD)是机体认知功能障碍最常见的病因。除临床诊断之外,AD的病理改变也被认为是其发病机制研究及新药开发研究的"金标准"。根据AD研究框架,神经退行性变发生在β-淀粉样蛋白和Tau蛋白沉积之后、认知功能下降之前。但因中低场强MRI技术的局限性,目前所能确定的神经退行性变的影像学特征大多出现在AD病程中晚期,难以成为早期预警信号。7T MRI是目前可用的最高场强的MRI技术,其高分辨率和高灵敏度使得早期检测神经退行性变成为可能。本文现围绕7T MRI在AD疾病谱中及与AD相关的脑结构中的最新研究进展进行综述,以期帮助临床同道进一步探索和完善7T MRI在AD研究中的应用。

关键词：阿尔茨海默病 7T MRI 神经退行性变

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Clustering and switching during a semantic verbal fluency test contribute to differential diagnosis of cognitive impairment

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Neuroscience Bulletin 2013年第1期29卷 75-82页

作者： Qianhua Zhao qihao guo Zhen Hong Department of Neurology Huashan Hospital Fudan University

The verbal fluency test （VFT） can be dissociated into ＂clustering＂（generating words within subcategories） and ＂switching＂（shifting between clusters）, which may be valuable in differential diagnosis. In the current study, we investigated the validity of VFT in the differential diagnosis of Alzheimer＇s disease （AD, n = 65）, vascular dementia （VaD, n = 65）, mild cognitive impairment （MCI, n = 92）, and vascular cognitive impairment without dementia （VCIND, n = 76） relative to cognitively normal senior controls （NC, n = 374）. We found that in the NC group, the total correct score was significantly correlated with age and education; males generated more subcategories; cluster size increased with education, and subcategory and switching decreased with age. A significantly progressive advantage was observed in VFT scores in the sequence NC 〉 MCI/VCIND 〉 AD/VaD, and this significantly discriminated dementia patients from the other groups. AD patients performed better in all four VFT scores than VaD patients. Subcategory and switching scores significantly distinguished AD from VaD patients （AD 〉 VaD; mean difference, 0.50 for subcategory, P 〈0.05; 0.71 for switching, P 〈0.05）. MCI patients scored higher than VCIND patients, but the difference did not reach statistical significance. These results suggest that semantic VFT is useful for the detection of MCI and VCIND, and in the differential diagnosis of cognitive impairment.

关键词： Alzheimer’s disease dementia verbal fluency mild cognitive impairment

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^(18)F-Florbetapir PET定量标准化Centiloid及其在中国临床前期阿尔茨海默病队列中的应用

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中华核医学与分子影像杂志 2024年第5期44卷 266-272页

作者：黄琪任树华管一晖崔亮黄琳郭起浩谢芳复旦大学附属华山医院核医学/PET中心上海200030 上海交通大学附属第六人民医院老年科上海200030

目的建立^(18)F-氟贝他吡(Florbetapir)PET图像的SUV比值(SUVR)标准化Centiloid(CL)的公式,并研究中国临床前期阿尔茨海默病(AD)(C-PAS)队列的β-淀粉样蛋白(Aβ)沉积情况。方法利用统计参数图(SPM)12对"Standard PIB"和"Florbetapir Calibration"公开数据库中的11C-匹兹堡化合物B(PIB)和^(18)F-Florbetapir图像进行预处理,得到SUVR标准化为CL的变换公式。回顾性纳入C-PAS队列于2018年10月至2023年8月在复旦大学附属华山医院核医学/PET中心接受^(18)F-Florbetapir PET检查的受试者942例[男357例、女585例,年龄(66.4±8.1)岁],计算其CL值并分析AD、轻度认知障碍(MCI)和认知未受损(CU)组的Aβ阳性率[CL值≤12为Aβ阴性,12

关键词：阿尔茨海默病认知功能障碍淀粉样β肽类乙二醇类噻唑类正电子发射断层显像术

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Neuropsychological features in post-stroke cognitive impairment with no dementia patients with different Traditional Chinese Medicine syndromes

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Journal of Traditional Chinese Medicine 2019年第1期39卷 97-102页

作者： Ma Jie Wang Yu Zhang Yunyun guo qihao Zhen Xiaomin Shi Moyi Department of Neurology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Department of Gerontology Shanghai Jiaotong University Affiliated Sixth People's HospitalShanghai 200233China Internal Medicine of Traditional Chinese Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

OBJECTIVE: To investigate neuropsychological features of post-stroke cognitive impairment with no dementia(PSCIND) patients with different Traditional Chinese Medicine(TCM) ***: We recruited 50 patients with PSCIND between April 2012 and March 2013. Patients were divided into different groups according to TCM classifications. Patients were assessed using neuropsychological tests, including cognitive screening(mini-mental state examination), memory testing (auditory verbal learning test), executive/attention[shape trails test, stroop color-word test(SCWT),reading the mind in the eyes test, the digit ordering test-A(DOT-A), and symbol digit modalities test], language(action naming test, Boston naming test, famous face test, similarity test, and verbal fluency test), and visuospatial functioning [complex figure test(CFT)].RESULTS: We found no significant differences between patients with and without a diagnosis of turbid phlegm blocking the upper orifices on neuropsychological test performance. Patients diagnosed with upper hyperactivity of liver Yang syndrome scored significantly lower on the SCWT-C executive test and the CFT-delayed recall memory test. Patients with excess syndrome scored significantly lower on the SCWT-C executive test, and significantly higher on the DOT-A executive ***: Neuropsychological characteristics differ between PSCIND patients with different TCM classifications.

关键词： Cognitive dysfunction Stroke Syndromes and signs Neuropsychological tests

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The potential impact of clinical factors on blood-based biomarkers for Alzheimer’s disease

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Translational Neurodegeneration 2023年第1期12卷 353-356页

作者： Fengfeng Pan Yan Lu Qi Huang Fang Xie Jingye Yang qihao guo Department of Gerontology Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China PET Center Huashan HospitalFudan UniversityShanghai 200233China

With the development of testing technologies,blood-based biomarkers for Alzheimer’s disease(AD)such as amyloid-β(Aβ),phosphorylated tau(P-tau),and neuro-filament light(NfL)have shown potential value in pre-dicting AD pathology and disease progression[1].To better interpret the detection results,it is essential to understand what factors would affect the concentrations of these *** standardized testing meth-ods may reduce the influence of pre-analytical factors,demographic factors and clinical comorbidities may still affect blood biomarker levels[2,3].Previous studies have shown inconsistent results in this *** example,the apolipoprotein E(APOE)ε4 genotype was associated with a lower Aβ42/Aβ40 ratio in a cohort with different cognitive status but not in a population with or without AD[2,4].In a cohort where most participants had no cognitive impairment,males had higher plasma P-tau levels than females,whereas this was not the case in another group composed mostly of cognitively impaired participants[3,5].

关键词： clinical Alzheimer impaired

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突触囊泡蛋白2A显像剂^(18)F-SynVesT-1在阿尔茨海默病患者中的应用

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中华核医学与分子影像杂志 2024年第5期44卷 291-296页

作者：何坤李骏鹏沙海钱玥王杰黄琪赵军郭起浩管一晖谢芳复旦大学附属华山医院核医学/PET中心上海200235 同济大学附属东方医院核医学科上海200120 上海交通大学附属第六人民医院老年病科上海200233

目的探讨突触囊泡蛋白2A显像剂(4R)-4-(3-[^(18)F]氟苯基-5-氟)-1-[(3-甲基吡啶-4-基)甲基]吡咯烷-2-酮(^(18)F-SynVesT-1)在阿尔茨海默病(AD)患者中的应用价值。方法回顾性纳入2021年12月至2022年12月间于复旦大学附属华山医院行^(18)F... 详细信息

目的探讨突触囊泡蛋白2A显像剂(4R)-4-(3-[^(18)F]氟苯基-5-氟)-1-[(3-甲基吡啶-4-基)甲基]吡咯烷-2-酮(^(18)F-SynVesT-1)在阿尔茨海默病(AD)患者中的应用价值。方法回顾性纳入2021年12月至2022年12月间于复旦大学附属华山医院行^(18)F-SynVesT-1 PET/MR和^(18)F-氟贝他吡(AV45)PET/CT显像的受检者40例,包括20例β-淀粉样蛋白(Aβ)沉积阳性的AD患者[男2例,女18例;年龄(66.4±8.1)岁]和20名Aβ沉积阴性的正常对照[NC;男9例,女11例,年龄(62.6±8.6)岁]。利用统计参数图(SPM)对脑^(18)F-SynVesT-1 PET图像进行预处理。采用两独立样本t检验或Mann-Whitney U检验进行基于ROI的2组间^(18)F-SynVesT-1摄取(突触密度)差异比较,并进行突触密度与认知能力的Spearman秩相关分析。通过构建广义线性模型,采用两样本独立t检验分析2组脑内突触密度差异,进一步构建多重线性回归模型分析^(18)F-SynVesT-1与认知能力的相关性。结果AD患者组相比于NC组,其大脑广泛皮质区域突触密度减低[P<0.05,错误发现率(FDR)校正],其中以内侧颞叶(0.84±0.09和1.04±0.09;t=-6.95,P<0.001)、外侧颞叶(1.15±0.13和1.31±0.08;t=-4.56,P<0.001)和外侧顶叶[1.24(1.04,1.26)和1.32(1.23,1.39);z=-3.25,P=0.001]较为显著;大脑广泛皮质区域的突触密度与简易精神状态检查量表(MMSE)和蒙特利尔认知评估基础量表(MoCA-B)评分呈正相关(P<0.05,FDR校正),其中MMSE和MoCA-B评分与外侧颞叶(rs值:0.71、0.74,均P<0.001)和内侧颞叶(rs值:0.71、0.74,均P<0.001)突触密度存在明显相关性。结论^(18)F-SynVesT-1 PET显像可用于评估大脑突触密度;AD患者脑内表现为大脑广泛皮质区域的突触密度降低,且可反映患者认知水平。

关键词：阿尔茨海默病淀粉样β肽类膜糖蛋白类吡咯烷类正电子发射断层显像术磁共振成像

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Thermal performance of cast-in-place piles with artificial ground freezing in permafrost regions

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Journal of Mountain Science 2024年第4期21卷 1307-1328页

作者： WANG Xinbin CHEN Kun YU qihao guo Lei YOU Yanhui JIN Mingyang State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

During the construction of cast-in-place piles in warm permafrost,the heat carried by concrete and the cement hydration reaction can cause strong thermal disturbance to the surrounding *** the bearing capacity of the pile is quite small before the full freeze-back,the quick refreezing of the native soils surrounding the cast-in-place pile has become the focus of the infrastructure construction in *** solve this problem,this paper innovatively puts forward the application of the artificial ground freezing(AGF)method at the end of the curing period of cast-in-place piles in permafrost.A field test on the AGF was conducted at the Beiluhe Observation and Research Station of Frozen Soil Engineering and Environment(34°51.2'N,92°56.4'E)in the Qinghai Tibet Plateau(QTP),and then a 3-D numerical model was established to investigate the thermal performance of piles using AGF under different engineering ***,the long-term thermal performance of piles after the completion of AGF under different conditions was *** experiment results demonstrate that AGF is an effective method to reduce the refreezing time of the soil surrounding the piles constructed in permafrost terrain,with the ability to reduce the pile-soil interface temperatures to below the natural ground temperature within 3 *** results further prove that AGF still has a good cooling effect even under unfavorable engineering conditions such as high pouring temperature,large pile diameter,and large pile ***,the application of this method is meaningful to save the subsequent latency time and solve the problem of thermal disturbance in pile construction in *** research results are highly relevant for the spread of AGF technology and the rapid building of pile foundations in permafrost.

关键词： Permafrost engineering Cast-in-place pile Artificial ground freezing Thermal performance.

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Comprehensive Management of Daily Living Activities,behavioral and Psychological Symptoms,and Cognitive Function in Patients with Alzheimer's Disease:A Chinese Consensus on Alzheimer's Disease

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Neuroscience Bulletin 2021年第7期37卷 1025-1038页

作者： Jianjun Jia Jun Xu Jun Liu Yongjun Wang Yanjiang Wang Yunpeng Cao qihao guo Qiuming Qu Cuibai Wei Wenshi Wei Junjian Zhang Enyan Yu Department of Neurology The Second Medical CenterPeople’s Liberation Army General HospitalBeijing 100853China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China Department of Neurology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Cognitive Impairment Department Shenzhen Kangning HospitalShenzhen 518118China Department of Neurology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Neurology The First Hospital of China Medical UniversityShenyang 210112China Department of Gerontology Shanghai Jiaotong University Affiliated Sixth People’s HospitalShanghai 200233China Department of Neurology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Department of Neurology Xuanwu Hospital Capital Medical UniversityBeijing 100053China Department of Neurology Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Psychology Chinese Academy of Sciences Cancer Hospital of the University of the Chinese Academy of SciencesHangzhou 310022China

Alzheimer's disease(AD)is the most common cognitive disorder in the *** main clinical manifestations are cognitive decline(C),behavioral and psychological symptoms(B),and a decline in the activities of daily living(A),also known as ABC *** identification and evaluation of ABC symptoms are helpful for establishing the accurate diagnosis,comprehensive treatment,and prognosis of *** guide Chinese clinical practice for optimization of the comprehensive management of AD,in 2018,The Academy of Cognitive Disorder of China gathered 22 neurologists and gerontologists in China to build a consensus on the comprehensive management of *** on a review of the evidence,the consensus summarizes the pathogenesis,pathological changes,clinical manifestations,evaluation,diagnosis,drug and non-drug treatment,and patient care for *** group discussion was used to establish a flowchart of comprehensive ABC management for AD *** new consensus provides a feasible AD management process for clinicians.

关键词： Alzheimer’s disease Comprehensive management Activities of daily living Behavioral and psychological symptoms Cognitive function

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Mechanism of action of the bile acid receptor TGR5 in obesity

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Acta Pharmaceutica Sinica B 2024年第2期14卷 468-491页

作者： Weijun Lun qihao Yan Xinghua guo Minchuan Zhou Yan Bai Jincan He Hua Cao Qishi Che Jiao guo Zhengquan Su Guangdong Engineering Research Center of Natural Products and New Drugs Guangdong Provincial University Engineering Technology Research Center of Natural Products and DrugsGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine Key Laboratory of Glucolipid Metabolic DisorderMinistry of Education of ChinaGuangdong TCM Key Laboratory for Metabolic DiseasesGuangdong Pharmaceutical UniversityGuangzhou 510006China School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510310China School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityZhongshan 528458China Guangzhou Rainhome Pharm&Tech Co. Ltd.Science CityGuangzhou 510663China

G protein-coupled receptors(GPCRs)are a large family of membrane protein receptors,and Takeda G protein-coupled receptor 5(TGR5)is a member of this *** a membrane receptor,TGR5 is widely distributed in different parts of the human body and plays a vital role in regulating metabolism,including the processes of energy consumption,weight loss and blood glucose *** studies have shown that TGR5 plays an important role in glucose and lipid metabolism disorders such as fatty liver,obesity and *** the global obesity situation becoming more and more serious,a comprehensive explanation of the mechanism of TGR5 and filling the gaps in knowledge concerning clinical ligand drugs are urgently *** this review,we mainly explain the anti-obesity mechanism of TGR5 to promote the further study of this target,and show the electron microscope structure of TGR5 and review recent studies on TGR5 ligands to illustrate the specific binding between TGR5 receptor binding sites and ligands,which can effectively provide new ideas for ligand research and promote drug research.

关键词： Obesity TGR5 Bile acids Ligand Appetite Metabolism GLP-1 Inflammation

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